CN105555274A - 用于提供疼痛减轻和麻醉的二氢埃托啡 - Google Patents

用于提供疼痛减轻和麻醉的二氢埃托啡 Download PDF

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Publication number
CN105555274A
CN105555274A CN201480042250.XA CN201480042250A CN105555274A CN 105555274 A CN105555274 A CN 105555274A CN 201480042250 A CN201480042250 A CN 201480042250A CN 105555274 A CN105555274 A CN 105555274A
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CN
China
Prior art keywords
dihydroetorphine
methods according
dosage
average
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480042250.XA
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English (en)
Chinese (zh)
Inventor
戴维·沃特金斯
亚历山大·奥克舍
凯文·史密斯
海基·曼西卡
保罗·贝利
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Euro Celtique SA
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Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of CN105555274A publication Critical patent/CN105555274A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
CN201480042250.XA 2013-05-30 2014-05-30 用于提供疼痛减轻和麻醉的二氢埃托啡 Pending CN105555274A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1309654.0A GB201309654D0 (en) 2013-05-30 2013-05-30 Method
GB1309654.0 2013-05-30
PCT/GB2014/000206 WO2014191710A1 (en) 2013-05-30 2014-05-30 Dihydroetorphine for the provision of pain relief and anaesthesia

Publications (1)

Publication Number Publication Date
CN105555274A true CN105555274A (zh) 2016-05-04

Family

ID=48805475

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480042250.XA Pending CN105555274A (zh) 2013-05-30 2014-05-30 用于提供疼痛减轻和麻醉的二氢埃托啡

Country Status (13)

Country Link
US (2) US10898479B2 (enExample)
EP (1) EP3003310A1 (enExample)
JP (3) JP2016520114A (enExample)
KR (1) KR20160013977A (enExample)
CN (1) CN105555274A (enExample)
AU (1) AU2014272924B2 (enExample)
BR (1) BR112015029709A2 (enExample)
CA (1) CA2913849A1 (enExample)
GB (1) GB201309654D0 (enExample)
HK (1) HK1222585A1 (enExample)
MX (1) MX2015016418A (enExample)
PH (1) PH12015502655A1 (enExample)
WO (1) WO2014191710A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108136028A (zh) * 2015-07-30 2018-06-08 欧洲凯尔特公司 经皮递送系统

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX369121B (es) 2011-03-04 2019-10-30 Gruenenthal Gmbh Formulacion farmaceutica acuosa de tapentadol para administracion oral.
EA036258B1 (ru) 2015-03-27 2020-10-20 Грюненталь Гмбх Стабильный препарат для парентерального введения тапентадола
CN109996533A (zh) 2016-09-23 2019-07-09 格吕伦塔尔有限公司 用于肠胃外施用他喷他多的稳定制剂
EP3585370A1 (en) 2017-02-23 2020-01-01 Grünenthal GmbH Tapentadol as local anesthetic

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108136028A (zh) * 2015-07-30 2018-06-08 欧洲凯尔特公司 经皮递送系统

Also Published As

Publication number Publication date
KR20160013977A (ko) 2016-02-05
AU2014272924A1 (en) 2016-01-28
WO2014191710A1 (en) 2014-12-04
US10898479B2 (en) 2021-01-26
BR112015029709A2 (pt) 2017-07-25
US20160106736A1 (en) 2016-04-21
JP2019123730A (ja) 2019-07-25
AU2014272924B2 (en) 2019-05-02
JP2020200345A (ja) 2020-12-17
JP2016520114A (ja) 2016-07-11
HK1222585A1 (zh) 2017-07-07
PH12015502655A1 (en) 2016-03-07
MX2015016418A (es) 2016-11-08
EP3003310A1 (en) 2016-04-13
GB201309654D0 (en) 2013-07-17
CA2913849A1 (en) 2014-12-04
US20210085673A1 (en) 2021-03-25

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