CN105980615A - 寡核苷酸探针及其用途 - Google Patents

寡核苷酸探针及其用途 Download PDF

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Publication number
CN105980615A
CN105980615A CN201480063091.1A CN201480063091A CN105980615A CN 105980615 A CN105980615 A CN 105980615A CN 201480063091 A CN201480063091 A CN 201480063091A CN 105980615 A CN105980615 A CN 105980615A
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disease
oligonucleotide
oligonucleotides
cancer
carcinoma
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Chinese (zh)
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大卫·斯佩兹勒
瓦列里·多曼俞克
年庆·肖
亚当·斯塔克
钟振宇
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Cary Science Co
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Caris Life Sciences Switzerland Holdings GmbH
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/1034—Isolating an individual clone by screening libraries
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
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CN201480063091.1A 2013-08-28 2014-08-28 寡核苷酸探针及其用途 Pending CN105980615A (zh)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US201361871107P 2013-08-28 2013-08-28
US61/871,107 2013-08-28
US201361874621P 2013-09-06 2013-09-06
US61/874,621 2013-09-06
US201361900975P 2013-11-06 2013-11-06
US61/900,975 2013-11-06
US201361912471P 2013-12-05 2013-12-05
US61/912,471 2013-12-05
US201461924192P 2014-01-06 2014-01-06
US61/924,192 2014-01-06
US201461949216P 2014-03-06 2014-03-06
US61/949,216 2014-03-06
US201461974949P 2014-04-03 2014-04-03
US61/974,949 2014-04-03
US201461990085P 2014-05-07 2014-05-07
US61/990,085 2014-05-07
US201461994704P 2014-05-16 2014-05-16
US61/994,704 2014-05-16
US201462024436P 2014-07-14 2014-07-14
US62/024,436 2014-07-14
PCT/US2014/053306 WO2015031694A2 (en) 2013-08-28 2014-08-28 Oligonucleotide probes and uses thereof

Publications (1)

Publication Number Publication Date
CN105980615A true CN105980615A (zh) 2016-09-28

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US (2) US20160319361A1 (https=)
EP (1) EP3039174B1 (https=)
JP (1) JP2016533752A (https=)
KR (1) KR20160080815A (https=)
CN (1) CN105980615A (https=)
AU (2) AU2014312211A1 (https=)
BR (1) BR112016004153A2 (https=)
CA (1) CA2922689A1 (https=)
IL (2) IL244236A0 (https=)
WO (1) WO2015031694A2 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109254089A (zh) * 2017-07-14 2019-01-22 株式会社岛津制作所 使用了质谱分析的认知功能障碍疾病生物标记物的定量方法和质谱分析装置
CN109251980A (zh) * 2017-07-14 2019-01-22 中国人民解放军第八医院 膀胱癌组织t细胞图谱模型及其构建方法和构建系统
CN109880903A (zh) * 2019-03-01 2019-06-14 南京医科大学 一种用于非小细胞肺癌辅助诊断的snp标志物及其应用
CN110045099A (zh) * 2019-04-01 2019-07-23 四川大学华西医院 一种慢性阻塞性肺疾病检测试剂盒
CN111386458A (zh) * 2017-09-27 2020-07-07 罗塞塔外排体株式会社 利用尺寸排阻色谱法的细胞外囊泡的分析方法及其用途
CN111830289A (zh) * 2020-07-24 2020-10-27 长春理工大学 一种利用原子力显微术对生物素化抗体-IgE免疫复合物直接成像的方法
CN115667925A (zh) * 2020-05-15 2023-01-31 阿雷克森制药公司 使用细胞外囊泡来检测补体激活的方法以及其用于评估和/或监测补体介导的疾病的治疗的用途
CN119959532A (zh) * 2025-01-03 2025-05-09 中国科学院精密测量科学与技术创新研究院 细胞色素c在制备elisa试剂盒方面的新用途

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006116362A2 (en) 2005-04-25 2006-11-02 The Trustees Of Boston University Structured substrates for optical surface profiling
EP4170031A1 (en) 2012-10-23 2023-04-26 Caris Science, Inc. Aptamers and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
AU2013361323B2 (en) 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
