CN105829589B - 用于分析人体微生物组及其组分的无细胞核酸 - Google Patents
用于分析人体微生物组及其组分的无细胞核酸 Download PDFInfo
- Publication number
- CN105829589B CN105829589B CN201480068555.8A CN201480068555A CN105829589B CN 105829589 B CN105829589 B CN 105829589B CN 201480068555 A CN201480068555 A CN 201480068555A CN 105829589 B CN105829589 B CN 105829589B
- Authority
- CN
- China
- Prior art keywords
- computer
- readable medium
- microbial
- microbiome
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/20—Sequence assembly
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Virology (AREA)
- Pathology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110128389.8A CN112877472A (zh) | 2013-11-07 | 2014-11-07 | 用于分析人体微生物组及其组分的无细胞核酸 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361901114P | 2013-11-07 | 2013-11-07 | |
| US61/901,114 | 2013-11-07 | ||
| US201361901857P | 2013-11-08 | 2013-11-08 | |
| US61/901,857 | 2013-11-08 | ||
| PCT/US2014/064669 WO2015070086A1 (en) | 2013-11-07 | 2014-11-07 | Cell-free nucleic acids for the analysis of the human microbiome and components thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110128389.8A Division CN112877472A (zh) | 2013-11-07 | 2014-11-07 | 用于分析人体微生物组及其组分的无细胞核酸 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105829589A CN105829589A (zh) | 2016-08-03 |
| CN105829589B true CN105829589B (zh) | 2021-02-02 |
Family
ID=53042160
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480068555.8A Active CN105829589B (zh) | 2013-11-07 | 2014-11-07 | 用于分析人体微生物组及其组分的无细胞核酸 |
| CN202110128389.8A Pending CN112877472A (zh) | 2013-11-07 | 2014-11-07 | 用于分析人体微生物组及其组分的无细胞核酸 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110128389.8A Pending CN112877472A (zh) | 2013-11-07 | 2014-11-07 | 用于分析人体微生物组及其组分的无细胞核酸 |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US10450620B2 (enExample) |
| EP (2) | EP4130350A1 (enExample) |
| JP (4) | JP7451070B2 (enExample) |
| KR (3) | KR102649364B1 (enExample) |
| CN (2) | CN105829589B (enExample) |
| AU (1) | AU2014346562B2 (enExample) |
| BR (1) | BR112016010095A2 (enExample) |
| CA (2) | CA3207499A1 (enExample) |
| GB (1) | GB2535382A (enExample) |
| IL (4) | IL285106B (enExample) |
| MX (5) | MX383494B (enExample) |
| WO (1) | WO2015070086A1 (enExample) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10179937B2 (en) | 2014-04-21 | 2019-01-15 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| CA2824387C (en) | 2011-02-09 | 2019-09-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| CN105829589B (zh) | 2013-11-07 | 2021-02-02 | 小利兰·斯坦福大学理事会 | 用于分析人体微生物组及其组分的无细胞核酸 |
| EP3080298B1 (en) | 2013-12-11 | 2018-10-31 | AccuraGen Holdings Limited | Methods for detecting rare sequence variants |
| US11859246B2 (en) * | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| US9703929B2 (en) | 2014-10-21 | 2017-07-11 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics |
| US10410749B2 (en) | 2014-10-21 | 2019-09-10 | uBiome, Inc. | Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions |
| US10325685B2 (en) | 2014-10-21 | 2019-06-18 | uBiome, Inc. | Method and system for characterizing diet-related conditions |
| AU2015364286B2 (en) | 2014-12-20 | 2021-11-04 | Arc Bio, Llc | Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using CRISPR/Cas system proteins |
| CN106103742B (zh) * | 2015-01-06 | 2019-12-10 | 深圳市海普洛斯生物科技有限公司 | 一种富集循环肿瘤dna的方法和试剂 |
| US10893509B2 (en) * | 2015-02-11 | 2021-01-12 | Qualcomm Incorporated | Multiple tri-state HARQ processes |
| DK3294906T3 (en) | 2015-05-11 | 2024-08-05 | Natera Inc | Methods for determining ploidy |
| AU2016264102A1 (en) * | 2015-05-18 | 2017-12-21 | Karius, Inc. | Compositions and methods for enriching populations of nucleic acids |
| CN107849599A (zh) * | 2015-06-30 | 2018-03-27 | 优比欧迈公司 | 用于诊断测试的方法和系统 |
| EP3985111A1 (en) | 2015-08-19 | 2022-04-20 | Arc Bio, LLC | Capture of nucleic acids using a nucleic acid-guided nuclease-based system |
| CA3005987A1 (en) * | 2015-09-09 | 2017-03-16 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with gastrointestinal health |
| EP3347496A4 (en) * | 2015-09-09 | 2019-08-07 | Ubiome Inc. | METHOD AND SYSTEM FOR DIAGNOSES DERIVED FROM MICROBIOMA AND THERAPEUTIC TREATMENTS FOR BUCCO-DENTAL HEALTH |
| EP3141612A1 (en) * | 2015-09-10 | 2017-03-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method and device for nucleic acid based diagnostic approaches including the determination of a deviant condtion, especially a health condition and/or pathogenic condition of a sample |
| EP3146974A1 (en) * | 2015-09-25 | 2017-03-29 | Universite Claude Bernard - Lyon 1 | Biomarkers for early determination of severity of influenza related disease |
| HK1259101A1 (zh) | 2015-10-09 | 2019-11-22 | Accuragen Holdings Limited | 用於富集扩增产物的方法及组合物 |
| EP3383994A4 (en) | 2015-12-03 | 2019-08-28 | Accuragen Holdings Limited | METHOD AND COMPOSITIONS FOR FORMING LIGATION PRODUCTS |
| CN105603075A (zh) * | 2016-01-29 | 2016-05-25 | 江汉大学 | 一种小麦微生物定性与定量的检测方法 |
| CN105603076A (zh) * | 2016-01-29 | 2016-05-25 | 江汉大学 | 一种土壤微生物定性与定量的检测方法 |
| CN105603074B (zh) * | 2016-01-29 | 2019-11-15 | 江汉大学 | 一种非诊断目的微生物定性与定量的检测方法 |
| CN105671150A (zh) * | 2016-01-29 | 2016-06-15 | 江汉大学 | 一种人体微生物定性与定量的检测方法 |
| CN105567831B (zh) * | 2016-01-29 | 2019-07-23 | 江汉大学 | 一种食品微生物定性与定量的检测方法 |
| EP3433382B1 (en) | 2016-03-25 | 2021-09-01 | Karius, Inc. | Synthetic nucleic acid spike-ins |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| CA3022294A1 (en) * | 2016-04-25 | 2017-11-02 | uBiome, Inc. | Method and system for characterizing skin-related conditions |
| EP3458586B1 (en) | 2016-05-16 | 2022-12-28 | Accuragen Holdings Limited | Method of improved sequencing by strand identification |
| FR3051482B1 (fr) * | 2016-05-19 | 2021-01-29 | Life & Soft | Procede de determination de la presence et quantification d'au moins un micro-organisme dans un echantillon biologique |
| WO2018005811A1 (en) * | 2016-06-30 | 2018-01-04 | Grail, Inc. | Differential tagging of rna for preparation of a cell-free dna/rna sequencing library |
| JP6966052B2 (ja) | 2016-08-15 | 2021-11-10 | アキュラーゲン ホールディングス リミテッド | 稀な配列変異体を検出するための組成物および方法 |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| IL266654B2 (en) * | 2016-11-17 | 2024-03-01 | Lgc Clinical Diagnostics Inc | Methods for preparing dna reference material and controls |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| JP2020515278A (ja) * | 2017-04-04 | 2020-05-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ドナー遺伝子型の非存在下での移植由来循環セルフリーdnaの定量化 |
| US11781188B2 (en) * | 2017-04-06 | 2023-10-10 | Cornell University | Methods of detecting cell-free DNA in biological samples |
| WO2018191563A1 (en) | 2017-04-12 | 2018-10-18 | Karius, Inc. | Sample preparation methods, systems and compositions |
| EP3431610A1 (en) * | 2017-07-19 | 2019-01-23 | Noscendo GmbH | Methods and devices for nucleic acid-based real-time determination of disease states |
| WO2019028462A1 (en) | 2017-08-04 | 2019-02-07 | Billiontoone, Inc. | TARGET-ASSOCIATED MOLECULES FOR CHARACTERIZATION ASSOCIATED WITH BIOLOGICAL TARGETS |
| KR102372572B1 (ko) | 2017-08-04 | 2022-03-08 | 빌리언투원, 인크. | 생물학적 표적과 연관된 정량화에서 표적 연관 분자를 이용한 서열분석 출력값 측정 및 분석 |
| US11519024B2 (en) | 2017-08-04 | 2022-12-06 | Billiontoone, Inc. | Homologous genomic regions for characterization associated with biological targets |
| WO2019060716A1 (en) | 2017-09-25 | 2019-03-28 | Freenome Holdings, Inc. | SAMPLE EXTRACTION METHODS AND SYSTEMS |
| CA3085933A1 (en) | 2017-12-14 | 2019-06-20 | Tai Diagnostics, Inc. | Assessing graft suitability for transplantation |
| DK3735470T3 (da) | 2018-01-05 | 2024-02-26 | Billiontoone Inc | Kvalitetskontroltemplates til sikring af validiteten af sekventeringsbaserede analyser |
| WO2019161244A1 (en) | 2018-02-15 | 2019-08-22 | Natera, Inc. | Methods for isolating nucleic acids with size selection |
| EP3765631A4 (en) * | 2018-03-13 | 2021-12-08 | Guardant Health, Inc. | METHOD OF NON-INVASIVE DETECTION AND MONITORING OF THERAPEUTIC NUCLEIC ACID CONSTRUCTS |
| CA3082601A1 (en) | 2018-03-16 | 2019-09-19 | Karius, Inc. | Sample series to differentiate target nucleic acids from contaminant nucleic acids |
| EP3785269A4 (en) * | 2018-03-29 | 2021-12-29 | Freenome Holdings, Inc. | Methods and systems for analyzing microbiota |
| EP3781714B1 (en) | 2018-04-14 | 2026-01-07 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| CN108660199A (zh) * | 2018-05-20 | 2018-10-16 | 北京宏微特斯生物科技有限公司 | 一种基于cfDNA高通量测序检测病原体的方法 |
| US12049665B2 (en) | 2018-06-12 | 2024-07-30 | Accuragen Holdings Limited | Methods and compositions for forming ligation products |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| EP3833776A4 (en) * | 2018-08-06 | 2022-04-27 | Billiontoone, Inc. | DILUTION MARKER FOR QUANTIFICATION OF BIOLOGICAL TARGETS |
| KR102114758B1 (ko) * | 2018-11-19 | 2020-05-26 | 경북대학교 산학협력단 | 멤브레인 구조물을 이용한 혈액 내 미생물의 핵산 추출을 위한 혈액 시료 전처리 방법 |
| DK4428234T3 (da) | 2018-11-21 | 2026-01-26 | Karius Inc | Direkte-til-bibliotek-fremgangsmåder, systemer og sammensætninger |
| US11512349B2 (en) | 2018-12-18 | 2022-11-29 | Grail, Llc | Methods for detecting disease using analysis of RNA |
| WO2020198664A1 (en) * | 2019-03-28 | 2020-10-01 | The Regents Of The University Of California | Methods and systems for sequencing cell-free microbiome dna |
| KR20220015367A (ko) | 2019-05-31 | 2022-02-08 | 프리놈 홀딩스, 인크. | 메틸화된 핵산의 고심도 시퀀싱 방법 및 시스템 |
| KR102503766B1 (ko) * | 2020-06-16 | 2023-02-23 | 씨제이바이오사이언스 주식회사 | 장내 마이크로바이옴 지수를 결정하기 위한 장치, 방법 및 명령을 기록한 기록 매체 |
| CA3198341A1 (en) * | 2020-11-12 | 2022-05-19 | Eddie Adams | Systems and methods to improve therapeutic outcomes |
| US20220195496A1 (en) * | 2020-12-17 | 2022-06-23 | Karius, Inc. | Sequencing microbial cell-free dna from asymptomatic individuals |
| KR20240045159A (ko) * | 2020-12-21 | 2024-04-05 | 카리우스, 인코포레이티드 | 염증, 2차 감염 및 질환 중증도를 검출하기 위한 미생물 세포-유리 핵산의 서열분석 |
| CN113061666A (zh) * | 2020-12-30 | 2021-07-02 | 中南大学湘雅二医院 | 肝移植后巨细胞病毒的检测方法、应用及系统 |
| BR112023018701A2 (pt) * | 2021-03-18 | 2023-11-28 | Natera Inc | Métodos para determinação de rejeição de transplante |
| US20250140417A1 (en) * | 2021-08-11 | 2025-05-01 | Immunosis Pty Ltd | Methods for determining secondary immunodeficiency |
| CA3249869A1 (en) * | 2022-01-24 | 2023-07-27 | Gusto Global, Llc | SINGLE-POINT TARGETED AMPLICO FRAGMENT SEQUENCING AT SINGLE AND MULTI-LOCI LOCI |
| CA3255101A1 (en) | 2022-03-21 | 2023-09-28 | Billion Toone, Inc. | Counting of circulating methylated cell-free DNA molecules for treatment monitoring |
| WO2025024111A1 (en) * | 2023-07-25 | 2025-01-30 | Gusto Global, Llc | Single point amplicon fragment sequencing and methods for diagnosing and monitoring disease |
| WO2025087333A1 (en) * | 2023-10-24 | 2025-05-01 | Centre For Novostics | Analysis of microbial dna for disease classification |
| US20250191691A1 (en) * | 2023-12-07 | 2025-06-12 | California Institute Of Technology | Methods for the translated alignment of transcriptomic data at single-cell resolution |
| WO2025175229A1 (en) * | 2024-02-16 | 2025-08-21 | Karius, Inc. | Multi-step methods for detecting nucleic acids |
| WO2025231437A1 (en) * | 2024-05-03 | 2025-11-06 | Karius, Inc. | Predicting cytokine release syndrome in car-t cell therapy |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013159035A2 (en) * | 2012-04-19 | 2013-10-24 | Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US6287850B1 (en) | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| USRE39920E1 (en) | 1997-05-30 | 2007-11-13 | Xenomics, Inc. | Methods for detection of nucleic acid sequences in urine |
| US20030022207A1 (en) | 1998-10-16 | 2003-01-30 | Solexa, Ltd. | Arrayed polynucleotides and their use in genome analysis |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| EP1218543A2 (en) | 1999-09-29 | 2002-07-03 | Solexa Ltd. | Polynucleotide sequencing |
| US6582938B1 (en) | 2001-05-11 | 2003-06-24 | Affymetrix, Inc. | Amplification of nucleic acids |
| GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
| US6897023B2 (en) | 2000-09-27 | 2005-05-24 | The Molecular Sciences Institute, Inc. | Method for determining relative abundance of nucleic acid sequences |
| US6753137B2 (en) | 2001-01-31 | 2004-06-22 | The Chinese University Of Hong Kong | Circulating epstein-barr virus DNA in the serum of patients with gastric carcinoma |
| US6996477B2 (en) * | 2001-04-19 | 2006-02-07 | Dana Farber Cancer Institute, Inc. | Computational subtraction method |
| DE10120797B4 (de) | 2001-04-27 | 2005-12-22 | Genovoxx Gmbh | Verfahren zur Analyse von Nukleinsäureketten |
| AU2002337030A1 (en) | 2001-08-29 | 2003-03-18 | Genovoxx Gmbh | Method for analyzing nucleic acid sequences and gene expression |
| JP2003101204A (ja) | 2001-09-25 | 2003-04-04 | Nec Kansai Ltd | 配線基板及び配線基板の製造方法並びに電子部品 |
| US20050227231A1 (en) | 2001-10-04 | 2005-10-13 | Dimitri Tcherkassov | Device for sequencing nucleic acid molecules |
| DE10149786B4 (de) | 2001-10-09 | 2013-04-25 | Dmitry Cherkasov | Oberfläche für Untersuchungen aus Populationen von Einzelmolekülen |
| US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US20050124022A1 (en) | 2001-10-30 | 2005-06-09 | Maithreyan Srinivasan | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US20050202414A1 (en) | 2001-11-15 | 2005-09-15 | The Regents Of The University Of California | Apparatus and methods for detecting a microbe in a sample |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| CA2477761A1 (en) | 2002-03-01 | 2003-09-12 | Ravgen, Inc. | Methods for detection of genetic disorders |
| DE10214395A1 (de) | 2002-03-30 | 2003-10-23 | Dmitri Tcherkassov | Verfahren zur Analyse von Einzelnukleotidpolymorphismen |
| US7442506B2 (en) | 2002-05-08 | 2008-10-28 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US7727720B2 (en) | 2002-05-08 | 2010-06-01 | Ravgen, Inc. | Methods for detection of genetic disorders |
| JP2005536200A (ja) * | 2002-07-01 | 2005-12-02 | バイロロジック,インコーポレーテッド | プロテアーゼ阻害剤に対する病原性ウイルスの感受性を決定するための組成物および方法 |
| AU2004209001B2 (en) | 2003-01-29 | 2007-10-11 | 454 Life Sciences Corporation | Bead emulsion nucleic acid amplification |
| EP1606417A2 (en) | 2003-03-07 | 2005-12-21 | Rubicon Genomics Inc. | In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna |
| WO2004091519A2 (en) | 2003-04-11 | 2004-10-28 | Medimmune, Inc. | Methods of preventing or treating respiratory conditions |
| DE10356837A1 (de) | 2003-12-05 | 2005-06-30 | Dmitry Cherkasov | Modifizierte Nukleotide und Nukleoside |
| EP1725572B1 (de) | 2003-11-05 | 2017-05-31 | AGCT GmbH | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| JP2007515414A (ja) | 2003-12-16 | 2007-06-14 | パレンテラル アー エス | 血漿置換剤およびその製造方法 |
| DE102004009704A1 (de) | 2004-02-27 | 2005-09-15 | Dmitry Cherkasov | Makromolekulare Nukleotidverbindungen und Methoden zu deren Anwendung |
| DE102004025695A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren und Oberfläche zur parallelen Sequenzierung von Nukleinsäureketten |
| DE102004025746A1 (de) | 2004-05-26 | 2005-12-15 | Dmitry Cherkasov | Verfahren, Oberfläche und Substrate zur hochparallelen Sequenzierung von Nukleinsäureketten |
| DE102004025744A1 (de) | 2004-05-26 | 2005-12-29 | Dmitry Cherkasov | Oberfläche für die Analysen an einzelnen Nukleinsäuremolekülen |
| DE102004025745A1 (de) | 2004-05-26 | 2005-12-15 | Cherkasov, Dmitry | Oberfläche für die Analysen an einzelnen Molekülen |
| DE102004025696A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren, Oberfläche und Substrate zu hochparallelen Analysen von Nukleinsäureketten |
| DE102004025694A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren und Oberfläche zu hochparallelen Analysen von Nukleinsäureketten |
| US20060002471A1 (en) | 2004-06-30 | 2006-01-05 | Lippincott Louis A | Motion estimation unit |
| US20060012793A1 (en) | 2004-07-19 | 2006-01-19 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
| US7276720B2 (en) | 2004-07-19 | 2007-10-02 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
| US20060024678A1 (en) | 2004-07-28 | 2006-02-02 | Helicos Biosciences Corporation | Use of single-stranded nucleic acid binding proteins in sequencing |
| ITRM20050068A1 (it) | 2005-02-17 | 2006-08-18 | Istituto Naz Per Le Malattie I | Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine. |
| EP1885877A2 (en) | 2005-02-17 | 2008-02-13 | Istituto Nazionale per le Malattie Infettive "Lazzaro Spallanzani" IRCCS | Compositions and methods for detecting pathogen specific nucleic acids in urine |
| AU2006214096B2 (en) | 2005-02-17 | 2011-06-16 | Trovagene, Inc. | Compositions and methods for detecting viral specific nucleic acids in urine |
| ITRM20050067A1 (it) | 2005-02-17 | 2006-08-18 | Istituto Naz Per Le Malattie I | Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine. |
| US7914982B2 (en) | 2005-02-17 | 2011-03-29 | Trovagene, Inc. | Methods for detecting pathogen specific nucleic acids in urine |
| US8532930B2 (en) | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
| US9218449B2 (en) | 2007-07-23 | 2015-12-22 | The Chinese University Of Hong Kong | Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis |
| IES20090464A2 (en) * | 2008-06-13 | 2010-03-03 | Nat Univ Ireland | SWI5 gene as a diagnostic target for the identification of fungal and yeast species |
| ES2595489T3 (es) | 2008-07-18 | 2016-12-30 | Trovagene, Inc. | Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR |
| WO2011015944A2 (en) | 2009-08-06 | 2011-02-10 | Cedars-Sinai Medical Center | Use of free dna as an early predictor of severity in acute pancreatitis |
| CA2779750C (en) | 2009-11-06 | 2019-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive diagnosis of graft rejection in organ transplant patients |
| EP2325312A1 (de) | 2009-11-19 | 2011-05-25 | Qiagen GmbH | Verfahren zur selektiven Anreicherung und Isolierung mikrobieller und optional zusätzlich viraler Nukleinsäuren |
| CN102071261A (zh) * | 2009-11-24 | 2011-05-25 | 上海复星医学科技发展有限公司 | 一种单纯疱疹病毒核酸检测方法及试剂盒 |
| US9573991B2 (en) | 2010-03-08 | 2017-02-21 | Celltrion, Inc. | Human monoclonal antibodies derived from human B cells and having neutralizing activity against influenza A viruses |
| US20120077185A1 (en) | 2010-08-06 | 2012-03-29 | Tandem Diagnostics, Inc. | Detection of genetic abnormalities and infectious disease |
| RU2644672C2 (ru) | 2011-04-01 | 2018-02-13 | Оккам Байолэбс, Инк. | Способы и наборы для обнаружения бесклеточных специфических для патогенов нуклеиновых кислот |
| WO2012159023A2 (en) * | 2011-05-19 | 2012-11-22 | Virginia Commonwealth University | Gut microflora as biomarkers for the prognosis of cirrhosis and brain dysfunction |
| WO2012168815A2 (en) * | 2011-06-06 | 2012-12-13 | Koninklijke Philips Electronics N.V. | Method for assembly of nucleic acid sequence data |
| US20130024127A1 (en) | 2011-07-19 | 2013-01-24 | John Stuelpnagel | Determination of source contributions using binomial probability calculations |
| EP2764458B1 (en) | 2011-10-06 | 2021-04-07 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP3584327A1 (en) | 2012-01-27 | 2019-12-25 | The Board of Trustees of the Leland Stanford Junior University | Methods for profiling and quantitating cell-free rna |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| EP2653562A1 (en) * | 2012-04-20 | 2013-10-23 | Institut Pasteur | Anellovirus genome quantification as a biomarker of immune suppression |
| US20140179805A1 (en) | 2012-06-15 | 2014-06-26 | Harry Stylli | Methods of detecting diseases or conditions |
| US20140066317A1 (en) | 2012-09-04 | 2014-03-06 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| IL269097B2 (en) | 2012-09-04 | 2024-01-01 | Guardant Health Inc | Systems and methods to detect rare mutations and copy number variation |
| DK2728014T3 (en) | 2012-10-31 | 2016-01-25 | Genesupport Sa | A non-invasive method for the detection of fetal chromosomal aneuploidy |
| US20140242582A1 (en) | 2013-02-28 | 2014-08-28 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities using ligation-based detection and digital pcr |
| EP4439566A3 (en) | 2013-03-15 | 2024-12-04 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| EP2971097B1 (en) | 2013-03-15 | 2018-08-01 | Verinata Health, Inc | Generating cell-free dna libraries directly from blood |
| CN105829589B (zh) | 2013-11-07 | 2021-02-02 | 小利兰·斯坦福大学理事会 | 用于分析人体微生物组及其组分的无细胞核酸 |
| US11035000B2 (en) | 2013-12-04 | 2021-06-15 | University Of Alaska Fairbanks | Methods and compositions for enriching non-host sequences in host samples |
| US10450650B2 (en) | 2015-09-24 | 2019-10-22 | The United States of America as represented by the Admininstrator of the National Aeronautics and Space Administration | Method of manufacturing large area graphene and graphene-based photonics devices |
| JP7577928B2 (ja) | 2019-06-19 | 2024-11-06 | 株式会社リコー | トナー及び現像剤 |
-
2014
- 2014-11-07 CN CN201480068555.8A patent/CN105829589B/zh active Active
- 2014-11-07 IL IL285106A patent/IL285106B/en unknown
- 2014-11-07 KR KR1020217001442A patent/KR102649364B1/ko active Active
- 2014-11-07 KR KR1020247008723A patent/KR102930443B1/ko active Active
- 2014-11-07 AU AU2014346562A patent/AU2014346562B2/en active Active
- 2014-11-07 BR BR112016010095A patent/BR112016010095A2/pt not_active Application Discontinuation
- 2014-11-07 CA CA3207499A patent/CA3207499A1/en active Pending
- 2014-11-07 EP EP22185212.2A patent/EP4130350A1/en active Pending
- 2014-11-07 JP JP2016528200A patent/JP7451070B2/ja active Active
- 2014-11-07 KR KR1020167013334A patent/KR102205950B1/ko active Active
- 2014-11-07 EP EP14860535.5A patent/EP3066236B1/en active Active
- 2014-11-07 GB GB1608448.5A patent/GB2535382A/en not_active Withdrawn
- 2014-11-07 CN CN202110128389.8A patent/CN112877472A/zh active Pending
- 2014-11-07 MX MX2016005798A patent/MX383494B/es unknown
- 2014-11-07 US US14/536,300 patent/US10450620B2/en active Active
- 2014-11-07 CA CA2929557A patent/CA2929557C/en active Active
- 2014-11-07 WO PCT/US2014/064669 patent/WO2015070086A1/en not_active Ceased
-
2016
- 2016-05-03 IL IL245446A patent/IL245446B/en active IP Right Grant
- 2016-05-04 MX MX2020004247A patent/MX2020004247A/es unknown
- 2016-05-04 MX MX2021006893A patent/MX2021006893A/es unknown
- 2016-05-04 MX MX2021006895A patent/MX2021006895A/es unknown
- 2016-05-04 MX MX2021006897A patent/MX2021006897A/es unknown
-
2019
- 2019-08-28 US US16/554,286 patent/US12195814B2/en active Active
-
2020
- 2020-02-17 IL IL272714A patent/IL272714B/en active IP Right Grant
- 2020-10-28 IL IL278349A patent/IL278349B/en unknown
- 2020-12-03 JP JP2020200921A patent/JP7813512B2/ja active Active
-
2021
- 2021-06-14 US US17/347,180 patent/US11401562B2/en active Active
- 2021-06-14 US US17/347,138 patent/US11365453B2/en active Active
- 2021-06-14 US US17/347,247 patent/US11427876B2/en active Active
-
2023
- 2023-03-08 JP JP2023035735A patent/JP7739349B2/ja active Active
- 2023-04-20 US US18/137,350 patent/US20230349011A1/en active Pending
-
2025
- 2025-04-02 JP JP2025061469A patent/JP2025106376A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013159035A2 (en) * | 2012-04-19 | 2013-10-24 | Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105829589B (zh) | 用于分析人体微生物组及其组分的无细胞核酸 | |
| US20230399696A1 (en) | Methods of monitoring immunosuppressive therapies in a transplant recipient | |
| Wootton et al. | Viral infection in acute exacerbation of idiopathic pulmonary fibrosis | |
| JP2023528777A (ja) | ドナー由来無細胞dnaの検出方法 | |
| JP2018527938A (ja) | サンプルの逸脱状態、特に健康状態および/または病原性状態の決定を含む核酸ベースの診断アプローチのための方法およびデバイス | |
| JP2023522964A (ja) | 無細胞dnaプロファイリングを使用して組織損傷、移植片対宿主疾患および感染を検出する方法 | |
| HK40082336A (en) | Cell-free nucleic acids for the analysis of the human microbiome and components thereof | |
| KR20260035294A (ko) | 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산 | |
| CN117957333A (zh) | 细环病毒(ttv)作为标志物以确定医疗保健机构收治的患者的并发症的风险的用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |