CN114190555B - A dripping pill with antioxidant effect and its preparation method - Google Patents
A dripping pill with antioxidant effect and its preparation method Download PDFInfo
- Publication number
- CN114190555B CN114190555B CN202111555901.3A CN202111555901A CN114190555B CN 114190555 B CN114190555 B CN 114190555B CN 202111555901 A CN202111555901 A CN 202111555901A CN 114190555 B CN114190555 B CN 114190555B
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- CN
- China
- Prior art keywords
- parts
- content
- dripping
- extract
- pill
- Prior art date
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Links
- 239000006187 pill Substances 0.000 title claims abstract description 120
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 230000003078 antioxidant effect Effects 0.000 title description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 45
- 230000000694 effects Effects 0.000 claims abstract description 33
- 108010010803 Gelatin Proteins 0.000 claims abstract description 29
- 238000001035 drying Methods 0.000 claims abstract description 29
- 229920000159 gelatin Polymers 0.000 claims abstract description 29
- 239000008273 gelatin Substances 0.000 claims abstract description 29
- 235000019322 gelatine Nutrition 0.000 claims abstract description 29
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 29
- 241000168517 Haematococcus lacustris Species 0.000 claims abstract description 28
- 229940094952 green tea extract Drugs 0.000 claims abstract description 28
- 235000020688 green tea extract Nutrition 0.000 claims abstract description 28
- 240000001341 Reynoutria japonica Species 0.000 claims abstract description 26
- 235000018167 Reynoutria japonica Nutrition 0.000 claims abstract description 26
- 229940001884 passion flower extract Drugs 0.000 claims abstract description 23
- 235000020689 passion flower extract Nutrition 0.000 claims abstract description 23
- 238000003860 storage Methods 0.000 claims abstract description 18
- 230000003064 anti-oxidating effect Effects 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000005303 weighing Methods 0.000 claims abstract description 17
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 15
- 229940067606 lecithin Drugs 0.000 claims abstract description 15
- 235000010445 lecithin Nutrition 0.000 claims abstract description 15
- 239000000787 lecithin Substances 0.000 claims abstract description 15
- 239000002775 capsule Substances 0.000 claims abstract description 10
- 239000003292 glue Substances 0.000 claims description 39
- 235000013824 polyphenols Nutrition 0.000 claims description 32
- 244000269722 Thea sinensis Species 0.000 claims description 31
- 235000013616 tea Nutrition 0.000 claims description 30
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 29
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims description 26
- 235000021283 resveratrol Nutrition 0.000 claims description 26
- 229940016667 resveratrol Drugs 0.000 claims description 26
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 25
- 239000000463 material Substances 0.000 claims description 25
- 235000000370 Passiflora edulis Nutrition 0.000 claims description 24
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 20
- 235000013793 astaxanthin Nutrition 0.000 claims description 20
- 239000001168 astaxanthin Substances 0.000 claims description 20
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 20
- 229940022405 astaxanthin Drugs 0.000 claims description 20
- 150000004676 glycans Chemical class 0.000 claims description 18
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- 239000005017 polysaccharide Substances 0.000 claims description 18
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- 239000000843 powder Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- 235000011187 glycerol Nutrition 0.000 claims description 15
- 239000005662 Paraffin oil Substances 0.000 claims description 12
- 229940057995 liquid paraffin Drugs 0.000 claims description 12
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 12
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- 235000013731 Passiflora van volxemii Nutrition 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 239000008213 purified water Substances 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 238000007873 sieving Methods 0.000 claims description 8
- 238000007872 degassing Methods 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 7
- 230000008018 melting Effects 0.000 claims description 7
- 230000003068 static effect Effects 0.000 claims description 7
- 238000010009 beating Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 6
- 239000011343 solid material Substances 0.000 claims description 5
- 239000002270 dispersing agent Substances 0.000 abstract description 13
- 238000000576 coating method Methods 0.000 abstract description 6
- 239000011248 coating agent Substances 0.000 abstract description 5
- 238000012360 testing method Methods 0.000 description 25
- 150000003254 radicals Chemical class 0.000 description 24
- 239000000047 product Substances 0.000 description 17
- 244000288157 Passiflora edulis Species 0.000 description 16
- 239000001301 oxygen Substances 0.000 description 15
- 229910052760 oxygen Inorganic materials 0.000 description 15
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 12
- 239000003921 oil Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- 239000003963 antioxidant agent Substances 0.000 description 10
- 235000006708 antioxidants Nutrition 0.000 description 10
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 8
- 241000699670 Mus sp. Species 0.000 description 8
- 102000019197 Superoxide Dismutase Human genes 0.000 description 8
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- 230000002000 scavenging effect Effects 0.000 description 8
- 210000002966 serum Anatomy 0.000 description 8
- 238000010923 batch production Methods 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 238000007254 oxidation reaction Methods 0.000 description 7
- -1 polyphenol compound Chemical class 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
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- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 4
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- 229940083037 simethicone Drugs 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 125000000468 ketone group Chemical group 0.000 description 2
- 235000021388 linseed oil Nutrition 0.000 description 2
- 239000000944 linseed oil Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 230000004792 oxidative damage Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000003813 safflower oil Substances 0.000 description 2
- 235000020238 sunflower seed Nutrition 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
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- 241000894006 Bacteria Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000006587 Glutathione peroxidase Human genes 0.000 description 1
- 108700016172 Glutathione peroxidases Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 230000010718 Oxidation Activity Effects 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 108010093894 Xanthine oxidase Proteins 0.000 description 1
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- 238000009825 accumulation Methods 0.000 description 1
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- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical group 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
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- 230000005764 inhibitory process Effects 0.000 description 1
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- 230000000968 intestinal effect Effects 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 241000238565 lobster Species 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a dripping pill with an antioxidation effect, which comprises a content and a capsule, wherein the content comprises the following components in parts by weight: 1-10 parts of haematococcus pluvialis, 1-10 parts of polygonum cuspidatum extract, 1-10 parts of passion flower extract, 1-10 parts of green tea extract, 20-80 parts of dispersing agent and 0.5-5 parts of lecithin; the rubber shell comprises the following components in parts by weight: 50-80 parts of gelatin, 5-40 parts of glycerol and 5-20 parts of water. The invention also provides a preparation method of the dripping pill with the antioxidation effect, which comprises the following steps: weighing, preparing content, dissolving gelatin, dripping, drying and selecting pills. The dripping pill has excellent antioxidation effect, has a capsule coating, isolates smell, prevents effective components from being damaged, and prolongs the storage time.
Description
Technical Field
The invention relates to the technical field of health products, in particular to a dripping pill with an antioxidant effect and a preparation method thereof.
Background
Modern medicine considers that free radicals are harmful chemical substances generated by human organisms during metabolism, have strong oxidability, harm normal cells of the human bodies, cause the decrease of cell viability and cause organism aging and a series of chronic diseases. Research shows that the supplement of the antioxidant has remarkable effect on improving the antioxidant capacity of the organism.
Astaxanthin, also called astaxanthin and lobster shell pigment, is a red natural carotenoid, has extremely strong antioxidant activity, can remove excessive active oxygen in the body, thereby playing roles in preventing various diseases such as aging, cardiovascular diseases, inflammation, senile dementia, cancer and the like, and haematococcus pluvialis is a freshwater single-cell green alga which can accumulate a large amount of astaxanthin under specific conditions such as strong light, less nitrogen, high salt and the like, and the astaxanthin content can reach about 1.5-4.0% of the dry weight of cells.
Resveratrol is a polyphenol compound mainly derived from rhizoma Polygoni Cuspidati extract, and has antibacterial, antiinflammatory, antioxidant, liver protecting, cardiovascular and cerebrovascular protecting effects.
The herba Passiflorae Caeruleae is herb vine of Passiflora of Passiflorae, also called passion fruit and passion fruit. Researches show that the passion fruit peel polysaccharide has better nutritional value and medicinal value, such as an antioxidant function and an anti-inflammatory function, and can enhance cellular immunity.
The tea polyphenol consists of more than 30 phenolic substances, the main components of the tea polyphenol comprise catechin and derivatives thereof, the tea polyphenol is a main chemical component with health care function in tea, and the tea polyphenol content in green tea is higher and accounts for 15-30% of the weight of the tea polyphenol. The tea polyphenol has various physiological activities of resisting oxidation, radiation, aging, blood lipid and blood sugar, etc.
There is not antioxidant drop pill of the same type in the market at present, the drop pill has the advantages of concentrated drug effect, high bioavailability, rapid curative effect, etc., but traditional drop pill adopts the matrix with viscosity to mix together with content in order to be easy to shape, but the matrix still can influence the activity of content when mixing with content, dilute the concentration of active ingredient, the preparation matrix is also comparatively loaded down with trivial details, and the general outer layer of drop pill has no parcel, can not isolate smell, is easily oxidized in contact with air, influence the activity of content, some drop pills can adopt the coating technology to wrap up, but the coating technology is comparatively complicated, secondary working after the drop pill, production efficiency is poor, and the coating is easy to drop. Therefore, a new solution is needed to solve the above problems.
Disclosure of Invention
The invention aims to provide a dripping pill with an antioxidant effect and a preparation method thereof, wherein the dripping pill has an excellent antioxidant effect, is wrapped by a rubber shell, isolates smell, prevents active ingredients from being damaged and prolongs the storage time.
In order to achieve the technical purpose and meet the technical requirements, the invention adopts the technical scheme that: a dripping pill with antioxidation effect comprises a content and a capsule, wherein the content comprises the following components in parts by weight: 1-10 parts of haematococcus pluvialis, 1-10 parts of polygonum cuspidatum extract, 1-10 parts of passion flower extract, 1-10 parts of green tea extract, 20-80 parts of dispersing agent and 0.5-5 parts of lecithin; the rubber shell comprises the following components in parts by weight: 50-80 parts of gelatin, 5-40 parts of glycerol and 5-20 parts of water.
As a preferable technical scheme, the dispersing agent comprises one or more of sunflower seed oil, linseed oil, safflower seed oil and medium chain triglyceride.
As a preferable technical scheme, the astaxanthin content in haematococcus pluvialis is not less than 4%, and the passion fruit peel polysaccharide in the passion fruit extract is not less than 4%.
As a preferable technical scheme, the resveratrol content in the polygonum cuspidatum extract is not less than 90%, and the tea polyphenol content in the green tea extract is not less than 50%.
As a preferred embodiment, the lecithin is non-transgenic lecithin.
The invention also provides a preparation method of the dripping pill with the antioxidation effect, which comprises the following steps:
s1: weighing: accurately weighing all raw materials and auxiliary materials according to batch production and product formulation, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 100-200-mesh sieve;
s2: preparing the following contents: adding haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract according to the formula amount into a dispersing agent, stirring for 10-20 minutes, passing through a colloid mill, performing primary stirring at the upper limit temperature of 50 ℃ under the pressure of 0.4MPa and the flow rate of 5-7 seconds, homogenizing by a high-pressure homogenizer at the maximum 20000psi, adding phospholipid, continuously stirring for 20-40 minutes until the content with the fluidity meeting the requirement is obtained, and pouring the content into a content storage tank of a pill dropping machine with double layers of drippers for standby after defoaming;
s3: and (3) glue melting: mixing purified water and glycerin, heating to 60+/-10 ℃, adding gelatin, heating to 80+/-10 ℃, heating for 15-25 minutes, degassing and standing for 15-25 minutes, and clarifying the gelatin solution for later use;
s4: and (3) dripping: pouring the glue solution into a glue solution storage tank of a pill dropping machine with double-layer drippers, keeping the temperature of the oil bath at 60-70 ℃, setting the temperature of the drippers at 60-70 ℃ and the temperature of the condensate at 5-10 ℃, wherein the flow rate ratio of the glue solution to the content is 1 (2-5), and adjusting the height of a discharge hole of the pill dropping machine with double-layer drippers, so that the content and the glue solution can be smoothly dripped into the condensate through the double-layer drippers without adhesion phenomenon, and the dripping pills dripped into the condensate form spheres due to the surface tension effect and are gradually cooled and solidified for molding;
s5: drying and pill selection: and pre-drying the coagulated and formed dripping pills for 1-2 hours by a rotating cage, placing the dripping pills into a drying room for static drying for 20-30 hours, selecting the dried dripping pills, and packaging to obtain the finished product.
As a preferable technical scheme: the condensate in the step 4 is liquid paraffin oil or dimethyl silicone oil.
As a preferable technical scheme: the viscosity of the content in the step 2 is not more than 100mm 2 /s。
As a preferable technical scheme, the fineness of the solid materials in the content of the step 2 is 10 nm-200 nm.
The beneficial effects of the invention are as follows:
1) The astaxanthin in haematococcus pluvialis has unsaturated ketone groups and hydroxyl groups, has extremely strong capability of clearing free radicals, resveratrol in the polygonum cuspidatum extract can clear free radicals and repair damaged DNA, passion fruit peel polysaccharide in the passion fruit extract has extremely good capability of clearing the hydroxyl free radicals, tea polyphenol in the green tea extract has extremely good capability of clearing the oxygen free radicals and can protect oxidative damage DNA, lecithin can encapsulate astaxanthin, resveratrol, passion fruit peel polysaccharide and tea polyphenol, the activity of the effective components is prevented from being reduced, the added value of the effective components is improved, and the astaxanthin, resveratrol, passion fruit peel polysaccharide and tea polyphenol have extremely good synergistic effects, can clear free radicals in all aspects, delay aging, and have the effects of resisting bacteria and inflammation, resisting oxidization, protecting liver, protecting heart and cerebral vessels and the like; meanwhile, the contents of the dripping pill are wrapped by the rubber shell, so that the effects of centralizing the drug effect, reducing the oxidation of the contents, preventing the invalidation of the contents, isolating the smell and the like are facilitated.
2) In the preparation process of the dripping pill, in order to ensure that the rubber shell wraps the content, a double-layer dripper is adopted, and the technological parameters are strictly controlled, so that the rubber shell well wraps the content, and the phenomena of leakage and the like are avoided.
Detailed Description
The invention is further described below with reference to examples;
the invention provides a dripping pill with an antioxidation effect, which comprises a content and a capsule, wherein the content comprises the following components in parts by weight: 1-10 parts of haematococcus pluvialis, 1-10 parts of polygonum cuspidatum extract, 1-10 parts of passion flower extract, 1-10 parts of green tea extract, 20-80 parts of dispersing agent and 0.5-5 parts of lecithin; the rubber shell comprises the following components in parts by weight: 50-80 parts of gelatin, 5-40 parts of glycerol and 5-20 parts of water.
The oxygen generates superoxide anions, hydrogen peroxide, hydroxyl radicals and singlet oxygen in the process of reducing the oxygen into water, the active oxygen plays an important role in the lipid peroxidation process, whether the dripping pill can resist oxidation, how the antioxidation efficiency is and the scavenging effect of the active oxygen on the oxygen radicals in different systems can be various, and the influence factors are various.
The astaxanthin in haematococcus pluvialis contains conjugated double bonds, and each aromatic ring at two ends of the chemical structure of the astaxanthin is provided with a hydroxyl group and an unsaturated ketone group, so that the astaxanthin has remarkable antioxidation capability, can quench singlet oxygen and directly remove oxygen free radicals, and can improve glutathione peroxidase activity and relieve malondialdehyde injury, thereby protecting damaged cells.
Resveratrol in rhizoma Polygoni Cuspidati extract is flavonoid, and can relieve H 2 O 2 The induced DNA oxidative damage, resveratrol can inhibit the generation of platelet oxygen free radicals and reduce the generation of platelet oxygen free radicals activated by thrombin, and can reduce the level of malondialdehyde in blood, generally the antioxidant capacity of resveratrol is in a dose-dependent relationship, but after the human body intakes resveratrol to a certain amount,the resveratrol blood concentration can reach the peak value, and then no matter how much resveratrol is ingested, the resveratrol blood concentration can not rise any more, which has certain deviation from the dependence relationship between the antioxidant capacity and the dosage of the resveratrol which is widely considered in the industry, excessive resveratrol ingestion can play a role, excessive resveratrol phenolic hydroxyl is consumed in the antioxidant process, and if the resveratrol cannot be timely reduced, the peroxidation reaction can be promoted, and the inventor sets the range of the polygonum cuspidatum extract to 1-10 parts.
The passion fruit extract contains passion fruit peel polysaccharide which is a high molecular compound and has stronger capability of removing hydroxyl free radicals and 1, 1-diphenyl-2-trinitrophenylhydrazine free radicals, and the range of the passion fruit peel polysaccharide is set to be 1-10 parts by the inventor.
The green tea extract also contains a large amount of tea polyphenol, the tea polyphenol can well remove free radicals generated by a polymorphonuclear leucocyte in an oxygen free radical system generated by the polymorphonuclear leucocyte, a superoxide anion free radical system is generated by using a light riboflavin/ethylenediamine tetraacetic acid and xanthine/xanthine oxidase system, and the superoxide anion free radicals under the system are respectively removed by using the tea polyphenol, curcumin, vitamin C and resveratrol, so that the removal rate of the tea polyphenol is better than that of other substances; the tea polyphenol has strong capability of scavenging oxygen free radicals in a myocardial ischemia reperfusion system, the tea polyphenol can be complexed with iron ions, and the tea polyphenol reacts with the oxygen free radicals to form semiquinone free radicals, so that the tea polyphenol has strong capability of scavenging lipid free radicals, the tea polyphenol has good inhibition effect on peroxynitroso oxidation activity, but the capability of scavenging hydroxyl free radicals of the tea polyphenol is not obvious, and the inventor sets the range of the green tea extract to 1-10 parts.
The inventor finds that the improvement of the antioxidant capacity is not obvious when the components of the content are selected, and the inventor finds that astaxanthin, resveratrol, tea polyphenol and passion fruit peel polysaccharide have good synergistic effect through a large number of experiments, the astaxanthin has strong capability of quenching single-wire oxygen and has strong capability of scavenging oxygen free radicals, the resveratrol can protect DNA damaged by oxidation, and has good capability of scavenging free radicals in a platelet free radical system, the tea polyphenol has strong capability of scavenging free radicals in a plurality of systems, and the passion fruit peel polysaccharide added has good synergistic effect of scavenging hydroxyl free radicals and stable free radicals, so that the excellent synergistic effect is generated.
The inventors have also considered another important factor in selecting the content, namely the flowability of the content during the preparation. The active ingredients in the invention are solid, and the suspension is prepared before preparing the dripping pill, the viscosity of the suspension is generally higher than that of the pure oil content due to the special dispersion system, and the traditional dripping pill is prepared by the following steps: the content and the matrix are mixed, and then the mixture is dripped into condensate by a dripping pill machine to prepare dripping pills, the traditional dripping pills have low requirement on fluidity of the content, the dripping pills on the market at present are not wrapped by rubber, because the dripping pills have cognitive deviation and process difficulties, in the traditional process, the rubber cannot wrap the content of the suspension, can be adhered with the suspension, and the dripping pills cannot be molded, so the dripping pills without the rubber wrapping on the market are not wrapped by the coating process even if the dripping pills are provided with so-called multi-layer dripping pills, and the dripping pills are easily dropped after being prepared by the dripping pill machine, so that the effect is poor.
The traditional dripping pill without the rubber has the following defects: 1. the smell cannot be isolated; 2. the content is easy to lose efficacy after being directly contacted with air; 3. the storage time is short. The inventor found that coating the capsule on the dripping pill solves the problems, but the capsule is easy to adhere to the content of the suspension and can not be molded, if a dripping pill machine with a double-layer dripping head is used for preparing the dripping pill with a capsule shell, the content needs to have certain fluidity, so the inventor considers the fluidity requirement when selecting the components of the content and the proportion among the components, the mixed content has the fluidity meeting the requirement, and after repeated experiments, the mixture obtained in the step 2 before the colloid mill has the fluidity meeting the requirement, and then the fluidity of the suspension is lower than 100mm through the colloid mill and homogenization treatment 2 /s。
In some embodiments, the dispersing agent comprises one or more of sunflower seed oil, linseed oil, safflower seed oil and medium chain triglyceride, and optimally, the dispersing agent adopts the medium chain triglyceride, the medium chain triglyceride is easy to be absorbed by human body, can be completely absorbed into small intestine mucosa to enter cells without bile salts, and the generated medium chain fatty acid does not need to be re-esterified and synthesized into triglyceride in intestinal cells, directly enters the liver from portal vein in the form of fatty acid, is rapidly and efficiently decomposed in the liver to generate energy, can rapidly supply energy to the human body, does not form fat accumulation in the human body, has the effects of improving cardiovascular functions, burning fat and the like, is suitable for patients with AIDS, diabetes mellitus and obesity, has a certain anti-adhesion effect, and provides a certain fluidity foundation for contents.
In some embodiments, the astaxanthin content in haematococcus pluvialis is not less than 4%, the passion fruit peel polysaccharide content in the passion fruit extract is not less than 4%, the resveratrol content in the polygonum cuspidatum extract is not less than 90%, and the tea polyphenol content in the green tea extract is not less than 50%, so that the content of active ingredients in the content meets the requirement, and the antioxidant effect is improved.
In some embodiments, the lecithin is non-transgenic lecithin, which encapsulates the particles in the contents, serves as a film, improves the uniformity of dispersion of the particles in the contents, and serves as a lubricant.
The invention also provides a preparation method of the dripping pill with the antioxidation effect, which comprises the following steps:
s1: weighing: accurately weighing all raw materials and auxiliary materials according to batch production and product formulation, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 100-200-mesh sieve;
s2: preparing the following contents: adding haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract according to the formula amount into a dispersing agent, stirring for 10-20 minutes, passing through a colloid mill, beating liquid once at the upper limit temperature of 50 ℃ and the flow rate of 5-7 s under the pressure of 0.4MPa, homogenizing by a high-pressure homogenizer at the maximum 20000psi and the flow rate of 300-400ml/min, and thenAdding phospholipid, stirring for 20-40 min to obtain content with fluidity meeting the requirement, wherein the fineness of solid material in the content is 10-200 nm, defoaming, pouring into the content storage tank of dripping pill machine with double-layer dripping head for use, and further measuring viscosity of the content at 35deg.C by capillary viscometer to obtain the final product with viscosity less than or equal to 100mm 2 The/s meets the requirement, and the content has good fluidity by adopting a method of combining a colloid mill and a high-pressure homogenizer, and the content is more uniformly dispersed;
s3: and (3) glue melting: mixing purified water and glycerin, heating to 60+/-10 ℃, adding gelatin, heating to 80+/-10 ℃, heating for 15-25 minutes, degassing and standing for 15-25 minutes, and clarifying the gelatin solution for later use;
s4: and (3) dripping: pouring the glue solution into a glue solution storage tank of a pill dropping machine with double-layer drippers, keeping the temperature of the oil bath at 60-70 ℃, setting the temperature of the drippers at 60-70 ℃ and the temperature of the condensate at 5-10 ℃, wherein the flow rate ratio of the glue solution to the content is 1 (2-5), regulating the height of a discharge port of the pill dropping machine with double-layer drippers, enabling the content and the glue solution to smoothly drip into the condensate through the double-layer drippers without adhesion phenomenon, enabling the dripping pills in the condensate to form a sphere under the action of surface tension, gradually cooling and solidifying to form, further, enabling the condensate to be liquid paraffin oil or simethicone, and strictly controlling the temperature of the oil bath and the temperature of the drippers when the dripping pills are operated in the pill dropping machine with double-layer drippers, preventing the dripping pills from being incapable of being formed due to the excessively high temperature or preventing the glue solution from adhering to the content due to excessively low temperature, and enabling the glue solution to wrap the content to be free from adhesion phenomenon in the condensate when the flow rate ratio of the glue solution to the content is 1 (2-5);
s5: drying and pill selection: the dripping pill after solidification and molding is pre-dried for 1 to 2 hours by a rotating cage, then is put into a drying room for static drying for 20 to 30 hours, and the dripping pill after drying is selected and packaged to obtain the finished product, thus the dripping pill with the capsule can be obtained after the dripping pill is dried by strictly controlling the temperature of a dripping head, the temperature of an oil bath, the temperature of condensate, the flow rate ratio of glue solution to content.
Example 1
A dripping pill with an antioxidation effect comprises, by weight, 5 parts of haematococcus pluvialis, 5 parts of polygonum cuspidatum extract, 5 parts of passion flower extract, 5 parts of green tea extract, 78 parts of medium chain triglyceride and 2 parts of non-transgenic lecithin; the gelatin shell comprises 65 parts of gelatin, 25 parts of glycerol and 10 parts of water by weight.
The haematococcus pluvialis contains 4% of astaxanthin, the polygonum cuspidatum extract contains 90% of resveratrol, the passion flower polysaccharide in the passion flower extract contains 4% of passion flower polysaccharide, and the green tea extract contains 50% of tea polyphenol.
A preparation method of a dripping pill with antioxidant effect mainly comprises the following steps:
s1: weighing: accurately weighing all raw materials and auxiliary materials according to batch production and product formulation, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 100-mesh sieve;
s2: preparing the content: preparing the following contents: adding haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract according to the formula amount into a dispersing agent, stirring for 10 minutes, passing through a colloid mill, performing liquid beating once at the upper limit temperature of 50 ℃ under the pressure of 0.4MPa and the flow rate of 5 seconds, homogenizing by adopting a high-pressure homogenizer at the treatment pressure of 18000psi and the flow rate of 300ml/min, adding phospholipid, continuously stirring for 20 minutes to obtain a content, obtaining the fineness of a solid material of the content of 50nm, and measuring the viscosity of the content of 95mm by adopting a capillary viscometer under the condition of 35 ℃ after defoaming 2 Pouring into a content storage tank of a pill dropping machine with double layers of dropping heads for standby;
s3: and (3) glue melting: mixing purified water and glycerol, heating to 60deg.C, adding gelatin, heating to 80deg.C for 20min, degassing, and standing for 20min to clarify the gelatin solution;
s4: and (3) dripping: pouring the glue solution into a glue solution storage tank of a pill dropping machine with double-layer drippers, keeping the oil bath at 65 ℃, setting the dripper temperature at 65 ℃ and the liquid paraffin oil temperature at 6 ℃, enabling the flow rate ratio of the glue solution to the content to be 1:3, adjusting the height of a discharge hole, enabling the content and the glue solution to smoothly drip into the liquid paraffin oil through the double-layer drippers without adhesion phenomenon, enabling the dripping pills in the liquid paraffin oil to form a sphere due to the surface tension effect, and gradually cooling and solidifying to form;
s5: drying and selecting pills: and pre-drying the coagulated and formed dripping pills for 1.5 hours by a rotating cage, placing the dripping pills into a drying room for static drying for 25 hours, selecting the dried dripping pills, and packaging to obtain the finished product.
Example 2
A dripping pill with an antioxidation effect comprises, by weight, 10 parts of haematococcus pluvialis, 10 parts of polygonum cuspidatum extract, 5 parts of passion flower extract, 5 parts of green tea extract, 65 parts of medium chain triglyceride and 5 parts of non-transgenic lecithin; the gelatin shell comprises 80 parts of gelatin, 15 parts of glycerol and 5 parts of water by weight.
The astaxanthin content in haematococcus pluvialis is 5%, the resveratrol content in the polygonum cuspidatum extract is 92%, the passion flower polysaccharide content in the passion flower extract is 5%, and the tea polyphenol content in the green tea extract is 55%.
A preparation method of a dripping pill with antioxidant effect mainly comprises the following steps:
s1: weighing: accurately weighing all raw materials and auxiliary materials according to batch production and product formulation, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 150-mesh sieve;
s2: preparing the following contents: adding haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract according to the formula amount into a dispersing agent, stirring for 20 minutes, passing through a colloid mill, performing liquid beating once at the upper limit temperature of 50 ℃ under the pressure of 0.4MPa and the flow rate of 6 seconds, homogenizing by adopting a high-pressure homogenizer at the treatment pressure of 20000psi and the flow rate of 350ml/min, adding phospholipid, continuously stirring for 30 minutes to obtain a content, wherein the fineness of a solid material in the content is 56nm, and measuring the viscosity of the content to 97mm by adopting a capillary viscometer under the condition of 35 ℃ after defoaming 2 Pouring into a content storage tank of a pill dropping machine with double layers of dropping heads for standby;
s3: and (3) glue melting: mixing purified water and glycerol, heating to 70deg.C, adding gelatin, heating to 90deg.C for 25 min, degassing, and standing for 25 min to clarify the gelatin solution;
s4: and (3) dripping: pouring the glue solution into a glue solution storage tank of a pill dropping machine with double-layer drippers, keeping an oil bath at 70 ℃, setting a dripper temperature at 70 ℃ and a liquid paraffin oil temperature at 10 ℃, enabling the flow rate ratio of the glue solution to the content to be 1:4, adjusting the height of a discharge hole of the pill dropping machine with the double-layer drippers, enabling the content and the glue solution to smoothly drip into the liquid paraffin oil through the double-layer drippers without adhesion phenomenon, enabling the dripping pills in the dripping solution to form a sphere under the action of surface tension, and gradually cooling and solidifying to be formed;
s5: drying and pill selection: and pre-drying the coagulated and formed dripping pills for 2 hours by a rotating cage, placing the dripping pills into a drying room for static drying for 30 hours, selecting the dried dripping pills, and packaging to obtain a finished product.
Example 3
A dripping pill with an antioxidation effect comprises 2 parts by weight of haematococcus pluvialis, 2.5 parts by weight of polygonum cuspidatum extract, 10 parts by weight of passion flower extract, 10 parts by weight of green tea extract, 75 parts by weight of medium chain triglyceride and 0.5 part by weight of non-transgenic lecithin; the gelatin shell comprises 80 parts of gelatin, 5 parts of glycerol and 15 parts of water by weight.
The astaxanthin content in haematococcus pluvialis is 5%, the resveratrol content in the polygonum cuspidatum extract is 92%, the passion flower polysaccharide content in the passion flower extract is 6%, and the tea polyphenol content in the green tea extract is 57%.
A preparation method of a dripping pill with antioxidant effect mainly comprises the following steps:
s1: weighing: accurately weighing all raw materials and auxiliary materials according to batch production and product formulation, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 200-mesh sieve;
s2: preparing the following contents: adding haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract according to the formula amount into a dispersing agent, stirring for 15 minutes, passing through a colloid mill, performing liquid beating once at the upper limit temperature of 50 ℃ under the pressure of 0.4MPa and the flow rate of 5 seconds, homogenizing by a high-pressure homogenizer at the treatment pressure of 20000psi and the flow rate of 400ml/min, adding phospholipid, continuously stirring for 40 minutes to obtain a content, wherein the fineness of the content is 49.5nm, and measuring the viscosity of the content to be 98mm by adopting a capillary viscometer under the condition of 35 ℃ after defoaming 2 S, pouring in a container with double sidesThe content storage tank of the pill dropping machine with the layer dripper is reserved for standby;
s3: and (3) glue melting: mixing purified water and glycerol, heating to 60deg.C, adding gelatin, heating to 80deg.C for 15 min, degassing, and standing for 15 min to clarify the gelatin solution;
s4: and (3) dripping: pouring the glue solution into a glue solution storage tank of a pill dropping machine with double-layer drippers, keeping an oil bath at 70 ℃, setting a dripper temperature at 70 ℃ and a simethicone temperature at 10 ℃, setting the flow rate ratio of the glue solution to the content to be 1:5, adjusting the height of a discharge port of the pill dropping machine with the double-layer drippers, enabling the content and the glue solution to smoothly drip into condensate through the double-layer drippers without adhesion phenomenon, enabling the dripping pills dripped into the simethicone to form a sphere under the action of surface tension, and gradually cooling and solidifying to form;
s5: drying and pill selection: and pre-drying the coagulated and formed dripping pills for 2 hours by a rotating cage, placing the dripping pills into a drying room for static drying for 30 hours, selecting the dried dripping pills, and packaging to obtain a finished product.
Comparative example 1
The formula and the proportion of the content are the same as those of the embodiment 1, and the preparation method is as follows:
s1: weighing: accurately weighing all raw materials and auxiliary materials according to batch production and product formulation, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 100-mesh sieve;
s2: preparing the content: preparing the following contents: adding haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract according to the formula amount into a dispersing agent, stirring for 15 minutes, passing through a colloid mill, beating liquid once at the upper limit temperature of 50 ℃ and the flow rate of 5 seconds under the pressure of 0.4MPa of compressed air, and then adding phospholipid, and continuously stirring for 20 minutes to obtain a content;
s3: and (3) dripping: pouring the content into a content storage tank of a pill dripping machine, maintaining the oil bath at 65deg.C, setting the temperature of the dripping head at 65deg.C, adjusting the temperature of liquid paraffin oil at 6deg.C, regulating the height of a discharge port, dripping into liquid paraffin oil to form spherical dripping pills due to surface tension, and gradually cooling and solidifying to form;
s4: drying and selecting pills: and pre-drying the coagulated and formed dripping pills for 1.5 hours by a rotating cage, placing the dripping pills into a drying room for static drying for 25 hours, selecting the dried dripping pills, and packaging to obtain the finished product.
Comparative example 2
A dripping pill with an antioxidation effect comprises, by weight, 5 parts of haematococcus pluvialis, 15 parts of polygonum cuspidatum extract, 5 parts of green tea extract, 78 parts of medium chain triglyceride and 2 parts of non-transgenic lecithin; the gelatin shell comprises 65 parts of gelatin, 25 parts of glycerol and 10 parts of water by weight.
The haematococcus pluvialis contains 4% of astaxanthin, the polygonum cuspidatum extract contains 90% of resveratrol, the passion flower polysaccharide in the passion flower extract contains 4% of passion flower polysaccharide, and the green tea extract contains 50% of tea polyphenol.
The preparation method is the same as in example 1.
Comparative example 3
A dripping pill with an antioxidation effect comprises, by weight, 10 parts of haematococcus pluvialis, 8 parts of polygonum cuspidatum extract, 10 parts of passion flower extract, 10 parts of green tea extract, 75 parts of medium chain triglyceride and 0.5 part of non-transgenic lecithin; the gelatin shell comprises 90 parts of gelatin, 12 parts of glycerol and 25 parts of water by weight.
The astaxanthin content in haematococcus pluvialis is 5%, the resveratrol content in the polygonum cuspidatum extract is 92%, the passion flower polysaccharide content in the passion flower extract is 6%, and the tea polyphenol content in the green tea extract is 57%.
A preparation method of a dripping pill with antioxidant effect mainly comprises the following steps:
s1: weighing: accurately weighing all raw materials and auxiliary materials according to batch production and product formulation, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 200-mesh sieve;
s2: preparing the following contents: adding haematococcus pluvialis, rhizoma Polygoni Cuspidati extract, herba Passiflorae Caeruleae extract and green tea extract into dispersant, stirring for 20min, grinding with colloid mill, and measuring content viscosity of 145mm with capillary viscometer 2 Pouring into a content storage tank of a pill dropping machine with double layers of dropping heads for standby;
s3: and (3) glue melting: mixing purified water and glycerol, heating to 60deg.C, adding gelatin, heating to 80deg.C for 15 min, degassing, and standing for 15 min to clarify the gelatin solution;
s4: and (3) dripping: pouring the glue solution into a glue solution storage tank of a pill dropping machine with double-layer drippers, keeping the temperature of the oil bath at 70 ℃, setting the temperature of the drippers at 70 ℃ and the temperature of the simethicone at 10 ℃, setting the flow rate ratio of the glue solution to the content at 1:5, and adjusting the height of a discharge hole of the pill dropping machine with double-layer drippers, wherein the content is adhered to the glue solution and cannot be formed.
Exposure experiments
Test purpose: whether the dripping pill product can effectively relieve the oxidation of the functional components is checked.
Test object: the dripping pills in example 1 and comparative example 1.
The test method comprises the following steps: example 1 and comparative example 1 were exposed to air for 30 days, respectively, and the acid value and peroxide value of the contents of both were compared, as shown in tables 1 and 2.
TABLE 1 acid number Change before and after test
| Project | Before the test | After the test |
| Example 1 | 0.04 mgKOH/g | 0.06 mgKOH/g |
| Comparative example 1 | 0.05 mgKOH/g | 0.28 mgKOH/g |
TABLE 2 peroxide value Change before and after test
| Project | Before the test | After the test |
| Example 1 | 0.12 meq/kg | 0.16 meq/kg |
| Comparative example 1 | 0.10 meq/kg | 0.59 meq/kg |
Test results:
the exposure test results show that the acid value and the peroxide value of the content of the example 1 are not obviously changed before and after the test, and the acid value and the peroxide value of the content of the comparative example 1 are obviously increased compared with those of the content of the comparative example 1 before the test, so that the dripping pill can effectively relieve the oxidation of the functional components.
Animal experiment
Test purpose: the dripping pill product of the invention is checked to see whether the dripping pill product has the health care function of antioxidation.
Test object: 50C 57BL/6 mice, 18-22 g in weight, were randomly divided into five groups of 10 mice each.
Test materials: the dripping pills prepared in examples 1-3 and comparative example 2 were non-toxic placebo.
