CN105308171B - Agse缺陷菌株 - Google Patents

Agse缺陷菌株 Download PDF

Info

Publication number
CN105308171B
CN105308171B CN201380038233.4A CN201380038233A CN105308171B CN 105308171 B CN105308171 B CN 105308171B CN 201380038233 A CN201380038233 A CN 201380038233A CN 105308171 B CN105308171 B CN 105308171B
Authority
CN
China
Prior art keywords
polypeptide
host cell
seq
activity
aspergillus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380038233.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN105308171A (zh
Inventor
诺尔·尼克拉斯·玛利亚·伊丽莎白·范·佩吉
马帝那·贝舒森
德·沃恩德沃尔特 彼得·约瑟夫·艾达·范
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN105308171A publication Critical patent/CN105308171A/zh
Application granted granted Critical
Publication of CN105308171B publication Critical patent/CN105308171B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C12N9/242—Fungal source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2431—Beta-fructofuranosidase (3.2.1.26), i.e. invertase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004—Glucose oxidase (1.1.3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01183—Alpha-1,3-glucan synthase (2.4.1.183)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01004—Phospholipase A2 (3.1.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0102—Alpha-glucosidase (3.2.1.20)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201380038233.4A 2012-07-19 2013-07-19 Agse缺陷菌株 Active CN105308171B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261673596P 2012-07-19 2012-07-19
US61/673,596 2012-07-19
EP12177172 2012-07-19
EP12177172.9 2012-07-19
PCT/EP2013/065348 WO2014013074A1 (en) 2012-07-19 2013-07-19 Agse-deficient strain

Publications (2)

Publication Number Publication Date
CN105308171A CN105308171A (zh) 2016-02-03
CN105308171B true CN105308171B (zh) 2019-03-08

Family

ID=49948320

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380038233.4A Active CN105308171B (zh) 2012-07-19 2013-07-19 Agse缺陷菌株

Country Status (13)

Country Link
US (2) US10035986B2 (https=)
EP (2) EP3327112B1 (https=)
JP (1) JP6468561B2 (https=)
CN (1) CN105308171B (https=)
AU (1) AU2013291936B2 (https=)
CA (1) CA2876287C (https=)
CL (1) CL2015000084A1 (https=)
DK (2) DK3327112T3 (https=)
EA (1) EA201500142A1 (https=)
IN (1) IN2014DN11163A (https=)
MX (1) MX357482B (https=)
NZ (1) NZ702962A (https=)
WO (1) WO2014013074A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2918682B1 (en) 2012-11-09 2019-04-10 Tohoku University Method for manufacturing useful substance in which high-density cultured strain of filamentous fungi is used
DK3077517T3 (en) 2013-12-02 2019-02-11 Dsm Ip Assets Bv ISSTRUCTURING PROTEIN
WO2016026839A1 (en) 2014-08-21 2016-02-25 Dsm Ip Assets B.V. Use of penicillium glucose oxidase in the baking industry for replacing bromate or azodicarbonamide
US20170313997A1 (en) * 2014-10-29 2017-11-02 Novozymes A/S Filamentous Fungal Double-Mutant Host Cells
WO2016110453A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a filamentous fungal host cell
AU2016245948B2 (en) 2015-04-10 2020-05-21 Dsm Ip Assets B.V. Method for preparing a dough
US10844397B2 (en) 2015-06-01 2020-11-24 Arizona Board Of Regents On Behalf Of The University Of Arizona Transgenic plant species engineered to inhibit biosynthesis of Aspergillus aflatoxin
WO2016193292A1 (en) 2015-06-02 2016-12-08 Dsm Ip Assets B.V. Use of ice structuring protein afp19 expressed in filamentous fungal strains for preparing food
CN105950482B (zh) * 2016-07-15 2019-04-02 南京林业大学 一株产菊粉酶的菌株及其应用
WO2018019948A1 (en) 2016-07-29 2018-02-01 Dsm Ip Assets B.V. Polypeptides having cellulolytic enhancing activity and uses thereof
WO2018114940A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114941A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114912A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
WO2018114938A1 (en) 2016-12-21 2018-06-28 Dsm Ip Assets B.V. Lipolytic enzyme variants
US20200063166A1 (en) * 2017-03-13 2020-02-27 Dsm Ip Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
BR112020025589A2 (pt) 2018-06-19 2021-03-23 Dsm Ip Assets B.V. variantes de enzima lipolítica
CN110184195B (zh) * 2019-04-25 2020-11-17 广东海洋大学 一株高产油脂的桔青霉Asc2-4-1及其应用
CN110713937B (zh) * 2019-09-20 2022-02-01 兰州大学 提高中华羊茅-内生真菌菌株pa次生代谢产物波胺含量的方法
CN111849809B (zh) * 2020-07-09 2021-12-24 南京农业大学 一种可降解菊粉果聚糖的菌株及其应用
CN112662572B (zh) * 2021-02-02 2022-03-15 中国科学院海洋研究所 一种高产壳聚糖酶的菌株及其应用
AU2022297881A1 (en) 2021-06-24 2024-01-18 Fonterra Co-Operative Group Limited Recombinant beta-lactoglobulin
EP4525615A2 (en) 2022-05-14 2025-03-26 Novozymes A/S Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections
US20250304938A1 (en) 2022-05-16 2025-10-02 Dsm Ip Assets B.V. Lipolytic enzyme variants
US12306320B2 (en) 2022-09-23 2025-05-20 Gregory Trammell Emergency beacon and light combination assembly
WO2025012325A1 (en) 2023-07-11 2025-01-16 Dsm Ip Assets B.V. Protein arginine deiminase

