CN105960415A - 用于治疗癌症的pd-1拮抗剂和vegfr抑制剂的组合 - Google Patents

用于治疗癌症的pd-1拮抗剂和vegfr抑制剂的组合 Download PDF

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Publication number
CN105960415A
CN105960415A CN201580007146.1A CN201580007146A CN105960415A CN 105960415 A CN105960415 A CN 105960415A CN 201580007146 A CN201580007146 A CN 201580007146A CN 105960415 A CN105960415 A CN 105960415A
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cancer
axitinib
antagonist
dosage
seq
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Chinese (zh)
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J-F·A·马蒂尼
J·C·塔拉齐
R·F·佩里尼
D·J·莫罗
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Merck Sharp and Dohme BV
Pfizer Corp SRL
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Pfizer Corp SRL
Merck Sharp and Dohme LLC
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Application filed by Pfizer Corp SRL, Merck Sharp and Dohme LLC filed Critical Pfizer Corp SRL
Priority to CN202410389501.7A priority Critical patent/CN118286440A/zh
Publication of CN105960415A publication Critical patent/CN105960415A/zh
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CN201580007146.1A 2014-02-04 2015-02-03 用于治疗癌症的pd-1拮抗剂和vegfr抑制剂的组合 Pending CN105960415A (zh)

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US201461935809P 2014-02-04 2014-02-04
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PCT/US2015/014212 WO2015119930A1 (en) 2014-02-04 2015-02-03 Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer

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Cited By (19)

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CN106963948A (zh) * 2017-05-12 2017-07-21 顾艳宏 阿帕替尼与Anti‑PD‑1抗体联用在制备结肠癌药物中的应用
WO2018068691A1 (zh) * 2016-10-10 2018-04-19 苏州盛迪亚生物医药有限公司 一种抗pd-1抗体和vegfr抑制剂联合在制备治疗癌症的药物中的用途
WO2018210230A1 (zh) 2017-05-16 2018-11-22 江苏恒瑞医药股份有限公司 一种pd-l1抗体药物组合物及其用途
CN109310761A (zh) * 2016-06-10 2019-02-05 诺华股份有限公司 C-raf抑制剂的治疗用途
CN110036030A (zh) * 2016-09-26 2019-07-19 英克隆有限责任公司 癌症的组合疗法
CN110392578A (zh) * 2017-03-06 2019-10-29 默克专利有限公司 水性抗pd-l1抗体制剂
CN110505882A (zh) * 2017-03-31 2019-11-26 默沙东公司 用pd-1的拮抗剂和抗ctla4抗体的组合治疗癌症的组合物和方法
CN110546277A (zh) * 2017-03-01 2019-12-06 豪夫迈·罗氏有限公司 用于癌症的诊断和治疗方法
CN110831580A (zh) * 2017-05-09 2020-02-21 特沙诺有限公司 用于治疗癌症的组合疗法
CN111065411A (zh) * 2017-11-16 2020-04-24 江苏恒瑞医药股份有限公司 Pd-1抗体和vegfr抑制剂联合治疗小细胞肺癌的用途
CN111225685A (zh) * 2017-10-13 2020-06-02 默克专利股份有限公司 Parp抑制剂和pd-1轴结合拮抗剂的组合
CN111328286A (zh) * 2017-08-09 2020-06-23 奥里尼斯生物科学有限公司 Pd-1和pd-l1结合剂
CN111386117A (zh) * 2017-09-29 2020-07-07 百时美施贵宝公司 治疗癌症的组合物和方法
CN111629729A (zh) * 2017-12-18 2020-09-04 辉瑞大药厂 治疗癌症的方法及组合疗法
CN112955464A (zh) * 2018-06-20 2021-06-11 因赛特公司 抗pd-1抗体及其用途
WO2022052874A1 (zh) 2020-09-09 2022-03-17 深圳微芯生物科技股份有限公司 西奥罗尼联合免疫检查点抑制剂在抗肿瘤治疗中的应用
CN115400115A (zh) * 2021-05-26 2022-11-29 石药集团中奇制药技术（石家庄）有限公司 多西他赛白蛋白组合物和免疫检查点抑制剂的组合及用途
WO2025002264A1 (zh) * 2023-06-30 2025-01-02 默沙东有限责任公司 包含偶联物的药物组合的治疗方法和用途
US12383542B2 (en) 2016-06-29 2025-08-12 Tesaro, Inc. Methods of treating ovarian cancer

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US20160303231A1 (en) * 2013-12-11 2016-10-20 Robert Iannone Treating cancer with a combination of a pd-1 antagonist and a vegfr inhibitor
SG11201604738TA (en) 2013-12-12 2016-07-28 Shanghai Hengrui Pharm Co Ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
EP3686219A1 (en) 2014-02-04 2020-07-29 Pfizer Inc Combination of a pd-1 antagonist and a 4-1bb agonist for treating cancer
CN118286440A (zh) * 2014-02-04 2024-07-05 辉瑞大药厂 用于治疗癌症的pd-1拮抗剂和vegfr抑制剂的组合
KR20160119867A (ko) * 2014-03-05 2016-10-14 브리스톨-마이어스 스큅 컴퍼니 항-pd-1 항체 및 또 다른 항암제의 조합물을 이용한 신장암의 치료
BR112017018234A2 (pt) 2015-02-26 2018-04-17 Merck Patent Gmbh inibidores de pd-1 / pd-l1 para o tratamento de câncer
ES2844799T5 (en) 2015-04-17 2025-01-16 Merck Sharp & Dohme Llc Blood-based biomarkers of tumor sensitivity to pd-1 antagonists
KR102712880B1 (ko) 2015-06-16 2024-10-02 메르크 파텐트 게엠베하 Pd-l1 길항제 조합 치료
SG11201804839WA (en) 2015-12-14 2018-07-30 Macrogenics Inc Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof
CN105669864B (zh) * 2015-12-23 2018-10-16 杭州尚健生物技术有限公司 抗人程序性死亡受体1抗体及其制备方法和用途
CN107126563B (zh) * 2016-02-26 2021-09-10 博生吉医药科技(苏州)有限公司 含低剂量阻断vegf信号通路的抗体的组合物及其用途
WO2018044888A1 (en) * 2016-08-29 2018-03-08 Chen James C Tumor vaccination systems, devices, and methods
WO2018058125A1 (en) * 2016-09-26 2018-03-29 Ensemble Group Holdings Methods of assessing and treating cancer in subjects having dysregulated lymphatic systems
MX2019003755A (es) 2016-10-06 2019-08-12 Pfizer Regimen de dosificacion de avelumab para el tratamiento de cancer.
BR112019013238A2 (pt) 2017-01-20 2020-02-11 Tayu Huaxia Biotech Medical Group Co., Ltd. Anticorpos anti-pd-1 e usos dos mesmos
WO2018219807A1 (en) * 2017-06-02 2018-12-06 Bayer Aktiengesellschaft Combination of regorafenib and pd-1/pd-l1(2) inhibitors for treating cancer
WO2019090263A1 (en) 2017-11-06 2019-05-09 Genentech, Inc. Diagnostic and therapeutic methods for cancer
MA52968A (fr) 2018-06-23 2021-04-28 Hoffmann La Roche Méthodes de traitement du cancer du poumon à l'aide d'un antagoniste de liaison à l'axe pd-1, d'un agent de platine et d'un inhibiteur de la topoisomérase ii
KR20210034622A (ko) 2018-07-18 2021-03-30 제넨테크, 인크. Pd-1 축 결합 길항제, 항 대사제, 및 백금 제제를 이용한 폐암 치료 방법
EP3823991A4 (en) * 2018-07-19 2022-08-03 Tayu Huaxia Biotech Medical Group Co., Ltd. ANTI-PD-1 ANTIBODIES, DOSAGE FORMS AND USES THEREOF
EP3847154A1 (en) 2018-09-03 2021-07-14 F. Hoffmann-La Roche AG Carboxamide and sulfonamide derivatives useful as tead modulators
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JP2020007359A (ja) 2020-01-16
TR201901507T4 (tr) 2019-02-21
MX386604B (es) 2025-03-19
ES2899457T3 (es) 2022-03-11
BR112016017256A2 (pt) 2017-10-17
PL3498734T3 (pl) 2022-02-14
KR20160108566A (ko) 2016-09-19
CY1121374T1 (el) 2020-05-29
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KR20250109796A (ko) 2025-07-17
JP2017506227A (ja) 2017-03-02
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DK3102605T3 (en) 2019-02-25
CN118286440A (zh) 2024-07-05
PT3102605T (pt) 2019-02-12
SI3498734T1 (sl) 2022-02-28
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