CN105051535B - 用于测定化学状态的系统和方法 - Google Patents
用于测定化学状态的系统和方法 Download PDFInfo
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- CN105051535B CN105051535B CN201380065943.6A CN201380065943A CN105051535B CN 105051535 B CN105051535 B CN 105051535B CN 201380065943 A CN201380065943 A CN 201380065943A CN 105051535 B CN105051535 B CN 105051535B
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Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977848B (zh) | 2007-04-06 | 2016-08-24 | 加利福尼亚技术学院 | 微流体装置 |
| EP2932266A4 (en) | 2012-12-17 | 2016-11-30 | Leukodx Ltd | SYSTEMS AND METHOD FOR DETERMINING A CHEMICAL CONDITION |
| US20140170678A1 (en) | 2012-12-17 | 2014-06-19 | Leukodx Ltd. | Kits, compositions and methods for detecting a biological condition |
| US10610861B2 (en) | 2012-12-17 | 2020-04-07 | Accellix Ltd. | Systems, compositions and methods for detecting a biological condition |
| CN110327993B (zh) | 2014-06-17 | 2021-07-13 | 生命技术公司 | 测序装置 |
| CN110987528B (zh) | 2014-11-24 | 2022-06-07 | 沙特基础工业全球技术有限公司 | 光学分析和采样系统 |
| WO2016189522A1 (en) | 2015-05-28 | 2016-12-01 | Leukodx, Ltd. | System and apparatus for blind deconvolution of flow cytometer particle emission |
| US10634602B2 (en) | 2015-06-12 | 2020-04-28 | Cytochip Inc. | Fluidic cartridge for cytometry and additional analysis |
| US10022720B2 (en) | 2015-06-12 | 2018-07-17 | Cytochip Inc. | Fluidic units and cartridges for multi-analyte analysis |
| EP3349899A4 (en) * | 2015-09-14 | 2019-03-27 | Singulex, Inc. | SINGLE MOLECULE DETECTION ON A CHIP |
| CN105203775B (zh) * | 2015-10-26 | 2017-10-17 | 深圳华迈兴微医疗科技有限公司 | 一种降钙素原定量检测的磁微粒化学发光微流控芯片 |
| US10379047B2 (en) * | 2016-11-30 | 2019-08-13 | Scientific Industries, Inc. | Apparatus for detecting pH and dissolved oxygen |
| CN205301177U (zh) * | 2015-12-31 | 2016-06-08 | 深圳市贝沃德克生物技术研究院有限公司 | 家用肺炎支原体感染检测系统 |
| WO2017138670A1 (ko) | 2016-02-11 | 2017-08-17 | (주)타스컴 | 생체 측정 시스템 |
| BR112018072252B1 (pt) * | 2016-04-29 | 2023-04-25 | Baebies, Inc | Cartucho bioquímico para triagem de recém-nascidos |
| CN106093328B (zh) * | 2016-06-14 | 2017-12-15 | 四川大学 | 一种Pb2+微流控检测芯片及水样中Pb2+的可视化检测方法 |
| USD862725S1 (en) * | 2016-11-03 | 2019-10-08 | This Ag | Cassette for ophthalmologic apparatus |
| CN114047112B (zh) * | 2016-11-07 | 2024-10-25 | 芯易诊有限公司 | 样品分析装置 |
| US9833783B1 (en) | 2016-12-28 | 2017-12-05 | Neogen Corporation | Fluid retainer cartridge assembly and method for utilizing the same |
| USD834721S1 (en) * | 2017-03-03 | 2018-11-27 | Neogen Corporation | Assay cartridge |
| FI3612838T3 (fi) * | 2017-04-20 | 2024-10-07 | Hemosonics Llc | Kertakäyttöjärjestelmä hemostaattisen toiminnan analyysiin |
| CN107764881B (zh) * | 2017-11-27 | 2024-09-20 | 民康医疗科技(天津)有限公司 | 一种基于电化学方法的便携式血液检测试剂盒装置 |
| KR102070931B1 (ko) * | 2018-08-16 | 2020-01-29 | (주)옵토레인 | 면역진단 카트리지 |
| CA3118105A1 (en) | 2018-10-31 | 2020-05-07 | Daicel Corporation | Fluorescent diamond and method for producing same |
| FR3088430B1 (fr) * | 2018-11-09 | 2023-12-08 | Commissariat Energie Atomique | Dispositif microfluidique de preparation d'echantillons offrant une grande repetabilite |
| CN109557109B (zh) * | 2018-12-29 | 2021-07-30 | 中国肉类食品综合研究中心 | 冷冻肉品包装状态的检测方法及装置 |
| US20220299511A1 (en) * | 2019-06-17 | 2022-09-22 | The Broad Institute, Inc. | Immune cell signature for bacterial sepsis |
| US11327084B2 (en) * | 2019-09-19 | 2022-05-10 | Invidx Corp. | Joint hematology and biochemistry point-of-care testing system |
| JP7751577B2 (ja) | 2019-12-06 | 2025-10-08 | ジュノー セラピューティクス インコーポレイテッド | Gprc5d標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法 |
| CA3163897A1 (en) | 2019-12-06 | 2021-06-10 | Juno Therapeutics, Inc. | Anti-idiotypic antibodies to bcma-targeted binding domains and related compositions and methods |
| JP7649506B2 (ja) * | 2020-03-30 | 2025-03-21 | 学校法人順天堂 | 疾患鑑別支援方法、疾患鑑別支援装置、及び疾患鑑別支援コンピュータプログラム |
| CN111530515A (zh) * | 2020-05-08 | 2020-08-14 | 北京森美希克玛生物科技有限公司 | 一种微流控芯片 |
| KR20230095918A (ko) | 2020-08-05 | 2023-06-29 | 주노 쎄러퓨티크스 인코퍼레이티드 | Ror1-표적 결합 도메인에 대한 항이디오타입 항체 및 관련 조성물 및 방법 |
| CN116438455A (zh) * | 2020-10-07 | 2023-07-14 | 艾塞利克斯有限公司 | 用于确定生物学状况的系统及其盒 |
| WO2023113788A1 (en) * | 2021-12-15 | 2023-06-22 | Hewlett-Packard Development Company, L.P. | A microfluidic device to dispense a metabolic indicator |
| WO2023125942A1 (zh) * | 2021-12-31 | 2023-07-06 | 深圳迈瑞生物医疗电子股份有限公司 | 血液细胞分析仪、方法以及感染标志参数的用途 |
| EP4462126A4 (en) * | 2021-12-31 | 2025-07-23 | Shenzhen Mindray Biomedical Electronics Co Ltd | BLOOD CELL ANALYZER, METHOD AND USE OF AN INFECTION MARKER PARAMETER |
| CN114931986B (zh) * | 2022-04-08 | 2022-12-27 | 厦门宝太生物科技股份有限公司 | 一种核酸检测微流控装置及其核酸检测方法 |
| WO2025210522A1 (en) * | 2024-04-02 | 2025-10-09 | Microx Labs Inc. | Automated sample preparation system implemented within a disposable cartridge |
Family Cites Families (193)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL287532A (enExample) | 1962-01-23 | |||
| US4233029A (en) | 1978-10-25 | 1980-11-11 | Eastman Kodak Company | Liquid transport device and method |
| IT1123573B (it) | 1979-09-10 | 1986-04-30 | Anic Spa | Composizione adatta al controllo di tessuti e/o liquidi biiologici e metodo impiegante la stessa |
| US4400370A (en) | 1980-03-12 | 1983-08-23 | Lawrence Kass | Metachromatic dye sorption means for differential determination of leukocytes |
| US4444879A (en) | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| US4500509A (en) | 1981-03-11 | 1985-02-19 | Lawrence Kass | Metachromatic dye sorption and fluorescent light emmisive means for differential determination of developmental stages of neutrophilic granulocytic cells and other leukocytes |
| JPS5971141A (ja) | 1982-10-14 | 1984-04-21 | Mitsubishi Electric Corp | 光学的信号読出し装置 |
| JPS59100862A (ja) | 1982-12-01 | 1984-06-11 | Hitachi Ltd | 自動分析装置 |
| US4554257A (en) | 1983-04-29 | 1985-11-19 | Aladjem Frederick J | Assaying immunoreactive and like substances by measurement of aggregate classes |
| US4660971A (en) | 1984-05-03 | 1987-04-28 | Becton, Dickinson And Company | Optical features of flow cytometry apparatus |
| JPH0823558B2 (ja) | 1984-11-27 | 1996-03-06 | オ−ジエニクス リミテツド | 検定装置 |
| US4745285A (en) | 1986-08-21 | 1988-05-17 | Becton Dickinson And Company | Multi-color fluorescence analysis with single wavelength excitation |
| US4882284A (en) | 1987-04-13 | 1989-11-21 | Ortho Pharmaceutical Corporation | Method for quantitating and differentiating white blood cells |
| EP0353589B1 (en) | 1988-08-02 | 1996-02-07 | Abbott Laboratories | Apparatus and method for providing assay calibration data |
| WO1993005478A1 (en) | 1991-08-28 | 1993-03-18 | Becton, Dickinson & Company | Gravitational attractor engine for adaptively autoclustering n-dimensional data streams |
| US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
| US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
| US5408314A (en) | 1993-02-24 | 1995-04-18 | Perry; Jeffrey | Dark current subtraction with abbreviated reference cycles and recursive filtering |
| US5427663A (en) | 1993-06-08 | 1995-06-27 | British Technology Group Usa Inc. | Microlithographic array for macromolecule and cell fractionation |
| US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