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002653A1 (en) * 1994-07-20 1996-02-01 Novo Nordisk Biotech, Inc. Thermophilic fungal expression system
WO2012001169A1 (en) * 2010-07-01 2012-01-05 Dsm Ip Assets B.V. A method for the production of a compound of interest
CN102618606A (zh) * 2011-01-30 2012-08-01 浙江海正药业股份有限公司 一种棘白菌素生物转化方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198345A (en) 1985-04-15 1993-03-30 Gist-Brocades N.V. Vectors in use in filamentous fungi
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
CA1341226C (en) 1988-08-16 2001-05-01 Wim Van Hartingsveldt Gene replacement as a tool for the construction of aspergillus strains
FR2679920A1 (fr) 1991-08-02 1993-02-05 Rhone Poulenc Rorer Sa Levures recombinantes hautement stables pour la production de proteines recombinantes, leur preparation et leur utilisation.
DE69432543T2 (de) 1993-07-23 2003-12-24 Dsm N.V., Te Heerlen Selektionmarker-genfreie rekombinante Stämme: Verfahren zur ihrer Herstellung und die Verwendung dieser Stämme
CN101659926A (zh) 1994-06-30 2010-03-03 诺沃奇梅兹有限公司 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子
JPH11501217A (ja) 1995-08-03 1999-02-02 ギスト ブロカデス ベスローテン フェンノートシャップ 選択マーカーとしての相同ａｍｄＳ遺伝子の利用
JP5303084B2 (ja) 1997-04-11 2013-10-02 コニンクリーケ デーエスエム ナムローゼ フェンノートシャップ 工業的組み換え生物を溝築するための手段としての遺伝子変換
EP1854890A1 (en) 1997-12-22 2007-11-14 DSM IP Assets B.V. Expression cloning in filamentous fungi
DK1117798T3 (da) 1998-10-05 2007-04-10 Novozymes As Fungal transskriptionel aktivator egnet ved fremgangsmåder til produktion af polypeptider
EP1157100B1 (en) 1999-02-22 2006-01-11 Novozymes A/S Oxaloacetate hydrolase deficient fungal host cells
CN100510096C (zh) 1999-03-22 2009-07-08 诺沃奇梅兹有限公司 用于在真菌细胞中表达基因的启动子
WO2001021779A2 (en) 1999-09-17 2001-03-29 Dsm N.V. Penicillium chrysogenum transcriptional activator blar, a pathway specific regulator of beta-lactam biosynthesis, and uses therof
DE60142226D1 (de) 2000-03-14 2010-07-08 Novozymes As Pilz transkriptionsaktivator zur verwendung in verfahren zur herstellung von polypeptiden
CA2403842C (en) 2000-03-24 2012-09-25 Genencor International, Inc. Increased production of secreted proteins by recombinant eukaryotic cells
EP1409530A2 (en) 2000-09-19 2004-04-21 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
WO2003020922A2 (en) * 2001-08-28 2003-03-13 Stichting Voor De Technische Wetenschappen Enzymes involved in cell wall biosynthesis in filamentous fungi
JP2006516399A (ja) 2003-02-05 2006-07-06 デーエスエム アイピー アセッツ ベー． ヴェー． ポリペプチドを製造するためのシュウ酸欠損Ａｓｐｅｒｇｉｌｌｕｓｎｉｇｅｒ菌株の使用
EP1644542B1 (en) 2003-07-15 2011-11-02 Mintek Oxidative leach process
WO2005026356A1 (en) 2003-09-12 2005-03-24 Commonwealth Scientific And Industrial Research Organisation Modified gene-silencing nucleic acid molecules and uses thereof
EP3351637B1 (en) 2004-04-02 2020-06-10 DSM IP Assets B.V. Filamentous fungal mutants with improved homologous recombination efficiency
EP1776461A2 (en) 2004-04-16 2007-04-25 DSMIP Assets B.V. Fungal promoters for expressing a gene in a fungal cell
ES2274664B1 (es) * 2004-04-30 2008-04-01 Consejo Sup. Investig. Cientificas Levaduras bgs4delta autoliticas, procedimiento de obtencion y sus aplicaciones en procedimientos de expresion de proteinas.
WO2005123763A1 (en) 2004-06-16 2005-12-29 Dsm Ip Assets B.V. Production of polypeptides by improved secretion
CN101094919B (zh) 2004-10-12 2014-09-03 帝斯曼知识产权资产管理有限公司 在生产多肽的方法中有用的真菌转录活化因子
CA2583460A1 (en) 2004-10-15 2006-04-20 Dsm Ip Assets B.V. Homologous amds genes as selectable marker
US8129143B2 (en) 2004-10-15 2012-03-06 Dsm Ip Assets B.V. Method for production of a compound in a eukaryotic cell
US7888489B2 (en) 2005-01-24 2011-02-15 Dsm Ip Assets B.V. Method for producing a compound of interest in a filamentous fungal cell
JP2008531031A (ja) 2005-03-01 2008-08-14 ディーエスエム アイピー アセッツ ビー．ブイ． 真菌細胞中で遺伝子を発現させるためのアスペルギルス（Ａｓｐｅｒｇｉｌｌｕｓ）プロモーター
EP1954812B1 (en) 2005-11-29 2012-11-21 DSM IP Assets B.V. Dna binding site of a transcriptional activator useful in gene expression
WO2008000632A1 (en) 2006-06-29 2008-01-03 Dsm Ip Assets B.V. A method for achieving improved polypeptide expression
WO2008053019A2 (en) 2006-11-02 2008-05-08 Dsm Ip Assets B.V. Method for reducing the expression of a gene in a filamentous fungal cell
EA018840B1 (ru) 2007-02-15 2013-11-29 ДСМ АйПи АССЕТС Б.В. Рекомбинантная клетка-хозяин для получения соединения, представляющего интерес
US8637101B2 (en) 2008-02-29 2014-01-28 Dsm Ip Assets B.V. Lipases with high specificity towards short chain fatty acids and uses thereof
ES2334421B1 (es) * 2008-05-29 2011-02-28 Consejo Superior De Investigaciones Cientificas (Csic) Levaduras vinicas recombinantes.
CN102741421B (zh) 2009-03-10 2015-03-25 帝斯曼知识产权资产管理有限公司 用于提高多肽产率的方法
EP2421986A1 (en) 2009-04-22 2012-02-29 DSM IP Assets B.V. Process for the production of a recombinant polypeptide of interest
EP3293264A1 (en) 2009-07-22 2018-03-14 DSM IP Assets B.V. Improved host cell for the production of a compound of interest

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002653A1 (en) * 1994-07-20 1996-02-01 Novo Nordisk Biotech, Inc. Thermophilic fungal expression system
WO2012001169A1 (en) * 2010-07-01 2012-01-05 Dsm Ip Assets B.V. A method for the production of a compound of interest
CN102618606A (zh) * 2011-01-30 2012-08-01 浙江海正药业股份有限公司 一种棘白菌素生物转化方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88;Herman J Pel1等;《natrue biotechnology》;20070128;第25卷(第2期);第221-231页，尤其是第222页第1段，Supplementary Table7第135页An09g03070 *
Robbert A.Damveld等.Expression of agsA, one of Wve 1,3- -D-glucan synthase-encoding genes in Aspergillus niger, is induced in response to cell wall stress.《Fungal Genetics and Biology》.2005,第42卷第165-177页. *
Two α(1-3) Glucan Synthases with Different Functions in Aspergillus fumigatus;A. Beauvais等;《APPLIED AND ENVIRONMENTAL MICROBIOLOGY》;20050331;第71卷(第3期);第1531-1538页 *
α1,3 Glucans Are Dispensable in Aspergillus fumigatus;Christine Henry等;《Eukaryotic Cell》;20111104;第11卷(第1期);第26-29页，尤其是第26页摘要、右栏第2段-第27页左栏第2段， *
复合诱变黑曲霉选育β-葡萄糖苷酶高产菌株;李平等;《菌物系统》;20001231;第19卷(第1期);第117-121页 *

Also Published As

Publication number Publication date
US20150191705A1 (en) 2015-07-09
JP6468561B2 (ja) 2019-02-13
EA201500142A1 (ru) 2015-07-30
IN2014DN11163A (https=) 2015-10-02
CA2876287A1 (en) 2014-01-23
US10035986B2 (en) 2018-07-31
EP3327112A1 (en) 2018-05-30
JP2015522288A (ja) 2015-08-06
MX357482B (es) 2018-07-11
NZ702962A (en) 2018-02-23
EP3327112B1 (en) 2020-02-12
EP2875119B1 (en) 2017-12-20
CL2015000084A1 (es) 2015-05-04
EP2875119A1 (en) 2015-05-27
DK2875119T3 (en) 2018-04-03
CA2876287C (en) 2022-11-22
WO2014013074A1 (en) 2014-01-23
US20170175158A1 (en) 2017-06-22
DK3327112T3 (en) 2020-05-04
US10100344B2 (en) 2018-10-16
CN105308171A (zh) 2016-02-03
AU2013291936B2 (en) 2019-01-17
MX2015000840A (es) 2015-04-08
AU2013291936A1 (en) 2015-01-22

Similar Documents

Publication Publication Date Title
CN105308171B (zh) Agse缺陷菌株
US9745563B2 (en) Amylase-deficient strain
US8945898B2 (en) Recombinant host cell with deficiency in non-ribosomal peptide synthase production
US9322045B2 (en) Host cell for the production of a compound of interest
JP2021040649A (ja) 真菌株および使用方法
US20200063166A1 (en) Zinc binuclear cluster transcriptional regulator-deficient strain

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant