CN101041010A - Medicine compound for treating diabetes and its preparation - Google Patents
Medicine compound for treating diabetes and its preparation Download PDFInfo
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- CN101041010A CN101041010A CN 200610041963 CN200610041963A CN101041010A CN 101041010 A CN101041010 A CN 101041010A CN 200610041963 CN200610041963 CN 200610041963 CN 200610041963 A CN200610041963 A CN 200610041963A CN 101041010 A CN101041010 A CN 101041010A
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Abstract
The invention provides a pharmaceutical composition for treating diabetes, which is prepared from the constituents of (by weight ratio) calcium sulphate 299 parts, anemarrhena rhizome 160 parts, dried rehmannia root 200 parts, ophiopogon root 160 parts, root of Chinese trichosannthes 239 parts, radix polygonati officinalis 200 parts, radix scrophulariae 160 parts, achyranthes and cyathula root 119 parts, radix salvia miltiorrhiza 200 parts, alisol 160 parts, root of pilose asiabell 160 parts, cornus officinalis 160 parts, loquat leaves 119 parts and schisandra fruit 99 parts.
Description
The present invention relates to a kind of medicine for the treatment of diabetes, specifically be a kind of be the Chinese patent medicine that effective ingredient is prepared from the Chinese herbal medicine, nomenclature of drug has clearing away heat and nourishing YIN for " recovering particles of quenching one's thirst ", the effect of promoting the production of body fluid to quench thirst is used for type ii diabetes intense heat due to deficiency of YIN type.Belong to the field of Chinese medicines.
Diabetes are a kind of common frequently-occurring diseases.At the end of the seventies, 300,000 census of the populations of 14 provinces and cities of China find that (diabetes) prevalence of quenching one's thirst only is 13.4 ‰.And find diabetes prevalence 24.6 ‰ according to Beijing, Liaoning and Shanxi three provinces and cities the end of the eighties; According to another report, 60～70 years old age bracket crowd prevalence of China by 1981 64 ‰, risen to 125 ‰ by 1991, increased by one times during the decade.Only Beijing area nineteen ninety sampling survey shows, more than 40 years old among the crowd diabetes prevalence up to 53 ‰, on the rise again in recent years.According to the authoritative sources, conservative estimation, the diabetics of China can reach more than 1,000 ten thousand at present.According to the international diabetes association report that is located at Brussels, the investigation of The World Health Organization (WHO) shows that the diabetics number worldwide increases sharply.The onset diabetes rate of Eastern Mediterranean, the Middle East, Southeast Asia and West Pacific region increases greatly.In these areas, adult population's 20% is subjected to the invasion and attack of this disease, and wherein in some place, this ratio is up to 50%.Report the whole world at present nearly 100,000,000 people 6% of the population of promptly growing up suffer from diabetes.In industrialized country's diabetes are the third-largest common dead factors, are only second to heart disease and cancer.
The medicine of treatment diabetes is divided into three major types at present: 1, pure Western medicine, such medicine is representative with the sulfonylureas glyburide of the insulin and the second filial generation, advantage is that controlling symptoms is rapid, effect is remarkable, but side effect is obvious, not only can damage liver, renal function, but also can cause leukocyte, granulocyte and hematoblastic minimizing, and can cause the insecondary inefficacy of patient's medicine; 2, Chinese and Western association class medicine, this class medicine is representative with a diabetes pill in the Guangzhou No.1 Chinese Pharmacy Factory production, in the main component of a diabetes pill Radix Astragali is arranged, Radix Rehmanniae, Radix Trichosanthis and Western medicine glyburide, this medical instrument have YIN nourishing to support kidney, the characteristics that supplementing QI for promoting the production of body fluid and curative effect are fast, but still contain the Western medicine glyburide of 0.25mg in every ball, thereby also have the deficiency of damaging liver, renal function and causing patient's medicine secondary failure; Though in 3, pure there be the medicine of medicinal pure treatment by Chinese herbs diabetes, as Zuogui Yin, LIUWEI DIHUANG WAN, ginseng glycopeptide injection, three capsule for eliminating, KELENING capsule, QIZHI JIANGTANG JIAONANG, the good wine granule etc. of quenching one's thirst more, effect is not fairly obvious, and the patient also will rely on insulin injection and treat.
The category of diabetes spp traditional Chinese medical science diabetes.Before two thousand years, China has just made write up to the Clinical symptoms and the complication of diabetes.That has put down in writing hundreds of treatment diabetes in successive dynasties medicine treatise has an efficacious prescriptions medicine.Therefore, inherit and develop motherland's medicine and pharmacology, research and development have broad prospects to diabetes curative effect height, Chinese medicine and Chinese medicine preparation that toxicity is little, and are significant to the control of diabetes.
The health of quenching one's thirst ties up to the old docter of TCM Jin Shu of Anhui Province and grows on the clinical proved recipe basis that the chief physician provides, and uses modern crafts and develops.Jin Shuzi is eight generation confucian physician old anies well-known family handed down from one's ancestors, according to traditional medical theory, through counting this prescription medicine of the specially for treating diabetes of groping and summing up for clinical practice: Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Fructus Corni, Radix Codonopsis, Fructus Schisandrae Chinensis, Folium Eriobotryae.Gypsum Fibrosum, the Rhizoma Anemarrhenae are monarch drug in the side.Gypsum Fibrosum nature and flavor suffering, sweet, Great Cold, be the key medicine of the bright edema caused by disorder of QI excess-heat of removing summer-heat sun; The Rhizoma Anemarrhenae is gone into lung, stomach, kidney three warps, analgesic relieving restlessness, the restlessness accompanied by ascending of QI of only quenching one's thirst, the Gypsum Fibrosum and the Rhizoma Anemarrhenae are the excess-heat of the bright edema caused by disorder of QI of removing summer-heat sun and establish with 5 in the Zhang Zhongjing Baihu Tang, both mutually 5, bring out the best in each other.Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae are ministerial drug, the product that all are replenishing YIN and removing heat, slake thirst and help produce saliva, help Gypsum Fibrosum, Rhizoma Anemarrhenae removing summer-heat gastric heat, promoting the production of body fluid to quench thirst, and Radix Ophiopogonis, Radix Rehmanniae, Radix Scrophulariae are ministerial drug, the product that all are replenishing YIN and removing heat, slake thirst and help produce saliva, help Gypsum Fibrosum, Rhizoma Anemarrhenae removing summer-heat gastric heat, promoting the production of body fluid to quench thirst, and Radix Ophiopogonis, Radix Rehmanniae, Radix Scrophulariae etc. except that go into stomach through, still go into lung, kidney channel.Rhizoma Alismatis, Fructus Corni, ZHUXI, Radix Salviae Miltiorrhizae, Radix Codonopsis, Fructus Schisandrae Chinensis, Folium Eriobotryae are adjuvant.Rhizoma Alismatis, Fructus Corni two flavors, one rushes down a benefit, rushes down the pathogenic fire of kidney channel, the vital essence of puckery kidney.ZHUXI is kind descending, walks and can mend, and with the Radix Salviae Miltiorrhizae promoting blood circulation to restore menstrual flow that is harmonious, gets the meaning of weeding out the old and bring forth the new.The patient that quenches one's thirst again mostly is prolonged illness and a little less than the middle deficiency of vital energy, is equipped with Radix Codonopsis, Fructus Schisandrae Chinensis, Folium Eriobotryae in the side, sets upright and the vital essence of the kidney of astringing the lung stomach function regulating and sending down the abnormal ascending QI.The all medicines of we are harmonious, and play replenishing YIN and removing heat altogether, the effect of promoting the production of body fluid to quench thirst, and reaching the lung heat clearing gastric heat, the effect of nourishing the stomach kidney yin, and can weed out the old and bring forth the new, stomach function regulating is set upright and is held back essence.
It is remarkable to the purpose of this invention is to provide a kind of blood sugar lowering, to the quench one's thirst medicine of (diabetes) of the treatment that patient health has no side effect.
Another object of the present invention provides the quench one's thirst preparation method of (diabetes) medicine of this treatment.
