NZ630569A - Process for the purification of diaminophenothiazinium compounds - Google Patents
Process for the purification of diaminophenothiazinium compoundsInfo
- Publication number
- NZ630569A NZ630569A NZ630569A NZ63056914A NZ630569A NZ 630569 A NZ630569 A NZ 630569A NZ 630569 A NZ630569 A NZ 630569A NZ 63056914 A NZ63056914 A NZ 63056914A NZ 630569 A NZ630569 A NZ 630569A
- Authority
- NZ
- New Zealand
- Prior art keywords
- diaminophenothiazinium
- purification
- azure
- stabilised
- protonated
- Prior art date
Links
- KPYHKEZPEDJERZ-UHFFFAOYSA-N 10h-phenothiazine-1,2-diamine Chemical class C1=CC=C2NC3=C(N)C(N)=CC=C3SC2=C1 KPYHKEZPEDJERZ-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- -1 diaminophenothiazinium compound Chemical class 0.000 abstract 5
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- YYGBVRCTHASBKD-UHFFFAOYSA-M methylene green Chemical compound [Cl-].C1=CC(N(C)C)=C([N+]([O-])=O)C2=[S+]C3=CC(N(C)C)=CC=C3N=C21 YYGBVRCTHASBKD-UHFFFAOYSA-M 0.000 abstract 1
- 229960000907 methylthioninium chloride Drugs 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Physics & Mathematics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Optics & Photonics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013903099A AU2013903099A0 (en) | 2013-08-15 | Purification method and compounds | |
| PCT/AU2014/000807 WO2015021500A1 (en) | 2013-08-15 | 2014-08-15 | Process for the purification of diaminophenothiazinium compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ630569A true NZ630569A (en) | 2017-06-30 |
Family
ID=52467850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ630569A NZ630569A (en) | 2013-08-15 | 2014-08-15 | Process for the purification of diaminophenothiazinium compounds |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9701648B2 (enExample) |
| EP (1) | EP3033331B1 (enExample) |
| JP (1) | JP6111381B2 (enExample) |
| KR (1) | KR101741235B1 (enExample) |
| CN (1) | CN105612148B (enExample) |
| BR (1) | BR112016002979A8 (enExample) |
| CA (1) | CA2920505C (enExample) |
| DK (1) | DK3033331T3 (enExample) |
| IL (1) | IL243937A (enExample) |
| MX (1) | MX354492B (enExample) |
| NZ (1) | NZ630569A (enExample) |
| SG (1) | SG11201601003PA (enExample) |
| TW (1) | TWI629267B (enExample) |
| WO (1) | WO2015021500A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3375777A1 (en) | 2017-03-15 | 2018-09-19 | MIKROCHEM spol. s.r.o. | Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide |
| CN112358475B (zh) * | 2020-11-30 | 2022-09-06 | 西北师范大学 | 一种苯并吡喃鎓-吩噻嗪衍生物及其制备方法和应用 |
| EP4512802A1 (en) * | 2022-04-19 | 2025-02-26 | Leadway (HK) Limited | Purification method for electron mediator |
| CN116947783A (zh) * | 2022-04-19 | 2023-10-27 | 英科隆生物技术（杭州）有限公司 | 一种电子媒介体的提纯方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2909520A (en) | 1959-10-20 | Process for making acylated | ||
| DE1886C (de) | 1877-12-15 | 1877-12-15 | Basf Ag | Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen |
| GB1293757A (en) * | 1968-10-22 | 1972-10-25 | Paines & Byrne Ltd | A nerve stain composition |
| GB0327672D0 (en) * | 2003-11-28 | 2003-12-31 | Photopharmica Ltd | Developments in biologically active methylene blue derivatives (phenothiazines) |
| AU2004295148A1 (en) * | 2003-11-28 | 2005-06-16 | Photopharmica Limited | Developments in biologically active methylene blue derivatives (2) |
| US7790881B2 (en) * | 2004-09-23 | 2010-09-07 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC) |
| PT1799662E (pt) | 2004-09-23 | 2013-07-09 | Wista Lab Ltd | Métodos de síntese química e purificação de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc) |
| HUE030621T2 (en) * | 2006-07-11 | 2017-05-29 | Wista Lab Ltd | Methods for the synthesis and / or purification of diaminophenothiazinium compounds |
| FR2903696B1 (fr) * | 2006-07-12 | 2011-02-11 | Provence Technologies | Procede de purification de composes diaminophenothiazium |
| EA025033B1 (ru) * | 2011-02-11 | 2016-11-30 | Уиста Лэборэтэриз Лтд. | Диаминиевые соли фенотиазина и их применение |
-
2014
- 2014-08-15 CN CN201480055983.7A patent/CN105612148B/zh not_active Expired - Fee Related
- 2014-08-15 US US14/911,813 patent/US9701648B2/en not_active Expired - Fee Related
- 2014-08-15 TW TW103128051A patent/TWI629267B/zh not_active IP Right Cessation
- 2014-08-15 SG SG11201601003PA patent/SG11201601003PA/en unknown
- 2014-08-15 WO PCT/AU2014/000807 patent/WO2015021500A1/en not_active Ceased
- 2014-08-15 EP EP14836833.5A patent/EP3033331B1/en active Active
- 2014-08-15 NZ NZ630569A patent/NZ630569A/en not_active IP Right Cessation
- 2014-08-15 DK DK14836833.5T patent/DK3033331T3/da active
- 2014-08-15 JP JP2016533750A patent/JP6111381B2/ja active Active
- 2014-08-15 KR KR1020167005820A patent/KR101741235B1/ko not_active Expired - Fee Related
- 2014-08-15 BR BR112016002979A patent/BR112016002979A8/pt not_active Application Discontinuation
- 2014-08-15 CA CA2920505A patent/CA2920505C/en active Active
- 2014-08-15 MX MX2016002085A patent/MX354492B/es active IP Right Grant
-
2016
- 2016-02-03 IL IL243937A patent/IL243937A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP6111381B2 (ja) | 2017-04-05 |
| EP3033331B1 (en) | 2018-02-21 |
| IL243937A (en) | 2017-01-31 |
| BR112016002979A8 (pt) | 2020-02-04 |
| US9701648B2 (en) | 2017-07-11 |
| JP2016528237A (ja) | 2016-09-15 |
| CA2920505A1 (en) | 2015-02-19 |
| DK3033331T3 (da) | 2018-04-30 |
| SG11201601003PA (en) | 2016-03-30 |
| TW201527287A (zh) | 2015-07-16 |
| TWI629267B (zh) | 2018-07-11 |
| AU2014306354A1 (en) | 2016-02-18 |
| KR20160042929A (ko) | 2016-04-20 |
| MX354492B (es) | 2018-03-07 |
| CN105612148B (zh) | 2018-09-14 |
| EP3033331A4 (en) | 2017-01-18 |
| US20160200696A1 (en) | 2016-07-14 |
| EP3033331A1 (en) | 2016-06-22 |
| CA2920505C (en) | 2018-04-03 |
| IL243937A0 (en) | 2016-04-21 |
| CN105612148A (zh) | 2016-05-25 |
| MX2016002085A (es) | 2016-06-23 |
| KR101741235B1 (ko) | 2017-05-29 |
| WO2015021500A1 (en) | 2015-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 15 AUG 2019 BY SPRUSON + FERGUSON Effective date: 20180801 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 15 AUG 2020 BY SPRUSON + FERGUSON Effective date: 20190715 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 15 AUG 2021 BY SPRUSON + FERGUSON PTY LTD Effective date: 20200715 |
|
| LAPS | Patent lapsed |