PT3083997T (pt) * 2013-12-20 2020-11-03 Univ Lausanne Utilizações diagnósticas, prognósticas e terapêuticas de rnas longos não codificadores para doenças cardíacas e medicina regenerativa
WO2016042202A1 (en) * 2014-09-17 2016-03-24 Wallac Oy Method for determining the risk of preterm birth
WO2016145128A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Oligonucleotide probes and uses thereof
US10772859B2 (en) 2015-05-21 2020-09-15 Indiana University Research And Technology Corporation Methods of targeting APE/Ref-1 to inhibit hypoxia signaling genes
EP3314027A4 (en) 2015-06-29 2019-07-03 Caris Science, Inc. THERAPEUTIC OLIGONUCLEOTIDES
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
AU2016327573B2 (en) 2015-09-22 2022-07-14 Trustees Of Boston University Multiplexed phenotyping of nanovesicles
WO2017112921A1 (en) * 2015-12-24 2017-06-29 The Arizona Board Of Regents On Behalf Of The University Of Arizona Systems and methods for characterizing sepsis
WO2017136676A1 (en) 2016-02-05 2017-08-10 Nanoview Diagnostics Inc. Detection of exosomes having surface markers
US10731166B2 (en) * 2016-03-18 2020-08-04 Caris Science, Inc. Oligonucleotide probes and uses thereof
EP3452591B1 (en) 2016-05-02 2023-08-16 Encodia, Inc. Macromolecule analysis employing nucleic acid encoding
WO2017205686A1 (en) * 2016-05-25 2017-11-30 Caris Science, Inc. Oligonucleotide probes and uses thereof
EP4219767A1 (en) * 2016-06-17 2023-08-02 F. Hoffmann-La Roche AG Papd5 and papd7 inhibitors for treating a hepatitis b infection
US20190276828A1 (en) * 2016-10-25 2019-09-12 Purdue Research Foundation Conjugates for sensing
CA3042723A1 (en) * 2016-11-02 2018-05-11 Biois Co.,Ltd Quantitative cluster analysis method of target protein by using next-generation sequencing and use thereof
CA3062250A1 (en) * 2017-05-08 2018-11-15 Augmanity Nano Ltd Treatment of rapidly evolving biological entities
US11408887B2 (en) 2017-05-22 2022-08-09 The National Institute for Biotechnology in the Negev Ltd. Biomarkers for diagnosis of lung cancer
EP4276201A3 (en) 2017-06-07 2024-01-17 Gen-Probe Incorporated Detecting babesia species nucleic acid in a sample
CN111511914B (zh) 2017-10-16 2023-11-17 豪夫迈·罗氏有限公司 减少PAPD5和PAPD7 mRNA的核酸分子用于治疗乙型肝炎感染
JP7390027B2 (ja) 2017-10-31 2023-12-01 エンコディア， インコーポレイテッド 核酸エンコーディングおよび／または標識を使用する解析のためのキット
CN108866215B (zh) * 2017-12-01 2022-02-08 苏州百源基因技术有限公司 一种用于产气肠杆菌检测的实时荧光定量pcr试剂盒
JP2021513342A (ja) * 2018-02-12 2021-05-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 腫瘍の遺伝的不均一性を評価することによって治療法に対する応答を予測する方法
WO2019232321A1 (en) 2018-06-01 2019-12-05 NanoView Biosciences, Inc. Compositions, systems, and methods for enhanced label-free and fluorescence - based detection of nanoparticles
GB201810571D0 (en) * 2018-06-27 2018-08-15 Cs Genetics Ltd Reagents and methods for the analysis of circulating microparticles
PE20210346A1 (es) 2018-07-03 2021-02-25 Hoffmann La Roche Oligonucleotidos para modular la expresion de tau
KR20210031927A (ko) * 2018-07-17 2021-03-23 유니버시티 오브 워싱톤 압타머 기반 가역적 세포 선택과 관련된 조성물 및 방법
EP3827082B1 (en) 2018-07-26 2025-05-14 Bracco Imaging SpA Icam-1 aptamers, diagnostic and therapeutic uses thereof
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
US11608356B1 (en) * 2019-02-22 2023-03-21 Base Pair Biotechnologies, Inc. Functional ligands to colistin
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MX2021012471A (es) * 2019-04-11 2022-01-04 Univ Arkansas Aptameros de adn especificos de cd40 como adyuvantes de vacunas.
WO2020219923A1 (en) * 2019-04-26 2020-10-29 The Johns Hopkins University Methods and materials for treating cancer
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WO2021076808A1 (en) * 2019-10-15 2021-04-22 Cornell University Methods for detecting and inhibiting brain metastasis
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CA3178255A1 (en) * 2020-05-15 2021-11-18 Krishna KANNAN On demand synthesis of polynucleotide sequences
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WO2023028035A1 (en) * 2021-08-23 2023-03-02 University Of Florida Research Foundation, Incorporated Lipid enveloped recombinant aav particles for gene therapy use
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CN121794401A (zh) * 2023-05-04 2026-04-03 宾夕法尼亚州大学信托人 使用红细胞检测肿瘤源性核酸
CN117230203B (zh) * 2023-11-14 2024-02-06 首都医科大学附属北京儿童医院 检测myod1基因突变的引物探针组及其试剂盒
EP4686766A1 (en) * 2024-08-01 2026-02-04 Siemens Healthineers AG Biomarkers and methods for the early detection of hepatocellular carcinoma
WO2026074434A1 (en) * 2024-10-01 2026-04-09 Fondazione Istituto Italiano Di Tecnologia Rad51/brca2 complex aptamers and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011066589A1 (en) * 2009-11-30 2011-06-03 Caris Life Sciences Luxembourg Holdings Methods and systems for isolating, storing, and analyzing vesicles
WO2011088226A2 (en) * 2010-01-13 2011-07-21 Caris Life Sciences Luxembourg Holdings Detection of gastrointestinal disorders
CN102301002A (zh) * 2008-11-12 2011-12-28 卡里斯生命科学卢森堡控股有限责任公司 使用外来体来确定表现型的方法和系统
WO2013022995A2 (en) * 2011-08-08 2013-02-14 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarker compositions and methods

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4551435A (en) 1983-08-24 1985-11-05 Immunicon, Inc. Selective removal of immunospecifically recognizable substances from solution
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US4925788A (en) 1986-10-24 1990-05-15 Immunicon Corporation Immunoassay system and procedure based on precipitin-like interaction between immune complex and Clq or other non-immunospecific factor
US5158871A (en) 1988-02-12 1992-10-27 University Of Connecticut Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates
US5108933A (en) 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
SE470347B (sv) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5707796A (en) 1990-06-11 1998-01-13 Nexstar Pharmaceuticals, Inc. Method for selecting nucleic acids on the basis of structure
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
ES2259800T3 (es) 1990-06-11 2006-10-16 Gilead Sciences, Inc. Procedimientos de uso de ligandos de acido nucleico.
US5861254A (en) 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5580737A (en) 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
US5648214A (en) 1990-06-11 1997-07-15 University Research Corporation High-affinity oligonucleotide ligands to the tachykinin substance P
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US6011020A (en) 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
ES2061416T3 (es) 1990-10-12 1997-03-01 Max Planck Gesellschaft Ribozimas modificadas.