Gypsum Fibrosum 199-399 part Rhizoma Anemarrhenae 60-260 part
Radix Rehmanniae 100-300 part 60-260 Radix Ophiopogonis part
Radix Trichosanthis 139-339 part Rhizoma Polygonati Odorati 100-300 part
Radix Scrophulariae 60-260 part Radix Achyranthis Bidentatae 19-219 part
Radix Salviae Miltiorrhizae 100-300 part Rhizoma Alismatis 60-260 part
Radix Codonopsis 60-260 part Fructus Corni 60-260 part
Folium Eriobotryae 19-219 part Fructus Schisandrae Sphenantherae 9-189 part
Preparing this treatment preferred weight umber scope of medicine each component of (diabetes) of quenching one's thirst is:
Gypsum Fibrosum 249-349 part Rhizoma Anemarrhenae 110-210 part
Radix Rehmanniae 150-250 part 110-210 Radix Ophiopogonis part
Radix Trichosanthis 189-289 part Rhizoma Polygonati Odorati 150-250 part
Radix Scrophulariae 110-210 part Radix Achyranthis Bidentatae 69-169 part
Radix Salviae Miltiorrhizae 150-250 part Rhizoma Alismatis 110-210 part
Radix Codonopsis 110-210 part Fructus Corni 110-210 part
Folium Eriobotryae 69-169 part Fructus Schisandrae Sphenantherae 49-149 part
Preparing the quench one's thirst optimum weight umber of medicine each component of (diabetes) of this treatment is:
160 parts of 299 parts of Rhizoma Anemarrhenaes of Gypsum Fibrosum
160 parts of Radix Rehmanniae 200 parts of Radix Ophiopogonis
200 parts of 239 portions of Rhizoma Polygonati Odorati of Radix Trichosanthis
119 parts of 160 parts of Radix Achyranthis Bidentataes of Radix Scrophulariae
160 parts of 200 portions of Rhizoma Alismatis of Radix Salviae Miltiorrhizae
160 parts of 160 parts of Fructus Corni of Radix Codonopsis
99 parts of 119 parts of Fructus Schisandrae Sphenantheraes of Folium Eriobotryae
The quench one's thirst preparation method of medicine of (diabetes) of this treatment is:
The extraction process of the health of quenching one's thirst is according to the contained effective ingredient of each flavour of a drug in the prescription, uses three kinds of extracting method: A, Gypsum Fibrosum master sulfur acid calcium and part trace element, and Rhizoma Anemarrhenae master contains water soluble ingredients such as Saponin class, and the two is a monarch drug, adopts decocting method to extract; B, Radix Salviae Miltiorrhizae, Fructus Corni, Fructus Schisandrae Chinensis three flavors are because of need are taken into account its contained fat-soluble effective ingredient, so use 70% alcohol extraction; Nine flavors such as C, Radix Rehmanniae are because of the main water soluble ingredients such as Saponin, iridoid glycoside that contain, for reducing dose, so extract with decoction alcohol precipitation method.To extracting and preparing on the basis of having done the orthogonal optimum seeking test respectively, worked out reasonably preparation technology.
(1) 299 parts in Gypsum Fibrosum, the Rhizoma Anemarrhenae add 10 times of amounts of water for 160 parts and decoct three times, and each 1.5 hours, collecting decoction filtered, and filtrate is concentrated into about 1000ml, leave standstill, and filtration, it is standby that filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).
(2) 200 parts of Radix Salviae Miltiorrhizaes, 99 parts of Fructus Schisandrae Sphenantheraes, 160 parts of usefulness of Fructus Corni, 70% alcohol reflux three times, each 2 hours, merge extractive liquid, reclaimed ethanol, filtration, and it is standby that filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).
(3) Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Codonopsis, Folium Eriobotryae nine flavors decoct with water secondary, and each 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.11～1.12 (70 ℃), is chilled to room temperature, adds ethanol and reaches 60% to containing the alcohol amount, stir evenly, left standstill 12 hours, and drew supernatant, reclaim ethanol, filter, it is standby that filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).
(4) merge above three kinds of clear paste, being concentrated into relative density is the thick paste of 1.35～1.38 (70 ℃), drying under reduced pressure, be ground into fine powder, add appropriate amount of auxiliary materials, make the suitable dosage form of regulation in the official preparation definition, comprising oral formulations such as granule (comprising effervescent granule), tablet (comprising dispersible tablet), capsule (comprising soft capsule), drop pill, pill, powder, lozenge, medicinal tea.
According to the contained main chemical compositions of each flavour of a drug in preparation technology and the prescription, quality standard has been worked out in the physicochemical property test of the health of having carried out quenching one's thirst on this basis.Determine to analyze with the TLC of the Rhizoma Anemarrhenae, Radix Salviae Miltiorrhizae, Fructus Corni, Fructus Schisandrae Chinensis and Radix Achyranthis Bidentatae, discriminating project as this product, with the hydrolyzate chinaroot greenbrier sapogenin of zhimusaponin in the Rhizoma Anemarrhenae quantitative target, use tlc-scanning determination, in order to the preparation technology and the product quality of control this product as this product.
