GB2530521B - Mass spectral analysis of patient samples for the detection of the human chorionic gonadotropin - Google Patents

Mass spectral analysis of patient samples for the detection of the human chorionic gonadotropin Download PDF

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Publication number
GB2530521B
GB2530521B GB1416868.6A GB201416868A GB2530521B GB 2530521 B GB2530521 B GB 2530521B GB 201416868 A GB201416868 A GB 201416868A GB 2530521 B GB2530521 B GB 2530521B
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GB
United Kingdom
Prior art keywords
detection
spectral analysis
mass spectral
patient samples
chorionic gonadotropin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1416868.6A
Other versions
GB201416868D0 (en
GB2530521A (en
Inventor
Kruse Iles Raymond
Butler Stephen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Map Ip Holding Ltd
Original Assignee
Map Ip Holding Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Map Ip Holding Ltd filed Critical Map Ip Holding Ltd
Priority to GB1416868.6A priority Critical patent/GB2530521B/en
Publication of GB201416868D0 publication Critical patent/GB201416868D0/en
Publication of GB2530521A publication Critical patent/GB2530521A/en
Application granted granted Critical
Publication of GB2530521B publication Critical patent/GB2530521B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Reproductive Health (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
GB1416868.6A 2014-09-24 2014-09-24 Mass spectral analysis of patient samples for the detection of the human chorionic gonadotropin Active GB2530521B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1416868.6A GB2530521B (en) 2014-09-24 2014-09-24 Mass spectral analysis of patient samples for the detection of the human chorionic gonadotropin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1416868.6A GB2530521B (en) 2014-09-24 2014-09-24 Mass spectral analysis of patient samples for the detection of the human chorionic gonadotropin

Publications (3)

Publication Number Publication Date
GB201416868D0 GB201416868D0 (en) 2014-11-05
GB2530521A GB2530521A (en) 2016-03-30
GB2530521B true GB2530521B (en) 2020-06-10

Family

ID=51869420

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1416868.6A Active GB2530521B (en) 2014-09-24 2014-09-24 Mass spectral analysis of patient samples for the detection of the human chorionic gonadotropin

Country Status (1)

Country Link
GB (1) GB2530521B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201808529D0 (en) * 2018-05-24 2018-07-11 Binding Site Group Ltd Identification of immunoglobulins usong mass spectrometry
CN115684606B (en) * 2022-10-21 2023-11-28 南方医科大学珠江医院 M protein detection method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2702494A1 (en) * 1993-03-11 1994-09-16 Lafon Labor Kit for the diagnosis of a cancer secreting hCG or fragments of hCG and vaccine intended for the immunotherapy of such a cancer
WO2006099126A2 (en) * 2005-03-11 2006-09-21 Ciphergen Biosystems, Inc. Biomarkers for ovarian cancer and endometrial cancer: hepcidin
US20090159793A1 (en) * 2007-12-21 2009-06-25 Hanas Jay S Identification of biomarkers in biological samples and methods of using same
WO2009138392A1 (en) * 2008-05-14 2009-11-19 ETH Zürich Method for biomarker and drug-target discovery for prostate cancer diagnosis and treatment as well as biomarker assays determined therewith

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2702494A1 (en) * 1993-03-11 1994-09-16 Lafon Labor Kit for the diagnosis of a cancer secreting hCG or fragments of hCG and vaccine intended for the immunotherapy of such a cancer
WO2006099126A2 (en) * 2005-03-11 2006-09-21 Ciphergen Biosystems, Inc. Biomarkers for ovarian cancer and endometrial cancer: hepcidin
US20090159793A1 (en) * 2007-12-21 2009-06-25 Hanas Jay S Identification of biomarkers in biological samples and methods of using same
WO2009138392A1 (en) * 2008-05-14 2009-11-19 ETH Zürich Method for biomarker and drug-target discovery for prostate cancer diagnosis and treatment as well as biomarker assays determined therewith

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Analytical and Bioanalytical Chemistry, vol. 405 issue 5, 2013, Lund et al, 'Sports drug testing using immuno-MS...' pp. 1569-1576 *
Clinical Chemistry, vol. 60 issue 8, 2014, Woldemariam et al, 'Immunoextraction-tandem mass spectrometry method...' pp. 1089-1097 *
International Journal of Gynecology & Obstetrics, Vol. 60 No. 1, 1998, Nishimura et al., "Molecular heterogeneity of hCG beta-related glycoproteins and the clinical relevance in trophoblastic and non-trophoblastic tumours" pages 29-32. *
Tumor Biology, vol. 35, 2014, Lund et al, 'Epitope analysis and detection of human chorionic gonadotropin (hCG) variants...' pp. 1013-1022 *

Also Published As

Publication number Publication date
GB201416868D0 (en) 2014-11-05
GB2530521A (en) 2016-03-30

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732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)

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