CN105709221A - 用于预防和/或治疗人中的hiv疾病的药物组合物 - Google Patents
用于预防和/或治疗人中的hiv疾病的药物组合物 Download PDFInfo
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- CN105709221A CN105709221A CN201510856888.3A CN201510856888A CN105709221A CN 105709221 A CN105709221 A CN 105709221A CN 201510856888 A CN201510856888 A CN 201510856888A CN 105709221 A CN105709221 A CN 105709221A
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Abstract
Description
Claims (23)
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CNPCT/CN2011/072481 | 2011-04-06 | ||
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US61/534,088 | 2011-09-13 | ||
CNPCT/CN2012/070761 | 2012-01-30 | ||
CNPCT/CN2012/070761 | 2012-01-30 | ||
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US61/609,051 | 2012-03-09 | ||
CN201280026590.4A CN103732248B (zh) | 2011-04-06 | 2012-04-06 | 用于预防和/或治疗人中的hiv疾病的药物组合物 |
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PT1397155E (pt) * | 2001-06-21 | 2015-12-07 | Genentech Inc | Formulação de libertação sustentada |
JO3753B1 (ar) | 2011-10-14 | 2021-01-31 | Otsuka Pharma Co Ltd | قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه |
CN107249627B (zh) * | 2015-01-30 | 2021-06-29 | 国立大学法人东京大学 | 含有来自hpv e7蛋白质的多肽的乳酸菌的组合物 |
US11077185B2 (en) | 2019-03-21 | 2021-08-03 | 21C Bio | Vaccine to pathogenic immune activation cells during infections |
AU2020243095A1 (en) * | 2019-03-21 | 2021-10-21 | 21C Bio | Vaccine to pathogenic immune activation cells during infections |
CN115996737A (zh) * | 2020-01-10 | 2023-04-21 | 依米诺比姆有限公司 | 新型植物乳杆菌菌株、源自菌株的多糖及其用途 |
CN117202926A (zh) * | 2021-02-02 | 2023-12-08 | 普罗瓦克萨斯股份有限公司 | 新型免疫调节平台及其使用方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5895758A (en) * | 1997-06-10 | 1999-04-20 | Bio-Energy Systems | Strain of lactobacillus Plantarum |
CN101291691A (zh) * | 2003-08-28 | 2008-10-22 | 免疫反应公司 | 免疫原性hiv组合物和相关方法 |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0243029A1 (en) | 1986-04-08 | 1987-10-28 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Recombinant vaccinia virus expressing human retrovirus gene |
JPS6485072A (en) | 1987-09-25 | 1989-03-30 | Nat Inst Health | Recombinant vaccinia virus |
JPH01148183A (ja) | 1987-12-04 | 1989-06-09 | Hiroshi Shibuta | 組み換えワクチニアウイルス |
JP3140757B2 (ja) | 1989-02-06 | 2001-03-05 | デイナ・フアーバー・キヤンサー・インステイテユート | パッケージング欠陥hivプロウイルス、細胞系及びその使用 |
GB8923123D0 (en) | 1989-10-13 | 1989-11-29 | Connaught Lab | A vaccine for human immunodeficiency virus |
US5861282A (en) | 1989-10-16 | 1999-01-19 | Whitehead Institute For Biomedical Research | Non-infectious HIV particles and uses therefor |
JPH05503629A (ja) | 1989-11-20 | 1993-06-17 | オンコーゲン リミテッド パートナーシップ | 抗ウィルス剤及び免疫原として使用される、非複製組換え製レトロウィルス粒子 |
DE69131513T3 (de) | 1990-03-21 | 2005-05-25 | Geneart Gmbh | Für abgeänderte retrovirale GAG-Polypeptide kodierende DNA-Sequenzen und diese enthaltende Impfstoffe oder Aggregate davon |
MY109299A (en) | 1990-08-15 | 1996-12-31 | Virogenetics Corp | Recombinant pox virus encoding flaviviral structural proteins |
US5766598A (en) | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products |
DE69233158T2 (de) | 1991-03-07 | 2004-05-13 | Connaught Technology Corp., Greenville | Gentechnologisch hergestellter stamm für impfstoffe |
CA2110489A1 (en) | 1991-06-14 | 1992-12-23 | Enzo Paoletti | Immunodeficiency virus recombinant poxvirus vaccine |
DK0538496T3 (da) | 1991-08-26 | 2004-02-23 | Baxter Healthcare Sa | Rekombinant fjerkrækoppevirus med intakt FPV tk-gen |
DE4141741A1 (de) | 1991-12-13 | 1993-06-17 | Gisela Kielmann | Verfahren zur bekaempfung des human imune deficiency virus |
US6511845B1 (en) | 1992-08-07 | 2003-01-28 | Alan R. Davis | Methods for producing an immune response against HIV-1 |
US6136318A (en) | 1993-02-26 | 2000-10-24 | Cochran; Mark D. | Recombinant fowlpox viruses and uses thereof |
WO1995007099A1 (fr) | 1993-09-09 | 1995-03-16 | The Nisshin Oil Mills, Ltd. | Vaccin et procede pour sa production |
JPH07170982A (ja) | 1993-09-09 | 1995-07-11 | Nisshin Oil Mills Ltd:The | ワクチンおよびその製造方法 |
US6080408A (en) | 1994-08-22 | 2000-06-27 | Connaught Laboratories Limited | Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles |
AU3958895A (en) | 1994-10-18 | 1996-05-06 | Board Of Regents, The University Of Texas System | Membrane expression of heterologous genes |
JPH11507241A (ja) | 1995-06-07 | 1999-06-29 | シントロ・コーポレーション | 組換え鶏痘ウイルスおよびその使用 |
US5741492A (en) | 1996-01-23 | 1998-04-21 | St. Jude Children's Research Hospital | Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses |
JPH1085072A (ja) | 1996-09-13 | 1998-04-07 | Kichinosuke Takemaru | 家具転倒防止器具 |
US6001155A (en) | 1997-03-17 | 1999-12-14 | Pease; John R. | Polyphasic pressurized homogenizer |
HRP980143A2 (en) * | 1997-04-09 | 1999-02-28 | Soo Sung Ko | 4,4-disubstituted-3,4-dihydro-2 (1h)-quinazolinones useful as hiv reverse transcriptase inhibitors |
CA2293826A1 (en) | 1997-06-11 | 1998-12-17 | Brigitte Gicquel | Attenuated recombinant mycobacteria useful as immunogens or as vaccine components |
JP3899165B2 (ja) | 1997-08-06 | 2007-03-28 | ビー・エル・オートテック株式会社 | ロボットアームの過負荷保護装置 |
US6716823B1 (en) | 1997-08-13 | 2004-04-06 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom, and uses thereof |
US6121021A (en) | 1997-12-16 | 2000-09-19 | Connaught Laboratories Limited | Constitutive expression of non-infectious HIV-like particles |
US7189402B1 (en) | 1998-02-06 | 2007-03-13 | Research Development Foundation | Live vaccine for human immunodeficiency virus |
US6828460B2 (en) | 1999-03-22 | 2004-12-07 | Pfizer Inc. | Resorcinol derivatives |
US20040009936A1 (en) | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
WO2001002607A1 (en) | 1999-07-06 | 2001-01-11 | Merck & Co., Inc. | Adenovirus carrying gag gene hiv vaccine |
EP1084709A1 (en) | 1999-09-17 | 2001-03-21 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Oral recombinant lactobacilli vaccines |
JP2003512077A (ja) | 1999-10-26 | 2003-04-02 | インターナショナル エイズ バクシーン イニシアティブ | アルファウイルスレプリコンを発現する侵襲性細菌 |
US20040105871A1 (en) | 2000-03-02 | 2004-06-03 | Robinson Harriet L. | Compositions and methods for generating an immune response |
US6544780B1 (en) | 2000-06-02 | 2003-04-08 | Genphar, Inc. | Adenovirus vector with multiple expression cassettes |
US20020155127A1 (en) | 2000-06-02 | 2002-10-24 | Danher Wang | Genetic vaccine against human immunodeficiency virus |
US6733993B2 (en) | 2000-09-15 | 2004-05-11 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications |
AU2001294562B2 (en) | 2000-09-15 | 2007-05-24 | Merck & Co., Inc. | Enhanced First Generation Adenovirus Vaccines Expressing Codon Optimized HIV1-Gag, Pol, Nef and Modifications |
US20040101957A1 (en) | 2001-09-14 | 2004-05-27 | Emini Emilio A. | Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol.nef and modifications |
WO2002031168A2 (en) | 2000-10-10 | 2002-04-18 | Genstar Therapeutics | Minimal adenoviral vector and recombinant vaccines based thereon |
GB0030857D0 (en) | 2000-12-18 | 2001-01-31 | Medical Res Council | Therapeutic compositions |
KR20020059856A (ko) | 2001-01-08 | 2002-07-16 | 김철중 | 에이치아이브이 유사입자의 제조 |
JP4554887B2 (ja) | 2001-03-08 | 2010-09-29 | アメリカ合衆国 | 改変HIVエンベロープ、gag、およびpol遺伝子を発現するMVA |
WO2002102409A1 (en) | 2001-06-19 | 2002-12-27 | Medical Research Council | Inactivated mycobacterial ompatb and uses thereof |
US20040253210A1 (en) | 2001-08-30 | 2004-12-16 | Marjorie Robert-Guroff | Adenovirus type7 vectors |
US20070077257A1 (en) | 2001-09-14 | 2007-04-05 | Emini Emilio A | Enhanced first generation adenovirus vaccines expressing condon optimized HIV1-Gag, Pol, Nef and modifications |
WO2003051288A2 (en) | 2001-11-14 | 2003-06-26 | Novavax, Inc. | Mycobacterial vaccine |
AU2002360353A1 (en) | 2001-12-11 | 2003-06-23 | University Of Iowa Research Foundation | Receptor-targeted adenoviral vectors |
US20040009937A1 (en) | 2002-01-31 | 2004-01-15 | Wei Chen | Methods and composition for delivering nucleic acids and/or proteins to the respiratory system |
WO2003063786A2 (en) | 2002-01-31 | 2003-08-07 | Symbigene, Inc. | Methods and composition for delivering nucleic acids and/or proteins to the respiratory system |
ATE424464T1 (de) | 2002-04-26 | 2009-03-15 | Inst Nat Sante Rech Med | Verbesserte chimäre glykoproteine und pseudotypisierte lentivirale vektoren |
JP2003321391A (ja) | 2002-04-30 | 2003-11-11 | Japan Science & Technology Corp | 組換えワクシニアウイルスを用いたhivワクチン |
DE10221411B4 (de) | 2002-05-14 | 2004-07-08 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Rekombinantes Fowlpox-Virus |
US7501127B2 (en) | 2002-05-16 | 2009-03-10 | Bavarian Nordic A/S | Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara |
WO2003101394A2 (en) * | 2002-05-31 | 2003-12-11 | Ciphergen Biosystems, Inc. | Defensins: use as antiviral agents |
CN1490056A (zh) | 2002-10-18 | 2004-04-21 | ��¡���ɵ°��̲��о����� | 针对hiv-1的免疫方法和组合物 |
EP2371380A1 (en) | 2003-03-28 | 2011-10-05 | The Government of the United States of America, represented by The Secretary, Department of Health and Human Services | MVA expressing modified hiv envelope, gag, and pol genes |
JP2007518460A (ja) | 2003-05-09 | 2007-07-12 | イントラヴァック インコーポレーテッド | 皮内、皮下及び筋肉内注射用の無針注射器及びアンプル |
US20100189747A1 (en) | 2003-07-31 | 2010-07-29 | Raymond Weinstein | Compositions and methods for treating or preventing hiv infection |
JP2007037402A (ja) | 2003-11-28 | 2007-02-15 | Primmune:Kk | 抗ヒト免疫不全ウイルス感染防御用キメラ5型/35型アデノウイルスベクター |
WO2005111205A1 (en) | 2004-05-18 | 2005-11-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Tuberculosis vaccine |
WO2005121378A2 (en) * | 2004-06-03 | 2005-12-22 | Saint Louis University | Methods and compositions for vaccination |
WO2006012320A1 (en) | 2004-06-25 | 2006-02-02 | Dow Agrosciences Llc | Process for the preparation of 4-trifluoromethyl-2(1h)-pyridinone |
WO2006026667A2 (en) | 2004-08-27 | 2006-03-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant mva viruses expressing glade a/g, clade b, and clade c modified hiv, gag and pol genes |
RU2396346C2 (ru) * | 2004-10-04 | 2010-08-10 | Биоваксим Лимитед | Применение инактивированного цельного вируса совместимого субтипа для получения бесклеточной вакцины и способ лечения вич-инфекции |
CA2853335A1 (en) * | 2005-02-24 | 2006-11-23 | Medical Research Council | Hivcon: an hiv immunogen and uses thereof |
JP5175178B2 (ja) | 2005-05-12 | 2013-04-03 | グラクソ グループ リミテッド | ワクチン組成物 |
EP1723965A1 (en) | 2005-05-18 | 2006-11-22 | Stallergenes Sa | Compositions for antigen-specific induction of immuno-tolerance via oral immunization |
US20100028449A1 (en) | 2006-06-06 | 2010-02-04 | Satya Prakash | Fermented milk product and use thereof |
SI2144626T1 (sl) | 2007-04-12 | 2015-04-30 | Mico Bio, Inc. | Cepivo proti tuberkulozi in postopek za njegovo uporabo |
WO2009093900A1 (en) | 2008-01-25 | 2009-07-30 | Stichting Top Institute Food And Nutrition | Mid-log phase lactic acid bacteria for inducing immune tolerance in a subject |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5895758A (en) * | 1997-06-10 | 1999-04-20 | Bio-Energy Systems | Strain of lactobacillus Plantarum |
CN101291691A (zh) * | 2003-08-28 | 2008-10-22 | 免疫反应公司 | 免疫原性hiv组合物和相关方法 |
Non-Patent Citations (1)
Title |
---|
GERALD K. CHEGE等: "A prime–boost immunisation regimen using recombinant BCG and Pr55gag virus-like particle vaccines based on HIV type 1 subtype C successfully elicits Gag-specific responses in baboons", 《VACCINE》 * |
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