MX354492B - Proceso para la purificacion de compuestos de diaminofenotiazinio. - Google Patents
Proceso para la purificacion de compuestos de diaminofenotiazinio.Info
- Publication number
- MX354492B MX354492B MX2016002085A MX2016002085A MX354492B MX 354492 B MX354492 B MX 354492B MX 2016002085 A MX2016002085 A MX 2016002085A MX 2016002085 A MX2016002085 A MX 2016002085A MX 354492 B MX354492 B MX 354492B
- Authority
- MX
- Mexico
- Prior art keywords
- purification
- diaminophenothiazinium
- compound
- diaminophenothiazinium compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Optics & Photonics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Se describe un proceso para la purificación de compuestos de diaminofenotiazinio y particularmente de azul de metileno. El proceso permite la purificación simple y eficiente mediante reducción de la post síntesis de un compuesto de diaminofenotiazinio comercialmente disponible para formar un complejo reducido del mismo. Éste puede purificarse de una manera más directa que el compuesto original, por ejemplo, por medio de recristalización antes de dejar que vuelva a oxidarse al compuesto de diaminofenotiazinio.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013903099A AU2013903099A0 (en) | 2013-08-15 | Purification method and compounds | |
| PCT/AU2014/000807 WO2015021500A1 (en) | 2013-08-15 | 2014-08-15 | Process for the purification of diaminophenothiazinium compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016002085A MX2016002085A (es) | 2016-06-23 |
| MX354492B true MX354492B (es) | 2018-03-07 |
Family
ID=52467850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016002085A MX354492B (es) | 2013-08-15 | 2014-08-15 | Proceso para la purificacion de compuestos de diaminofenotiazinio. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9701648B2 (es) |
| EP (1) | EP3033331B1 (es) |
| JP (1) | JP6111381B2 (es) |
| KR (1) | KR101741235B1 (es) |
| CN (1) | CN105612148B (es) |
| BR (1) | BR112016002979A8 (es) |
| CA (1) | CA2920505C (es) |
| DK (1) | DK3033331T3 (es) |
| IL (1) | IL243937A (es) |
| MX (1) | MX354492B (es) |
| NZ (1) | NZ630569A (es) |
| SG (1) | SG11201601003PA (es) |
| TW (1) | TWI629267B (es) |
| WO (1) | WO2015021500A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3375777A1 (en) | 2017-03-15 | 2018-09-19 | MIKROCHEM spol. s.r.o. | Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide |
| CN112358475B (zh) * | 2020-11-30 | 2022-09-06 | 西北师范大学 | 一种苯并吡喃鎓-吩噻嗪衍生物及其制备方法和应用 |
| WO2023202464A1 (zh) * | 2022-04-19 | 2023-10-26 | 英科隆生物技术（杭州）有限公司 | 一种电子媒介体的提纯方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2909520A (en) | 1959-10-20 | Process for making acylated | ||
| DE1886C (de) | 1877-12-15 | 1877-12-15 | Basf Ag | Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen |
| GB1293757A (en) * | 1968-10-22 | 1972-10-25 | Paines & Byrne Ltd | A nerve stain composition |
| GB0327672D0 (en) * | 2003-11-28 | 2003-12-31 | Photopharmica Ltd | Developments in biologically active methylene blue derivatives (phenothiazines) |
| AU2004295148A1 (en) * | 2003-11-28 | 2005-06-16 | Photopharmica Limited | Developments in biologically active methylene blue derivatives (2) |
| US7790881B2 (en) * | 2004-09-23 | 2010-09-07 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
| SI2322517T1 (sl) | 2004-09-23 | 2019-06-28 | Wista Laboratories Ltd. | Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC) |
| CN101511803B (zh) | 2006-07-11 | 2012-10-31 | 维斯塔实验室有限公司 | 二氨基吩噻嗪*化合物的合成和/或纯化方法 |
| FR2903696B1 (fr) | 2006-07-12 | 2011-02-11 | Provence Technologies | Procede de purification de composes diaminophenothiazium |
| JP5898701B2 (ja) * | 2011-02-11 | 2016-04-13 | ウィスタ ラボラトリーズ リミテッド | フェノチアジンジアミニウム塩およびそれらの使用 |
-
2014
- 2014-08-15 CA CA2920505A patent/CA2920505C/en active Active
- 2014-08-15 NZ NZ630569A patent/NZ630569A/en not_active IP Right Cessation
- 2014-08-15 MX MX2016002085A patent/MX354492B/es active IP Right Grant
- 2014-08-15 US US14/911,813 patent/US9701648B2/en active Active
- 2014-08-15 BR BR112016002979A patent/BR112016002979A8/pt not_active Application Discontinuation
- 2014-08-15 CN CN201480055983.7A patent/CN105612148B/zh not_active Expired - Fee Related
- 2014-08-15 KR KR1020167005820A patent/KR101741235B1/ko active IP Right Grant
- 2014-08-15 WO PCT/AU2014/000807 patent/WO2015021500A1/en active Application Filing
- 2014-08-15 JP JP2016533750A patent/JP6111381B2/ja active Active
- 2014-08-15 EP EP14836833.5A patent/EP3033331B1/en active Active
- 2014-08-15 TW TW103128051A patent/TWI629267B/zh not_active IP Right Cessation
- 2014-08-15 DK DK14836833.5T patent/DK3033331T3/da active
- 2014-08-15 SG SG11201601003PA patent/SG11201601003PA/en unknown
-
2016
- 2016-02-03 IL IL243937A patent/IL243937A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US9701648B2 (en) | 2017-07-11 |
| BR112016002979A8 (pt) | 2020-02-04 |
| SG11201601003PA (en) | 2016-03-30 |
| EP3033331B1 (en) | 2018-02-21 |
| TWI629267B (zh) | 2018-07-11 |
| JP2016528237A (ja) | 2016-09-15 |
| US20160200696A1 (en) | 2016-07-14 |
| KR20160042929A (ko) | 2016-04-20 |
| CA2920505A1 (en) | 2015-02-19 |
| IL243937A0 (en) | 2016-04-21 |
| KR101741235B1 (ko) | 2017-05-29 |
| JP6111381B2 (ja) | 2017-04-05 |
| MX2016002085A (es) | 2016-06-23 |
| CA2920505C (en) | 2018-04-03 |
| AU2014306354A1 (en) | 2016-02-18 |
| WO2015021500A1 (en) | 2015-02-19 |
| TW201527287A (zh) | 2015-07-16 |
| EP3033331A1 (en) | 2016-06-22 |
| CN105612148A (zh) | 2016-05-25 |
| IL243937A (en) | 2017-01-31 |
| EP3033331A4 (en) | 2017-01-18 |
| DK3033331T3 (da) | 2018-04-30 |
| CN105612148B (zh) | 2018-09-14 |
| NZ630569A (en) | 2017-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |