KR20160013977A - 통증 완화 및 마취의 제공을 위한 디히드로에토르핀 - Google Patents
통증 완화 및 마취의 제공을 위한 디히드로에토르핀 Download PDFInfo
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- KR20160013977A KR20160013977A KR1020157036442A KR20157036442A KR20160013977A KR 20160013977 A KR20160013977 A KR 20160013977A KR 1020157036442 A KR1020157036442 A KR 1020157036442A KR 20157036442 A KR20157036442 A KR 20157036442A KR 20160013977 A KR20160013977 A KR 20160013977A
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- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 229940072690 valium Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4824—Touch or pain perception evaluation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Psychiatry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB1309654.0 | 2013-05-30 | ||
| GBGB1309654.0A GB201309654D0 (en) | 2013-05-30 | 2013-05-30 | Method |
| PCT/GB2014/000206 WO2014191710A1 (en) | 2013-05-30 | 2014-05-30 | Dihydroetorphine for the provision of pain relief and anaesthesia |
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| Publication Number | Publication Date |
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| KR20160013977A true KR20160013977A (ko) | 2016-02-05 |
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| KR1020157036442A Ceased KR20160013977A (ko) | 2013-05-30 | 2014-05-30 | 통증 완화 및 마취의 제공을 위한 디히드로에토르핀 |
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|---|---|
| US (2) | US10898479B2 (enExample) |
| EP (1) | EP3003310A1 (enExample) |
| JP (3) | JP2016520114A (enExample) |
| KR (1) | KR20160013977A (enExample) |
| CN (1) | CN105555274A (enExample) |
| AU (1) | AU2014272924B2 (enExample) |
| BR (1) | BR112015029709A2 (enExample) |
| CA (1) | CA2913849A1 (enExample) |
| GB (1) | GB201309654D0 (enExample) |
| HK (1) | HK1222585A1 (enExample) |
| MX (1) | MX2015016418A (enExample) |
| PH (1) | PH12015502655A1 (enExample) |
| WO (1) | WO2014191710A1 (enExample) |
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| EP3685827A1 (en) | 2011-03-04 | 2020-07-29 | Grünenthal GmbH | Aqueous pharmaceutical formulation of tapentadol for oral administration |
| JP6923447B2 (ja) | 2015-03-27 | 2021-08-18 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールの非経口投与のための安定な製剤 |
| GB201513442D0 (en) * | 2015-07-30 | 2015-09-16 | Euro Celtique Sa | Transdermal patch |
| EP3515412B1 (en) | 2016-09-23 | 2025-04-23 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
| WO2018153947A1 (en) | 2017-02-23 | 2018-08-30 | Grünenthal GmbH | Tapentadol as local anesthetic |
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| GB925723A (en) | 1960-09-05 | 1963-05-08 | J F Macfarlan & Company Ltd | Novel thebaine derivatives |
| GB937214A (en) | 1961-06-02 | 1963-09-18 | J F Macfarlan & Company Ltd | Oripavine derivatives |
| JPS59184182A (ja) | 1983-04-02 | 1984-10-19 | Res Inst For Prod Dev | ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン |
| JPS62153214A (ja) | 1985-12-26 | 1987-07-08 | Nitto Electric Ind Co Ltd | 医薬製剤 |
| JPS62281815A (ja) | 1986-05-27 | 1987-12-07 | Teisan Seiyaku Kk | 貼付剤及びその製造法 |
| JPS63201119A (ja) | 1987-02-17 | 1988-08-19 | Kao Corp | 貼付剤組成物 |
| US4891377A (en) | 1988-12-02 | 1990-01-02 | Board Of Regents Acting For And On Behalf Of University Of Michigan | Transdermal delivery of the narcotic analgesics etorphine and analogs |
| PT95069B (pt) | 1989-08-24 | 1997-10-31 | Searle & Co | Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos |
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| WO2003061594A2 (en) | 2002-01-23 | 2003-07-31 | The Regents Of The University Of California | Methods and compositions for reducing the development of drug tolerance and/or physical dependence |
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| US20040033253A1 (en) | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
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| JP5875748B2 (ja) | 2007-03-06 | 2016-03-02 | マリンクロッド エルエルシー | 第４級ｎ−アルキルモルフィナンアルカロイド塩の調製のための方法 |
| CN101147739B (zh) | 2007-07-06 | 2010-12-08 | 北京康倍得医药技术开发有限公司 | 含罗替戈汀的组合物及其制药用途以及含该组合物的透皮贴剂 |
| KR100929560B1 (ko) | 2008-01-09 | 2009-12-03 | 에코 퍼시픽 엘티디 | 그라니세트론을 함유한 매트릭스 형태의 경피 흡수제 |
| JP5547065B2 (ja) | 2008-05-15 | 2014-07-09 | 久光製薬株式会社 | パロノセトロンを含有する経皮吸収製剤 |
| TWI630208B (zh) | 2008-12-08 | 2018-07-21 | 歐陸斯迪公司 | 二氫羥戊甲嗎啡 |
| EP2298277A1 (en) | 2009-09-09 | 2011-03-23 | Labtec GmbH | Transdermal patch formulation |
| DE102010040299A1 (de) | 2010-09-06 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner) |
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2013
- 2013-05-30 GB GBGB1309654.0A patent/GB201309654D0/en not_active Ceased
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2014
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- 2014-05-30 US US14/894,775 patent/US10898479B2/en not_active Expired - Fee Related
- 2014-05-30 WO PCT/GB2014/000206 patent/WO2014191710A1/en not_active Ceased
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2020
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- 2020-09-30 US US17/038,651 patent/US20210085673A1/en not_active Abandoned
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| CA2913849A1 (en) | 2014-12-04 |
| EP3003310A1 (en) | 2016-04-13 |
| AU2014272924B2 (en) | 2019-05-02 |
| AU2014272924A1 (en) | 2016-01-28 |
| US10898479B2 (en) | 2021-01-26 |
| MX2015016418A (es) | 2016-11-08 |
| WO2014191710A1 (en) | 2014-12-04 |
| JP2019123730A (ja) | 2019-07-25 |
| US20210085673A1 (en) | 2021-03-25 |
| JP2016520114A (ja) | 2016-07-11 |
| BR112015029709A2 (pt) | 2017-07-25 |
| CN105555274A (zh) | 2016-05-04 |
| JP2020200345A (ja) | 2020-12-17 |
| PH12015502655A1 (en) | 2016-03-07 |
| GB201309654D0 (en) | 2013-07-17 |
| HK1222585A1 (zh) | 2017-07-07 |
| US20160106736A1 (en) | 2016-04-21 |
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