KR101741235B1 - 디아미노페노티아지니움 화합물을 정제하는 방법 - Google Patents

디아미노페노티아지니움 화합물을 정제하는 방법 Download PDF

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Publication number
KR101741235B1
KR101741235B1 KR1020167005820A KR20167005820A KR101741235B1 KR 101741235 B1 KR101741235 B1 KR 101741235B1 KR 1020167005820 A KR1020167005820 A KR 1020167005820A KR 20167005820 A KR20167005820 A KR 20167005820A KR 101741235 B1 KR101741235 B1 KR 101741235B1
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South Korea
Prior art keywords
acid
blue
complex
protonated
lucomethylene
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KR1020167005820A
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English (en)
Korean (ko)
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KR20160042929A (ko
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말빈 유틱
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유파마 피티와이 엘티디
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Physics & Mathematics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
KR1020167005820A 2013-08-15 2014-08-15 디아미노페노티아지니움 화합물을 정제하는 방법 Expired - Fee Related KR101741235B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2013903099 2013-08-15
AU2013903099A AU2013903099A0 (en) 2013-08-15 Purification method and compounds
PCT/AU2014/000807 WO2015021500A1 (en) 2013-08-15 2014-08-15 Process for the purification of diaminophenothiazinium compounds

Publications (2)

Publication Number Publication Date
KR20160042929A KR20160042929A (ko) 2016-04-20
KR101741235B1 true KR101741235B1 (ko) 2017-05-29

Family

ID=52467850

Family Applications (1)

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KR1020167005820A Expired - Fee Related KR101741235B1 (ko) 2013-08-15 2014-08-15 디아미노페노티아지니움 화합물을 정제하는 방법

Country Status (14)

Country Link
US (1) US9701648B2 (enExample)
EP (1) EP3033331B1 (enExample)
JP (1) JP6111381B2 (enExample)
KR (1) KR101741235B1 (enExample)
CN (1) CN105612148B (enExample)
BR (1) BR112016002979A8 (enExample)
CA (1) CA2920505C (enExample)
DK (1) DK3033331T3 (enExample)
IL (1) IL243937A (enExample)
MX (1) MX354492B (enExample)
NZ (1) NZ630569A (enExample)
SG (1) SG11201601003PA (enExample)
TW (1) TWI629267B (enExample)
WO (1) WO2015021500A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3375777A1 (en) 2017-03-15 2018-09-19 MIKROCHEM spol. s.r.o. Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide
CN112358475B (zh) * 2020-11-30 2022-09-06 西北师范大学 一种苯并吡喃鎓-吩噻嗪衍生物及其制备方法和应用
EP4512802A1 (en) * 2022-04-19 2025-02-26 Leadway (HK) Limited Purification method for electron mediator
CN116947783A (zh) * 2022-04-19 2023-10-27 英科隆生物技术（杭州）有限公司 一种电子媒介体的提纯方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008007074A2 (en) * 2006-07-11 2008-01-17 Wista Laboratories Ltd. Methods of synthesis and/or purification of diaminophenothiazinium compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909520A (en) 1959-10-20 Process for making acylated
DE1886C (de) 1877-12-15 1877-12-15 Basf Ag Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen
GB1293757A (en) * 1968-10-22 1972-10-25 Paines & Byrne Ltd A nerve stain composition
GB0327672D0 (en) * 2003-11-28 2003-12-31 Photopharmica Ltd Developments in biologically active methylene blue derivatives (phenothiazines)
AU2004295148A1 (en) * 2003-11-28 2005-06-16 Photopharmica Limited Developments in biologically active methylene blue derivatives (2)
US7790881B2 (en) * 2004-09-23 2010-09-07 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
PT1799662E (pt) 2004-09-23 2013-07-09 Wista Lab Ltd Métodos de síntese química e purificação de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc)
FR2903696B1 (fr) * 2006-07-12 2011-02-11 Provence Technologies Procede de purification de composes diaminophenothiazium
EA025033B1 (ru) * 2011-02-11 2016-11-30 Уиста Лэборэтэриз Лтд. Диаминиевые соли фенотиазина и их применение

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008007074A2 (en) * 2006-07-11 2008-01-17 Wista Laboratories Ltd. Methods of synthesis and/or purification of diaminophenothiazinium compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J AOAC Int,. 1997., Vol.80, No.1., pp 31-35*

Also Published As

Publication number Publication date
JP6111381B2 (ja) 2017-04-05
EP3033331B1 (en) 2018-02-21
IL243937A (en) 2017-01-31
BR112016002979A8 (pt) 2020-02-04
US9701648B2 (en) 2017-07-11
JP2016528237A (ja) 2016-09-15
CA2920505A1 (en) 2015-02-19
DK3033331T3 (da) 2018-04-30
SG11201601003PA (en) 2016-03-30
TW201527287A (zh) 2015-07-16
TWI629267B (zh) 2018-07-11
AU2014306354A1 (en) 2016-02-18
KR20160042929A (ko) 2016-04-20
MX354492B (es) 2018-03-07
NZ630569A (en) 2017-06-30
CN105612148B (zh) 2018-09-14
EP3033331A4 (en) 2017-01-18
US20160200696A1 (en) 2016-07-14
EP3033331A1 (en) 2016-06-22
CA2920505C (en) 2018-04-03
IL243937A0 (en) 2016-04-21
CN105612148A (zh) 2016-05-25
MX2016002085A (es) 2016-06-23
WO2015021500A1 (en) 2015-02-19

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