CN105439978B - 阿考替胺中间体的制备方法 - Google Patents
阿考替胺中间体的制备方法 Download PDFInfo
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- CN105439978B CN105439978B CN201510938183.6A CN201510938183A CN105439978B CN 105439978 B CN105439978 B CN 105439978B CN 201510938183 A CN201510938183 A CN 201510938183A CN 105439978 B CN105439978 B CN 105439978B
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- acotiamide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CN201510938183.6A CN105439978B (zh) | 2015-12-15 | 2015-12-15 | 阿考替胺中间体的制备方法 |
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CN201510938183.6A CN105439978B (zh) | 2015-12-15 | 2015-12-15 | 阿考替胺中间体的制备方法 |
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CN105439978A CN105439978A (zh) | 2016-03-30 |
CN105439978B true CN105439978B (zh) | 2018-02-16 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109053434A (zh) * | 2018-07-18 | 2018-12-21 | 上海华堇生物技术有限责任公司 | 一种2,4-二甲氧基苯甲酰氯的新制备方法 |
CN114478213B (zh) * | 2020-10-23 | 2023-12-08 | 广州一品红制药有限公司 | 一种利用微通道器制备依他佐辛中间体的方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050143581A1 (en) * | 2002-03-20 | 2005-06-30 | Mitsui Chemicals, Inc. | Process for preparation of alkoxybenzamides and thiazolyl isocyanates |
CN103665023A (zh) * | 2013-12-23 | 2014-03-26 | 华润赛科药业有限责任公司 | 一种盐酸阿考替胺的合成方法 |
CN103930409A (zh) * | 2011-09-23 | 2014-07-16 | 拜尔斯道夫股份公司 | 芳香性酰胺基噻唑、含有它的化妆或皮肤科制剂以及它们的克服和预防不期望的皮肤色素沉着的用途 |
CN104031001A (zh) * | 2014-06-30 | 2014-09-10 | 山东诚创医药技术开发有限公司 | 一锅烩制备2-[n-(2,4,5-三甲氧基苯甲胺基)氨基]-4-乙氧羰基-1,3-噻唑的方法 |
CN104045606A (zh) * | 2014-07-11 | 2014-09-17 | 杭州新博思生物医药有限公司 | 一锅法制备阿考替胺盐酸盐的方法 |
CN104592147A (zh) * | 2013-10-30 | 2015-05-06 | 江苏豪森药业股份有限公司 | 盐酸阿考替胺中间体的制备方法 |
CN104892544A (zh) * | 2014-03-04 | 2015-09-09 | 北京海步国际医药科技发展有限公司 | 阿考替胺中间体的一种改进的制备方法 |
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2015
- 2015-12-15 CN CN201510938183.6A patent/CN105439978B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050143581A1 (en) * | 2002-03-20 | 2005-06-30 | Mitsui Chemicals, Inc. | Process for preparation of alkoxybenzamides and thiazolyl isocyanates |
CN103930409A (zh) * | 2011-09-23 | 2014-07-16 | 拜尔斯道夫股份公司 | 芳香性酰胺基噻唑、含有它的化妆或皮肤科制剂以及它们的克服和预防不期望的皮肤色素沉着的用途 |
CN104592147A (zh) * | 2013-10-30 | 2015-05-06 | 江苏豪森药业股份有限公司 | 盐酸阿考替胺中间体的制备方法 |
CN103665023A (zh) * | 2013-12-23 | 2014-03-26 | 华润赛科药业有限责任公司 | 一种盐酸阿考替胺的合成方法 |
CN104892544A (zh) * | 2014-03-04 | 2015-09-09 | 北京海步国际医药科技发展有限公司 | 阿考替胺中间体的一种改进的制备方法 |
CN104031001A (zh) * | 2014-06-30 | 2014-09-10 | 山东诚创医药技术开发有限公司 | 一锅烩制备2-[n-(2,4,5-三甲氧基苯甲胺基)氨基]-4-乙氧羰基-1,3-噻唑的方法 |
CN104045606A (zh) * | 2014-07-11 | 2014-09-17 | 杭州新博思生物医药有限公司 | 一锅法制备阿考替胺盐酸盐的方法 |
Non-Patent Citations (3)
Title |
---|
A Three-Step Synthesis of Acotiamide for the Treatment of Patients with Functional Dyspepsia;Kai Fu 等;《Org. Process Res. Dev.》;20151113;第19卷;第2006-2011页 * |
盐酸阿考替胺三水合物的合成;白晓光 等;《中国医药工业杂志》;20150331;第46卷(第3期);第230-232页 * |
阿考替胺的合成进展;俞波 等;《海峡药学》;20151130;第27卷(第11期);第245-247页 * |
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CN105439978A (zh) | 2016-03-30 |
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Address after: 255129 Zichuan District Economic Development Zone, Zibo, Shandong Patentee after: SHANDONG JINCHENG PHARMACEUTICAL CO.,LTD. Address before: 255129 Zichuan District Economic Development Zone, Zibo, Shandong Patentee before: SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL Co.,Ltd. |
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Address after: 255129 No. 1 Shuangshan Road, Zichuan Economic Development Zone, Zibo City, Shandong Province Patentee after: SHANDONG JINCHENG PHARMACEUTICAL GROUP CO.,LTD. Address before: 255129 Zichuan District Economic Development Zone, Zibo, Shandong Patentee before: SHANDONG JINCHENG PHARMACEUTICAL CO.,LTD. |
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Effective date of registration: 20201228 Address after: No.26, Kunxin Road, Kui Si Village, Kunlun town, Zichuan District, Zibo City, Shandong Province Patentee after: Shandong Jincheng Kunlun Pharmaceutical Co.,Ltd. Address before: 255129 No. 1 Shuangshan Road, Zichuan Economic Development Zone, Zibo City, Shandong Province Patentee before: SHANDONG JINCHENG PHARMACEUTICAL GROUP Co.,Ltd. |