CN105873589B - 制造苯并喹啉化合物的方法 - Google Patents

制造苯并喹啉化合物的方法 Download PDF

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Publication number
CN105873589B
CN105873589B CN201480066154.9A CN201480066154A CN105873589B CN 105873589 B CN105873589 B CN 105873589B CN 201480066154 A CN201480066154 A CN 201480066154A CN 105873589 B CN105873589 B CN 105873589B
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compound
certain embodiments
acid
water
methanol
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CN105873589A (zh
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C·张
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Osbaikos Pharmaceutical Co ltd
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Auspex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201480066154.9A 2013-12-03 2014-11-24 制造苯并喹啉化合物的方法 Active CN105873589B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361911214P 2013-12-03 2013-12-03
US61/911,214 2013-12-03
PCT/US2014/067117 WO2015084622A1 (en) 2013-12-03 2014-11-24 Methods of manufacturing benzoquinoline compounds

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Publication Number Publication Date
CN105873589A CN105873589A (zh) 2016-08-17
CN105873589B true CN105873589B (zh) 2019-11-01

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US (8) US20150152099A1 (cg-RX-API-DMAC7.html)
EP (2) EP3424504A1 (cg-RX-API-DMAC7.html)
JP (1) JP6542222B2 (cg-RX-API-DMAC7.html)
KR (1) KR102391134B1 (cg-RX-API-DMAC7.html)
CN (1) CN105873589B (cg-RX-API-DMAC7.html)
AU (4) AU2014357518A1 (cg-RX-API-DMAC7.html)
BR (1) BR112016012747B1 (cg-RX-API-DMAC7.html)
CA (1) CA2930744A1 (cg-RX-API-DMAC7.html)
EA (2) EA032920B1 (cg-RX-API-DMAC7.html)
HK (1) HK1224222A1 (cg-RX-API-DMAC7.html)
IL (1) IL245539B (cg-RX-API-DMAC7.html)
MX (1) MX369956B (cg-RX-API-DMAC7.html)
NZ (1) NZ720301A (cg-RX-API-DMAC7.html)
WO (1) WO2015084622A1 (cg-RX-API-DMAC7.html)

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CA2883641C (en) 2012-09-18 2021-09-14 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
US9550780B2 (en) 2012-09-18 2017-01-24 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
CN105873589B (zh) 2013-12-03 2019-11-01 奥斯拜客斯制药有限公司 制造苯并喹啉化合物的方法
JP6932641B2 (ja) 2015-03-06 2021-09-08 オースペックス ファーマシューティカルズ インコーポレイテッド 異常不随意運動障害の処置のための方法
WO2017182916A1 (en) 2016-04-22 2017-10-26 Lupin Limited Novel process for preparation of tetrabenazine and deutetrabenazine
US10703750B2 (en) 2017-01-10 2020-07-07 Sandoz Ag Crystalline valbenazine free base
CA3054238A1 (en) 2017-02-27 2018-08-30 Sandoz Ag Crystalline forms of valbenazine salts
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WO2019130252A2 (en) * 2017-12-29 2019-07-04 Mylan Laboratories Ltd Methods and intermediates for preparing deutetrabenazine
WO2019150387A1 (en) * 2018-02-01 2019-08-08 Alaparthi Lakshmi Prasad A novel process for preparation of deutetrabenazine
BR112021007060A2 (pt) 2018-10-18 2021-07-20 Oncopeptides Ab compostos contendo deutério
TW202033521A (zh) * 2018-10-24 2020-09-16 美商紐羅克里生物科學有限公司 製備囊泡單胺轉運蛋白2(vmat2)抑制劑之方法
CN111960999B (zh) * 2020-07-20 2021-11-02 暨明医药科技（苏州）有限公司 一种丁苯那嗪中间体的合成方法

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US20200347008A1 (en) 2020-11-05
CN105873589A (zh) 2016-08-17
MX2016007056A (es) 2017-01-06
US20170197957A1 (en) 2017-07-13
AU2014357518A1 (en) 2016-06-09
US10513488B2 (en) 2019-12-24
US20180230083A1 (en) 2018-08-16
KR102391134B1 (ko) 2022-04-28
JP2017501141A (ja) 2017-01-12
US20170190654A1 (en) 2017-07-06
NZ720301A (en) 2022-01-28
CA2930744A1 (en) 2015-06-11
WO2015084622A1 (en) 2015-06-11
US20230060294A1 (en) 2023-03-02
AU2021209150A1 (en) 2021-08-19
EP3076970A1 (en) 2016-10-12
AU2020201091B2 (en) 2021-04-29
KR20160087904A (ko) 2016-07-22
AU2020201091A1 (en) 2020-03-05
BR112016012747B1 (pt) 2022-07-12
EA201691162A1 (ru) 2016-11-30
IL245539A0 (en) 2016-06-30
HK1223020A1 (zh) 2017-07-21
BR112016012747A2 (cg-RX-API-DMAC7.html) 2017-08-08
US20150152099A1 (en) 2015-06-04
EA201791466A1 (ru) 2017-11-30
EP3424504A1 (en) 2019-01-09
AU2023203246B2 (en) 2025-02-27
US20200331846A1 (en) 2020-10-22
IL245539B (en) 2021-06-30
MX369956B (es) 2019-11-27
US20190092719A1 (en) 2019-03-28
EA032920B1 (ru) 2019-08-30
JP6542222B2 (ja) 2019-07-10
EP3076970A4 (en) 2017-07-26
AU2023203246A1 (en) 2023-06-15
US12077487B2 (en) 2024-09-03
HK1224222A1 (zh) 2017-08-18

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