CN1052490C - 提高L－天冬氨酰基－L－苯丙氨酸偶合反应中α与β比例的方法 - Google Patents

提高L－天冬氨酰基－L－苯丙氨酸偶合反应中α与β比例的方法 Download PDF

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Publication number
CN1052490C
CN1052490C CN91101784A CN91101784A CN1052490C CN 1052490 C CN1052490 C CN 1052490C CN 91101784 A CN91101784 A CN 91101784A CN 91101784 A CN91101784 A CN 91101784A CN 1052490 C CN1052490 C CN 1052490C
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CN
China
Prior art keywords
phenylalanine
solvent
carboxylic acid
acetate
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN91101784A
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English (en)
Chinese (zh)
Other versions
CN1055539A (zh
Inventor
叶菲姆·格尔曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nutrasweet Co
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Nutrasweet Co
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Publication date
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Publication of CN1055539A publication Critical patent/CN1055539A/zh
Application granted granted Critical
Publication of CN1052490C publication Critical patent/CN1052490C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Arrangement And Mounting Of Devices That Control Transmission Of Motive Force (AREA)
  • Mechanical Operated Clutches (AREA)
  • Seasonings (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
CN91101784A 1990-03-12 1991-03-12 提高L－天冬氨酰基－L－苯丙氨酸偶合反应中α与β比例的方法 Expired - Fee Related CN1052490C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49252490A 1990-03-12 1990-03-12
US492,524 1990-03-12

Publications (2)

Publication Number Publication Date
CN1055539A CN1055539A (zh) 1991-10-23
CN1052490C true CN1052490C (zh) 2000-05-17

Family

ID=23956610

Family Applications (1)

Application Number Title Priority Date Filing Date
CN91101784A Expired - Fee Related CN1052490C (zh) 1990-03-12 1991-03-12 提高L－天冬氨酰基－L－苯丙氨酸偶合反应中α与β比例的方法

Country Status (21)

Country Link
EP (1) EP0471833B1 (enExample)
CN (1) CN1052490C (enExample)
AT (1) ATE123782T1 (enExample)
AU (1) AU650647B2 (enExample)
BG (1) BG61687B1 (enExample)
CA (1) CA2058932C (enExample)
CZ (1) CZ281204B6 (enExample)
DE (1) DE69110374T2 (enExample)
DK (1) DK0471833T3 (enExample)
ES (1) ES2073162T3 (enExample)
HR (1) HRP921061A2 (enExample)
HU (1) HU212897B (enExample)
IE (1) IE68315B1 (enExample)
NO (1) NO920158L (enExample)
PT (1) PT97021B (enExample)
RO (1) RO111571B1 (enExample)
SK (1) SK279939B6 (enExample)
TW (1) TW207991B (enExample)
WO (1) WO1991013860A1 (enExample)
YU (1) YU44291A (enExample)
ZA (1) ZA911810B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104628819B (zh) * 2014-10-23 2019-05-21 常茂生物化学工程股份有限公司 一种偶合反应生成阿斯巴甜的工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
FR2516077A1 (fr) * 1981-11-06 1983-05-13 Human Pharm Sa Laboratoires Procede de preparation de l'ester-methylique de l'a-aspartyl phenylalanine
IT8419324A0 (it) * 1984-01-26 1984-01-26 Pierrel Spa Procedimento per la sintesi di derivati n-acilici dell'aspartame.
JPH07636B2 (ja) * 1984-12-17 1995-01-11 三井東圧化学株式会社 Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
JPH085912B2 (ja) * 1986-09-04 1996-01-24 味の素株式会社 Ｎ−ホルミルアスパルチル−フエニルアラニンまたはそのメチルエステルの製造方法
US4946988A (en) * 1988-07-14 1990-08-07 The Nutrasweet Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride

Also Published As

Publication number Publication date
ATE123782T1 (de) 1995-06-15
DE69110374T2 (de) 1995-11-02
ZA911810B (en) 1992-01-29
HRP921061A2 (en) 1996-02-29
CA2058932C (en) 1998-08-25
DE69110374D1 (de) 1995-07-20
PT97021B (pt) 1998-07-31
RO111571B1 (ro) 1996-11-29
BG95616A (bg) 1993-12-24
HU913775D0 (en) 1992-04-28
EP0471833B1 (en) 1995-06-14
HU212897B (en) 1996-12-30
HUT61268A (en) 1992-12-28
AU650647B2 (en) 1994-06-30
AU7545291A (en) 1991-10-10
IE910826A1 (en) 1991-09-25
EP0471833A4 (en) 1993-06-16
CS9100639A2 (en) 1991-12-17
BG61687B1 (bg) 1998-03-31
DK0471833T3 (da) 1995-09-25
EP0471833A1 (en) 1992-02-26
TW207991B (enExample) 1993-06-21
YU44291A (sh) 1994-05-10
NO920158D0 (no) 1992-01-13
NO920158L (no) 1992-01-13
PT97021A (pt) 1991-10-31
SK279939B6 (sk) 1999-06-11
CZ281204B6 (cs) 1996-07-17
WO1991013860A1 (en) 1991-09-19
IE68315B1 (en) 1996-06-12
ES2073162T3 (es) 1995-08-01
CA2058932A1 (en) 1991-09-13
CN1055539A (zh) 1991-10-23

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C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
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C19 Lapse of patent right due to non-payment of the annual fee
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