US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5186827A (en) 1991-03-25 1993-02-16 Immunicon Corporation Apparatus for magnetic separation featuring external magnetic means
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5817635A (en) 1993-08-09 1998-10-06 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Modified ribozymes
US5736330A (en) 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
US5612473A (en) 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
US6051698A (en) 1997-06-06 2000-04-18 Janjic; Nebojsa Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
RU2177950C2 (ru) 1996-10-25 2002-01-10 Нексстар Фармасьютикалз, Инк. Комплексы нуклеиновых кислот - лигандов сосудистого эндотелиального фактора роста (vegf)
CA2306501C (en) 1997-10-14 2011-03-29 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
US6719868B1 (en) 1998-03-23 2004-04-13 President And Fellows Of Harvard College Methods for fabricating microfluidic structures
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6269957B1 (en) 1998-12-04 2001-08-07 Orbital Biosciences, Llc Ultrafiltration device and method of forming same
US6623526B1 (en) 1999-01-08 2003-09-23 Corin Limited Knee prosthesis
FR2788780B1 (fr) 1999-01-27 2001-03-30 Ap Cells Inc Procede de preparation de vesicules membranaires
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7601270B1 (en) 1999-06-28 2009-10-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
US20030204075A9 (en) * 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US6790328B2 (en) 2000-01-12 2004-09-14 Ut-Battelle, Llc Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
US7452713B2 (en) 2000-02-29 2008-11-18 Stmicroelectronics S.R.L. Process for manufacturing a microfluidic device with buried channels
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
WO2001078087A2 (en) 2000-04-06 2001-10-18 Luminex Corporation Magnetically-responsive microspheres
US6812023B1 (en) 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
US6645432B1 (en) 2000-05-25 2003-11-11 President & Fellows Of Harvard College Microfluidic systems including three-dimensionally arrayed channel networks
EP1311854A2 (en) 2000-08-23 2003-05-21 Imego AB Microfuidic device and method with trapping of sample in carities having lids that can be opened or closed
US20020048821A1 (en) 2000-08-24 2002-04-25 David Storek Sample preparing arrangement and a method relating to such an arrangement
US6822454B2 (en) 2000-12-01 2004-11-23 Protasis Corporation Microfluidic device with multiple microcoil NMR detectors and field gradient focusing
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US6802342B2 (en) 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
WO2002099077A2 (en) 2001-06-06 2002-12-12 Proteologics, Inc. Methods and compositions related to tagging of membrane surface proteins
US7390463B2 (en) 2001-09-07 2008-06-24 Corning Incorporated Microcolumn-based, high-throughput microfluidic device
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
US7253003B2 (en) 2001-10-19 2007-08-07 Wisconsin Alumni Research Foundation Method for monitoring the environment within a microfluidic device
US7189580B2 (en) 2001-10-19 2007-03-13 Wisconsin Alumni Research Foundation Method of pumping fluid through a microfluidic device
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
WO2003048736A2 (en) 2001-12-05 2003-06-12 University Of Washington Microfluidic device and surface decoration process for solid phase affinity binding assays
US7238255B2 (en) 2001-12-31 2007-07-03 Gyros Patent Ab Microfluidic device and its manufacture
US6958119B2 (en) 2002-02-26 2005-10-25 Agilent Technologies, Inc. Mobile phase gradient generation microfluidic device
US7195986B1 (en) 2002-03-08 2007-03-27 Caliper Life Sciences, Inc. Microfluidic device with controlled substrate conductivity
