JP2010159213A - Antioxidant - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antioxidant, an anti-oxidizing external preparation for skins, and an anti-oxidizing cosmetic which each contain the extract of a new plant whose good safety can be expected and which have an anti-oxidizing action. <P>SOLUTION: The antioxidant, the anti-oxidizing external preparation for skins, and the anti-oxidizing cosmetic each include an extract of one or more plants selected from Ficus benghalensis, Asparagus racemosus, Achyranthes aspera, Lawsonia alba, and Plumbago zeylanica. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an antioxidant containing an extract of a specific plant as an active ingredient, an antioxidant skin external preparation and an antioxidant cosmetic, and a cosmetic method using the cosmetic.

  In order to maintain human life, aerobic energy metabolism is carried out in vivo. During the metabolic process, active oxygen and free radicals such as superoxide, hydroxy radical, and hydrogen peroxide are removed from oxygen taken into the body. It is known to generate. The generated active oxygen and free radicals are detoxified by enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase. However, due to the effects of the decrease in the expression level of the enzyme due to aging and the acceleration of the generation of active oxygen and free radicals due to external stimuli, detoxification of the active oxygen and free radicals by the aforementioned enzymes becomes insufficient, and as a result, Reactive oxygen and free radicals cause cell damage and tissue damage. In particular, the skin tissue is directly stimulated by ultraviolet rays in sunlight and environmental factors such as air pollutants, so that active oxygen and free radicals are easily generated in the tissue, and various oxidative damages are likely to occur. Such oxidative damage is a major cause of pigmentation such as spots and freckles, and skin aging such as wrinkles and sagging.

  For this reason, for skin external preparations and cosmetics to protect against oxidative damage of skin tissue caused by active oxygen and free radicals, vitamin E, vitamin C and other vitamin-based antioxidants, dibutylhydroxytoluene (BHT), Attempts have been made to incorporate synthetic antioxidants such as butylhydroxyanisole (BHA). However, it may not be said that the effect of preventing oxidative injury of skin external preparations and cosmetics containing these antioxidants is sufficient, and these vitamin antioxidants are sufficiently stable under oxidizing conditions. However, synthetic antioxidants have problems such as suspected carcinogenicity.

Therefore, a specific plant extract having an antioxidant action is selected from natural plant extracts that can be expected to have good safety for the human body, and is blended in an external skin preparation as an antioxidant. For example, plant extracts such as an acerola seed extract (Patent Document 1), a Paloazule extract (Patent Document 2), an extract of an octopus butterfly (Patent Document 3) are expected as an antioxidant. Yes.

Japanese Patent No. 4088829 Japanese Patent No. 3563947 JP 2006-321730 A

  However, since the types of plant extracts described in Patent Documents 1 to 3 are very limited, the degree of freedom in selecting plant extracts during the production of a skin external preparation must be reduced. In addition, some skin external preparations and cosmetics formulated with these plant extracts may not be sufficiently effective in preventing oxidative damage. For this reason, the extract of the new plant which has an antioxidant action different from the plant extract described in patent documents 1-3 is always calculated | required.

  The present invention is intended to solve the above-described problems of the prior art, and can be expected to have good safety, and contains an anti-oxidant and antioxidant skin containing a new plant extract having an anti-oxidant action. An object is to provide external preparations and antioxidant cosmetics.

  In view of the above-mentioned object, the present inventors have studied the effectiveness as natural antioxidants for plant-derived components that have been used for humans for a long time and are considered to have no safety problems. It has been found that an extract of a specific plant for which no report has been made has an antioxidant action suitable for blending into an antioxidant skin external preparation or an antioxidant cosmetic, and has completed the present invention.

  That is, the present invention relates to a species selected from the group consisting of Bengal voyage (Ficus benghalensis), Asparagus racemosus (Asparagus recimosus), Asylanthes aspera, Lawsonia alba, and Ceylon pine. Provided are an antioxidant, an antioxidant skin external preparation, and an antioxidant cosmetic characterized by containing an extract of a plant, and a cosmetic method using the antioxidant cosmetic.

  The antioxidant, antioxidant skin external preparation, and antioxidant cosmetic of the present invention contain an extract of a specific plant. This plant extract can be expected to be highly safe against the skin and has a good antioxidant effect. In the cosmetic method of the present invention, the above-described antioxidant cosmetic of the present invention is applied to the epidermis. Therefore, according to the present invention, it is possible to prevent or suppress the occurrence of pigmentation such as stains and freckles due to aging or sunburn, and further excellent preventive / improving effects against skin aging such as wrinkles and sagging Can be expected.

  As described above, the present invention may be selected from the group consisting of Bengalbodaiju (Ficus benghalensis), Asparagus recimosus (Aspranhes aspera), Shikoko (Lawsonia alba), and Ceylon matsu. An anti-oxidant, an anti-oxidant external preparation for skin, an anti-oxidant cosmetic, and a cosmetic method using the anti-oxidant cosmetic, characterized by containing an extract of a plant of more than one species. First, although the above-mentioned plant is demonstrated, the production center of these plants is not specifically limited.

  Bengal voyage (Ficus benghalensis) is a plant belonging to the genus Asteraceae and is known as an evergreen tree widely distributed in tropical Asia.

  Asparagus recimosus (Asparagus recimosus) is a plant belonging to the genus Asparagus, which is a perennial monocotyledon and widely distributed in the tropical regions of Asia and Africa.

  Achylanthes aspera is a plant belonging to the genus Inokozuchi, and is known as an annual plant distributed from the temperate zone to the tropics.

  Lawsonia alba is a plant native to North Africa and Southwest Asia belonging to the genus Lawsonia, and is also known to have been used as a dye for coloring nails and hair for a long time.

  Ceylon pine (Plumbago zeylanica) is a plant belonging to the genus Rurimatsuri, which is a dicotyledonous plant, and is widely distributed worldwide from the tropics to the cold zone.

  As used in the present invention, bengal scallop (Ficus benghalensis), asparagus racemosus (Asparagus recimosus), moss (Achylanthes aspera), mushroom (Lawsonia alba), and Ceylon pine (Plume glue) The plant leaves, stems, trunks, bark, buds, flowers, fruits, seeds, roots, etc. can be used as a mixture of one part or a plurality of parts or extracted from the whole plant. Among them, an extract of a sprout or a young leaf is preferably used in the case of a bengal body (Ficus benghalensis), and an extract of a root is preferably used in the case of an asparagus recimosus. Aspera) is preferably an extract of whole grass, in the case of Lawsonia alba, preferably an extract of leaves, and in the case of Plumbago zylanica, preferably roots. An extract is used.

  When obtaining extracts from these plants, each part may be used as it is, but after appropriate pretreatment such as drying, shredding, crushing, pressing or fermentation, the solvent is used at low or warm temperature. It is preferable to extract using. Although the extraction method is not specifically limited, For example, the method of immersing one site | part of the said plant body, or 2 or more types of site | parts in the solvent under low temperature or room temperature-heating is mention | raise | lifted. The extraction time is set according to the type of extraction solvent and the extraction temperature, but is preferably about 1 to 2 weeks.

  Examples of the extraction solvent include water, lower monohydric alcohols (methyl alcohol, ethyl alcohol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols (glycerin, propylene glycol, dipropylene glycol). 1,3-butylene glycol etc.), lower esters (ethyl acetate, butyl acetate etc.), hydrocarbons (benzene, hexane, pentane etc.), ketones (acetone, methyl ethyl ketone etc.), ethers (diethyl ether, tetrahydrofuran, di Propyl ether, etc.), acetonitrile and the like, and one or more of them can be used. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used. If necessary, purification treatment such as deodorization and decolorization may be further performed within a range not affecting the effects of the present invention. Further, if necessary, an antiseptic / antifungal agent (phenoxyethanol, paraoxybenzoic acid ester, etc.) may be added and then stored at a low temperature for 1 to 2 days, followed by filtration.

  Extracts of Bengalvodige (Ficus benghalensis), Asparagus recimosus (Asparagus recimosus), Achiranthes aspera, and extract of Prunus lapulis (Plumbaga) As an example of the method, a plant is immersed in hydrous ethyl alcohol or 1,3-butylene glycol having a concentration of 0 to 100 vol%, extracted at room temperature or heated for 1 to 10 days, filtered, and obtained filtrate. Can be aged at room temperature or at room temperature for an additional week and then filtered again.

  In the antioxidant, antioxidant skin external preparation or antioxidant cosmetic of the present invention, Bengalbodis extract, Asparagus recimosus extract, Asylanthus aspera extract, The total content of the extract of Lawsonia alba and the extract of Ceylon pine (Plumbago zeylica) is preferably 0.00001 to 10% by mass, more preferably 0.00001 to 2% by mass as the dry solid content. is there. If the total content of these plant extracts is within this range, the plant extract can be stably blended, has high safety to the skin, and exhibits high medicinal or cosmetic effects. it can.

  Further, in the present invention, the antioxidant, the antioxidative skin external preparation or the antioxidant cosmetic is a variety of commonly used medicinal ingredients such as a moisturizer, a whitening agent, an anti-inflammatory agent, a cell activator, and an ultraviolet protective agent. It can be used in combination with one or more medicinal agents selected from blood circulation promoters and other antioxidants. Thereby, the effect of the present invention can be further enhanced.

  Examples of humectants include aspartic acid, aspartate, alanine, arginine, alginic acid, sodium alginate, xylitol, glycine, glucose, cystine, cysteine, serine, polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, polyglycerin, 1 , 3-butylene glycol, 1,2-pentanediol, hexylene glycol, xylitol, sorbitol, POE methylglucoside, maltitol, maltose, mannitol, lysine, honey, royal jelly, chondroitin sulfate, chondroitin sulfate, hyaluronic acid, hyaluronic acid Sodium, sodium acetyl hyaluronate, mucoitin sulfate, caronic acid, tranexamic acid, betaine, trehalose, chito , Urea, ceramide, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salt, dl-pyrrolidone carboxylate, soluble collagen, diglycerin (EO) PO adduct, ashitaba extract, asparagus extract , Izayoi rose extract, quince seed extract, guava leaf extract, yarrow extract, merirot extract and the like.

  Examples of whitening agents include L-ascorbic acid, L-ascorbate, ethyl L-ascorbate, L-ascorbic acid dipalmitate, L-ascorbic acid monopalmitate, tetra-2-hexyldecanoate ascorbyl, L-ascorbic acid-2-sodium sulfate, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid stearate, L-ascorbic acid-2-glucoside, DL-α -Vitamin C such as tocopherol-L-ascorbic acid phosphate diester dipotassium, placental extract, kojic acid, ellagic acid, chamomile extract, fire spine extract, rensch extract, tocotrienol, glutathione, arbutin, tranexamic acid, walrus Extract, Yukinoshita extract, Acerola extract, Ages extract, Ferulic acid, Adenosine phosphate disodium, Linoleic acid, 4-n-butylresorcin, 4- (4-hydroxyphenyl) -2-butanol, 5,5 Examples include '-dipropyl-biphenyl-2,2'-diol, potassium 4-methoxysalicylate, hydroquinone, hydroquinone monobenzyl ether, pantethein-s-calcium sulfonate, oil-soluble licorice extract and the like.

  Anti-inflammatory agents include, for example, aminocaproic acid, allantoin, indomethacin, bisabolol, saponin, lysothium chloride, azulene, guaiazulene, guaiazulene sulfonate, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, salicylic acid and its derivatives, hinokitiol, photosensitivity Examples thereof include elemental, tranexamic acid and derivatives thereof, zinc oxide, turmeric extract, ginger extract, button extract, litchi extract, and bitumen extract.

  Examples of cell activators include, for example, aminobutyric acid, ginkgo biloba extract, fennel extract, Dutch mustard extract, carrot extract, clara extract, chlorella extract, saffron extract, soybean extract, tiso extract, nicotinic acid, Examples thereof include nicotinamide, pantothenic acid and derivatives thereof, biotin, retinol, leucine, photosensitizer, riboflavin and derivatives thereof, pyridoxine and derivatives thereof, and the like.

  Examples of UV protection agents include oxybenzone, oxybenzonesulfonic acid, tetrahydroxybenzophenone, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenonesulfonate, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5. -Sulfonate, sinoxate, glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, methyl diisopropylcinnamate, methyl methoxycinnamate, octyl paramethoxycinnamate, isopropyl diisopropylcinnamate paramethoxycinnamate Cinnamic acid ester mixture, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylbenzoate, paraamino Benzoic acid (PABA), ethyl paraaminobenzoate, ethylene glycol salicylate, octyl salicylate, phenyl salicylate, homomenthyl salicylate, urocanic acid, ethyl urocanate, ethylhexyltriazone, drometrizole, drometrizol trisiloxane, 4-methoxy- Examples thereof include 4′-tert-butyldibenzoylmethane, titanium oxide, talc, carmine, bentonite, kaolin, and zinc oxide.

  As a blood circulation promoter, for example, salamander extract, ginger extract, gypsum extract, chimpi extract, pepper extract, ginger extract, button extract, nonyl acid valenylamide, nicotinic acid benzyl ester, nicotinic acid β- Examples include butoxyethyl ester, capsaicin, cantalis tincture, ictamol, caffeine, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, acetylcholine, cephalanthin, and γ-oryzanol.

  Examples of other antioxidants include astaxanthin, β-carotene, γ-oryzanol, kinetin, tocopherol, dibutylhydroxytoluene, flavonoids, SOD, catalase, fullerene, phytic acid, ferulic acid, chlorogenic acid, propyl gallate, and green tea extraction , Rosemary extract, Rosehip extract, Shobu extract, Horsetail extract, Hamamelis extract, Parsley extract, Loquat leaf extract, Grapefruit extract, Citrus extract, Lychee extract, Artemisia extract, Peach Examples include leaf extract, mango extract, button pi extract, pine bark extract, platinum, ubiquinone, α-lipoic acid and the like.

  In addition to the above components, the antioxidant, antioxidant skin external preparation or antioxidant cosmetic of the present invention is water that is a component usually used for external preparations within a range not impairing the effects of the present invention. , Oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols, esters, plant extracts, vitamins, water-soluble polymers, surfactants, metal soaps, alcohol, polyhydric alcohols, pH adjusters , Ingredients such as preservatives, fragrances, powders, thickeners, pigments, chelating agents, and the like can be appropriately blended.

  The dosage form of the antioxidant, antioxidant skin external preparation or antioxidant cosmetic of the present invention is not particularly limited, and examples thereof include low-viscosity liquids, pastes, creams, foams, emulsions, packs, ointments, powders, and aerosols. And patches. The present invention can be applied to any of cosmetics, quasi drugs, and pharmaceuticals. Specifically, for example, it can be applied to lotions, cosmetic creams, cosmetic milks, cosmetic liquids, cosmetic packs, cosmetic cleaning agents, bath preparations, makeup cosmetics, and the like.

If the amount of the antioxidant, antioxidant external preparation or antioxidant cosmetic of the present invention applied to the epidermis is too small, the effect of the invention cannot be obtained, and if it is too large, an effect commensurate with the amount added can be obtained. Absent. Therefore, it is preferably 0.0002 to 1340 μg / cm ² · day, more preferably 0.0002 to 270 μg / cm ² · day per unit area (1 cm ² ) in terms of plant extract (dry solid content). .

  Moreover, the antioxidant cosmetic composition of the present invention can be preferably applied to a cosmetic method for preventing and improving skin aging for cosmetic purposes. This cosmetic method is characterized in that the antioxidant cosmetic composition of the present invention is applied to the epidermis in order to prevent and improve skin aging for cosmetic purposes. In this beauty method, as a method for applying the antioxidant cosmetic to the epidermis, a normal beauty method such as application with bare hands or aerosol spraying can be employed. Preferred application times include after bathing and after face washing.

  The antioxidants, antioxidant skin external preparations and antioxidant cosmetics of the present invention, and cosmetic methods will be described more specifically with reference to preparation examples, test examples, and examples. There are no restrictions.

<Preparation example of plant extract>
New shoots of bengal scallop (Ficus benghalensis), roots of asparagus recimosus, whole plants of Achyranthes aspera, leaves of abalone (Lawsonia alba), ay z 100 g of each part was pulverized, put into separate 2 liter glass containers, mixed with 1000 mL of 50% aqueous ethanol solution, and sealed. After standing at room temperature for 7 days, the insoluble matter was removed by filtration, and the extract of bengalbodaiju (Ficus benghalensis), asparagus recimosus, extract of Asylanthus aspera, mushroom ( Lawsonia alba) extract and Ceylon pine (Plumbago zylanica) extract were obtained, respectively. This extract was used as a plant extract in the following test examples and examples.

<Test Examples> Antioxidant Action Tests Bengal voyage, Asparagus recimosus, Asylanthus aspera, and Lawsonia and Lawsonaia obtained in plant extract preparation examples. For each plant extract of (Plumbago zeylanica), a radical scavenging experiment using 1,1-diphenyl-2-picryl-hydrazyl (1,1-diphenyl-2-picrylhydrazyl: hereinafter referred to as DPPH) is explained as follows. went.

That is, the antioxidant effect was evaluated by measuring the decrease in absorbance at 520 nm caused by the reduction of DPPH, which is a stable radical substance having a maximum absorption at 520 nm, by the antioxidant contained in the extract. Specifically, each plant extract was diluted to 2 vol% with phosphate buffered saline (PBS), and 50 μL of the resulting diluted solution was added to a 96-well microplate. Thereto, 50 μL of a 2.5 × 10 ⁻⁴ mol / L DPPH ethanol solution was added and mixed well, and then allowed to stand at room temperature in a dark place for 30 minutes. Finally, the absorbance was measured with an absorbance plate reader (Tecan, Infinite 200F) using a 520 nm filter (half width 10 nm). In addition, the absorbance was measured in the same manner using a reaction solution in which only ethanol not containing DPPH was added instead of the DPPH ethanol solution as a blank solution. The numerical value measured by the above method was substituted into the following equation to calculate the antioxidant rate. The obtained results are shown in Table 1.

  In the above formula, A is the absorbance of the reaction solution containing the plant extract, B is the absorbance of the blank solution containing the plant extract, C is the absorbance of the reaction solution not containing the plant extract, and , D is the absorbance of the blank solution containing no plant extract.

  From Table 1, an antioxidant effect was recognized in the reaction solution containing the extract of a specific plant. Therefore, it turns out that each plant extract of Table 1 is an effective antioxidant.

Examples 1 to 5 and Comparative Example 1 (Preparation of liquid skin external preparation)
A liquid skin external preparation was prepared by uniformly mixing and dissolving the blending components in Table 2.

Examples 6 to 10, Comparative Example 2 (Preparation of external skin cream)
Among the blending components in Table 3, the components (1) to (6) are heated and mixed to prepare a mixture 1A at 75 ° C. Separately, the components (7) to (10) are added to the component (12). A mixture 1B at 75 ° C. was prepared by heating and mixing. The resulting mixture 1A and mixture 1B were mixed and emulsified using a homomixer and allowed to cool to room temperature to prepare mixture 1C. Component (11) was uniformly mixed with the obtained mixture 1C to obtain an external skin cream.

Examples 11 to 15 and Comparative Example 3 (Preparation of lotion)
Among the blended components in Table 4, components (1) to (6) are mixed and dissolved at room temperature to prepare mixture 2A. Separately, components (7) to (13) are mixed and dissolved at room temperature. Mixture 2B was prepared. The obtained mixture 2A and mixture 2B were uniformly mixed using a stirrer to obtain a skin lotion.

Examples 16-20, comparative example 4 (preparation of emulsion)
Among the blended components in Table 5, the components (1) to (8) are heated and mixed to prepare a mixture 3A at 75 ° C. Separately, the components (9) to (13) are added to the component (15). A mixture 3B at 75 ° C. was prepared by heating and mixing. The resulting mixture 3A and mixture 3B were mixed and emulsified using a homomixer and allowed to cool to room temperature to prepare mixture 3C. Component (14) was uniformly mixed with the obtained mixture 3C to obtain an emulsion.

Examples 21 to 25, Comparative Example 5 (Preparation of pack agent)
Among the blending components in Table 6, the mixture (1) to (6) is heated to 70 ° C. with mixing and dissolved to prepare the mixture 4A. Separately, the components (7) to (10) are mixed at room temperature. The mixture 4B was prepared by mixing and dissolving. The obtained mixture 4A and mixture 4B were mixed using a stirrer and allowed to cool to room temperature to obtain a pack agent.

Examples 26-30, Comparative Example 6 (Preparation of emulsion foundation)
Among the blending components in Table 7, components (1) to (6) were mixed and dissolved at room temperature, and components (12) to (16) were added and mixed by heating to prepare a mixture 5A at 70 ° C. Separately, components (7) to (11) and (18) were heated and mixed to prepare a mixture 5B at 70 ° C. The mixture 5A was added to the resulting mixture 5B, emulsified using a homomixer, and allowed to cool to room temperature to prepare a mixture 5C. Component (17) was uniformly mixed with the obtained mixture 5C to obtain an emulsion foundation.

<Evaluation test>
As for skin creams for external use shown in Examples 6 to 10 and Comparative Example 2 (prepared by substituting the plant extract of the present invention in the formulation of Examples with purified water), the effect of improving skin roughness will be described below. Test evaluation.

<Roughness improvement effect evaluation method>
40 female subjects (25 to 60 years old) with marked skin roughness were divided into two groups in half, and each of the agents of Examples and Comparative Examples was divided into two groups each day (in the morning face wash and at night) After bathing), the face was used for 3 months, and the degree of improvement in rough skin before and after use was observed by a beauty technician and evaluated according to the following evaluation criteria. Table 8 shows the obtained results. In addition, the number in a table | surface is the number of test subjects applicable to the said item.

(Evaluation criteria)
Evaluation rank: Content A (effective): Rough skin was improved.
B (somewhat effective): Rough skin was slightly improved.
C (invalid): Improvement of rough skin is not observed.

  As is clear from Table 8, in the case of rough skin, when the agents of Examples 6 to 10 containing a specific plant extract were used, the rough skin was more prominent than when the corresponding comparative agent was used. Improvement effect was observed. Furthermore, in the above-described evaluation test, none of the groups using Examples 6 to 10 complained of skin disorders such as skin irritation and allergic reaction.

  In addition, the result similar to Examples 6-10 was obtained also about the agent of Examples other than Examples 6-10.

  As mentioned above, the agent of the Example of this invention had the improvement effect excellent with respect to rough skin compared with the corresponding comparative example, and was a thing with high safety | security.

  The antioxidants, antioxidant skin external preparations and antioxidant cosmetics of the present invention have excellent antioxidant action, are safe and stable against oxidation, and therefore can be applied as cosmetics. Is preferred. In addition, it can prevent and improve skin oxidative damage, exhibit its effectiveness in rough skin and skin aging, and protect the skin. Therefore, the antioxidant, the antioxidant skin external preparation, the antioxidant cosmetic, and the cosmetic method of the present invention are useful in the medical field and the cosmetic field.

Claims (4)

  Bengalbodaiju (Fusus benghalensis), Asparagus rasemosus (Asparagus recimosus), Achylanthus aspera, Shiwuka (Lawsonia alba), Ceylon pine (Plumbaz) Antioxidant characterized by that.   Bengalbodaiju (Fusus benghalensis), Asparagus rasemosus (Asparagus recimosus), Achylanthus aspera, Shiwuka (Lawsonia alba), Ceylon pine (Plumbaz) Antioxidant skin external preparation.   Bengalbodaiju (Fusus benghalensis), Asparagus rasemosus (Asparagus recimosus), Achylanthus aspera, Shiwuka (Lawsonia alba), Ceylon pine (Plumbaz) Antioxidant cosmetics.   A cosmetic method comprising applying the cosmetic according to claim 3 to the skin for cosmetic purposes.