CN104435355A - Xanthophyll soft capsule and preparation method thereof - Google Patents
Xanthophyll soft capsule and preparation method thereof Download PDFInfo
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- CN104435355A CN104435355A CN201410675058.6A CN201410675058A CN104435355A CN 104435355 A CN104435355 A CN 104435355A CN 201410675058 A CN201410675058 A CN 201410675058A CN 104435355 A CN104435355 A CN 104435355A
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- soft capsule
- fructus lycii
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/55—Linaceae (Flax family), e.g. Linum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a xanthophyll soft capsule. The soft capsule consists of two parts of liquid medicine and a capsule shell. The soft capsule is characterized in that the liquid medicine consists of 5-30mg of xanthophyll, 10-40mg of Chinese wolfberry extracts, 1-10mg of vitamin E and 100-400mg of linseed oil, wherein the liquid medicine of each soft capsule contains 5-40mg of xanthophyll and Chinese wolfberry extracts in parts by weight. According to the invention, high-purity xanthophyll crystal powder is used as a raw material to be made into the soft capsule, the absorption is better, the action is more prominent, and the effect is more significant. Research results show that whether the soft capsule is placed at a room temperature or the soft capsule is in a high-temperature high-moisture accelerated test, the phenomena that the outer shells of the capsule are deformed and cracked and contents overflow are avoided; besides, effective components are all stable when the soft capsule is in a disintegration test, qualitative identification and content measurement, which indicates that the stability of the xanthophyll composite soft capsule preparation disclosed by the invention is good.
Description
Technical field
The invention belongs to technical field of medicine, relate to a kind of xanthophyll soft capsule and preparation method thereof.
Background technology
Phylloxanthin is a kind of natural materials be extensively present in the plants such as vegetable, flowers, fruit, belongs to " carotenoids class " race's material.Medical experiment proves that natural carotenol contained in plant is a kind of antioxidant of excellent performance, in food, add a certain amount of phylloxanthin can prevent cell ageing and biological organs aging, the visual deterioration that senile eyeball retina macular degeneration simultaneously also can be prevented to cause and blind, by a series of medical research, carotenoid has been proposed as cancer prevention agent, life extends agent, ulcer inhibitor, the inhibitor of heart attack and coronary artery disease.Meanwhile, phylloxanthin also can be used as painted for poultry meat egg of feed additive, is also used as painted with nourishing healthy agent in the food industry simultaneously.The symptoms such as phylloxanthin has important protective effect to the macula lutea in retina, easily draws macular degeneration and blurred vision, and then occur visual deterioration during shortage, myopia.Phylloxanthin is the precursor of NA, can be converted into VA in human body.The main Physiological Function of phylloxanthin to eyes is as antioxidant and photoprotection. optic nerve is non-renewable, is very easily subject to the injury of harmful free radicals, and the antioxidation of phylloxanthin can suppress the formation of harmful free radicals.
Chinese patent CN200510095096 compound soft lutein capsule, disclose a kind of compound soft lutein capsule product in patent, capsule content forms: the lutein oleoresin containing phylloxanthin 1 ~ 10mg, the perilla oil containing alpha-linolenic acid 100 ~ 300mg, VA 0 ~ 5mg, VE 0 ~ 7.5mg.Capsule material is made up of gelatin, glycerol, water, opacifier or food coloring.Phylloxanthin adopts supercritical carbon dioxide extraction method to obtain, and this method production technology is advanced, has certain preventive and therapeutic action to age-related macular degeneration disease, cataract, cardiovascular and cerebrovascular disease.But existing product mostly is lutein ester and makes, or phylloxanthin adds the complex agent type such as blue berry, and the health-care effect of phylloxanthin is outstanding not, absorbs bad, and bioavailability is low, and some dosage forms very easily to cause phylloxanthin oxidation Decomposition ineffective.
Summary of the invention
This patent is intended to solve poor, the oxidizable and defect not easily absorbed of phylloxanthin product stability, develop bioavailability high, good absorbing, the phylloxanthin health promoting product of stability and safety, xanthophyll soft capsule constant product quality, its bioavailability of other dosage form is higher relatively, absorption is better; Good airproof performance, energy stay active for long periods and effective ingredient, have certain preventive and therapeutic action to age-related macular degeneration disease, cataract, cardiovascular and cerebrovascular disease.
Summary of the invention
The invention discloses following technology contents for achieving the above object
A kind of xanthophyll soft capsule, it is made up of medicinal liquid and softgel shell two parts: it is characterized in that medicinal liquid is made up of following raw material:
Phylloxanthin 5-30mg, Fructus Lycii extract 10-40mg,
Vitamin E 1-10mg, Semen Lini oil 100-400mg;
Wherein, by weight, every containing phylloxanthin, Fructus Lycii extract 5-40mg for medicinal liquid;
Softgel shell is made up of weight water 6-12 part, gelatin 6-10 part, glycerol 3-4 part, opacifier 1-2 part; One or more in the ferrum oxide that opacifier wherein refers to, white carbon black, titanium dioxide.
The preferred xanthophyll soft capsule of the present invention, is characterized in that it is made up of following raw material:
90% lutein crystal powder 5-20 mg
Fructus Lycii extract 20-40mg
Semen Lini oil 150-400mg
Vitamin E 3-10mg;
Softgel shell is made up of water 6-12 parts of parts by weight, gelatin 6-10 part, glycerol 3-4 part, opacifier 1-2 part;
90% lutein crystal powder refers to: Hydrolysis kinetics saponification from medicinal marigold flower and (the having commercially available) that obtain
The preparation method of xanthophyll soft capsule of the present invention, is characterized in that being undertaken by following step:
The preparation of capsule material: get gelatin, water is stirred to dissolving, adds glycerol and appropriate opacifier, and the vacuumize degassing that stirs is steeped, and forms capsule skin;
The preparation of content: take phylloxanthin 5-30mg by recipe quantity, Fructus Lycii extract 10-40mg, vitamin E 1-10mg, Semen Lini oil 100-400mg mixing and stirring, crosses colloid mill, makes suspension, and room temperature leaves standstill;
Wherein: described Fructus Lycii extract refers to the Fructus Lycii extract that Fructus Lycii obtains through extraction with aqueous solution, extracting method is as follows: get Fructus Lycii decoction pieces, add the soak by water twice of 5 ~ 12 times of weight at every turn, 0.5 ~ 2 hour first time, second time 0.5 ~ 2 hour, collecting decoction, filter, filtrate is concentrated into relative density 1.10 ~ 1.13(50 DEG C) soft extracts, spraying dry, to obtain final product;
The compacting of soft capsule: poured into by the medicinal liquid prepared in medicinal liquid bucket, through soft capsule of preparing burden, be pressed into mould, sizing drying, inspection ball, packs; The metering of xanthophyll soft capsule is that every 100g is containing phylloxanthin 10g.
The bioavailability of the present invention's main research capsule content on formula composition, the content of the aspects such as the compatibility potentiation of capsule content, compare with CN200510095096 compound soft lutein capsule, emphasis of the present invention solves:
(1) in patent CN200510095096 with lutein ester be raw material, lutein ester generates phylloxanthin through the combined effect of bile and pancreatic lipase in vivo, is absorbed, and then play a role by small intestinal mucosa.The present invention directly with high purity lutein powder for raw material, can directly play a role after entering human body, improve bioavailability;
(2) this patent phylloxanthin high purity 98% used, is raw material compared to CN200510095096 patent Lutein ester, decreases the amount of impurity;
(3) consider the therapeutical effect to eye, this patent with the addition of Fructus Lycii extract as ancillary drug simultaneously, improves effect.
The following content of compound soft lutein capsule finished product paper examines prepared by the present invention:
1, compound soft lutein capsule room temperature of the present invention places 3 months, carries out stability observing, the results are shown in Table 1:
Stability test result of study:
2, compound soft lutein capsule of the present invention is placed in 35-40 DEG C, preserves 90 days, carry out Acceleration study observation, the results are shown in Table 2 in the thermostatic drier of relative humidity more than 75%:
Table 2 accelerated stability experimental studies results:
Illustrate: slaking test was with reference to version States Pharmacopoeia specifications in 2010, and soft capsule is through disintegrate overtime check, and in 1 hour, whole disintegrate also should pass through screen cloth, above-mentioned slaking test meets States Pharmacopoeia specifications.
Result of study shows: routine examination, is no matter that room temperature is placed or hot and humid accelerated test, soft gelatin capsule all without casing deformation, break, content spillover.Simultaneously slaking test, qualitative identification, assay effective ingredient are all stable, and the good stability of compound soft lutein capsule preparation of the present invention is described.
Relatively:
Absorb bad, bioavailability is low, and some dosage forms very easily to cause phylloxanthin oxidation Decomposition ineffective.
The safety of compound soft lutein capsule of the present invention is proved by animal pharmacological experiment below:
Xanthophyll soft capsule prepared by the present invention October 8 in 2013 Qing Health Food Function Detection Center, Applied Literature and Science College, B detect, result is as follows:
Xanthophyll soft capsule prepared by employing, is all greater than 15g/kgBW to the maximum tolerated dose (MTD) of the Mouse and rat per os of two kinds of sexes, belongs to nontoxic level by acute toxicity classification.Through Salmonella reversion test, mice bone marrow micronucleus, mouse inbred strain, result is feminine gender, within the scope of study dosage, be showed no Mutagenicity.Rat 30 days feeding trials, rat body weight, weightening finish, food ration, food utilization, internal organs inspection, organ weights, dirty/body ratio, hematology and blood biochemical analysis check result show, each dosage group compares with solvent control group, and each inspection item are all without significant difference (P > 0.05).Histopathologic examination's result shows, solvent control group and high dose group is female, male rat liver, kidney, stomach, intestinal, spleen, ovary and testis all do not find obvious damaging pathological change, and 30 days feeding trials do not find that this sample has obvious toxicity.
Xanthophyll soft capsule prepared by the present invention is compared with CN200510095096:
Conclusion:
(1) in patent CN200510095096 with lutein ester be raw material, lutein ester generates phylloxanthin through the combined effect of bile and pancreatic lipase in vivo, is absorbed, and then play a role by small intestinal mucosa.The present invention directly with high purity lutein powder for raw material, can directly play a role after entering human body, absorption rate is high, improve bioavailability;
(2) this patent phylloxanthin high purity 90% used, is raw material compared to CN200510095096 patent Lutein ester, decreases the amount of impurity, improve curative effect;
Model case:
Lee, 57 years old, started from 2013, eyes tingle, foreign body sensation, does examination of ocular fundus, say it is the maculopathy of degenerative, eat always FUFANG XUESHUANTONG and and XUEMINGMU PIAN, February in this year feels that again eyes have foreign body sensation, February 17, evening, eyes were congested suddenly, there is swelling burning sensation, near the left eye pupil, have the thing of rough picture lump, take xanthophyll soft capsule every day 2 times, each 2-4 sheet, after taking 10 days, symptom is clearly better.
Marquis, female, 56 years old, suffers from ocular disease always, blurring of vision, long-term dropping eye drop, see that TV eye of a specified duration can very pain, during every autumn, eye will be dry and astringent especially, after taking soft capsule of the present invention 20 days, see that TV can not pain, and eye can not feel dry and astringent, and still continue to take.
Xanthophyll soft capsule disclosed by the invention has following feature:
(1) this patent dosage form is soft capsule, content phylloxanthin be from natural free of contamination Flos Tagetis Erectae Hydrolysis kinetics saponification obtain, through the residual process of precipitation, purity is the lutein crystal powder of more than 90%, has that content is high, pollution-free, free from extraneous odour, the advantage such as can directly be absorbed by the body; Because phylloxanthin is liposoluble substance; be soluble in oils solvent; choosing Semen Lini oil in the present invention is solvent; containing the life core substance alpha-linolenic acid maintaining the evolution of mankind's brain in a large number in Semen Lini oil, increase intelligence, vision protection; reduce blood fat, cholesterol; slow down aging, antiallergic, the effects such as the generation of suppression cancer and transfer.Xanthophyll soft capsule good stability of the present invention, can completely cut off air, avoids phylloxanthin effective ingredient oxidized, thus improves the absorption rate of human body, and product design is attractive in appearance, taking convenience.
(2) this patent adopts high purity lutein crystal powder to be that soft capsule made by raw material, absorbs better, acts on more outstanding, more remarkable effect.
(3) the present invention adopts Semen Lini oil to be solvent, and containing the life core substance alpha-linolenic acid maintaining the evolution of mankind's brain in a large number in oleum lini, be maintain human body to evolve, the necessary fatty acid of the human body kept fit is the indispensable material of human body.
Detailed description of the invention
In order to simple and clearly object, the hereafter appropriate description eliminating known technology, in order to avoid the unnecessary description of details impact to the technical program.Below in conjunction with comparative example, the present invention is described further.Wherein 90% lutein crystal powder has commercially available, and the Chinese crude drug used by other all has commercially available.
Embodiment 1
A kind of xanthophyll soft capsule, it is made up of medicinal liquid and softgel shell two parts: it is characterized in that medicinal liquid is made up of following raw material:
Phylloxanthin 5mg, Fructus Lycii extract 10mg, vitamin E 1mg, Semen Lini oil 100mg; Wherein, by weight, every containing phylloxanthin, Fructus Lycii extract 5mg for medicinal liquid; Softgel shell is made up of weight water 6 parts, 6 parts, gelatin, glycerol 3 parts, opacifier (ferrum oxide) 1 part.
Preparation method: get gelatin, water is stirred to dissolving, adds glycerol and appropriate opacifier, and the vacuumize degassing that stirs is steeped, and forms capsule skin;
The preparation of content: take phylloxanthin by recipe quantity, Fructus Lycii extract, vitamin A, Semen Lini oil and pharmaceutic adjuvant mixing and stirring, make suspension, crosses colloid mill, and room temperature leaves standstill; Wherein:
The preparation (purchase) of (1) 90% lutein crystal powder
(2) Fructus Lycii extract described in refers to: get Fructus Lycii decoction pieces, adds the soak by water twice of 8 times of weight at every turn, 1.5 hours first times, second time 1 hour, collecting decoction, filters, filtrate is concentrated into the soft extracts of relative density 1.10 ~ 1.1350 DEG C, and spraying dry, to obtain final product.
The compacting of soft capsule: poured into by the medicinal liquid prepared in Pharmaceutical bucket, through soft capsule of preparing burden, be pressed into mould, sizing drying, inspection ball, packs.
Embodiment 2
Xanthophyll soft capsule, is characterized in that it is made up of following raw material:
90% lutein crystal powder 5mg
Fructus Lycii extract 20mg
Semen Lini oil 150mg
Vitamin E 3mg;
Softgel shell is made up of 12 parts, the water of parts by weight, 10 parts, gelatin, glycerol 4 parts, opacifier (white carbon black) 2 parts;
90% lutein crystal powder refers to: Hydrolysis kinetics saponification from Flos Tagetis Erectae and (the having commercially available) that obtain.
The preparation of capsule material: get glycerol adding after gelatin, water heating for dissolving, appropriate antiseptic, mixing, vacuum outgas; Form capsule skin, through batching, pelleting, sizing drying, inspection ball, packaging.
Preparation should comprise:
The preparation of content: take phylloxanthin 5-30mg by recipe quantity, Fructus Lycii extract 10-40mg, vitamin E 1-10mg, Semen Lini oil 100-400mg and pharmaceutic adjuvant mixing and stirring, make suspension, and room temperature leaves standstill;
The compacting of soft capsule: poured into by the medicinal liquid prepared in medicinal liquid bucket, through soft capsule of preparing burden, be pressed into mould, sizing drying, inspection ball, packs.
Embodiment 3
Phylloxanthin 30mg, Fructus Lycii extract 40mg, vitamin E 10mg, Semen Lini oil 400mg; Wherein, by weight, every containing phylloxanthin, Fructus Lycii extract 5-40mg for medicinal liquid; Described Fructus Lycii extract refers to the Fructus Lycii extract that Fructus Lycii obtains through extraction with aqueous solution;
Softgel shell is made up of weight water 12 parts, 10 parts, gelatin, glycerol 4 parts, opacifier (white lead) 2 parts.
The preparation of capsule material: get glycerol adding after gelatin, water heating for dissolving, appropriate opacifier, mixing, vacuum outgas; Form capsule skin, through batching, pelleting, sizing drying, inspection ball, packaging.
The preparation of content: take phylloxanthin 5-30mg by recipe quantity, Fructus Lycii extract 10-40mg, vitamin E 1-10mg, Semen Lini oil 100-400mg and pharmaceutic adjuvant mixing and stirring, make suspension, and room temperature leaves standstill;
The compacting of soft capsule: poured into by the medicinal liquid prepared in Pharmaceutical bucket, through soft capsule of preparing burden, be pressed into mould, sizing drying, inspection ball, packs.
Claims (3)
1. an xanthophyll soft capsule, it is made up of medicinal liquid and softgel shell two parts: it is characterized in that medicinal liquid is made up of following raw material:
Phylloxanthin 5-30mg, Fructus Lycii extract 10-40mg,
Vitamin E 1-10mg, Semen Lini oil 100-400mg;
Wherein, by weight, every containing phylloxanthin, Fructus Lycii extract 5-40mg for medicinal liquid;
Softgel shell is made up of weight water 6-12 part, gelatin 6-10 part, glycerol 3-4 part, opacifier 1-2 part;
One or more in the ferrum oxide that opacifier wherein refers to, white carbon black, titanium dioxide;
Described Fructus Lycii extract refers to the Fructus Lycii extract that Fructus Lycii obtains through extraction with aqueous solution.
2. xanthophyll soft capsule described in claim 1, is characterized in that it is made up of following raw material:
90% lutein crystal powder 5-20 mg
Fructus Lycii extract 20-40mg
Semen Lini oil 150-400mg
Vitamin E 3-10mg;
Softgel shell is made up of water 6-12 parts of parts by weight, gelatin 6-10 part, glycerol 3-4 part, opacifier 1-2 part.
3. the preparation method of xanthophyll soft capsule described in any one of claim 1-2, is characterized in that being undertaken by following step:
The preparation of capsule material: get gelatin, water is stirred to dissolving, adds glycerol and appropriate opacifier, and the vacuumize degassing that stirs is steeped, and forms capsule skin;
The preparation of content: take phylloxanthin 5-30mg by recipe quantity, Fructus Lycii extract 10-40mg, vitamin E 1-10mg, Semen Lini oil 100-400mg mixing and stirring, crosses colloid mill, makes suspension, and room temperature leaves standstill;
Wherein: the extracting method of described Fructus Lycii extract is as follows: get Fructus Lycii decoction pieces, add the soak by water twice of 5 ~ 12 times of weight at every turn, 0.5 ~ 2 hour first time, second time 0.5 ~ 2 hour, collecting decoction, filters, filtrate is concentrated into relative density 1.10 ~ 1.13, the soft extracts of 50 DEG C, spraying dry, to obtain final product;
The compacting of soft capsule: poured into by the medicinal liquid prepared in Pharmaceutical bucket, through soft capsule of preparing burden, be pressed into mould, sizing drying, inspection ball, packs; The metering of xanthophyll soft capsule is that every 100g is containing phylloxanthin 10g.
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| CN105146273A (en) * | 2015-10-09 | 2015-12-16 | 青海泰柏特生物科技有限公司 | Lycium ruthenicum anthocyanin soft capsules and preparation method thereof |
| CN106215168A (en) * | 2016-08-17 | 2016-12-14 | 吴冰滢 | Compositions of prevention Age related macular and preparation method thereof |
| CN106579453A (en) * | 2016-12-09 | 2017-04-26 | 宁夏沃福百瑞枸杞产业股份有限公司 | Preparation method of lycium barbarum polysaccharide and lyceum barbarum seed oil soft capsule |
| CN106723031A (en) * | 2016-12-12 | 2017-05-31 | 宁夏沃福百瑞枸杞产业股份有限公司 | Matrimony vine zeaxanthin, lutein, the preparation method of vitamin E soft capsule |
| CN107595911A (en) * | 2017-09-27 | 2018-01-19 | 广州市范乐医药科技有限公司 | A kind of lutein capsule for improving eyesight |
| CN109700011A (en) * | 2019-01-23 | 2019-05-03 | 王鸿雁 | A kind of health food and preparation method thereof improving sleep |
| CN113397020A (en) * | 2021-07-06 | 2021-09-17 | 广西壮元医药科技有限公司 | Soft candy added with water-soluble lutein and preparation method thereof |
| CN114468294A (en) * | 2022-01-24 | 2022-05-13 | 河南农业大学 | Nano-emulsion simultaneously loaded with linseed oil and lutein and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105146273A (en) * | 2015-10-09 | 2015-12-16 | 青海泰柏特生物科技有限公司 | Lycium ruthenicum anthocyanin soft capsules and preparation method thereof |
| CN106215168A (en) * | 2016-08-17 | 2016-12-14 | 吴冰滢 | Compositions of prevention Age related macular and preparation method thereof |
| CN106579453A (en) * | 2016-12-09 | 2017-04-26 | 宁夏沃福百瑞枸杞产业股份有限公司 | Preparation method of lycium barbarum polysaccharide and lyceum barbarum seed oil soft capsule |
| CN106723031A (en) * | 2016-12-12 | 2017-05-31 | 宁夏沃福百瑞枸杞产业股份有限公司 | Matrimony vine zeaxanthin, lutein, the preparation method of vitamin E soft capsule |
| CN107595911A (en) * | 2017-09-27 | 2018-01-19 | 广州市范乐医药科技有限公司 | A kind of lutein capsule for improving eyesight |
| CN109700011A (en) * | 2019-01-23 | 2019-05-03 | 王鸿雁 | A kind of health food and preparation method thereof improving sleep |
| CN113397020A (en) * | 2021-07-06 | 2021-09-17 | 广西壮元医药科技有限公司 | Soft candy added with water-soluble lutein and preparation method thereof |
| CN114468294A (en) * | 2022-01-24 | 2022-05-13 | 河南农业大学 | Nano-emulsion simultaneously loaded with linseed oil and lutein and preparation method thereof |
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