KR20150057737A - Whitening cosmetics composition - Google Patents
Whitening cosmetics composition Download PDFInfo
- Publication number
- KR20150057737A KR20150057737A KR1020130141475A KR20130141475A KR20150057737A KR 20150057737 A KR20150057737 A KR 20150057737A KR 1020130141475 A KR1020130141475 A KR 1020130141475A KR 20130141475 A KR20130141475 A KR 20130141475A KR 20150057737 A KR20150057737 A KR 20150057737A
- Authority
- KR
- South Korea
- Prior art keywords
- extract
- skin
- cosmetic composition
- lactic acid
- persimmon leaf
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
Description
The present invention relates to a cosmetic composition having skin whitening and wrinkle improving activity, and more particularly, to a cosmetic composition having an excellent effect on skin whitening effect by providing melanin inhibitory activity, preventing skin aging and improving wrinkles will be.
Skin is the largest organ in the human body and its area is about 1.6m2 in size. It is a large organ which weighs 16% of body weight. Skin is the most basic covering covering the body to protect internal organs. It is also a very important institution that performs many functions.
Skin melanogenesis is a defense mechanism against stimuli such as ultraviolet light in melanocyte-producing cells (melanocyte), and a large amount of melanin produced by the melanin is transferred to keratinocyte and accumulated on the skin surface layer Results. Although melanin protects the skin, hyperpigmentation of the skin causes skin irritation, freckles, darkening of the skin after inflammation of the skin and aging pigmentation spots. This causes the discomfort of the person not only the cosmetic discomfort but also the psychological negative affect on the social activities. . Melanin is produced by tyrosine tyrosine, an enzyme called tyrosinase, converted into DOPA or dopaquinone, and then enzymatically oxidized to form an abnormal deposit in the skin And it is known that it produces spots and black spots. Materials for inhibiting melanin production such as hydroquinone, arbutin, vitamin C and derivatives thereof have been developed for the relief, prevention and treatment of such pigment deposits, stains and spots, and whitening cosmetics containing them have been disclosed And Korean Patent Publication No. 2005-0509848 discloses a whitening cosmetic composition containing a keractone derivative isolated from Korean Patent Publication No. 2005-0509848. Korean Patent Publication No. 2005-0479741 discloses a whitening cosmetic containing a glucose acylated derivative. Of these, hydroquinone is generally recognized for its effectiveness, but is generally limited in its use because of its sensitivity.
On the other hand, the skin of the human being is exposed to chemical and physical stimuli of the outside, the normal function of the skin is deteriorated and problems are caused, and the aging phenomenon of the skin is promoted and the skin is damaged. Skin wrinkles are one of the aging of such skin. Generally, it is known that skin wrinkles are generated by a complex action of various factors such as moisture content of skin, collagen content and immunity against external environment. Among these factors, collagenase, which is the collagenase which decreases collagen production and collagen content, has the greatest influence on the formation of wrinkles.
Various compositions have been conventionally used to inhibit whitening and wrinkling of the skin as described above. For example, various extracts extracted from L-ascorbic acid and its derivatives, hydroquinone, arbutin, licorice, and bark extract are used as skin lightening agents and wrinkle removers. However, L-ascorbic acid is easily oxidized to cause irritation to the skin. The cosmetic composition containing the L-ascorbic acid causes discoloration and irregularity, and the substances derived from the plant extract have a strong effect on the homogeneity of the product And arbutin has a disadvantage in that the effect is low.
Disclosure of the Invention The present invention has been proposed in order to solve the problems of the prior art as described above. The object of the present invention is to provide a skin care cosmetic composition which can be safely used but also provides melanin inhibitory activity to prevent skin whitening, skin aging, Composition.
The technical problem of the present invention as described above is achieved by the following means.
(1) A cosmetic composition for skin whitening and wrinkle improvement comprising the extract of Lilac, Liliaceae extract, Liliaceae extract, and Persimmon leaf extract as active ingredients.
(2) The cosmetic composition for skin whitening and wrinkle improvement according to the above (1), wherein the extract of Lambskin and Persimmon leaves is fermented by adding lactic acid bacteria after concentrating the hot water extract of lambskin or persimmon leaves under reduced pressure.
(3) The cosmetic composition for skin whitening and wrinkle improvement according to (2), wherein the lactic acid bacterium is Lactobacillus perfumeum L. fermentum and Lactobacillus casei.
(4) In the above (1), the extract of the wheat extract is prepared by adding, as a lactic acid bacterium, to a lyophilized powder of wheat germ in a weight ratio of L. fermentum and L. casei of 7: 3 to 8: And the mixture is fermented with lactic acid bacteria at 30 to 35 DEG C, and the extract is extracted with ethanol.
(5) The cosmetic composition for skin whitening according to (1), wherein the extract of wheat is added in an amount of 0.1 to 1.0% by weight.
The cosmetic composition according to the present invention provides a melanin inhibitory activity while being safe to use, has an excellent effect on skin whitening effect, prevents skin aging and provides a wrinkle-reducing effect.
The cosmetic composition according to the present invention is characterized by containing a ginseng extract as a main component.
The wheat extract according to the present invention includes a hot-water extract of wheat, an ethanol extract, or an extract using a mixture of water and ethanol, or a supercritical extract.
In the case of the hot-water extract, it is preferable to add 1 to 10 times of water and extract at 1 to 2 atm and 80 to 120 캜 for 1 to 12 hours. The ethanol extract may be an extraction solvent composed of 50 to 100% ethanol, and the supercritical extract may be performed under the pressure of 250 to 350 bar using ethanol as an extraction solvent.
In the present invention, the wheat germ can be safely used as a natural plant material, but also has excellent melanin inhibitory activity and provides excellent activity for skin whitening.
Preferably, the above-mentioned wheat extract is a mixture of L. fermentum and L. casei in a weight ratio of 7: 3 to 8: 2 as a lactic acid bacterium to a lyophilized powder of wheat And fermented with lactic acid bacteria at 30 to 35 ° C by extraction with ethanol.
The cosmetic composition according to the present invention further comprises a Houttuynia cordata extract, a camel root extract, and a persimmon leaf extract.
The above-mentioned Hwasung extract, Liliaceae extract and Persimmon leaf extract are mixed with the extract to enhance the whitening effect, prevent aging of the skin and provide a wrinkle-reducing effect.
The extracts of Hwanggeuk extract, Persimmon extract and Persimmon leaf extract may be hot water extract, ethanol extract, or a mixture using water and ethanol, or supercritical extract as in the extract, After concentration, it is assumed that lactic acid bacteria (preferably Lactobacillus fermentum and L. casei) are added and fermented.
It is preferable that the above-mentioned extract of wheat germ, gangbyeol extract, camellia japonica extract, and persimmon leaf extract are added in the range of 0.1 to 1.0 wt% with respect to the total weight of the cosmetic composition, and whitening activity and wrinkle- Loses.
The liquid or solid cosmetic composition containing the extract of the present invention as a main component may contain components conventionally used in cosmetic compositions and may contain components commonly used in cosmetic compositions, such as antioxidants, stabilizers, solubilizers, vitamins, Conventional adjuvants, and carriers.
The cosmetic composition of the present invention may be prepared in any form conventionally produced in the art and may be in the form of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant- , Oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it can be manufactured in the form of a flexible lotion, a convergent lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.
When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .
When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.
When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.
In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.
When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.
Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. However, the present invention is not limited thereto.
[Example 1] Production of cream
Example 1 and Comparative Formulation 1 were prepared with the compositions shown in Table 1 below. The extracts of the wheat extracts were obtained by fermenting the lyophilized powder with the mixed lactic acid bacteria (L. fermentum and L. casei at a weight ratio of 7: 3 by weight) for 1 day at 30 ° C, . The extracts of Bacillus thuringiensis extracts were obtained by extracting at 80 ° C for 2 hours. The extracts of Panax ginseng and Persimmon leaves were subjected to extraction with hot water extract, respectively, by mixing the lactic acid bacteria (Lactobacillus perfumeum Lacterium and Lactobacillus casei Fermented at 30 ° C for 1 day using 7: 3 mixture).
[Example 2] Production of nutrition lotion
Example 2 and Comparative Formulation 2 were prepared with the compositions shown in Table 2 below.
[Example 3] Production of softening longevity
Example 3 and Comparative Formulation 1 were prepared with the compositions of Table 3 below.
[Experimental Example 1] Confirmation of pigmentation inhibition effect
Experiments were carried out in the following manner to verify the effect of inhibiting pigment formation by the formulations prepared in Examples 1 to 3 and Comparative Formulations 1 to 3.
Eighty healthy subjects were selected and aluminum foil having a diameter of 7 mm and having a diameter of 7 mm and having 2 lines was attached to the lower part of both arms. Using an ORIEL solar simulator 1000W at a distance of 10 cm from the arm, / cm < 2 > Before irradiation, the irradiated sites were washed well with 70% aqueous ethanol solution. Formulations 1 to 3 and Comparative Formulations 1 to 3 were applied in duplicate to the same row 3 days before irradiation to 8 weeks after irradiation, twice a day.
The panel was divided into 20 groups in group 1 and tested in 4 groups. The determination of the whitening effect was made by visually determining the degree of discoloration of the formulations and the comparative formulations, and the degree of inhibition of the pigmentation by the formulation compared to the comparative formulations was evaluated in three steps of marked effect, effect, and no difference , And the results are shown in Table 4 below.
As shown in Table 4, the cosmetics of formulations 1 to 3 containing the substances of the present invention showed a superior skin whitening effect as compared with conventional cosmetics.
[Experimental Example 1] Measurement of inhibitory effect on melanin formation
The whitening effect at the cellular level was investigated by adding the extract of Liliaceae, Rhizopus japonicus, Lycopersicon esculentum and Persimmon Leaf to the culture medium of rat melanoma cells (B-16 mouse melanoma cell) (Lotan R., Lotan D. Cancer Res , ≪ / RTI > 40 , pp. 3345-3350, 1980). The resulting compounds were added to the culture medium of B-16 melanoma cells so as to have a final concentration of 5 / / ml and 15 / / ml, respectively. After culturing for 3 days, the cells were treated with trypsin Melanin was extracted after centrifugation from the container. Was added 1 N sodium hydroxide solution, 1ml the extract dissolved melanin boiled for 10 minutes, using a spectrophotometer 475 nanometers (nm) in the amount of the produced melanin unit cell allowance by measuring the absorbance at (10 6 cell) absorbance (Repeated three times). The relative amount of melanin production relative to the control group was calculated as the inhibition rate (%), and the results are shown in Table 5.
As described above, it was confirmed that the whitish extract, the whitetoptera extract, the camel root extract, and the persimmon leaf extract according to the present invention have an effect of inhibiting melanin formation, and thus, the whitening cosmetic composition is effective.
[Experimental Example 2] Wrinkle-improving effect test
The effect of wrinkle improvement can be generally measured as collagen biosynthesis performance, collagenase degradation inhibition ability, and human clinical test. Human normal fibroblasts were inoculated into 6-well microplates containing DMEM medium
(2 × 10 5 cells / well) in a 5% CO 2 incubator at 37 ° C. for 24 hours. After 24 hours, the medium was removed from each well, samples were treated at different concentrations, and then cultured again for 24 hours. After 24 hours, the cell culture medium was collected to prepare a sample. The amount of collagen synthesis was measured by using a procollagen type I C-peptide (type I C-peptide) in a cell culture medium using a collagen measurement kit (Procollagen type I C-peptide EIA kit (MK101), Takara, : PICP) was measured and analyzed. An antibody against collagenase was used as a method for measuring the activity of collagenase degrading collagen. The collagenase activity was measured using a Type I collagenase assay kit (Amersham Biosciences, RPN2629) and the absorbance was measured with an ELISA reader. The measured values were expressed as mean ± standard deviation, and the significance was tested by t-test using the SPSS / PC + program. The results are shown in Table 6 below.
(Concentration of each extract 1 占 퐂 / ml)
(Concentration of each extract 5 / / ml)
(Concentration of each extract was 10 占 퐂 / ml)
As shown in Table 6, the composition according to the present invention increased collagen synthesis in a concentration-dependent manner and inhibited collagenase activity in a concentration-dependent manner. Therefore, the composition according to the present invention has a wrinkle-reducing effect.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims. It can be understood that
Claims (5)
And the persimmon leaf extract and persimmon leaf extract are fermented by adding lactic acid bacterium after concentrating the hot water extract of roots or persimmon leaves under reduced pressure, respectively, to make a skin whitening and wrinkle improving cosmetic composition.
Wherein the lactic acid bacterium is Lactobacillus perfumeum (L. fermentum) and Lactobacillus casei (L. casei).
The extract was prepared by adding a mixture of L. fermentum and L. casei at a weight ratio of 7: 3 to 8: 2 to the lyophilized powder of wheat, A cosmetic composition for skin whitening and wrinkle improvement characterized by extracting the mixture obtained by fermenting lactic acid bacteria at 35 DEG C with ethanol.
Wherein the extract is added in an amount of 0.1 to 1.0% by weight.
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KR1020130141475A KR20150057737A (en) | 2013-11-20 | 2013-11-20 | Whitening cosmetics composition |
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KR1020130141475A KR20150057737A (en) | 2013-11-20 | 2013-11-20 | Whitening cosmetics composition |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101950382B1 (en) * | 2017-10-11 | 2019-02-20 | 주식회사 코리아나화장품 | Cosmetic Composition for Whitening of the Skin Comprising Fermented Extracts of Cassia tora, Phragmites communis, Sasa quelpaertensis, Anemarrhena asphodeloides and Gardenia jasminoides Ellis |
KR20230011590A (en) * | 2021-07-14 | 2023-01-25 | 박규림 | Composition for anti-oxidant, anti-inflammation, whitening and anti-wrinkle comprising fermented Hibiscus manihot as effective component |
-
2013
- 2013-11-20 KR KR1020130141475A patent/KR20150057737A/en not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101950382B1 (en) * | 2017-10-11 | 2019-02-20 | 주식회사 코리아나화장품 | Cosmetic Composition for Whitening of the Skin Comprising Fermented Extracts of Cassia tora, Phragmites communis, Sasa quelpaertensis, Anemarrhena asphodeloides and Gardenia jasminoides Ellis |
KR20230011590A (en) * | 2021-07-14 | 2023-01-25 | 박규림 | Composition for anti-oxidant, anti-inflammation, whitening and anti-wrinkle comprising fermented Hibiscus manihot as effective component |
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