| US5627041A (en) | 1994-09-02 | 1997-05-06 | Biometric Imaging, Inc. | Disposable cartridge for an assay of a biological sample |
| US20020186874A1 (en) | 1994-09-07 | 2002-12-12 | Jeffrey H. Price | Method and means for image segmentation in fluorescence scanning cytometry |
| WO1997000442A1 (en) | 1995-06-16 | 1997-01-03 | The University Of Washington | Microfabricated differential extraction device and method |
| US5716852A (en) | 1996-03-29 | 1998-02-10 | University Of Washington | Microfabricated diffusion-based chemical sensor |
| US6168948B1 (en) | 1995-06-29 | 2001-01-02 | Affymetrix, Inc. | Miniaturized genetic analysis systems and methods |
| JPH09189704A (ja) * | 1996-01-10 | 1997-07-22 | Hitachi Ltd | 自動化学分析装置 |
| US5747349A (en) | 1996-03-20 | 1998-05-05 | University Of Washington | Fluorescent reporter beads for fluid analysis |
| US6541213B1 (en) | 1996-03-29 | 2003-04-01 | University Of Washington | Microscale diffusion immunoassay |
| US20020090644A1 (en) | 1999-05-21 | 2002-07-11 | Weigl Bernhard H. | Microscale diffusion immunoassay |
| US6586193B2 (en) | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
| US6184978B1 (en) | 1996-05-15 | 2001-02-06 | International Remote Imaging Systems, Inc. | Method and apparatus for verifying uniform flow of a fluid sample through a flow cell and distribution on a slide |
| JP2000512744A (ja) | 1996-05-16 | 2000-09-26 | アフィメトリックス,インコーポレイテッド | 標識材料を検出するシステムおよび方法 |
| US5726404A (en) * | 1996-05-31 | 1998-03-10 | University Of Washington | Valveless liquid microswitch |
| US5998759A (en) * | 1996-12-24 | 1999-12-07 | General Scanning, Inc. | Laser processing |
| DE19802367C1 (de) | 1997-02-19 | 1999-09-23 | Hahn Schickard Ges | Mikrodosiervorrichtungsarray und Verfahren zum Betreiben desselben |
| US20030103981A1 (en) | 1997-02-27 | 2003-06-05 | Incyte Genomics, Inc. | Methods of use of a prostate-associated protease in the diagnosis and treatment of prostate cancer |
| US6426230B1 (en) | 1997-08-01 | 2002-07-30 | Qualigen, Inc. | Disposable diagnostic device and method |
| US6540895B1 (en) | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
| CA2320296A1 (en) * | 1998-05-18 | 1999-11-25 | University Of Washington | Liquid analysis cartridge |
| GB9816088D0 (en) | 1998-07-23 | 1998-09-23 | Axis Biochemicals Asa | System |
| US20010008760A1 (en) * | 1998-08-25 | 2001-07-19 | Chester F. King | Reagent system and kit for detecting hiv infected cells |
| US6637463B1 (en) | 1998-10-13 | 2003-10-28 | Biomicro Systems, Inc. | Multi-channel microfluidic system design with balanced fluid flow distribution |
| US6136610A (en) * | 1998-11-23 | 2000-10-24 | Praxsys Biosystems, Inc. | Method and apparatus for performing a lateral flow assay |
| US20040053290A1 (en) | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
| AU4701200A (en) | 1999-05-07 | 2000-11-21 | Quantum Dot Corporation | A method of detecting an analyte using semiconductor nanocrystals |
| EP1192447A2 (en) | 1999-05-12 | 2002-04-03 | Aclara BioSciences, Inc. | Multiplexed fluorescent detection in microfluidic devices |
| US6635163B1 (en) | 1999-06-01 | 2003-10-21 | Cornell Research Foundation, Inc. | Entropic trapping and sieving of molecules |
| US6524456B1 (en) | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
| US6696022B1 (en) | 1999-08-13 | 2004-02-24 | U.S. Genomics, Inc. | Methods and apparatuses for stretching polymers |
| US7217573B1 (en) | 1999-10-05 | 2007-05-15 | Hitachi, Ltd. | Method of inspecting a DNA chip |
| US7024316B1 (en) | 1999-10-21 | 2006-04-04 | Dakocytomation Colorado, Inc. | Transiently dynamic flow cytometer analysis system |
| JP4733331B2 (ja) | 2000-03-14 | 2011-07-27 | マイクロニックス、インコーポレーテッド | マイクロ流動体分析用デバイス |
| US7058658B2 (en) | 2000-03-28 | 2006-06-06 | Dana-Farber Cancer Institute, Inc. | Molecular database for antibody characterization |
| EP1285106A2 (en) * | 2000-03-31 | 2003-02-26 | Micronics, Inc. | Protein crystallization in microfluidic structures |
| CN1214340C (zh) | 2000-04-24 | 2005-08-10 | 国际遥距成象系统公司 | 多个神经网络的成像设备和方法 |
| US7236623B2 (en) | 2000-04-24 | 2007-06-26 | International Remote Imaging Systems, Inc. | Analyte recognition for urinalysis diagnostic system |
| WO2001088195A1 (en) | 2000-05-12 | 2001-11-22 | Caliper Technologies Corp. | Detection of nucleic acid hybridization by fluorescence polarization |
| US20060263888A1 (en) | 2000-06-02 | 2006-11-23 | Honeywell International Inc. | Differential white blood count on a disposable card |
| US7471394B2 (en) * | 2000-08-02 | 2008-12-30 | Honeywell International Inc. | Optical detection system with polarizing beamsplitter |
| US8071051B2 (en) * | 2004-05-14 | 2011-12-06 | Honeywell International Inc. | Portable sample analyzer cartridge |
| US7641856B2 (en) | 2004-05-14 | 2010-01-05 | Honeywell International Inc. | Portable sample analyzer with removable cartridge |
| US7630063B2 (en) * | 2000-08-02 | 2009-12-08 | Honeywell International Inc. | Miniaturized cytometer for detecting multiple species in a sample |
| US8329118B2 (en) | 2004-09-02 | 2012-12-11 | Honeywell International Inc. | Method and apparatus for determining one or more operating parameters for a microfluidic circuit |
| US7277166B2 (en) | 2000-08-02 | 2007-10-02 | Honeywell International Inc. | Cytometer analysis cartridge optical configuration |
| US6382228B1 (en) | 2000-08-02 | 2002-05-07 | Honeywell International Inc. | Fluid driving system for flow cytometry |
| US6875973B2 (en) | 2000-08-25 | 2005-04-05 | Amnis Corporation | Auto focus for a flow imaging system |
| US6372516B1 (en) * | 2000-09-07 | 2002-04-16 | Sun Biomedical Laboratories, Inc. | Lateral flow test device |
| US6674058B1 (en) | 2000-09-20 | 2004-01-06 | Compucyte Corporation | Apparatus and method for focusing a laser scanning cytometer |
| AU2002230524A1 (en) | 2000-11-16 | 2002-05-27 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
| US6734963B2 (en) | 2001-01-22 | 2004-05-11 | Unisearch Associates Inc. | Development of a compact Raman spectrometer for detecting product interfaces in a flow path |
| US7223363B2 (en) * | 2001-03-09 | 2007-05-29 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
| WO2002073200A1 (en) | 2001-03-12 | 2002-09-19 | Cellomics, Inc. | Methods to increase the capacity of high content cell-based screening assays |
| WO2002081934A2 (en) | 2001-04-03 | 2002-10-17 | Micronics, Inc. | Pneumatic valve interface for use in microfluidic structures |
| CA2446207A1 (en) | 2001-05-04 | 2002-11-14 | Health Research, Inc. | A high throughput assay for identification of gene expression modifiers |
| US7344507B2 (en) | 2002-04-19 | 2008-03-18 | Pelikan Technologies, Inc. | Method and apparatus for lancet actuation |
| AU2002318269A1 (en) | 2001-07-18 | 2003-03-03 | The Regents Of The University Of Michigan | Gas-focusing flow cytometer cell and flow cytometer detection system with waveguide optics |
| WO2003014711A1 (en) | 2001-08-07 | 2003-02-20 | Mitsubishi Chemical Corporation | Surface plasmon resonance sensor chip, and sample analysis method and analysis apparatus using the same |
| US6636623B2 (en) | 2001-08-10 | 2003-10-21 | Visiongate, Inc. | Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease |
| US20030073089A1 (en) * | 2001-10-16 | 2003-04-17 | Mauze Ganapati R. | Companion cartridge for disposable diagnostic sensing platforms |
| US7247274B1 (en) | 2001-11-13 | 2007-07-24 | Caliper Technologies Corp. | Prevention of precipitate blockage in microfluidic channels |
| US20030166264A1 (en) | 2001-12-04 | 2003-09-04 | Dave Smith | Drug and alcohol assay assembly |
| US7192560B2 (en) | 2001-12-20 | 2007-03-20 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using anion exchange |
| US7347976B2 (en) | 2001-12-20 | 2008-03-25 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix |
| US7419821B2 (en) * | 2002-03-05 | 2008-09-02 | I-Stat Corporation | Apparatus and methods for analyte measurement and immunoassay |
| IL148664A0 (en) | 2002-03-13 | 2002-09-12 | Yeda Res & Dev | Auto-focusing method and device |
| US7223371B2 (en) | 2002-03-14 | 2007-05-29 | Micronics, Inc. | Microfluidic channel network device |
| US7465555B2 (en) | 2002-04-02 | 2008-12-16 | Becton, Dickinson And Company | Early detection of sepsis |
| US6843263B2 (en) * | 2002-06-24 | 2005-01-18 | Industrial Technology Research Institute | Partially closed microfluidic system and microfluidic driving method |
| EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
| CN1739071B (zh) | 2002-11-18 | 2010-12-08 | 国际遥距成象系统公司 | 多层次控制器系统 |
| GB0227765D0 (en) | 2002-11-28 | 2003-01-08 | Secr Defence | Apparatus for processing a fluid sample |
| US6897954B2 (en) | 2002-12-20 | 2005-05-24 | Becton, Dickinson And Company | Instrument setup system for a fluorescence analyzer |
| US20050221281A1 (en) * | 2003-01-08 | 2005-10-06 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
| US7419638B2 (en) | 2003-01-14 | 2008-09-02 | Micronics, Inc. | Microfluidic devices for fluid manipulation and analysis |
| EP1603674B1 (en) | 2003-02-05 | 2016-01-06 | Iquum, Inc. | Sample processing |
| US20040191783A1 (en) | 2003-03-31 | 2004-09-30 | Guy Leclercq | Low density micro-array analysis in human breast cancer |
| JP2004309145A (ja) * | 2003-04-02 | 2004-11-04 | Hitachi High-Technologies Corp | 化学分析装置及び化学分析用構造体 |
| US20040248205A1 (en) * | 2003-04-16 | 2004-12-09 | Stern Lawrence J. | Major histocompatibility complex (MHC)-peptide arrays |
| DE10336849A1 (de) | 2003-08-11 | 2005-03-10 | Thinxxs Gmbh | Flusszelle |
| US20050069958A1 (en) | 2003-09-26 | 2005-03-31 | Mills Rhonda A. | Method for simultaneous evaluation of a sample containing a cellular target and a soluble analyte |
| EP1689288B1 (en) | 2003-11-06 | 2010-04-21 | Grace Laboratories, Inc. | Immunosorbent blood tests for assessing paroxysmal cerebral discharges |
| US7099778B2 (en) | 2003-12-30 | 2006-08-29 | Caliper Life Sciences, Inc. | Method for determining diffusivity and molecular weight in a microfluidic device |
| WO2005070291A1 (en) | 2004-01-08 | 2005-08-04 | Inlight Solutions, Inc. | Noninvasive determination of alcohol in tissue |
| KR100634498B1 (ko) | 2004-01-12 | 2006-10-13 | 삼성전자주식회사 | 체내성분 측정장치 및 방법 |
| US7473529B1 (en) * | 2004-03-31 | 2009-01-06 | Iowa State University Research Foundation, Inc. | System and method for detecting cells or components thereof |
| WO2005098379A1 (en) | 2004-04-08 | 2005-10-20 | Purdue Research Foundation | Multi-spectral detector and analysis system |
| US8852862B2 (en) * | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US7511285B2 (en) | 2004-07-16 | 2009-03-31 | The Charles Stark Draper Laboratory, Inc. | Methods and apparatus for biomolecule identification |
| US8097225B2 (en) | 2004-07-28 | 2012-01-17 | Honeywell International Inc. | Microfluidic cartridge with reservoirs for increased shelf life of installed reagents |
| US7704730B2 (en) | 2004-10-14 | 2010-04-27 | Meso Scale Technologies, Llc | Multiplexed assay methods |
| EP1836557A4 (en) | 2004-11-19 | 2009-01-21 | Trillium Diagnostics Llc | SOFTWARE-INTEGRATED FLOW CYTOMETRY TEST FOR QUANTITATING THE HUMAN POLYMORPH-ACID LEUKOCYTIC FC RI RECEPTOR (CD64) |
| CN101099082B (zh) | 2004-12-03 | 2013-03-27 | 塞通诺米/St有限责任公司 | 用于粒子处理的整体式盒 |
| US20060205012A1 (en) | 2004-12-09 | 2006-09-14 | Meso Scale Technologies, Llc | Diagnostic test |
| WO2006076567A2 (en) | 2005-01-13 | 2006-07-20 | Micronics, Inc. | Microfluidic rare cell detection device |
| EP1710579B1 (en) * | 2005-03-30 | 2014-07-30 | Sysmex Corporation | Method and apparatus for counting megakaryocytes |
| JP4927817B2 (ja) | 2005-04-14 | 2012-05-09 | ギロス・パテント・エービー | 多数の弁を備えるマイクロ流体装置 |
| US20070015179A1 (en) | 2005-04-26 | 2007-01-18 | Trustees Of Boston University | Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples |
| US8841076B2 (en) * | 2005-05-09 | 2014-09-23 | Theranos, Inc. | Systems and methods for conducting animal studies |
| US20070059685A1 (en) * | 2005-06-03 | 2007-03-15 | Kohne David E | Method for producing improved results for applications which directly or indirectly utilize gene expression assay results |
| US7618590B2 (en) * | 2005-06-29 | 2009-11-17 | Cascade Microtech, Inc. | Fluid dispensing system |
| JP4995197B2 (ja) | 2005-07-01 | 2012-08-08 | ハネウェル・インターナショナル・インコーポレーテッド | 3d流体力学的集束を有する成形カートリッジ |
| WO2007005973A2 (en) | 2005-07-01 | 2007-01-11 | Honeywell International, Inc. | A microfluidic card for rbc analysis |
| CN1715916B (zh) * | 2005-07-21 | 2011-04-20 | 中国科学院光电技术研究所 | 一种用于生化分子检测的微纳生化传感芯片 |
| JP2007121275A (ja) * | 2005-09-27 | 2007-05-17 | Fujifilm Corp | マイクロチップ、このマイクロチップを用いた液体の混合方法及び血液検査方法 |
| US20070098594A1 (en) | 2005-11-03 | 2007-05-03 | Roche Molecular Systems, Inc. | Analytical multi-spectral optical detection system |
| US9056291B2 (en) * | 2005-11-30 | 2015-06-16 | Micronics, Inc. | Microfluidic reactor system |
| US7763453B2 (en) * | 2005-11-30 | 2010-07-27 | Micronics, Inc. | Microfluidic mixing and analytic apparatus |
| CN101389947B (zh) * | 2005-12-29 | 2013-08-21 | 霍尼韦尔国际公司 | 微流格式的测定工具 |
| US7995202B2 (en) | 2006-02-13 | 2011-08-09 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
| WO2007106580A2 (en) * | 2006-03-15 | 2007-09-20 | Micronics, Inc. | Rapid magnetic flow assays |
| ES2692380T3 (es) | 2006-03-24 | 2018-12-03 | Handylab, Inc. | Método para realizar PCR con un cartucho con varias pistas |
| US7470403B2 (en) | 2006-04-26 | 2008-12-30 | Wisconsin Alumni Research Foundation | Microfluidic platform and method of generating a gradient therein |
| US20080176253A1 (en) | 2006-05-10 | 2008-07-24 | The Board Of Regents Of The University Of Texas System | Detecting human or animal immunoglobin-e |
| US8007999B2 (en) | 2006-05-10 | 2011-08-30 | Theranos, Inc. | Real-time detection of influenza virus |
| EP2487248A1 (en) * | 2006-05-10 | 2012-08-15 | The Board of Regents of the University of Texas System | Detecting tumor biomarker in oral cancer |
| JP4771864B2 (ja) | 2006-05-31 | 2011-09-14 | ローム株式会社 | 生化学分析装置 |
| EP2038655A2 (en) | 2006-06-02 | 2009-03-25 | Luminex Corporation | Systems and methods for performing measurements of one or more materials |
| EP2041573B1 (en) * | 2006-06-23 | 2019-09-04 | PerkinElmer Health Sciences, Inc. | Methods and devices for microfluidic point-of-care immunoassays |
| WO2008030666A2 (en) | 2006-07-25 | 2008-03-13 | The Board Of Trustees Of The University Of Illinois | Multispectral plasmonic crystal sensors |
| JP2008066696A (ja) | 2006-08-10 | 2008-03-21 | Denso Corp | 半導体製造装置および半導体製造方法 |
| WO2008140568A2 (en) | 2006-11-15 | 2008-11-20 | Idaho Technology, Inc. | High density self-contained biological analysis |
| US20100093019A1 (en) | 2007-01-12 | 2010-04-15 | Environmental Biotechnology Crc Pty Limited | Sample handling device |
| ES2534579T3 (es) | 2007-02-23 | 2015-04-24 | Lonza Cologne Gmbh | Dispositivo y procedimiento para estabilizar el flujo a través de una cámara |
| US8722327B2 (en) | 2007-03-28 | 2014-05-13 | Bionano Genomics, Inc. | Methods of macromolecular analysis using nanochannel arrays |
| US8425861B2 (en) | 2007-04-04 | 2013-04-23 | Netbio, Inc. | Methods for rapid multiplexed amplification of target nucleic acids |
| CN103977848B (zh) | 2007-04-06 | 2016-08-24 | 加利福尼亚技术学院 | 微流体装置 |
| EP2167537A2 (en) | 2007-07-03 | 2010-03-31 | Dako Denmark A/S | Compiled methods for analysing and sorting samples |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| CN105543084B (zh) | 2007-07-23 | 2019-09-06 | 美艾利尔技术公司 | 分析系统 |
| WO2009114532A2 (en) | 2008-03-10 | 2009-09-17 | National Jewish Health | Markers for diagnosis of pulmonary inflammation and methods related thereto |
| EP2128617A1 (en) | 2008-05-27 | 2009-12-02 | Koninklijke Philips Electronics N.V. | Device and methods for detecting analytes in saliva |
| US8697007B2 (en) | 2008-08-06 | 2014-04-15 | The Trustees Of The University Of Pennsylvania | Biodetection cassette with automated actuator |
| US8158082B2 (en) * | 2008-08-29 | 2012-04-17 | Incube Labs, Llc | Micro-fluidic device |
| US8247191B2 (en) * | 2008-11-13 | 2012-08-21 | Ritzen Kalle | Disposable cassette and method of use for blood analysis on blood analyzer |
| US8672532B2 (en) * | 2008-12-31 | 2014-03-18 | Integenx Inc. | Microfluidic methods |
| EP2440672B1 (en) * | 2009-06-12 | 2016-03-30 | Micronics, Inc. | Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices |
| DE102009032744A1 (de) | 2009-07-11 | 2011-01-13 | Thinxxs Microtechnology Ag | Fluidspeicher |
| US20120329878A1 (en) | 2009-07-20 | 2012-12-27 | University College Dublin | Phenotyping tumor-infiltrating leukocytes |
| US20120164036A1 (en) | 2009-07-21 | 2012-06-28 | Seth Stern | Microfluidic devices and uses thereof |
| WO2011042422A1 (de) | 2009-10-05 | 2011-04-14 | Boehringer Ingelheim Microparts Gmbh | Fügeverfahren und fügeverbindung für mikrofluidische bauteile |
| KR101472581B1 (ko) | 2009-10-21 | 2014-12-16 | 비오까르띠 엔브이 | 평행한 공압 계면판을 갖춘 마이크로 유체 카트리지 |
| US20110094577A1 (en) | 2009-10-28 | 2011-04-28 | Dilip Kumar Chatterjee | Conductive metal oxide films and photovoltaic devices |
| GB0919159D0 (en) | 2009-11-02 | 2009-12-16 | Sec Dep For Environment Food A | Device and apparatus |
| EP3514519B1 (en) | 2009-12-07 | 2022-02-09 | Meso Scale Technologies, LLC. | Assay cartridges |
| CN102740976B (zh) * | 2010-01-29 | 2016-04-20 | 精密公司 | 取样-应答微流体盒 |
| EP2558870B1 (en) | 2010-04-15 | 2017-06-07 | Leukodx Ltd | System and method for rapid determination of a medical condition |
| DE102011015184B4 (de) | 2010-06-02 | 2013-11-21 | Thinxxs Microtechnology Ag | Vorrichtung für den Transport kleiner Volumina eines Fluids, insbesondere Mikropumpe oder Mikroventil |
| CA2802531C (en) | 2010-07-21 | 2017-02-14 | F. Hoffmann-La Roche Ag | Increase of usable dynamic range in photometry |
| US20130323737A1 (en) | 2010-08-10 | 2013-12-05 | Bioaccel | Method and system for analyzing a sample |
| WO2012037369A1 (en) * | 2010-09-15 | 2012-03-22 | Mbio Diagnostics, Inc. | System and method for detecting multiple molecules in one assay |
| EP2615445B1 (en) | 2010-10-13 | 2014-05-21 | Olympus Corporation | Method of measuring a diffusion characteristic value of a particle |
| US20120225475A1 (en) * | 2010-11-16 | 2012-09-06 | 1087 Systems, Inc. | Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells |
| EP3290534B1 (en) | 2010-11-22 | 2023-10-25 | Barrick Gold Corporation | Alkaline and acid pressure oxidation of precious metal-containing materials |
| JP5727218B2 (ja) * | 2010-12-24 | 2015-06-03 | 積水化学工業株式会社 | マイクロ流体デバイス、微生物夾雑物検出システム、並びに、微生物夾雑物の検出方法 |
| WO2012092010A1 (en) * | 2010-12-29 | 2012-07-05 | Abbott Point Of Care Inc. | Multi-fluidic cartridges for sample analysis and methods for using same |
| EP2661485A4 (en) | 2011-01-06 | 2018-11-21 | Meso Scale Technologies, LLC | Assay cartridges and methods of using the same |
| KR101779611B1 (ko) | 2011-01-20 | 2017-09-18 | 엘지전자 주식회사 | 표적 항원 검출용 카트리지 및 이를 이용한 표적 항원의 검출 방법 |
| JP6116490B2 (ja) * | 2011-03-09 | 2017-04-19 | ピクセル メディカル テクノロジーズ リミテッド | 分析対象の細胞を含む試料流体の調製に用いる使い捨てカートリッジ |
| KR101799518B1 (ko) | 2011-05-03 | 2017-11-21 | 삼성전자 주식회사 | 형광 검출 광학계 및 이를 포함하는 다채널 형광 검출 장치 |
| EP2718721A4 (en) * | 2011-06-07 | 2014-10-01 | Caris Life Sciences Luxembourg Holdings S A R L | CIRCULATING BIOMARKERS FOR CANCER |
| EP2743682B1 (en) * | 2011-08-11 | 2017-05-31 | Olympus Corporation | Method for detecting target particles |
| JP5772425B2 (ja) | 2011-09-13 | 2015-09-02 | ソニー株式会社 | 微小粒子測定装置 |
| US8894946B2 (en) | 2011-10-21 | 2014-11-25 | Integenx Inc. | Sample preparation, processing and analysis systems |
| US20130137135A1 (en) | 2011-11-28 | 2013-05-30 | California Institute Of Technology | Compositions and methods for leukocyte differential counting |
| US20130177543A1 (en) | 2011-12-20 | 2013-07-11 | Creative Medical Health Inc. | Natural Means of Augmenting Endogenous Stem Cell Numbers |
| JP5870851B2 (ja) | 2012-05-29 | 2016-03-01 | ソニー株式会社 | 情報処理装置、情報処理方法、及びプログラム |
| US9513224B2 (en) | 2013-02-18 | 2016-12-06 | Theranos, Inc. | Image analysis and measurement of biological samples |
| JP1628116S (enExample) | 2012-10-24 | 2019-04-01 | ||
| US20150338401A1 (en) | 2012-11-16 | 2015-11-26 | Ayal Ram | Multiplexed bioassay techniques |
| US20140170678A1 (en) | 2012-12-17 | 2014-06-19 | Leukodx Ltd. | Kits, compositions and methods for detecting a biological condition |
| EP2932266A4 (en) | 2012-12-17 | 2016-11-30 | Leukodx Ltd | SYSTEMS AND METHOD FOR DETERMINING A CHEMICAL CONDITION |
| US10060937B2 (en) | 2013-06-28 | 2018-08-28 | William Marsh Rice University | Integrated instrumentation for the analysis of biofluids at the point-of-care |
| JP5989251B2 (ja) | 2013-09-12 | 2016-09-07 | 三菱電機株式会社 | 操作入力装置及び方法、並びにプログラム及び記録媒体 |
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| JP6871958B2 (ja) | 2021-05-19 |
| JP2018136318A (ja) | 2018-08-30 |
| JP2016509202A (ja) | 2016-03-24 |
| US20180299443A1 (en) | 2018-10-18 |
| EP3508848A1 (en) | 2019-07-10 |
| JP6493897B2 (ja) | 2019-04-03 |
| EP2932266A1 (en) | 2015-10-21 |
| US20200386756A1 (en) | 2020-12-10 |
| CN105051535A (zh) | 2015-11-11 |
| WO2014097287A8 (en) | 2015-07-02 |
| CN107941706A (zh) | 2018-04-20 |
| EP2932266A4 (en) | 2016-11-30 |
| JP2016506519A (ja) | 2016-03-03 |
| US20170370914A1 (en) | 2017-12-28 |
| WO2014097287A1 (en) | 2014-06-26 |
| EP3462172A1 (en) | 2019-04-03 |
| EP2932268A4 (en) | 2016-10-19 |
| JP6298474B2 (ja) | 2018-03-20 |
| WO2014097286A1 (en) | 2014-06-26 |
| JP2019109249A (ja) | 2019-07-04 |
| CN105051538B (zh) | 2018-06-15 |
| WO2014097286A8 (en) | 2015-07-02 |
| JP6349327B2 (ja) | 2018-06-27 |
| US10761094B2 (en) | 2020-09-01 |
| EP3462172B1 (en) | 2023-09-06 |
| EP2932268A1 (en) | 2015-10-21 |
| CN105051538A (zh) | 2015-11-11 |
| EP3508848B1 (en) | 2022-10-05 |
| US11703506B2 (en) | 2023-07-18 |
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