CN106579453A - Preparation method of lycium barbarum polysaccharide and lyceum barbarum seed oil soft capsule - Google Patents
Preparation method of lycium barbarum polysaccharide and lyceum barbarum seed oil soft capsule Download PDFInfo
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- CN106579453A CN106579453A CN201611132269.0A CN201611132269A CN106579453A CN 106579453 A CN106579453 A CN 106579453A CN 201611132269 A CN201611132269 A CN 201611132269A CN 106579453 A CN106579453 A CN 106579453A
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- soft capsule
- seed oil
- lycium barbarum
- barbarum polysaccharide
- polysaccharide
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- 239000007901 soft capsule Substances 0.000 title claims abstract description 129
- 235000015112 vegetable and seed oil Nutrition 0.000 title claims abstract description 100
- 239000008518 lycium barbarum polysaccharide Substances 0.000 title claims abstract description 97
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 244000241838 Lycium barbarum Species 0.000 claims abstract description 99
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- 238000003756 stirring Methods 0.000 claims abstract description 58
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of a lycium barbarum polysaccharide and lyceum barbarum seed oil soft capsule. The method comprises the steps that lyceum barbarum seeds are subjected to supercritical carbon dioxide extraction to obtain lyceum barbarum seed oil; meanwhile, lycium barbarum dry fruits are extracted by a water solution; a four-stage ultrafiltration membrane is used for separation to obtain lycium barbarum polysaccharide; the lyceum barbarum seed oil and the lycium barbarum polysaccharide are weighed and are mixed and uniformly stirred to obtain a soft capsule content material, wherein the mixing and uniform stirring are performed in low-temperature environment; gelatin is weighed; water is added for stirring till dissolution; glycerin and an opacifying agent are added for uniform stirring to obtain a soft capsule case material; the soft capsule content material and the soft capsule case material are subjected to bag pressing treatment on pressing equipment to obtain the lycium barbarum polysaccharide and lyceum barbarum seed oil soft capsule. The embodiment provided by the invention has the advantages that two kinds of lycium barbarum nutrition: lycium barbarum polysaccharide and the lyceum barbarum seed oil are extracted for the first time, and are filled into the soft capsule; the nutrition of the soft capsule is more comprehensive; the effect is more obvious; further, the health care function of the soft capsule is effectively enhanced.
Description
Technical field
The present invention relates to biological health technical field, more particularly to a kind of lycium barbarum polysaccharide, the preparation of boxthorn seed oil soft capsule
Method.
Background technology
Mature fruit of the Fructus Lycii for matrimony vine of solanaceae plant, has critical role in traditional medicine, and its medical value is standby
Praised highly by successive dynasties medical expert.According to《Compendium of Materia Medica》Record：Fructus Lycii, kidney-tonifying sperm-generating, nourishing the liver, item, hard essence bone, fatigue taking away, easily
Color, improving eyesight are calmed the nerves, and make us long-lived.Principle active component of the lycium barbarum polysaccharide for medlar biological active function.Modern medicine study
Show, lycium barbarum polysaccharide has the several functions such as regulation immunity, antitumor, resisting fatigue, antioxidation, slow down aging, blood sugar lowering.
Boxthorn seed oil belongs to the Oleic acid-linoleic acid type for having special physiological effect, is a kind of nutritive value and economic worth
All very high vegetable oil, linoleic acid content are up to 66.5%, and contain gamma-linolenic acid, and ω -3 unsaturated fatty acid etc. is mesh
One of front nutritive value highest vegetable oil, containing substantial amounts of nutritional labeling and biological active substanceies, can be used for hypertension,
The auxiliary treatment of the cardiovascular and cerebrovascular diseases such as hyperlipidemia, arteriosclerosis.
Lycium barbarum polysaccharide (LBP, Lycium Bar～barum Polysaccharides) is that a kind of extraction from Fructus Lycii obtains
Water soluble polysaccharide, be one of effective ingredient of Fructus Lycii, and in vegetable polysaccharidess it is rare containing protein-polysaccharide.Divide from Fructus Lycii
From the lycium barbarum polysaccharide for obtaining, it is made up of rhamnose, arabinose, xylose, mannose, galactose, the own carbon sugar of six kinds of glucose
The protein main chain of polysaccharide side chain and 18 kinds of aminoacid compositions, and connected in Glycml-O-Der modes, this glycoprotein tool
There is biological activity, be a kind of immunostimulant of high intensity.
In view of the excellent nutrition of lycium barbarum polysaccharide, boxthorn seed oil and medical value, the present invention is first by both Fructus Lyciis
Nutrition is extracted, and into soft capsule, more comprehensive to obtain nutrition, effect is more significantly for fill.
The content of the invention
The goal of the invention of the present invention is to provide a kind of lycium barbarum polysaccharide, the preparation method of boxthorn seed oil soft capsule, from Fructus Lycii
The two kinds of effective ingredient of lycium barbarum polysaccharide and boxthorn seed oil extracted in product are concentrated in soft capsule, to improve two kinds of effective ingredient
Bioavailability.
Embodiments in accordance with the present invention, there is provided a kind of lycium barbarum polysaccharide, the preparation method of boxthorn seed oil soft capsule, including：
To seed of Fructus Lycii supercritical carbon dioxide extraction, boxthorn seed oil is obtained, while water-soluble extraction is adopted to dried fruit of lycium barbarum, four
Level Ultra filtration membrane obtains lycium barbarum polysaccharide；
The boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring are weighed, soft capsule content material is obtained, it is described mixed
Conjunction stirs；
Weigh gelatin and stirring is added water to dissolving, add glycerol and opacifier to stir, obtain soft capsule shell material；
The soft capsule content material and the soft capsule shell material are carried out pressing capsule to process on press device, Fructus Lycii is obtained
Polysaccharide, boxthorn seed oil soft capsule.
Further, it is described that the soft capsule content material and the soft capsule shell material are carried out into pressure Nang Chu on press device
Reason, the step of obtain lycium barbarum polysaccharide, boxthorn seed oil soft capsule after methods described also include：
By drying of shaping after soft capsule arrangement, qualified, sterilization packaging is checked.
Further, it is described to weigh the boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring, obtain soft capsule content
The step of material, includes：
The boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring are weighed, content mix thing is obtained；
The content mix thing is crossed into colloid mill grinding, soft capsule content material is obtained.
Further, the gelatin that weighs adds water stirring to dissolving, and adds glycerol and opacifier to stir, obtains soft capsule
The step of shell material, includes；
Weigh gelatin and stirring is added water to dissolving, add glycerol and opacifier to stir, obtain shell material mixed material；
By the shell material mixed material, under vacuum environment, degassing process obtains soft capsule shell material.
Further, it is described to include the step of weigh the lycium barbarum polysaccharide and the boxthorn seed oil mixing and stirring：
It is described to weigh described lycium barbarum polysaccharide 5-15 part and boxthorn seed oil 35-100 part mixing and stirrings.
Further, weigh gelatin and stirring is added water to dissolving, add glycerol and opacifier to include the step of stirring：
Gelatin 4-12 is weighed, adds the water of 5-10 parts to stir to dissolving, add 2-5 parts glycerol and the stirring of 1-2 parts opacifier
Uniformly.
Further, the opacifier be ferrum oxide, white carbon black, one or more mixing in titanium dioxide.
Further, water-soluble extraction is adopted to dried fruit of lycium barbarum, the step of level Four Ultra filtration membrane obtains lycium barbarum polysaccharide in, it is described
The purity of lycium barbarum polysaccharide is 35%-65%.
From above technical scheme, the embodiment of the present invention illustrates a kind of lycium barbarum polysaccharide, the preparation of boxthorn seed oil soft capsule
Method, methods described include：To seed of Fructus Lycii supercritical carbon dioxide extraction, boxthorn seed oil is obtained, while adopting to dried fruit of lycium barbarum
Water-soluble extraction, level Four Ultra filtration membrane obtain lycium barbarum polysaccharide；Weigh the boxthorn seed oil and the lycium barbarum polysaccharide is mixed
It is even, soft capsule content material is obtained, the mixing and stirring is carried out at low ambient temperatures；Weigh gelatin stirring is added water to molten
Solution, adds glycerol and opacifier to stir, obtains soft capsule shell material；By the soft capsule content material and the soft capsule shell
Material carries out pressing capsule to process on press device, obtains lycium barbarum polysaccharide, boxthorn seed oil soft capsule.The embodiment of the present invention is first by Fructus Lycii
Polysaccharide and boxthorn seed oil both Chinese-wolfberry nutritives are extracted, and into soft capsule, the soft capsule nutrition is more comprehensive, effect for fill
It is more significantly, and then effectively strengthen the health care of the soft capsule.After soft capsule enters human body, boxthorn seed oil in vivo
Carry lycium barbarum polysaccharide Jing lymph and enter blood, do not affected by first pass effect, directly can play a role, thus produce higher
Bioavailability.
Description of the drawings
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to institute in embodiment
The accompanying drawing that needs are used is briefly described, it should be apparent that, drawings in the following description are only some enforcements of the present invention
Example, for those of ordinary skill in the art, on the premise of not paying creative work, can be being obtained according to these accompanying drawings
Obtain other accompanying drawings.
Fig. 1 be according to one be preferable to carry out exemplifying a kind of lycium barbarum polysaccharide, boxthorn seed oil soft capsule preparation method；
Fig. 2 is according to a flow chart for being preferable to carry out the step of exemplifying S102.
Specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete
Whole description, it is clear that described embodiment is only a part of embodiment of the invention, rather than the embodiment of whole.It is based on
Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of creative work is not made
Embodiment, belongs to the scope of protection of the invention.
The embodiment of the present invention illustrates a kind of lycium barbarum polysaccharide, the preparation method of boxthorn seed oil soft capsule, as shown in figure 1, described
Method includes：
S101 obtains boxthorn seed oil to seed of Fructus Lycii supercritical carbon dioxide extraction, while being carried using water-soluble to dried fruit of lycium barbarum
Take, level Four Ultra filtration membrane obtains lycium barbarum polysaccharide；
S102 weighs the boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring, obtains soft capsule content material, institute
Stating mixing and stirring is carried out at low ambient temperatures；
S103 weighs gelatin and adds water stirring to dissolving, and adds glycerol and opacifier to stir, obtains soft capsule shell material；
The soft capsule content material and the soft capsule shell material are carried out pressing capsule to process on press device by S104, are obtained
Lycium barbarum polysaccharide, boxthorn seed oil soft capsule.
Specifically, boxthorn seed oil is, with the later side-product-seed of Fructus Lycii of medlar fresh fruit extracting juice, through rinsing, to dry, water
Dividing less than 15%, crushing, fineness 40-60 mesh, boxthorn seed oil is extracted through supercritical carbon dioxide extraction method, main component is sub-
Oleic acid 65.3%, Oleic acid 19.1%, and contain gamma-linolenic acid, ω -3 grade higher unsaturated fatty acid.
Fructus Lycii is screened, impurity therein and disease fruit is removed, Fructus Lycii is carried out hot air drying dehydration, after being dried
Fructus Lycii Jing coarse granules crush crusher machine, then Jing three-levels screening separate out sarcocarp powder and seed of Fructus Lycii；Sarcocarp powder is crossed into 20 mesh sieves
After carry out supercritical CO2Extraction；The fluid extraction pressure is 27MPa, and extraction temperature is 50 DEG C, and extraction time is 2.5h；Will
Sarcocarp powder after extraction is put into extraction pot, is subsequently adding pure water and is soaked, and soak time is 6h, and extraction temperature is 57 DEG C；Institute
Pure water consumption is stated for 8 times of sarcocarp powder；Soaked sarcocarp powder is cooled to into 45 DEG C, adds enzyme to carry out insulation 1.5 hours, thenEnterOK
Centrifugation, the filtrate and filtering residue after separation are collected respectively；The addition of the enzyme for sarcocarp silty amount 1.5%；The enzyme
1 is pressed by pectase and cellulase：1 composition；The centrifuge is lined with the filter cloth of 300 mesh；By the filtrate electric osmose after separation
Analysis carries out desalination, salt rejection rate 92%；By the juice after desalination respectively through 200,000,100,000,30,000,10,000 molecular weight ultrafilter membrane,
Again by less than 100,000,10,000 ultrafiltrates derived above carry out reverse osmosis concentration；The ultrafilter membrane adopts polysulfone membrane, the retention of film
Molecular weight is ten thousand dalton of 1-20, and filter pressure is 0.1MPa.Concentration filtrate is carried out into drying bu sublimation, low-temperature grinding, Jing
Lycium barbarum polysaccharide is after packaging.
The concentration of the lycium barbarum polysaccharide is 35%-65%.
The boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring are weighed, soft capsule content material is obtained, it is described mixed
Conjunction stirs；
The mixing and stirring must be carried out under cryogenic, generally less than -15 DEG C.
Research show boxthorn seed oil belong to the Oleic acid-linoleic acid type for having special physiological effect, be a kind of nutritive value and
The all very high vegetable oil of economic worth, linoleic acid content are up to 66.5%, and contain gamma-linolenic acid, ω -3 unsaturated fatty acidss
Acid etc., meanwhile, lycium barbarum polysaccharide is rare containing protein-polysaccharide in vegetable polysaccharidess.The isolated lycium barbarum polysaccharide from Fructus Lycii,
The polysaccharide side chain being made up of rhamnose, arabinose, xylose, mannose, galactose, the own carbon sugar of six kinds of glucose and 18 kinds of amino
The protein main chain of acid composition, and connected in Glycml-O-Der modes, this glycoprotein has biological activity, is a kind of high
The immunostimulant of intensity.By lycium barbarum polysaccharide, both Chinese-wolfberry nutritives are extracted the embodiment of the present invention with the boxthorn seed oil present invention first
Out, into soft capsule, acquisition nutrition is more comprehensive, and effect is more significantly, and then can effectively strengthen the soft capsule for fill
Health care.
The lycium barbarum polysaccharide that the embodiment of the present invention is adopted, if through ptyalin enzyme effect after oral, and monosaccharide is hydrolyzed into,
It is difficult to play its effect；The embodiment of the present invention is packaged in soft capsule jointly using boxthorn seed oil and lycium barbarum polysaccharide；Fructus Lycii in vivo
Seed oil keeper carries lycium barbarum polysaccharide Jing lymph and enters blood, is not affected by first pass effect, thus produces higher bioavailability.
Lycium barbarum polysaccharide, boxthorn seed oil soft capsule shown in the embodiment of the present invention has higher bioavailability and with higher peace
Quan Xing, its bioavailability is also than the high several times of other products on the market.
Weigh gelatin and stirring is added water to dissolving, add glycerol and opacifier to stir, obtain soft capsule shell material；
, it is known that the special physico-chemical property of soft capsule shell material, has a direct impact to the qualitative of soft capsule, such as soft capsule is in storage
Occur seepage and adhesion and mass transport, prolonged disintegration, dissolution during depositing unqualified etc. associated.Therefore, from suitable
Suitable soft capsule shell material, is to solve the problems, such as Stability of Soft Capsules, improves one of key of soft capsule quality.
In visible and ultraviolet region, illumination is larger to the stability influence of lycium barbarum polysaccharide；It is present in solid food
Lycium barbarum polysaccharide is more stable under normal temperature condition, more sensitive to sunlight.
Research simultaneously shows that boxthorn seed oil is to light sensitive.
Two kinds of content materials in the embodiment of the present invention are more sensitive to light application ratio, therefore in order to extend the soft capsule
The holding time embodiment of the present invention adds opacifier in the soft capsule shell material.
The soft capsule content material and the soft capsule shell material carry out pressing capsule to process on press device, obtain Fructus Lycii many
Sugar, boxthorn seed oil soft capsule.
Lycium barbarum polysaccharide, boxthorn seed oil are prepared into soft capsule by the embodiment of the present invention, the effective ingredient (Chinese holly in the soft capsule
Qi polysaccharide, boxthorn seed oil) rate of release, work than injection slow, but than tablet, granule be rapid-action, bioavailability is high.
Liquid soft capsule content material is directly enclosed in soft capsule, and research shows, gelatin epithelium exceedes poly- to oxygen barrier property
More than 30 times of vinyl film.It is highly stable to oxygen in air, air oxidation moisture absorption etc. can be prevented.
The embodiment of the present invention dissolves effective ingredient using boxthorn seed oil simultaneously, and after human body intake, effective ingredient discharges rapidly,
Internal utilization rate, absorbance are high.
Effective ingredient is dissolved using boxthorn seed oil, each effective ingredient homogeneity is good, and content deviation is very low.It is simultaneously of the invention
The abnormal flavour of boxthorn seed oil can be covered using the softgel shell contents of parcel material of soft capsule.
Further, it is described that the soft capsule content material and the soft capsule shell material are carried out into pressure Nang Chu on press device
Reason, the step of obtain lycium barbarum polysaccharide, boxthorn seed oil soft capsule after methods described also include：
Drying of shaping after soft capsule arrangement is checked qualified, sterilization packaging by S105.
Soft capsule is tested, shell deformation, the lycium barbarum polysaccharide that sunken, content overflows, boxthorn seed oil soft capsule is removed.
Further, as shown in Fig. 2 described weigh the boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring, obtain
The step of soft capsule content material, includes：
S1021 weighs the boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring, obtains content mix thing；
The content mix thing is crossed colloid mill grinding by S1022, obtains soft capsule content material；
Specifically, the boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring are weighed, content mix thing is obtained；By institute
State content mix thing and cross colloid mill grinding, the mixture after being ground；
The colloid mill carries out low temperature, miscible, glue to content mixture (boxthorn seed oil and lycium barbarum polysaccharide)
Body mill dispersion, so as to obtain the boxthorn seed oil and lycium barbarum polysaccharide of satisfied retrofit.Colloid mill is than traditional ball simultaneously
Grinding machine raising power is nearly 10 times, and processing fineness is also greatly improved, the granularity control of the content mix thing after colloid mill grinding
System is obtained soft capsule content material between 1～5nm；
In the embodiment of the present invention, lycium barbarum polysaccharide is miscible, scattered form is present in the boxthorn seed oil, the soft capsule
In effective ingredient (lycium barbarum polysaccharide and boxthorn seed oil) rate of release, work than injection slow, but than tablet, granule work
Hurry up, bioavailability is high.
Further, the gelatin that weighs adds water stirring to dissolving, and adds glycerol and opacifier to stir, obtains soft capsule
The step of shell material, includes；
Weigh gelatin and stirring is added water to dissolving, add glycerol and opacifier to stir, obtain shell material mixed material；
By the shell material mixed material, under vacuum environment, degassing process obtains soft capsule shell material.
The purpose of vacuum outgass is that the gas being mixed in whipping process in shell material mixed material is removed, and degassing must be thorough
Bottom, it is ensured that the softgel shell uniform bubble-free of formation.
Further, it is described to include the step of weigh the boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring：
It is described to weigh described lycium barbarum polysaccharide 5-15 part and boxthorn seed oil 35-100 part mixing and stirrings；
So the lycium barbarum polysaccharide powder of solid is just dispersed in liquid boxthorn seed oil, it is necessary to carry out under cryogenic,
Generally less than -15 DEG C of temperature, lycium barbarum polysaccharide ratio cannot be uniformly dispersed greatly very much.
Meanwhile, work as lycium barbarum polysaccharide：The mass ratio of boxthorn seed oil is 5-15：During 35-100, the lycium barbarum polysaccharide, boxthorn seed oil
In soft capsule, each nutrition is balanced, meets the standard of human body requirements, and boxthorn seed oil can strengthen with the synergism of the lycium barbarum polysaccharide
The bioavailability of a nutrient substance in lycium barbarum polysaccharide, boxthorn seed oil soft capsule.
Experiment shows, the disintegrate of the composition of soft capsule shell material to lycium barbarum polysaccharide, boxthorn seed oil soft capsule has improvement result.
When gelatin in lycium barbarum polysaccharide, the shell material of boxthorn seed oil soft capsule：Water：Glycerol：The mass ratio of opacifier reaches (4-
12)：(5-10)：(2-5)：(1-2) aging speed of soft capsule when, can substantially be slowed down.
In order to further verify the stability of lycium barbarum polysaccharide, boxthorn seed oil soft capsule, the embodiment of the present invention is right by testing
Lycium barbarum polysaccharide, the stability of boxthorn seed oil soft capsule are verified.
First lycium barbarum polysaccharide, boxthorn seed oil soft capsule room temperature are placed 3 months, stability observing is carried out.
Then unchanged to the complete appearance of lycium barbarum polysaccharide, boxthorn seed oil soft capsule every other month, color and luster, taste, taste enter
Performing check；
Records tests result；
Content content is carried out to lycium barbarum polysaccharide, boxthorn seed oil soft capsule simultaneously, disintegrative is tested and recorded Chinese holly
Qi polysaccharide and boxthorn seed oil changes of contents situation；
Experimental result is as shown in the table：
It can be seen that the lycium barbarum polysaccharide, soft capsule obtained in the preparation method of boxthorn seed oil soft capsule shown in the embodiment of the present invention exists
There is in the time of 3 months preferable stability.Slaking test is with reference to version States Pharmacopoeia specifications in 2015, the inspection of soft capsule metrorrhagia solution time limit
Look into, should be in the disintegrates of 1 hour whole and by screen cloth, above-mentioned slaking test meets States Pharmacopoeia specifications.
The lycium barbarum polysaccharide checked in the embodiment of the present invention, boxthorn seed oil soft capsule whole disintegrates can lead at 1 hour
Cross screen cloth, and the equal non-housing deformation of soft capsule, sunken, content spillover.While slaking test, active constituent content situation
Stablize unchanged, illustrate that the lycium barbarum polysaccharide of the present invention, boxthorn seed oil Stability of Soft Capsules are good.
Further the embodiment of the present invention carries out accelerated test to lycium barbarum polysaccharide, boxthorn seed oil soft capsule；
Specifically, lycium barbarum polysaccharide, boxthorn seed oil soft capsule are placed in into 35-40 DEG C, the constant temperature of relative humidity more than 75% is done
Preserve 3 months in dry device, carry out accelerated test observation.
First lycium barbarum polysaccharide, boxthorn seed oil soft capsule room temperature are placed 3 months, stability observing is carried out.
Then unchanged to the complete appearance of lycium barbarum polysaccharide, boxthorn seed oil soft capsule every other month, color and luster, taste, taste enter
Performing check；
Records tests result；
Content content is carried out to lycium barbarum polysaccharide, boxthorn seed oil soft capsule simultaneously, disintegrative is tested and recorded Chinese holly
Qi polysaccharide and boxthorn seed oil changes of contents situation；
Experimental result is as shown in the table：
Test and accelerated test, the equal non-housing deformation of capsule, sunken, content spillover are placed by room temperature.Simultaneously
Slaking test, active constituent content situation stablize unchanged, illustrate that the lycium barbarum polysaccharide of the present invention, boxthorn seed oil soft capsule are stable
Property is good.
Further, the opacifier be ferrum oxide, white carbon black, one or more mixing in titanium dioxide.
In order to further increase the barrier effectiveness embodiment of the present invention employingization ferrum to light of opacifier, white carbon black, titanium dioxide
In one or more mixture as opacifier.
