CN105518145A - Aav载体和用于抗aav（腺相关病毒）中和抗体的检测 - Google Patents

Aav载体和用于抗aav（腺相关病毒）中和抗体的检测 Download PDF

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Publication number
CN105518145A
CN105518145A CN201480039270.1A CN201480039270A CN105518145A CN 105518145 A CN105518145 A CN 105518145A CN 201480039270 A CN201480039270 A CN 201480039270A CN 105518145 A CN105518145 A CN 105518145A
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aav
cell
reporter transgene
sequence
biological sample
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Chinese (zh)
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凯瑟琳·A·海
费德里科·麦格兹
陈一峰
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Childrens Hospital of Philadelphia CHOP
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Childrens Hospital of Philadelphia CHOP
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Priority to CN202310061410.6A priority Critical patent/CN116004721A/zh
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/701—Specific hybridization probes
    • A—HUMAN NECESSITIES
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14131—Uses of virus other than therapeutic or vaccine, e.g. disinfectant
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • G01N2333/01—DNA viruses
    • G01N2333/075—Adenoviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

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CN201480039270.1A 2013-07-12 2014-07-11 Aav载体和用于抗aav（腺相关病毒）中和抗体的检测 Pending CN105518145A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310061410.6A CN116004721A (zh) 2013-07-12 2014-07-11 Aav载体和用于抗aav（腺相关病毒）中和抗体的检测

Applications Claiming Priority (3)

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US201361845841P 2013-07-12 2013-07-12
US61/845,841 2013-07-12
PCT/US2014/046428 WO2015006743A1 (en) 2013-07-12 2014-07-11 Aav vector and assay for anti-aav (adeno-associated virus) neutralizing antibodies

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CN202310061410.6A Pending CN116004721A (zh) 2013-07-12 2014-07-11 Aav载体和用于抗aav（腺相关病毒）中和抗体的检测

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US (3) US11408899B2 (https=)
EP (2) EP4039813A1 (https=)
JP (4) JP2016525347A (https=)
KR (1) KR102445330B1 (https=)
CN (2) CN105518145A (https=)
AU (1) AU2014287005C1 (https=)
CA (1) CA2918038C (https=)
HK (1) HK1222673A1 (https=)
IL (1) IL243438B (https=)
MX (2) MX2016000345A (https=)
RU (1) RU2705249C2 (https=)
WO (1) WO2015006743A1 (https=)

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CN107828821A (zh) * 2017-11-15 2018-03-23 四川大学 一种腺相关病毒感染敏感的细胞系的构建方法及腺相关病毒中和抗体含量测定的检测方法
CN110846392A (zh) * 2018-08-20 2020-02-28 武汉纽福斯生物科技有限公司 一种重组腺相关病毒或含其的试剂盒及其应用
CN112004925A (zh) * 2018-04-05 2020-11-27 吉尼松公司 具有降低的肝向性的AAV9和AAVrh74的杂合重组腺相关病毒血清型
CN112143712A (zh) * 2020-09-30 2020-12-29 中国科学院深圳先进技术研究院 一种重组腺相关病毒及其制备方法和在抗体检测的应用
CN113614236A (zh) * 2018-11-16 2021-11-05 星火治疗有限公司 用于检测腺相关病毒(aav)载体转导的增强子和抑制剂和/或检测或定量抗aav结合抗体的体外测定
CN114277090A (zh) * 2021-12-17 2022-04-05 宁波熙宁检测技术有限公司 Aav8中和抗体检测方法和检测试剂盒
CN115047188A (zh) * 2022-06-10 2022-09-13 上海鼎新基因科技有限公司 一种抗腺相关病毒中和抗体的检测方法
CN115698294A (zh) * 2020-04-12 2023-02-03 诺瓦斯科普知识产权有限公司 颗粒、dna和rna
WO2023207918A1 (en) * 2022-04-25 2023-11-02 Beijing Hanmoluojie Technology Co., Ltd. Aav capsid 3d molecular surface feature mapping

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RU2021102893A (ru) 2015-11-05 2021-03-03 Бамбу Терапьютикс, Инк. Модифицированные гены атаксии фридрейха и векторы для генной терапии
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US20210228738A1 (en) * 2017-07-17 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins
CA3086046C (en) * 2017-12-29 2023-02-21 Helixmith Co., Ltd. Adeno-associated virus (aav) vector having hybrid hgf gene introduced thereto
CN111902164A (zh) 2018-02-01 2020-11-06 同源药物公司 用于恢复pah基因功能的腺相关病毒组合物及其使用方法
US10610606B2 (en) 2018-02-01 2020-04-07 Homology Medicines, Inc. Adeno-associated virus compositions for PAH gene transfer and methods of use thereof
CN112041437A (zh) 2018-02-19 2020-12-04 同源药物公司 用于恢复f8基因功能的腺相关病毒组合物和其使用方法
EP3796980A4 (en) * 2018-05-22 2022-03-23 The Brigham & Women's Hospital, Inc. NEW THERAPY FOR ALZHEIMER'S DISEASE
EP3918308A4 (en) * 2019-01-31 2023-09-27 Precision Bioservices, Inc. METHOD FOR DETECTING AND CHARACTERIZING ANTIVIRAL VECTOR ANTIBODIES
AU2020263757B2 (en) 2019-04-24 2025-08-28 Takara Bio Inc. AAV mutant having brain-targeting property
WO2020242892A1 (en) 2019-05-24 2020-12-03 The Brigham And Women's Hospital, Inc. Gene therapy for alzheimer's disease
IL293285A (en) 2019-11-29 2022-07-01 Paros Bio Inc Gene therapy for neurodegenerative disorders
TW202140791A (zh) 2020-01-13 2021-11-01 美商霍蒙拉奇醫藥公司 治療苯酮尿症之方法
KR20220133969A (ko) 2020-01-28 2022-10-05 프리라인 테라퓨틱스 리미티드 바이러스 벡터에 대한 중화 항체 역가를 결정하기 위한 개선된 분석법
TW202208632A (zh) 2020-05-27 2022-03-01 美商同源醫藥公司 用於恢復ｐａｈ基因功能的腺相關病毒組成物及其使用方法
PL4211231T3 (pl) * 2020-09-10 2024-11-04 Genethon Kapsyd AAV modyfikowany peptydem
WO2023114816A1 (en) 2021-12-14 2023-06-22 Neurogene, Inc. Recombinant optimized galc constructs and methods for treating galc-associated disorders
GB202201242D0 (en) 2022-01-31 2022-03-16 Univ Edinburgh Recombinant optimized mecp2 cassettes and methods for treating rett syndrome and related disorders
GB202206336D0 (en) 2022-04-29 2022-06-15 Univ Edinburgh Recombinant therapeutic FMR1 constructs and methods of treating fragile X syndrome and related disorders
CN119562959A (zh) * 2022-05-13 2025-03-04 费城儿童医院 用于靶向脑微脉管系统的腺相关病毒载体
EP4536862A1 (en) * 2022-06-09 2025-04-16 Wisconsin Alumni Research Foundation Generation of next generation recombinant aav gene therapy vectors that adopt 3d conformation
CN117802161A (zh) * 2022-06-30 2024-04-02 苏州吉恒基因科技有限公司 精准重组腺相关病毒载体及其用途
US20250352580A1 (en) * 2022-11-04 2025-11-20 The Children's Hospital Of Philadelphia Compositions and methods for b cell directed immunotherapies for anti-aav neutralizing alloantibodies
CN117285620B (zh) * 2023-11-27 2024-02-13 恺佧生物科技(上海)有限公司 抗aav9抗体及aav9滴度测定elisa试剂盒
WO2025119252A1 (en) * 2023-12-06 2025-06-12 Immvira Biopharmaceuticals Co., Limited Methods for detecting an anti-hsv antibody in a sample
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CN107828821A (zh) * 2017-11-15 2018-03-23 四川大学 一种腺相关病毒感染敏感的细胞系的构建方法及腺相关病毒中和抗体含量测定的检测方法
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