MX2016005798A - Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo. - Google Patents
Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo.Info
- Publication number
- MX2016005798A MX2016005798A MX2016005798A MX2016005798A MX2016005798A MX 2016005798 A MX2016005798 A MX 2016005798A MX 2016005798 A MX2016005798 A MX 2016005798A MX 2016005798 A MX2016005798 A MX 2016005798A MX 2016005798 A MX2016005798 A MX 2016005798A
- Authority
- MX
- Mexico
- Prior art keywords
- analysis
- components
- cell
- nucleic acids
- free nucleic
- Prior art date
Links
- 244000005702 human microbiome Species 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 230000037213 diet Effects 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 238000011285 therapeutic regimen Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/20—Sequence assembly
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Abstract
Se proporcionan métodos, dispositivos, composiciones y equipos para el análisis del microbioma o componentes individuales del mismo en un individuo. Los métodos encuentran uso en una determinación de infección, en el análisis de la estructura del microbioma, la determinación de la inmunocompetencia de un individuo, y similares. En algunas modalidades de la invención, el individuo es tratado con un régimen terapéutico, por ejemplo, fármacos, dieta, terapia de radiación, y similares.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361901114P | 2013-11-07 | 2013-11-07 | |
US201361901857P | 2013-11-08 | 2013-11-08 | |
PCT/US2014/064669 WO2015070086A1 (en) | 2013-11-07 | 2014-11-07 | Cell-free nucleic acids for the analysis of the human microbiome and components thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016005798A true MX2016005798A (es) | 2016-11-28 |
Family
ID=53042160
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016005798A MX2016005798A (es) | 2013-11-07 | 2014-11-07 | Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo. |
MX2021006893A MX2021006893A (es) | 2013-11-07 | 2016-05-04 | Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo. |
MX2021006897A MX2021006897A (es) | 2013-11-07 | 2016-05-04 | Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo. |
MX2020004247A MX2020004247A (es) | 2013-11-07 | 2016-05-04 | Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo. |
MX2021006895A MX2021006895A (es) | 2013-11-07 | 2016-05-04 | Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo. |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021006893A MX2021006893A (es) | 2013-11-07 | 2016-05-04 | Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo. |
MX2021006897A MX2021006897A (es) | 2013-11-07 | 2016-05-04 | Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo. |
MX2020004247A MX2020004247A (es) | 2013-11-07 | 2016-05-04 | Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo. |
MX2021006895A MX2021006895A (es) | 2013-11-07 | 2016-05-04 | Acidos nucleicos libres de celulas para el analisis del microbioma humano y componentes del mismo. |
Country Status (12)
Country | Link |
---|---|
US (6) | US10450620B2 (es) |
EP (2) | EP3066236B1 (es) |
JP (3) | JP7451070B2 (es) |
KR (3) | KR102649364B1 (es) |
CN (2) | CN105829589B (es) |
AU (1) | AU2014346562B2 (es) |
BR (1) | BR112016010095A2 (es) |
CA (2) | CA3207499A1 (es) |
GB (1) | GB2535382A (es) |
IL (4) | IL285106B (es) |
MX (5) | MX2016005798A (es) |
WO (1) | WO2015070086A1 (es) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
CN105829589B (zh) | 2013-11-07 | 2021-02-02 | 小利兰·斯坦福大学理事会 | 用于分析人体微生物组及其组分的无细胞核酸 |
US11859246B2 (en) * | 2013-12-11 | 2024-01-02 | Accuragen Holdings Limited | Methods and compositions for enrichment of amplification products |
RU2717641C2 (ru) | 2014-04-21 | 2020-03-24 | Натера, Инк. | Обнаружение мутаций и плоидности в хромосомных сегментах |
US10325685B2 (en) | 2014-10-21 | 2019-06-18 | uBiome, Inc. | Method and system for characterizing diet-related conditions |
