CN105612148B - 用于纯化二氨基吩噻嗪化合物的方法 - Google Patents

用于纯化二氨基吩噻嗪化合物的方法 Download PDF

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Publication number
CN105612148B
CN105612148B CN201480055983.7A CN201480055983A CN105612148B CN 105612148 B CN105612148 B CN 105612148B CN 201480055983 A CN201480055983 A CN 201480055983A CN 105612148 B CN105612148 B CN 105612148B
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CN
China
Prior art keywords
methylene blue
acid
complex
ascorbic acid
diaminophenothiazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480055983.7A
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English (en)
Chinese (zh)
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CN105612148A (zh
Inventor
马尔文·欧帝克
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Eupharma Pty Ltd
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Eupharma Pty Ltd
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Filing date
Publication date
Priority claimed from AU2013903099A external-priority patent/AU2013903099A0/en
Application filed by Eupharma Pty Ltd filed Critical Eupharma Pty Ltd
Publication of CN105612148A publication Critical patent/CN105612148A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Physics & Mathematics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
CN201480055983.7A 2013-08-15 2014-08-15 用于纯化二氨基吩噻嗪化合物的方法 Expired - Fee Related CN105612148B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2013903099 2013-08-15
AU2013903099A AU2013903099A0 (en) 2013-08-15 Purification method and compounds
PCT/AU2014/000807 WO2015021500A1 (en) 2013-08-15 2014-08-15 Process for the purification of diaminophenothiazinium compounds

Publications (2)

Publication Number Publication Date
CN105612148A CN105612148A (zh) 2016-05-25
CN105612148B true CN105612148B (zh) 2018-09-14

Family

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Family Applications (1)

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CN201480055983.7A Expired - Fee Related CN105612148B (zh) 2013-08-15 2014-08-15 用于纯化二氨基吩噻嗪化合物的方法

Country Status (14)

Country Link
US (1) US9701648B2 (enExample)
EP (1) EP3033331B1 (enExample)
JP (1) JP6111381B2 (enExample)
KR (1) KR101741235B1 (enExample)
CN (1) CN105612148B (enExample)
BR (1) BR112016002979A8 (enExample)
CA (1) CA2920505C (enExample)
DK (1) DK3033331T3 (enExample)
IL (1) IL243937A (enExample)
MX (1) MX354492B (enExample)
NZ (1) NZ630569A (enExample)
SG (1) SG11201601003PA (enExample)
TW (1) TWI629267B (enExample)
WO (1) WO2015021500A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3375777A1 (en) 2017-03-15 2018-09-19 MIKROCHEM spol. s.r.o. Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide
CN112358475B (zh) * 2020-11-30 2022-09-06 西北师范大学 一种苯并吡喃鎓-吩噻嗪衍生物及其制备方法和应用
EP4512802A1 (en) * 2022-04-19 2025-02-26 Leadway (HK) Limited Purification method for electron mediator
CN116947783A (zh) * 2022-04-19 2023-10-27 英科隆生物技术（杭州）有限公司 一种电子媒介体的提纯方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012107706A1 (en) * 2011-02-11 2012-08-16 Wista Laboratories Ltd. Phenothiazine diaminium salts and their use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909520A (en) 1959-10-20 Process for making acylated
DE1886C (de) 1877-12-15 1877-12-15 Basf Ag Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen
GB1293757A (en) * 1968-10-22 1972-10-25 Paines & Byrne Ltd A nerve stain composition
GB0327672D0 (en) * 2003-11-28 2003-12-31 Photopharmica Ltd Developments in biologically active methylene blue derivatives (phenothiazines)
AU2004295148A1 (en) * 2003-11-28 2005-06-16 Photopharmica Limited Developments in biologically active methylene blue derivatives (2)
US7790881B2 (en) * 2004-09-23 2010-09-07 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
PT1799662E (pt) 2004-09-23 2013-07-09 Wista Lab Ltd Métodos de síntese química e purificação de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc)
HUE030621T2 (en) * 2006-07-11 2017-05-29 Wista Lab Ltd Methods for the synthesis and / or purification of diaminophenothiazinium compounds
FR2903696B1 (fr) * 2006-07-12 2011-02-11 Provence Technologies Procede de purification de composes diaminophenothiazium

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012107706A1 (en) * 2011-02-11 2012-08-16 Wista Laboratories Ltd. Phenothiazine diaminium salts and their use

Also Published As

Publication number Publication date
JP6111381B2 (ja) 2017-04-05
EP3033331B1 (en) 2018-02-21
IL243937A (en) 2017-01-31
BR112016002979A8 (pt) 2020-02-04
US9701648B2 (en) 2017-07-11
JP2016528237A (ja) 2016-09-15
CA2920505A1 (en) 2015-02-19
DK3033331T3 (da) 2018-04-30
SG11201601003PA (en) 2016-03-30
TW201527287A (zh) 2015-07-16
TWI629267B (zh) 2018-07-11
AU2014306354A1 (en) 2016-02-18
KR20160042929A (ko) 2016-04-20
MX354492B (es) 2018-03-07
NZ630569A (en) 2017-06-30
EP3033331A4 (en) 2017-01-18
US20160200696A1 (en) 2016-07-14
EP3033331A1 (en) 2016-06-22
CA2920505C (en) 2018-04-03
IL243937A0 (en) 2016-04-21
CN105612148A (zh) 2016-05-25
MX2016002085A (es) 2016-06-23
KR101741235B1 (ko) 2017-05-29
WO2015021500A1 (en) 2015-02-19

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