Pharmacodynamic test of active extract: to the phonetic noisy property hyperglycemic rat of four oxygen, ig administration 10 days is compared with the water group, the health of quenching one's thirst 13.34 crude drugs/kg group (being equivalent to 20 times of clinical amounts) and 6.67g crude drug/kg (being equivalent to 10 times of clinical amounts) group, and its P is all＜0.01; 3.33g crude drug/kg (being equivalent to 5 times of clinical amounts) group, P＜0.05.To alloxan hyperglycemia rabbit, ig administration 8 days is compared with the water group, the health of quenching one's thirst 13.34g crude drug/kg group and 6.67g crude drug/kg group, and its P is all＜0.05.In the rat carbohydrate tolerance test, give G, S front and back self relatively, the health of quenching one's thirst 13.34g group all had remarkable hypoglycemic activity at 1 hour and 2 hours; This group rat blood serum insulin content and matched group are relatively, and be on the rise.6.67g group had hypoglycemic activity in the time of 1 hour.In addition, experimental result shows that also the health of quenching one's thirst does not have obvious influence to normal rat blood sugar.To epinephrine type hyperglycemic rat, ig administration 20 days, three dosage groups there is no obvious influence.To epinephrine type hyperglycemic rat, ig administration 20 days, three dosage groups there is no obvious hypoglycemic activity.
Acute toxicity test: adopt the ig route of administration, dosage 220g crude drug/kg is equivalent to 328 times of clinical amounts, and ig is three times in one day, observes 7 days, and test mice is all survived; Adopt the ip route of administration, LD50 is 54.20g crude drug/kg, the 95% average credible 54.20g ± 4.84g crude drug/kg that is limited to.
Long term toxicity test: test with rat, observed 6 months, the heavy dose of group of the health of quenching one's thirst (36.66g crude drug/kg, 55 times of quite clinical amounts) and small dose group (8.00g crude drug/kg, 12 times of quite clinical amounts), none rats death in 6 months, and its body weight, expression, hair color, baking urine etc. there is no unusual.After 6 months, survey body weight ECG, fasting glucose, hepatic and renal function, blood picture and potassium sodium chloride ion, each group is all in normal range; Main organs such as pancreas are through pathological anatomy, and naked eyes and light microscopy checking also show no obvious abnormalities.
Claims (4)
1, a kind of treatment pharmaceutical composition of (diabetes) of quenching one's thirst is characterized in that being being made by the crude drug of following weight component:
Gypsum Fibrosum 199-399 part Rhizoma Anemarrhenae 60-260 part Radix Rehmanniae 100-300 part
Radix Ophiopogonis 60-260 part Radix Trichosanthis 139-339 part Rhizoma Polygonati Odorati 100-300 part
Radix Scrophulariae 60-260 part Radix Achyranthis Bidentatae 19-219 part Radix Salviae Miltiorrhizae 100-300 part
Rhizoma Alismatis 60-260 part Radix Codonopsis 60-260 part Fructus Corni 60-260 part
Folium Eriobotryae 19-219 part Fructus Schisandrae Sphenantherae 9-189 part
2, the treatment according to claim 1 medicine of (diabetes) of quenching one's thirst is characterized in that it is made up of the medicine of following weight parts ratio range:
Gypsum Fibrosum 249-349 part Rhizoma Anemarrhenae 110-210 part Radix Rehmanniae 150-250 part
Radix Ophiopogonis 110-210 part Radix Trichosanthis 189-289 part Rhizoma Polygonati Odorati 150-250 part
Radix Scrophulariae 110-210 part Radix Achyranthis Bidentatae 69-169 part Radix Salviae Miltiorrhizae 150-250 part
Rhizoma Alismatis 110-210 part Radix Codonopsis 110-210 part Fructus Corni 110-210 part
Folium Eriobotryae 69-169 part Fructus Schisandrae Sphenantherae 49-149 part
3, the treatment according to claim 1 medicine of (diabetes) of quenching one's thirst is characterized in that the parts by weight of each component are:
200 parts of 160 parts of Radix Rehmanniae of 299 parts of Rhizoma Anemarrhenaes of Gypsum Fibrosum
200 parts of 239 portions of Rhizoma Polygonati Odorati of 160 parts of Radix Trichosanthis Radix Ophiopogonis
200 parts of 119 parts of Radix Salviae Miltiorrhizaes of 160 parts of Radix Achyranthis Bidentataes of Radix Scrophulariae
160 parts of 160 parts of Fructus Corni of 160 parts of Radix Codonopsis of Rhizoma Alismatis
99 parts of 119 parts of Fructus Schisandrae Sphenantheraes of Folium Eriobotryae
4,, it is characterized in that its preparation method is according to the pharmaceutical composition of claim 1,2,3 described treatment diabetes:
(1) 299 parts in Gypsum Fibrosum, the Rhizoma Anemarrhenae add 10 times of amounts of water for 160 parts and decoct three times, and each 1.5 hours, collecting decoction filtered, and filtrate is concentrated into about 1000ml, leave standstill, and filtration, it is standby that filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).
(2) 200 parts of Radix Salviae Miltiorrhizaes, 99 parts of Fructus Schisandrae Sphenantheraes, 160 parts of usefulness of Fructus Corni, 70% alcohol reflux three times, each 2 hours, merge extractive liquid, reclaimed ethanol, filtration, and it is standby that filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).
(3) Radix Rehmanniae, Radix Ophiopogonis, Radix Trichosanthis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Achyranthis Bidentatae, Rhizoma Alismatis, Radix Codonopsis, Folium Eriobotryae nine flavors decoct with water secondary, and each 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.11～1.12 (70 ℃), is chilled to room temperature, adds ethanol and reaches 60% to containing the alcohol amount, stir evenly, left standstill 12 hours, and drew supernatant, reclaim ethanol, filter, it is standby that filtrate is concentrated into the clear paste of relative density 1.25～1.28 (70 ℃).
(4) merge above three kinds of clear paste, being concentrated into relative density is the thick paste of 1.35～1.38 (70 ℃), drying under reduced pressure, be ground into fine powder, add appropriate amount of auxiliary materials, make the suitable dosage form of regulation in the official preparation definition, comprising oral formulations such as granule (comprising effervescent granule), tablet (comprising dispersible tablet), capsule (comprising soft capsule), drop pill, pill, powder, lozenge, medicinal tea.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610041963 CN101041010A (en) | 2006-03-22 | 2006-03-22 | Medicine compound for treating diabetes and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610041963 CN101041010A (en) | 2006-03-22 | 2006-03-22 | Medicine compound for treating diabetes and its preparation |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101816770A (en) * | 2010-06-02 | 2010-09-01 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diabetes and preparation method thereof |
| CN102836353A (en) * | 2012-09-12 | 2012-12-26 | 沈信堂 | Chinese medicine for treating diabetes |
| CN103461610A (en) * | 2013-09-30 | 2013-12-25 | 叶新 | Health-care loquat leaf tea |
| CN105770367A (en) * | 2016-04-26 | 2016-07-20 | 郑州市中医院 | Radix codonopsis and radix salviae miltiorrhizae soup capable of quenching thirst and preparation method of radix codonopsis and radix salviae miltiorrhizae soup |
| CN106728502A (en) * | 2016-11-17 | 2017-05-31 | 李瑜 | A kind of hypoglycemic medicinal liquor and its production method |
| CN109908261A (en) * | 2017-12-13 | 2019-06-21 | 河北万邦复临药业有限公司 | A kind of preparation method for treating diabetes medicament |
-
2006
- 2006-03-22 CN CN 200610041963 patent/CN101041010A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101816770A (en) * | 2010-06-02 | 2010-09-01 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating diabetes and preparation method thereof |
| CN102836353A (en) * | 2012-09-12 | 2012-12-26 | 沈信堂 | Chinese medicine for treating diabetes |
| CN102836353B (en) * | 2012-09-12 | 2013-09-11 | 沈信堂 | Chinese medicine for treating diabetes |
| CN103461610A (en) * | 2013-09-30 | 2013-12-25 | 叶新 | Health-care loquat leaf tea |
| CN105770367A (en) * | 2016-04-26 | 2016-07-20 | 郑州市中医院 | Radix codonopsis and radix salviae miltiorrhizae soup capable of quenching thirst and preparation method of radix codonopsis and radix salviae miltiorrhizae soup |
| CN106728502A (en) * | 2016-11-17 | 2017-05-31 | 李瑜 | A kind of hypoglycemic medicinal liquor and its production method |
| CN109908261A (en) * | 2017-12-13 | 2019-06-21 | 河北万邦复临药业有限公司 | A kind of preparation method for treating diabetes medicament |
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Open date: 20070926 |