CN105523922B - 一种罗氟司特中间体的制备方法 - Google Patents
一种罗氟司特中间体的制备方法 Download PDFInfo
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- CN105523922B CN105523922B CN201610136088.9A CN201610136088A CN105523922B CN 105523922 B CN105523922 B CN 105523922B CN 201610136088 A CN201610136088 A CN 201610136088A CN 105523922 B CN105523922 B CN 105523922B
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- difluoro
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- methoxy
- benzaldehyde
- oxidant
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610136088.9A CN105523922B (zh) | 2016-03-10 | 2016-03-10 | 一种罗氟司特中间体的制备方法 |
Applications Claiming Priority (1)
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CN201610136088.9A CN105523922B (zh) | 2016-03-10 | 2016-03-10 | 一种罗氟司特中间体的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN105523922A CN105523922A (zh) | 2016-04-27 |
CN105523922B true CN105523922B (zh) | 2017-12-29 |
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CN201610136088.9A Expired - Fee Related CN105523922B (zh) | 2016-03-10 | 2016-03-10 | 一种罗氟司特中间体的制备方法 |
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CN (1) | CN105523922B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1802353A (zh) * | 2002-12-30 | 2006-07-12 | 细胞基因公司 | 氟烷氧基取代的1,3-二氢-异吲哚化合物及其药物用途 |
CN102503815A (zh) * | 2011-11-11 | 2012-06-20 | 南京天海医药科技有限公司 | 一种罗氟司特中间体的制备方法 |
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2016
- 2016-03-10 CN CN201610136088.9A patent/CN105523922B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1802353A (zh) * | 2002-12-30 | 2006-07-12 | 细胞基因公司 | 氟烷氧基取代的1,3-二氢-异吲哚化合物及其药物用途 |
CN102503815A (zh) * | 2011-11-11 | 2012-06-20 | 南京天海医药科技有限公司 | 一种罗氟司特中间体的制备方法 |
Non-Patent Citations (1)
Title |
---|
Design,Synthesis,andStructure Activity Relationship,Molecular Modeling,and NMR Studies of a Series of Phenyl Alkyl Ketones as Highly Potent and Selective Phosphodiesterase-4 Inhibitors;ShilongZheng et al.;《J.Med.Chem.》;20081202;第51卷;7673-7688 * |
Also Published As
Publication number | Publication date |
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CN105523922A (zh) | 2016-04-27 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Nie Hongmei Inventor after: Zhang Na Inventor after: Yu Jianmei Inventor before: He Baohong |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20171204 Address after: 276399 No. 2, unit 14, building 70, building 401, Yuquanlu Road, Linyi, Shandong, Yinan Applicant after: Nie Hongmei Applicant after: Zhang Na Applicant after: Yu Jianmei Address before: Qingdao City, Shandong province 266000 flood ditch cleaning village 106 2 Applicant before: Chen Hong |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171229 Termination date: 20190310 |