GB2388189B (en) 2002-04-29 2006-01-11 Robert Jeffrey Geddes Carr Optical detection and analysis of particles
US7189581B2 (en) 2002-04-30 2007-03-13 Wisconsin Alumni Research Foundation Method of obtaining a sample concentration of a solution in a microfluidic device
ATE407096T1 (de) 2002-05-16 2008-09-15 Micronit Microfluidics Bv Verfahren zur herstellung eines mikrofluidischen bauteiles
AU2003251935A1 (en) 2002-07-15 2004-02-02 James Madison University Hybrid polymers for functional tuning of microfluidic device surfaces
US7135147B2 (en) 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
US7452509B2 (en) 2002-07-26 2008-11-18 Applied Biosystems Inc. Microfluidic device including displaceable material trap, and system
US7201881B2 (en) 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
KR100480338B1 (ko) 2002-08-08 2005-03-30 한국전자통신연구원 극소량의 유체제어를 위한 미세 유체제어소자
TW536524B (en) 2002-09-17 2003-06-11 Fan-Gen Tzeng Network-type micro-channel device for micro-fluid
US7118661B2 (en) 2002-09-30 2006-10-10 The Regents Of The University Of California Nanolaminate microfluidic device for mobility selection of particles
AU2003279811A1 (en) 2002-10-04 2004-05-04 Carl Cotman Microfluidic multi-compartment device for neuroscience research
FR2848125B1 (fr) 2002-12-04 2006-06-09 Commissariat Energie Atomique Dispositif microfluidique dans lequel l'interface liquide/fluide est stabilisee
US7467928B2 (en) 2002-12-12 2008-12-23 Board Of Trustees Of The University Of Arkansas Microfluidic device utilizing magnetohydrodynamics and method for fabrication thereof
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7338637B2 (en) 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
US7413709B2 (en) 2003-02-12 2008-08-19 Agilent Technologies, Inc. PAEK-based microfluidic device with integrated electrospray emitter
JP3856763B2 (ja) 2003-03-11 2006-12-13 財団法人川村理化学研究所 マイクロ流体素子の製造方法
CA2521171C (en) 2003-04-03 2013-05-28 Fluidigm Corp. Microfluidic devices and methods of using same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7422725B2 (en) 2003-05-01 2008-09-09 Enplas Corporation Sample handling unit applicable to microchip, and microfluidic device having microchips
JP4758891B2 (ja) 2003-06-06 2011-08-31 マイクロニクス， インコーポレイテッド 微小流体デバイス上の加熱、冷却および熱サイクリングのためのシステムおよび方法
FR2862007B1 (fr) 2003-11-12 2005-12-23 Commissariat Energie Atomique Dispositif microfluidique muni d'un nez d'electronebulisation.
US7329391B2 (en) 2003-12-08 2008-02-12 Applera Corporation Microfluidic device and material manipulating method using same
EP1547688A1 (en) 2003-12-23 2005-06-29 STMicroelectronics S.r.l. Microfluidic device and method of locally concentrating electrically charged substances in a microfluidic device
US7099778B2 (en) 2003-12-30 2006-08-29 Caliper Life Sciences, Inc. Method for determining diffusivity and molecular weight in a microfluidic device
US7351380B2 (en) 2004-01-08 2008-04-01 Sandia Corporation Microfluidic structures and methods for integrating a functional component into a microfluidic device
SG10201405756WA (en) 2004-01-25 2014-11-27 Fluidigm Corp Crystal forming devices and systems and methods for making and using the same
US7402229B2 (en) 2004-03-31 2008-07-22 Intel Corporation Fabrication and use of semipermeable membranes and gels for the control of electrolysis in a microfluidic device
EP1744986A2 (en) 2004-04-02 2007-01-24 Eksigent Technologies, LLC Microfluidic device
US7419639B2 (en) 2004-05-12 2008-09-02 The Board Of Trustees Of The Leland Stanford Junior University Multilayer microfluidic device
CN103884698B (zh) 2004-06-07 2017-04-12 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
CA2587956A1 (en) 2004-11-17 2006-05-26 Luminex Corporation Device and method for managing data from a flow analyzer
US7488596B2 (en) 2004-12-17 2009-02-10 Samsung Electronics Co., Ltd. Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
CN101663576B (zh) 2005-04-12 2012-05-23 卡钳生命科学股份有限公司 用于微流体器件的紧凑型光检测系统
KR100590581B1 (ko) 2005-05-10 2006-06-19 삼성전자주식회사 미세유동장치 및 그 제조방법
JP4992201B2 (ja) 2005-06-07 2012-08-08 富士ゼロックス株式会社 マイクロ流体制御方法、マイクロ流体素子およびその製造方法
TWI274040B (en) 2005-12-23 2007-02-21 Ind Tech Res Inst Microfluidic device and method of manufacturing the same
US7568399B2 (en) 2006-01-05 2009-08-04 Integrated Sensing Systems, Inc. Microfluidic device
US7581429B2 (en) 2006-01-06 2009-09-01 Integrated Sensing Systems, Inc. Microfluidic device and method of operation
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
DK3517151T3 (da) 2006-03-09 2021-07-12 Aethlon Medical Inc Ekstrakorporal fjernelse af mikrovesikulære partikler
CN102851369B (zh) 2006-12-13 2015-01-21 卢米耐克斯公司 用于实时pcr多重分析的系统和方法
US8008019B2 (en) 2007-11-28 2011-08-30 Luminex Molecular Diagnostics Use of dual-tags for the evaluation of genomic variable repeat regions
WO2011109451A1 (en) * 2010-03-01 2011-09-09 Aptamatrix, Inc. Library compositions and methosds for acyclic identification of aptamers
US7888035B2 (en) * 2008-10-30 2011-02-15 Caris Mpi, Inc. Methods for assessing RNA patterns
WO2010065765A2 (en) 2008-12-04 2010-06-10 Aethlon Medical, Inc. Affinity capture of circulating biomarkers
EP2202522A1 (en) 2008-12-23 2010-06-30 Universiteit Leiden Methods for immobilizing microvesicles, means and methods for detecting them, and uses thereof
EP3722810A3 (en) 2009-02-11 2021-01-13 Caris MPI, Inc. Molecular profiling of tumors
US20120077263A1 (en) 2009-06-05 2012-03-29 Mayo Foundation For Medical Education And Research Methods and materials for isolating exosomes
EP2494077A4 (en) 2009-10-27 2013-08-21 Caris Mpi Inc MOLECULAR PROFILING FOR PERSONALIZED MEDICINE
WO2011106376A2 (en) * 2010-02-23 2011-09-01 The General Hospital Corporation Use of microvesicles in the treatment of medical conditions
EP2542696B1 (en) * 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarkers for theranostics
JP2013526852A (ja) * 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
JP2014519340A (ja) 2011-06-16 2014-08-14 カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． バイオマーカー組成物および方法
WO2014082083A1 (en) 2012-11-26 2014-05-30 Caris Science, Inc. Biomarker compositions and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102301002A (zh) * 2008-11-12 2011-12-28 卡里斯生命科学卢森堡控股有限责任公司 使用外来体来确定表现型的方法和系统
WO2011066589A1 (en) * 2009-11-30 2011-06-03 Caris Life Sciences Luxembourg Holdings Methods and systems for isolating, storing, and analyzing vesicles
WO2011088226A2 (en) * 2010-01-13 2011-07-21 Caris Life Sciences Luxembourg Holdings Detection of gastrointestinal disorders
WO2013022995A2 (en) * 2011-08-08 2013-02-14 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarker compositions and methods

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109254089A (zh) * 2017-07-14 2019-01-22 株式会社岛津制作所 使用了质谱分析的认知功能障碍疾病生物标记物的定量方法和质谱分析装置
CN109251980A (zh) * 2017-07-14 2019-01-22 中国人民解放军第八医院 膀胱癌组织t细胞图谱模型及其构建方法和构建系统
CN111386458A (zh) * 2017-09-27 2020-07-07 罗塞塔外排体株式会社 利用尺寸排阻色谱法的细胞外囊泡的分析方法及其用途
CN109880903A (zh) * 2019-03-01 2019-06-14 南京医科大学 一种用于非小细胞肺癌辅助诊断的snp标志物及其应用
CN109880903B (zh) * 2019-03-01 2021-12-14 南京医科大学 一种用于非小细胞肺癌辅助诊断的snp标志物及其应用
CN110045099A (zh) * 2019-04-01 2019-07-23 四川大学华西医院 一种慢性阻塞性肺疾病检测试剂盒
CN110045099B (zh) * 2019-04-01 2022-03-04 四川大学华西医院 一种慢性阻塞性肺疾病检测试剂盒
CN115667925A (zh) * 2020-05-15 2023-01-31 阿雷克森制药公司 使用细胞外囊泡来检测补体激活的方法以及其用于评估和/或监测补体介导的疾病的治疗的用途
CN111830289A (zh) * 2020-07-24 2020-10-27 长春理工大学 一种利用原子力显微术对生物素化抗体-IgE免疫复合物直接成像的方法
CN119959532A (zh) * 2025-01-03 2025-05-09 中国科学院精密测量科学与技术创新研究院 细胞色素c在制备elisa试剂盒方面的新用途

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