Ferrum oxide that the embodiment of the present invention is adopted, white carbon black, opacifiers of one or more mixing in titanium dioxide, consumption is very
It is few, the stop to light is just can reach, most in actual production is ferrum oxide, or ferrum oxide and white carbon black 1:1, prevent light
Penetrating for line, destroys effective ingredient.
It is reported that, to preparing in the glue of soft capsule, add brown iron oxide and store the sample of 1 year half and collapsed in vitro
Solution test, has occurred disintegrate difficulty (simulated gastric fluid of version in 1977).Jing is compareed, and sample is stored 2 months at 45 DEG C, oxygen containing brown
Change the capsule 2h not disintegrates of ferrum, the sample 1.5h disintegrates without brown iron oxide.
When production needs lycium barbarum polysaccharide, the boxthorn seed oil soft capsule of quick some disintegrates, generally shading is adopted for titanium white
Powder (titanium dioxide).
From above technical scheme, the embodiment of the present invention illustrates a kind of lycium barbarum polysaccharide, the preparation of boxthorn seed oil soft capsule
Method, methods described include：To seed of Fructus Lycii supercritical carbon dioxide extraction, boxthorn seed oil is obtained, while adopting to dried fruit of lycium barbarum
Water-soluble extraction, level Four Ultra filtration membrane obtain lycium barbarum polysaccharide；Weigh the boxthorn seed oil and the lycium barbarum polysaccharide is mixed
It is even, soft capsule content material is obtained, the mixing and stirring is carried out at low ambient temperatures；Weigh gelatin stirring is added water to molten
Solution, adds glycerol and opacifier to stir, obtains soft capsule shell material；By the soft capsule content material and the soft capsule shell
Material carries out pressing capsule to process on press device, obtains lycium barbarum polysaccharide, boxthorn seed oil soft capsule.The embodiment of the present invention is first by Fructus Lycii
Polysaccharide and boxthorn seed oil both Chinese-wolfberry nutritives are extracted, and into soft capsule, the soft capsule nutrition is more comprehensive, effect for fill
It is more significantly, and then effectively strengthen the health care of the soft capsule.After soft capsule enters human body, boxthorn seed oil in vivo
Carry lycium barbarum polysaccharide Jing lymph and enter blood, do not affected by first pass effect, directly can play a role, thus produce higher
Bioavailability.
Those skilled in the art will readily occur to its of the present invention after considering description and putting into practice invention disclosed herein
Its embodiment.The application is intended to any modification of the present invention, purposes or adaptations, these modifications, purposes or
Person's adaptations follow the general principle of the present invention and including the undocumented common knowledge in the art of the present invention
Or conventional techniques.Description and embodiments are considered only as exemplary, and true scope and spirit of the invention are by following
Claim is pointed out.
It should be appreciated that the precision architecture for being described above and being shown in the drawings is the invention is not limited in, and
And various modifications and changes can be being carried out without departing from the scope.The scope of the present invention is limited only by appended claim.
Claims (8)
1. a kind of lycium barbarum polysaccharide, the preparation method of boxthorn seed oil soft capsule, it is characterised in that include：
To seed of Fructus Lycii supercritical carbon dioxide extraction, boxthorn seed oil is obtained, while adopting water-soluble extraction, level Four to surpass to dried fruit of lycium barbarum
The isolated lycium barbarum polysaccharide of filter membrane；
The boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring are weighed, soft capsule content material is obtained, the mixing is stirred
Mixing uniformly is carried out at low ambient temperatures；
Weigh gelatin and stirring is added water to dissolving, add glycerol and opacifier to stir, obtain soft capsule shell material；
The soft capsule content material and the soft capsule shell material are carried out pressing capsule to process on press device, Fructus Lycii is obtained many
Sugar, boxthorn seed oil soft capsule.
2. method according to claim 1, it is characterised in that described by the soft capsule content material and the soft capsule
Shell material carries out pressing capsule to process on press device, the step of obtain lycium barbarum polysaccharide, boxthorn seed oil soft capsule after methods described also
Including：
By drying of shaping after soft capsule arrangement, qualified, sterilization packaging is checked.
3. method according to claim 1, it is characterised in that described to weigh the boxthorn seed oil and the lycium barbarum polysaccharide is mixed
Conjunction stirs, and includes the step of obtain soft capsule content material：
The boxthorn seed oil and the lycium barbarum polysaccharide mixing and stirring are weighed, content mix thing is obtained；
The content mix thing is crossed into colloid mill grinding, soft capsule content is obtained.
4. method according to claim 1, it is characterised in that the gelatin that weighs adds water stirring to dissolving, and adds glycerol
Stir with opacifier, include the step of obtain soft capsule shell material；
Weigh gelatin and stirring is added water to dissolving, add glycerol and opacifier to stir, obtain shell material mixed material；
By the shell material mixed material, under vacuum environment, degassing process obtains soft capsule shell material.
5. the method according to any one of claim 1-4, it is characterised in that described to weigh the lycium barbarum polysaccharide and the Chinese holly
The step of Qi seed oil mixing and stirring, includes：
It is described to weigh described lycium barbarum polysaccharide 5-15 part and boxthorn seed oil 35-100 part mixing and stirrings.
6. the method according to any one of claim 1-4, it is characterised in that the gelatin that weighs adds water stirring to dissolving,
Glycerol and opacifier is added to include the step of stirring：
Gelatin 4-12 is weighed, is added the water of 5-10 parts to stir to dissolving, is added 2-5 parts glycerol and 1-2 part opacifiers to stir.
7. the method according to any one of claim 1-4, it is characterised in that the opacifier is ferrum oxide, white carbon black, titanium white
One or more mixing in powder.
8. the method according to any one of claim 1-4, it is characterised in that described that water-soluble extraction is adopted to dried fruit of lycium barbarum,
In the step of level Four Ultra filtration membrane obtains lycium barbarum polysaccharide, the purity of the lycium barbarum polysaccharide is 35%-65%.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111202243A (en) * | 2020-02-29 | 2020-05-29 | 宁夏全通枸杞供应链管理股份有限公司 | Special dietary food of soft capsule for strengthening eyesight and its preparation method |
| CN113750071A (en) * | 2021-08-24 | 2021-12-07 | 宁夏沃福百瑞枸杞产业股份有限公司 | Preparation method of lycium barbarum polysaccharide-lycium barbarum seed oil soft capsule |
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| CN104435355A (en) * | 2014-11-24 | 2015-03-25 | 福建省科奥生物技术研发中心有限公司 | Xanthophyll soft capsule and preparation method thereof |
| CN105146273A (en) * | 2015-10-09 | 2015-12-16 | 青海泰柏特生物科技有限公司 | Lycium ruthenicum anthocyanin soft capsules and preparation method thereof |
| CN105495138A (en) * | 2014-09-25 | 2016-04-20 | 赵军 | Chinese wolfberry essence soft capsule and preparation method thereof |
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| CN105495138A (en) * | 2014-09-25 | 2016-04-20 | 赵军 | Chinese wolfberry essence soft capsule and preparation method thereof |
| CN104435355A (en) * | 2014-11-24 | 2015-03-25 | 福建省科奥生物技术研发中心有限公司 | Xanthophyll soft capsule and preparation method thereof |
| CN105146273A (en) * | 2015-10-09 | 2015-12-16 | 青海泰柏特生物科技有限公司 | Lycium ruthenicum anthocyanin soft capsules and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111202243A (en) * | 2020-02-29 | 2020-05-29 | 宁夏全通枸杞供应链管理股份有限公司 | Special dietary food of soft capsule for strengthening eyesight and its preparation method |
| CN113750071A (en) * | 2021-08-24 | 2021-12-07 | 宁夏沃福百瑞枸杞产业股份有限公司 | Preparation method of lycium barbarum polysaccharide-lycium barbarum seed oil soft capsule |
| CN113750071B (en) * | 2021-08-24 | 2023-08-29 | 宁夏沃福百瑞枸杞产业股份有限公司 | Preparation method of wolfberry polysaccharide-wolfberry seed oil soft capsule |
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Application publication date: 20170426 |