The test method comprises the following steps: the first group was orally administered 1 (gavage) per day, 1 (0.04 g) per day for 1 month with placebo, the second group was orally administered 1 (gavage) per day, 1 (0.04 g) per day with the dripping pill of example 1 for 1 month, the third group was orally administered 1 (gavage) per day, 1 (0.04 g) per day with the dripping pill of example 2 for 1 month, the fourth group was orally administered 1 (gavage) per day, 1 (0.04 g) per day with the dripping pill of example 3 for 1 month, the fifth group was orally administered 1 (gavage) per day, 1 (0.04 g) per day with the dripping pill of comparative example 2 for 1 month, and tail blood was taken to detect superoxide dismutase (SOD) and Malondialdehyde (MDA) levels in the serum of mice.
Experimental data:
TABLE 3 variation of serum MDA content before and after the test
| Project | Before the test | After the test |
| First group of | 6.46±0.35μml/ml | 6.55±0.96μml/ml |
| Second group of | 6.63±0.57μml/ml | 5.91±0.67μml/ml |
| Third group of | 6.42±0.68μml/ml | 5.83±0.54μml/ml |
| Fourth group | 6.71±0.32μml/ml | 6.05±0.47μml/ml |
| Fifth group of | 6.57±0.3μml/ml | 6.32±0.74μml/ml |
TABLE 4 variation of serum SOD Activity before and after the test
| Project | Before the test | After the test |
| First group of | 52.07±4.02U/ml | 54.38±4.85U/ml |
| Second group of | 50.16±4.38U/ml | 67.04±5.02U/ml |
| Third group of | 53.42±4.18U/ml | 70.05±5.36U/ml |
| Fourth group | 52.64±4.24U/ml | 68.32±5.17U/ml |
| Fifth group of | 51.37±4.15U/ml | 55.26±4.71U/ml |
Test results:
animal test results show that the MDA content and SOD activity of the serum of the mice in the control group before and after the first group are not obviously changed, the superoxide dismutase (SOD) activity in the serum of the mice is obviously enhanced and the MDA content is obviously reduced compared with the serum of the mice before the test after the second group to the fourth group, although the superoxide dismutase (SOD) activity in the serum of the mice is enhanced and the MDA content is reduced compared with the serum of the mice before the test after the fifth group, the effect is not better than that of adding 5 parts of the passion flower extract, and the synergistic effect of the passion flower extract and other substances is better, so that the antioxidant capacity of the dripping pill can be obviously improved, and the proportion of each substance is not as much as better. The experiments prove that the dripping pill has definite antioxidation health care function; as is found from comparative example 3, the viscosity of the suspension was not satisfactory, the content was adhered to the dope, and the formation was impossible.
The above examples are provided for the purpose of clearly illustrating the invention and are not to be construed as limiting the invention, and other variants and modifications of the various forms may be made by those skilled in the art based on the description, which are not intended to be exhaustive of all embodiments, and obvious variants or modifications of the invention may be found within the scope of the invention.
Claims (1)
1. A dripping pill with antioxidation effect is prepared from contents and a capsule, and is characterized in that: the composition comprises, by weight, 5 parts of haematococcus pluvialis, 5 parts of polygonum cuspidatum extract, 5 parts of passion flower extract, 5 parts of green tea extract, 78 parts of medium chain triglyceride and 2 parts of non-transgenic lecithin; the capsule comprises 65 parts of gelatin, 25 parts of glycerin and 10 parts of purified water by weight, wherein the astaxanthin content in haematococcus pluvialis is 4%, the resveratrol content in polygonum cuspidatum extract is 90%, the passion flower polysaccharide content in passion flower extract is 4%, and the tea polyphenol content in green tea extract is 50%, and the preparation method comprises the following steps:
s1: weighing: accurately weighing all raw materials and auxiliary materials according to a product formula, and completely crushing all solid powder materials and sieving the crushed solid powder materials with a 100-mesh sieve;
s2: preparing the content: adding haematococcus pluvialis, polygonum cuspidatum extract, passion flower extract and green tea extract according to the formula amount into medium chain triglyceride, stirring for 10 minutes, passing through a colloid mill, performing liquid beating once at the upper limit temperature of 50 ℃ under the pressure of 0.4MPa and the flow rate of 5 seconds, homogenizing by a high-pressure homogenizer at the treatment pressure of 18000psi and the flow rate of 300ml/min, adding non-transgenic lecithin, continuously stirring for 20 minutes to obtain a content, obtaining the fineness of a solid material of the content of 50nm, and measuring the viscosity of the content of 95mm by adopting a capillary viscometer under the condition of 35 ℃ after defoaming 2 Pouring into a content storage tank of a pill dropping machine with double layers of dropping heads for standby;
s3: and (3) glue melting: mixing purified water and glycerol, heating to 60deg.C, adding gelatin, heating to 80deg.C for 20min, degassing, and standing for 20min to clarify the gelatin solution;
s4: and (3) dripping: pouring the glue solution into a glue solution storage tank of a pill dropping machine with double-layer drippers, keeping the oil bath at 65 ℃, setting the dripper temperature at 65 ℃ and the liquid paraffin oil temperature at 6 ℃, enabling the flow rate ratio of the glue solution to the content to be 1:3, adjusting the height of a discharge hole, enabling the content and the glue solution to smoothly drip into the liquid paraffin oil through the double-layer drippers without adhesion phenomenon, enabling the dripping pills in the liquid paraffin oil to form a sphere due to the surface tension effect, and gradually cooling and solidifying to form;
s5: drying and selecting pills: and pre-drying the coagulated and formed dripping pills for 1.5 hours by a rotating cage, placing the dripping pills into a drying room for static drying for 25 hours, selecting the dried dripping pills, and packaging to obtain the finished product.
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