AU2015335907A1 (en) | 2014-10-21 | 2017-04-13 | Psomagen, Inc. | Method and system for microbiome-derived diagnostics and therapeutics |
US10410749B2 (en) | 2014-10-21 | 2019-09-10 | uBiome, Inc. | Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions |
WO2017044901A1 (en) * | 2015-09-09 | 2017-03-16 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with gastrointestinal health |
CA2971444A1 (en) | 2014-12-20 | 2016-06-23 | Arc Bio, Llc | Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using crispr/cas system proteins |
WO2016109939A1 (zh) * | 2015-01-06 | 2016-07-14 | 深圳市海普洛斯生物科技有限公司 | 一种富集循环肿瘤dna的方法和试剂 |
US10893509B2 (en) | 2015-02-11 | 2021-01-12 | Qualcomm Incorporated | Multiple tri-state HARQ processes |
US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
JP6873921B2 (ja) * | 2015-05-18 | 2021-05-19 | カリウス・インコーポレイテッド | 核酸の集団を濃縮するための組成物および方法 |
CN107849599A (zh) * | 2015-06-30 | 2018-03-27 | 优比欧迈公司 | 用于诊断测试的方法和系统 |
DK3337898T3 (da) | 2015-08-19 | 2021-10-18 | Arc Bio Llc | Indfangning af nukleinsyrer ved anvendelse af et nukleinsyre-styret nuclease-baseret system |
CA3006059A1 (en) * | 2015-09-09 | 2017-03-16 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for oral health |
EP3141612A1 (en) * | 2015-09-10 | 2017-03-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method and device for nucleic acid based diagnostic approaches including the determination of a deviant condtion, especially a health condition and/or pathogenic condition of a sample |
EP3146974A1 (en) * | 2015-09-25 | 2017-03-29 | Universite Claude Bernard - Lyon 1 | Biomarkers for early determination of severity of influenza related disease |
JP7008016B2 (ja) | 2015-10-09 | 2022-01-25 | アキュラジェン ホールディングス リミテッド | 増幅産生物の富化のための方法および組成物 |
CN105671150A (zh) * | 2016-01-29 | 2016-06-15 | 江汉大学 | 一种人体微生物定性与定量的检测方法 |
CN105603075A (zh) * | 2016-01-29 | 2016-05-25 | 江汉大学 | 一种小麦微生物定性与定量的检测方法 |
CN105603076A (zh) * | 2016-01-29 | 2016-05-25 | 江汉大学 | 一种土壤微生物定性与定量的检测方法 |
CN105603074B (zh) * | 2016-01-29 | 2019-11-15 | 江汉大学 | 一种非诊断目的微生物定性与定量的检测方法 |
CN105567831B (zh) * | 2016-01-29 | 2019-07-23 | 江汉大学 | 一种食品微生物定性与定量的检测方法 |
MX2018011429A (es) | 2016-03-25 | 2019-06-06 | Karius Inc | Añadiduras de ácidos nucleicos sintéticos. |
WO2017189614A1 (en) * | 2016-04-25 | 2017-11-02 | uBiome, Inc. | Method and system for characterizing skin related conditions |
WO2017201102A1 (en) | 2016-05-16 | 2017-11-23 | Accuragen Holdings Limited | Method of improved sequencing by strand identification |
FR3051482B1 (fr) * | 2016-05-19 | 2021-01-29 | Life & Soft | Procede de determination de la presence et quantification d'au moins un micro-organisme dans un echantillon biologique |
EP4257701A3 (en) * | 2016-06-30 | 2023-12-20 | Grail, LLC | Differential tagging of rna for preparation of a cell-free dna/rna sequencing library |
CA3033749A1 (en) | 2016-08-15 | 2018-02-22 | Accuragen Holdings Limited | Compositions and methods for detecting rare sequence variants |
US11485996B2 (en) | 2016-10-04 | 2022-11-01 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
IL307463A (en) * | 2016-11-17 | 2023-12-01 | Lgc Clinical Diagnostics Inc | Methods for preparing reference material for DNA and controls |
US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
EP3607088A4 (en) * | 2017-04-04 | 2020-12-23 | The Board of Trustees of the Leland Stanford Junior University | QUANTIFICATION OF CIRCULATING ACELLULAR DNA DERIVED FROM TRANSPLANT IN THE ABSENCE OF A DONOR GENOTYPE |
WO2018187521A2 (en) * | 2017-04-06 | 2018-10-11 | Cornell University | Methods of detecting cell-free dna in biological samples |
WO2018191563A1 (en) | 2017-04-12 | 2018-10-18 | Karius, Inc. | Sample preparation methods, systems and compositions |
EP3431610A1 (en) * | 2017-07-19 | 2019-01-23 | Noscendo GmbH | Methods and devices for nucleic acid-based real-time determination of disease states |
US11646100B2 (en) | 2017-08-04 | 2023-05-09 | Billiontoone, Inc. | Target-associated molecules for characterization associated with biological targets |
US11430543B2 (en) | 2017-08-04 | 2022-08-30 | Billiontoone, Inc. | Sequencing output determination and analysis with target-associated molecules in quantification associated with biological targets |
US11519024B2 (en) | 2017-08-04 | 2022-12-06 | Billiontoone, Inc. | Homologous genomic regions for characterization associated with biological targets |
WO2019060716A1 (en) | 2017-09-25 | 2019-03-28 | Freenome Holdings, Inc. | SAMPLE EXTRACTION METHODS AND SYSTEMS |
AU2018399524B2 (en) | 2018-01-05 | 2022-05-26 | Billiontoone, Inc. | Quality control templates for ensuring validity of sequencing-based assays |
EP3765631A4 (en) * | 2018-03-13 | 2021-12-08 | Guardant Health, Inc. | METHOD OF NON-INVASIVE DETECTION AND MONITORING OF THERAPEUTIC NUCLEIC ACID CONSTRUCTS |
EP3765592A4 (en) | 2018-03-16 | 2021-12-08 | Karius Inc. | SERIES OF SAMPLES TO DIFFERENTIATE TARGET NUCLEIC ACIDS FROM CONTAMINATING NUCLEIC ACIDS |
CN108660199A (zh) * | 2018-05-20 | 2018-10-16 | 北京宏微特斯生物科技有限公司 | 一种基于cfDNA高通量测序检测病原体的方法 |
US20200040380A1 (en) * | 2018-08-06 | 2020-02-06 | Billiontoone, Inc. | Dilution tagging for quantification of biological targets |
KR102114758B1 (ko) * | 2018-11-19 | 2020-05-26 | 경북대학교 산학협력단 | 멤브레인 구조물을 이용한 혈액 내 미생물의 핵산 추출을 위한 혈액 시료 전처리 방법 |
WO2020106893A1 (en) | 2018-11-21 | 2020-05-28 | Karius, Inc. | Direct-to-library methods, systems, and compositions |
WO2020132144A1 (en) | 2018-12-18 | 2020-06-25 | Grail, Inc. | Methods for detecting disease using analysis of rna |
WO2020198664A1 (en) * | 2019-03-28 | 2020-10-01 | The Regents Of The University Of California | Methods and systems for sequencing cell-free microbiome dna |
KR102503766B1 (ko) * | 2020-06-16 | 2023-02-23 | 씨제이바이오사이언스 주식회사 | 장내 마이크로바이옴 지수를 결정하기 위한 장치, 방법 및 명령을 기록한 기록 매체 |
CN113061666A (zh) * | 2020-12-30 | 2021-07-02 | 中南大学湘雅二医院 | 肝移植后巨细胞病毒的检测方法、应用及系统 |
AU2022237538A1 (en) * | 2021-03-18 | 2023-09-21 | Natera, Inc. | Methods for determination of transplant rejection |
WO2023015353A1 (en) * | 2021-08-11 | 2023-02-16 | Immunosis Pty Ltd | Methods for determining secondary immunodeficiency |
WO2023141347A2 (en) * | 2022-01-24 | 2023-07-27 | Gusto Global, Llc | Single-loci and multi-loci targeted single point amplicon fragment sequencing |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
US6287850B1 (en) | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
USRE39920E1 (en) | 1997-05-30 | 2007-11-13 | Xenomics, Inc. | Methods for detection of nucleic acid sequences in urine |
US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
US20030022207A1 (en) | 1998-10-16 | 2003-01-30 | Solexa, Ltd. | Arrayed polynucleotides and their use in genome analysis |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
WO2001023610A2 (en) | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
US6582938B1 (en) | 2001-05-11 | 2003-06-24 | Affymetrix, Inc. | Amplification of nucleic acids |
GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
WO2002027029A2 (en) | 2000-09-27 | 2002-04-04 | Lynx Therapeutics, Inc. | Method for determining relative abundance of nucleic acid sequences |
US6753137B2 (en) | 2001-01-31 | 2004-06-22 | The Chinese University Of Hong Kong | Circulating epstein-barr virus DNA in the serum of patients with gastric carcinoma |
US6996477B2 (en) * | 2001-04-19 | 2006-02-07 | Dana Farber Cancer Institute, Inc. | Computational subtraction method |
DE10120797B4 (de) | 2001-04-27 | 2005-12-22 | Genovoxx Gmbh | Verfahren zur Analyse von Nukleinsäureketten |
WO2003020968A2 (de) | 2001-08-29 | 2003-03-13 | Genovoxx Gmbh | Verfahren zur analyse von nukleinsäurekettensequenzen und der genexpression |
JP2003101204A (ja) | 2001-09-25 | 2003-04-04 | Nec Kansai Ltd | 配線基板及び配線基板の製造方法並びに電子部品 |
WO2003031947A2 (de) | 2001-10-04 | 2003-04-17 | Genovoxx Gmbh | Gerät zur sequenzierung von nukleinsäuremolekülen |
DE10149786B4 (de) | 2001-10-09 | 2013-04-25 | Dmitry Cherkasov | Oberfläche für Untersuchungen aus Populationen von Einzelmolekülen |
US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
US20050124022A1 (en) | 2001-10-30 | 2005-06-09 | Maithreyan Srinivasan | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
US20050202414A1 (en) | 2001-11-15 | 2005-09-15 | The Regents Of The University Of California | Apparatus and methods for detecting a microbe in a sample |
US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
AU2003217826B2 (en) | 2002-03-01 | 2008-07-31 | Ravgen, Inc. | Methods for detection of genetic disorders |
DE10214395A1 (de) | 2002-03-30 | 2003-10-23 | Dmitri Tcherkassov | Verfahren zur Analyse von Einzelnukleotidpolymorphismen |
US7442506B2 (en) | 2002-05-08 | 2008-10-28 | Ravgen, Inc. | Methods for detection of genetic disorders |
US7727720B2 (en) | 2002-05-08 | 2010-06-01 | Ravgen, Inc. | Methods for detection of genetic disorders |
ES2396245T3 (es) | 2003-01-29 | 2013-02-20 | 454 Life Sciences Corporation | Método de amplificación y secuenciamiento de ácidos nucleicos |
US20040209299A1 (en) | 2003-03-07 | 2004-10-21 | Rubicon Genomics, Inc. | In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA |
EP1617805A4 (en) * | 2003-04-11 | 2012-07-04 | Medimmune Llc | METHODS FOR PREVENTING OR TREATING RESPIRATORY CONDITIONS |
EP1725572B1 (de) | 2003-11-05 | 2017-05-31 | AGCT GmbH | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
DE10356837A1 (de) | 2003-12-05 | 2005-06-30 | Dmitry Cherkasov | Modifizierte Nukleotide und Nukleoside |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
JP2007515414A (ja) * | 2003-12-16 | 2007-06-14 | パレンテラル アー エス | 血漿置換剤およびその製造方法 |
DE102004009704A1 (de) | 2004-02-27 | 2005-09-15 | Dmitry Cherkasov | Makromolekulare Nukleotidverbindungen und Methoden zu deren Anwendung |
DE102004025695A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren und Oberfläche zur parallelen Sequenzierung von Nukleinsäureketten |
DE102004025696A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren, Oberfläche und Substrate zu hochparallelen Analysen von Nukleinsäureketten |
DE102004025744A1 (de) | 2004-05-26 | 2005-12-29 | Dmitry Cherkasov | Oberfläche für die Analysen an einzelnen Nukleinsäuremolekülen |
DE102004025745A1 (de) | 2004-05-26 | 2005-12-15 | Cherkasov, Dmitry | Oberfläche für die Analysen an einzelnen Molekülen |
DE102004025694A1 (de) | 2004-05-26 | 2006-02-23 | Dmitry Cherkasov | Verfahren und Oberfläche zu hochparallelen Analysen von Nukleinsäureketten |
DE102004025746A1 (de) | 2004-05-26 | 2005-12-15 | Dmitry Cherkasov | Verfahren, Oberfläche und Substrate zur hochparallelen Sequenzierung von Nukleinsäureketten |
US20060002471A1 (en) | 2004-06-30 | 2006-01-05 | Lippincott Louis A | Motion estimation unit |
US7276720B2 (en) | 2004-07-19 | 2007-10-02 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
US20060012793A1 (en) | 2004-07-19 | 2006-01-19 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
US20060024678A1 (en) | 2004-07-28 | 2006-02-02 | Helicos Biosciences Corporation | Use of single-stranded nucleic acid binding proteins in sequencing |
CA2597948A1 (en) | 2005-02-17 | 2006-08-24 | Istituto Nazionale Per Le Malattie Infettive Irccs Lazzaro Spallanzani | Compositions and methods for detecting viral specific nucleic acids in urine |
US7914982B2 (en) | 2005-02-17 | 2011-03-29 | Trovagene, Inc. | Methods for detecting pathogen specific nucleic acids in urine |
ITRM20050067A1 (it) | 2005-02-17 | 2006-08-18 | Istituto Naz Per Le Malattie I | Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine. |
EP1885877A2 (en) | 2005-02-17 | 2008-02-13 | Istituto Nazionale per le Malattie Infettive "Lazzaro Spallanzani" IRCCS | Compositions and methods for detecting pathogen specific nucleic acids in urine |
ITRM20050068A1 (it) | 2005-02-17 | 2006-08-18 | Istituto Naz Per Le Malattie I | Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine. |
US8532930B2 (en) | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
US9218449B2 (en) | 2007-07-23 | 2015-12-22 | The Chinese University Of Hong Kong | Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis |
ES2595489T3 (es) | 2008-07-18 | 2016-12-30 | Trovagene, Inc. | Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR |
WO2011015944A2 (en) | 2009-08-06 | 2011-02-10 | Cedars-Sinai Medical Center | Use of free dna as an early predictor of severity in acute pancreatitis |
DK2496720T3 (da) * | 2009-11-06 | 2020-09-28 | Univ Leland Stanford Junior | Ikke-invasiv diagnose af transplantatafstødning i organ-transplanterede patienter |
EP2325312A1 (de) * | 2009-11-19 | 2011-05-25 | Qiagen GmbH | Verfahren zur selektiven Anreicherung und Isolierung mikrobieller und optional zusätzlich viraler Nukleinsäuren |
EA021977B1 (ru) * | 2010-03-08 | 2015-10-30 | Селлтрион, Инк. | Моноклональные антитела человека, полученные из в-клеток человека и обладающие нейтрализующей активностью против вирусов гриппа а |
US20120077185A1 (en) | 2010-08-06 | 2012-03-29 | Tandem Diagnostics, Inc. | Detection of genetic abnormalities and infectious disease |
AU2012236109A1 (en) | 2011-04-01 | 2013-11-21 | Occam Biolabs, Inc. | Methods and kits for detecting cell-free pathogen-specific nucleic acids |
US20140179726A1 (en) * | 2011-05-19 | 2014-06-26 | Virginia Commonwealth University | Gut microflora as biomarkers for the prognosis of cirrhosis and brain dysfunction |
EP2718862B1 (en) | 2011-06-06 | 2018-10-31 | Koninklijke Philips N.V. | Method for assembly of nucleic acid sequence data |
US20130024127A1 (en) | 2011-07-19 | 2013-01-24 | John Stuelpnagel | Determination of source contributions using binomial probability calculations |
WO2013052907A2 (en) | 2011-10-06 | 2013-04-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US20130252835A1 (en) * | 2012-01-27 | 2013-09-26 | Lian Chye Winston Koh | Methods for profiling and quantitating cell-free rna |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
US10385396B2 (en) * | 2012-04-19 | 2019-08-20 | The Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free DNA |
EP2653562A1 (en) * | 2012-04-20 | 2013-10-23 | Institut Pasteur | Anellovirus genome quantification as a biomarker of immune suppression |
CA2876731A1 (en) | 2012-06-15 | 2013-12-19 | Harry Stylli | Methods of detecting diseases or conditions |
WO2014149134A2 (en) | 2013-03-15 | 2014-09-25 | Guardant Health Inc. | Systems and methods to detect rare mutations and copy number variation |
KR102393608B1 (ko) | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
US20140066317A1 (en) | 2012-09-04 | 2014-03-06 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
DK2728014T3 (en) | 2012-10-31 | 2016-01-25 | Genesupport Sa | A non-invasive method for the detection of fetal chromosomal aneuploidy |
US20140242582A1 (en) | 2013-02-28 | 2014-08-28 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities using ligation-based detection and digital pcr |
AU2014233373B2 (en) | 2013-03-15 | 2019-10-24 | Verinata Health, Inc. | Generating cell-free DNA libraries directly from blood |
CN105829589B (zh) | 2013-11-07 | 2021-02-02 | 小利兰·斯坦福大学理事会 | 用于分析人体微生物组及其组分的无细胞核酸 |
US11035000B2 (en) | 2013-12-04 | 2021-06-15 | University Of Alaska Fairbanks | Methods and compositions for enriching non-host sequences in host samples |
US10450650B2 (en) | 2015-09-24 | 2019-10-22 | The United States of America as represented by the Admininstrator of the National Aeronautics and Space Administration | Method of manufacturing large area graphene and graphene-based photonics devices |
JP2021002031A (ja) | 2019-06-19 | 2021-01-07 | 株式会社リコー | トナー及び現像剤 |
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