CN1840079A - Soft capsule preparation with ultramicro powder and preparation method thereof - Google Patents
Soft capsule preparation with ultramicro powder and preparation method thereof Download PDFInfo
- Publication number
- CN1840079A CN1840079A CN 200510033962 CN200510033962A CN1840079A CN 1840079 A CN1840079 A CN 1840079A CN 200510033962 CN200510033962 CN 200510033962 CN 200510033962 A CN200510033962 A CN 200510033962A CN 1840079 A CN1840079 A CN 1840079A
- Authority
- CN
- China
- Prior art keywords
- radix
- soft capsule
- preparation
- capsule preparation
- styrax
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a soft capsule preparation and its preparing process, wherein the capsule is prepared from root of red rooted saliva, radix paeoniae rubrathe, Ligusticum wallichii, safflower, fragrant solomonseal rhizome, notoginseng, gen-seng, liquidambar orientalis mill, and baras camphor through the steps of disintegrating and water extracting.
Description
Technical field
The present invention relates to a kind of Chinese medicinal soft capsule preparation and preparation method thereof, said preparation is made up of Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Polygonati Odorati, Radix Notoginseng, Radix Ginseng, Styrax, Borneolum Syntheticum.
Background technology
The quiet capsule of coronary disease (WS-10594-(ZD-0594)-2002) is applied to clinical, be compound Chinese medicinal preparation, make by Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Polygonati Odorati, Radix Notoginseng, Radix Ginseng, Styrax, Borneolum Syntheticum, has blood circulation promoting and blood stasis dispelling, effects such as supplementing qi and invigorating vasculum, be used for the thoracic obstruction that blood stasis due to qi deficiency causes clinically, chest pain, the cardiopalmus of breathing hard and coronary heart disease see above-mentioned symptom person.
The quiet capsule disintegration time of coronary disease is long, again because capsule includes the crude drug powder, and absorption difference, bioavailability is low, has influenced the quiet capsule curative effect of coronary disease.
The present invention makes the quiet soft capsule of coronary disease by using ultramicro communication technique and soft capsule preparation Technology exactly, thereby overcomes the quiet capsular above defective of coronary disease, and its therapeutical effect is given full play to.
Summary of the invention
The object of the present invention is to provide a kind of is the quiet soft capsule preparation of new coronary disease of foundation with the quiet capsular medicament composing prescription of coronary disease, and said preparation is made up of Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Polygonati Odorati, Radix Notoginseng, Radix Ginseng, Styrax, Borneolum Syntheticum.
The invention provides a kind of preparation method of the quiet soft capsule preparation of making by Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Polygonati Odorati, Radix Notoginseng, Radix Ginseng, Styrax, Borneolum Syntheticum of coronary disease.
Contain salviamiltiorrhizabung, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Polygonati Odorati, Radix Notoginseng, Radix Ginseng, Styrax, Borneolum Syntheticum in the quiet soft capsule prescription of coronary disease of the present invention.Whenever making 1000 used medical material proportionings of soft capsule is:
Radix Salviae Miltiorrhizae 31.25-250g
Radix Paeoniae Rubra 15.625-125g
Rhizoma Chuanxiong 15.625-125g
Flos Carthami 15.625-125g
Rhizoma Polygonati Odorati 15.625-125g
Radix Notoginseng 6.25-50g
Radix Ginseng 3.125-25g
Styrax 1.28-10g
Borneolum Syntheticum 0.3125-2.5g
Be preferably:
Radix Salviae Miltiorrhizae 62.5-125g
Radix Paeoniae Rubra 31.25-62.5g
Rhizoma Chuanxiong 31.25-62.5g
Flos Carthami 31.25-62.5g
Rhizoma Polygonati Odorati 31.25-62.5g
Radix Notoginseng 12.5-25g
Radix Ginseng 6.25-12.5g
Styrax 2.5-5g
Borneolum Syntheticum 0.625-1.25g
More than fill a prescription, wherein Rhizoma Chuanxiong, Radix Notoginseng, Radix Ginseng are used as medicine as active component through micronizing, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Flos Carthami, Rhizoma Polygonati Odorati are used as medicine as active component through micronizing with the extract of water mixed extraction, Styrax, Borneolum Syntheticum are imitated composition as the activity of medicine and directly are used as medicine, and make soft capsule preparation.
The quiet preparation of soft capsule method of coronary disease provided by the invention is: get 1 weight portion active component and add in the 1-5 weight diluent, fully mixing utilizes the rubber compacting to form.
Diluent is to add an amount of suspending agent (Cera Flava, Petiolus Trachycarpi wet goods) in vegetable oil or the vegetable oil to form.The main component of rubber is gelatin, glycerol etc.
Below through detecting explanation beneficial effect of the present invention:
One, detects index and method
Disintegration: inspection technique disintegration (appendix XIIA of Chinese Pharmacopoeia version in 2000) is checked
Two, the quiet capsule disintegration time of commercially available coronary disease testing result: 22 minutes
Three, preparation example 1 sample disintegration time testing result is 12 minutes
Four, preparation example 2 sample disintegration time testing results are 13 minutes
The specific embodiment
Preparation example 1
With 31.25g Rhizoma Chuanxiong, 12.5g Radix Notoginseng, 6.25g Radix Ginseng micronizing; Get 62.5g Radix Salviae Miltiorrhizae, 31.25g Radix Paeoniae Rubra, 31.25g Flos Carthami, 31.25g Rhizoma Polygonati Odorati, add 15 times of water gagings and decoct 2 times, each 2 hours, merging filtrate, filtrate is concentrated into thick paste, behind the drying under reduced pressure, micronizing; Add (adding 15g Cera Flava in the 285g soybean oil) in the 300g diluent together with 2.5g Styrax, 0.625g Borneolum Syntheticum, mixing is made medicinal liquid.Get the 500g gelatin, 150g glycerol and 500g water are made glue.Utilize pressing, make 1000 of soft capsules, promptly.
Preparation example 2
With 41.7g Rhizoma Chuanxiong, 16.7g Radix Notoginseng, 8.3g Radix Ginseng micronizing; Get 83.3g Radix Salviae Miltiorrhizae, 41.7g Radix Paeoniae Rubra, 41.7g Flos Carthami, 41.7g Rhizoma Polygonati Odorati, add 15 times of water gagings and decoct 2 times, each 2 hours, merging filtrate, filtrate is concentrated into thick paste, behind the drying under reduced pressure, micronizing; Add (adding 10g Petiolus Trachycarpi oil in the 340g olive oil) in the 350g diluent together with 3.3g Styrax, 0.8g Borneolum Syntheticum, mixing is made medicinal liquid.Get the 450g gelatin, 200g glycerol and 450g water are made glue.Utilize pressing, make 1000 of soft capsules, promptly.
Claims (6)
1. a soft capsule preparation for the treatment of cardiovascular disease is characterized in that said preparation is that raw material is made with Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Flos Carthami, Rhizoma Polygonati Odorati, Radix Notoginseng, Radix Ginseng, Styrax, Borneolum Syntheticum.
2. according to the soft capsule preparation of claim 1, it is characterized in that per 1000 soft capsules are made by following proportion raw material:
Radix Salviae Miltiorrhizae 31.25-250g
Radix Paeoniae Rubra 15.625-125g
Rhizoma Chuanxiong 15.625-125g
Flos Carthami 15.625-125g
Rhizoma Polygonati Odorati 15.625-125g
Radix Notoginseng 6.25-50g
Radix Ginseng 3.125-25g
Styrax 1.28-10g
Borneolum Syntheticum 0.3125-2.5g
3. according to the soft capsule preparation of claim 2, it is characterized in that per 1000 soft capsules are made by following proportion raw material:
Radix Salviae Miltiorrhizae 62.5-125g
Radix Paeoniae Rubra 31.25-62.5g
Rhizoma Chuanxiong 31.25-62.5g
Flos Carthami 31.25-62.5g
Rhizoma Polygonati Odorati 31.25-62.5g
Radix Notoginseng 12.5-25g
Radix Ginseng 6.25-12.5g
Styrax 2.5-5g
Borneolum Syntheticum 0.625-1.25g
4. according to the soft capsule preparation of claim 1-3, it is characterized in that, Rhizoma Chuanxiong in the prescription, Radix Notoginseng, Radix Ginseng are used as medicine as active component through micronizing, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Flos Carthami, Rhizoma Polygonati Odorati are used as medicine as active component through micronizing with the extract of water mixed extraction, and Styrax, Borneolum Syntheticum are imitated composition as the activity of medicine and directly be used as medicine.
5. according to the soft capsule preparation of claim 1-3, the activity in the claim 4 is imitated composition, get 1 weight portion active component and add in the 1-5 weight diluent, fully mixing utilizes the rubber compacting to form.
6. according to the soft capsule preparation of claim 5, described diluent is to add an amount of suspending agent (Cera Flava, Petiolus Trachycarpi wet goods) in vegetable oil or the vegetable oil to form.The main component of rubber is gelatin, glycerol etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510033962 CN1840079A (en) | 2005-03-30 | 2005-03-30 | Soft capsule preparation with ultramicro powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510033962 CN1840079A (en) | 2005-03-30 | 2005-03-30 | Soft capsule preparation with ultramicro powder and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1840079A true CN1840079A (en) | 2006-10-04 |
Family
ID=37029382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510033962 Pending CN1840079A (en) | 2005-03-30 | 2005-03-30 | Soft capsule preparation with ultramicro powder and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1840079A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728877A (en) * | 2017-02-15 | 2017-05-31 | 南京市第医院 | It is a kind of to treat medicament of coronary disease and angina pectoris and preparation method thereof |
| CN107752017A (en) * | 2017-11-09 | 2018-03-06 | 王慧 | A kind of preparation method of ginseng submicron powder soft capsule |
| CN110907576A (en) * | 2019-11-06 | 2020-03-24 | 河北医科大学 | Method for simultaneously determining content of 16 active ingredients in Guanxinjing capsule |
-
2005
- 2005-03-30 CN CN 200510033962 patent/CN1840079A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106728877A (en) * | 2017-02-15 | 2017-05-31 | 南京市第医院 | It is a kind of to treat medicament of coronary disease and angina pectoris and preparation method thereof |
| CN107752017A (en) * | 2017-11-09 | 2018-03-06 | 王慧 | A kind of preparation method of ginseng submicron powder soft capsule |
| CN110907576A (en) * | 2019-11-06 | 2020-03-24 | 河北医科大学 | Method for simultaneously determining content of 16 active ingredients in Guanxinjing capsule |
| CN110907576B (en) * | 2019-11-06 | 2022-02-11 | 河北医科大学 | Method for simultaneously determining content of 16 active ingredients in Guanxinjing capsule |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101347563B (en) | Medicament for treating baldness and white hair and preparation method thereof | |
| US20060188586A1 (en) | Compositions and methods for enhancing therapeutic effects | |
| CN100342891C (en) | Medicine composition for hypertension and its preparation thereof | |
| CN1305483C (en) | Heart failure regulating Chinese medicine | |
| CN1679904A (en) | Chinese medicine for treating cardiac failure | |
| CN101856405B (en) | Medicinal composition for treating type II diabetes mellitus and preparation method thereof | |
| CN101347557B (en) | Medicament composition for refreshment and intelligence development and preparation and use thereof | |
| CN101095768B (en) | Chinese traditional medicine capsule for treating primary hypertension for persons in middle and old age | |
| CN1840079A (en) | Soft capsule preparation with ultramicro powder and preparation method thereof | |
| CN100337660C (en) | Hypertension treating Chinese medicine composition | |
| CN101041010A (en) | Medicine compound for treating diabetes and its preparation | |
| CN110507772A (en) | A kind of Chinese medicinal ointment and preparation method thereof for treating chronic bronchitis | |
| CN101036708A (en) | Medicine composition for treatment of cardio-cerebralvascular disease | |
| CN108355055A (en) | A kind of pharmaceutical composition for treating hypertension | |
| CN1745795A (en) | Medicine for preventing coronary heart disease and its preparation | |
| CN101966239B (en) | Chinese medicinal composition for preventing and treating cardiac cerebral and vascular diseases and preparation method thereof | |
| CN1245197C (en) | Chinese medicine preparation for treating coronary heart disease and viral myocarditis | |
| CN1182862C (en) | Chinese medicine prepn for treating coronary heart disease and angina pectoris and its prepn | |
| CN1840080A (en) | Pill preparation with ultramicro powder and preparation method thereof | |
| CN110478406A (en) | It is a kind of to have effects that alleviate Chinese medicine composition of hypothyroidism and preparation method thereof, application and product | |
| CN1739606A (en) | Active extract composition of epimedium and red sage and its medicinal use | |
| CN1840140A (en) | Soft capsule of ultra-micro powder and preparation method thereof | |
| CN1931352A (en) | Chinese medicine composition and its prepn process | |
| CN1309412C (en) | Medicine composition for treating AIDS and preparing method thereof | |
| CN1183297A (en) | Katsutoxin pill for tumor and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |