JP6349327B2 - 化学的状態を判定するためのシステムおよび方法 - Google Patents

化学的状態を判定するためのシステムおよび方法 Download PDF

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JP6349327B2
JP6349327B2 JP2015548882A JP2015548882A JP6349327B2 JP 6349327 B2 JP6349327 B2 JP 6349327B2 JP 2015548882 A JP2015548882 A JP 2015548882A JP 2015548882 A JP2015548882 A JP 2015548882A JP 6349327 B2 JP6349327 B2 JP 6349327B2
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present
composition
cartridge
chamber
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JP2016506519A5 (enExample
JP2016506519A (ja
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カスダン,ハービー,リー
メイッソンニエル,ジュリエン
ズタ,ヨアブ
ロゼン,ミチャ
ヒンメル,ヤエル
ブロダー,イェホシュア
デイビス,ブルース
ゴールドマン,ブルース
ギロン,ボアズ
ボテサザン,ジオン
ブラスバーグ,エリエツァー
センメル,イラン
アスチケナシー,ジャックエス
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レウコドゥックス,リミテッド
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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103977848B (zh) 2007-04-06 2016-08-24 加利福尼亚技术学院 微流体装置
EP2932266A4 (en) 2012-12-17 2016-11-30 Leukodx Ltd SYSTEMS AND METHOD FOR DETERMINING A CHEMICAL CONDITION
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
CN110327993B (zh) 2014-06-17 2021-07-13 生命技术公司 测序装置
CN110987528B (zh) 2014-11-24 2022-06-07 沙特基础工业全球技术有限公司 光学分析和采样系统
WO2016189522A1 (en) 2015-05-28 2016-12-01 Leukodx, Ltd. System and apparatus for blind deconvolution of flow cytometer particle emission
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
US10022720B2 (en) 2015-06-12 2018-07-17 Cytochip Inc. Fluidic units and cartridges for multi-analyte analysis
EP3349899A4 (en) * 2015-09-14 2019-03-27 Singulex, Inc. SINGLE MOLECULE DETECTION ON A CHIP
CN105203775B (zh) * 2015-10-26 2017-10-17 深圳华迈兴微医疗科技有限公司 一种降钙素原定量检测的磁微粒化学发光微流控芯片
US10379047B2 (en) * 2016-11-30 2019-08-13 Scientific Industries, Inc. Apparatus for detecting pH and dissolved oxygen
CN205301177U (zh) * 2015-12-31 2016-06-08 深圳市贝沃德克生物技术研究院有限公司 家用肺炎支原体感染检测系统
WO2017138670A1 (ko) 2016-02-11 2017-08-17 (주)타스컴 생체 측정 시스템
BR112018072252B1 (pt) * 2016-04-29 2023-04-25 Baebies, Inc Cartucho bioquímico para triagem de recém-nascidos
CN106093328B (zh) * 2016-06-14 2017-12-15 四川大学 一种Pb2+微流控检测芯片及水样中Pb2+的可视化检测方法
USD862725S1 (en) * 2016-11-03 2019-10-08 This Ag Cassette for ophthalmologic apparatus
CN114047112B (zh) * 2016-11-07 2024-10-25 芯易诊有限公司 样品分析装置
US9833783B1 (en) 2016-12-28 2017-12-05 Neogen Corporation Fluid retainer cartridge assembly and method for utilizing the same
USD834721S1 (en) * 2017-03-03 2018-11-27 Neogen Corporation Assay cartridge
FI3612838T3 (fi) * 2017-04-20 2024-10-07 Hemosonics Llc Kertakäyttöjärjestelmä hemostaattisen toiminnan analyysiin
CN107764881B (zh) * 2017-11-27 2024-09-20 民康医疗科技(天津)有限公司 一种基于电化学方法的便携式血液检测试剂盒装置
KR102070931B1 (ko) * 2018-08-16 2020-01-29 (주)옵토레인 면역진단 카트리지
CA3118105A1 (en) 2018-10-31 2020-05-07 Daicel Corporation Fluorescent diamond and method for producing same
FR3088430B1 (fr) * 2018-11-09 2023-12-08 Commissariat Energie Atomique Dispositif microfluidique de preparation d'echantillons offrant une grande repetabilite
CN109557109B (zh) * 2018-12-29 2021-07-30 中国肉类食品综合研究中心 冷冻肉品包装状态的检测方法及装置
US20220299511A1 (en) * 2019-06-17 2022-09-22 The Broad Institute, Inc. Immune cell signature for bacterial sepsis
US11327084B2 (en) * 2019-09-19 2022-05-10 Invidx Corp. Joint hematology and biochemistry point-of-care testing system
JP7751577B2 (ja) 2019-12-06 2025-10-08 ジュノー セラピューティクス インコーポレイテッド Gprc5d標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法
CA3163897A1 (en) 2019-12-06 2021-06-10 Juno Therapeutics, Inc. Anti-idiotypic antibodies to bcma-targeted binding domains and related compositions and methods
JP7649506B2 (ja) * 2020-03-30 2025-03-21 学校法人順天堂 疾患鑑別支援方法、疾患鑑別支援装置、及び疾患鑑別支援コンピュータプログラム
CN111530515A (zh) * 2020-05-08 2020-08-14 北京森美希克玛生物科技有限公司 一种微流控芯片
KR20230095918A (ko) 2020-08-05 2023-06-29 주노 쎄러퓨티크스 인코퍼레이티드 Ror1-표적 결합 도메인에 대한 항이디오타입 항체 및 관련 조성물 및 방법
CN116438455A (zh) * 2020-10-07 2023-07-14 艾塞利克斯有限公司 用于确定生物学状况的系统及其盒
WO2023113788A1 (en) * 2021-12-15 2023-06-22 Hewlett-Packard Development Company, L.P. A microfluidic device to dispense a metabolic indicator
WO2023125942A1 (zh) * 2021-12-31 2023-07-06 深圳迈瑞生物医疗电子股份有限公司 血液细胞分析仪、方法以及感染标志参数的用途
EP4462126A4 (en) * 2021-12-31 2025-07-23 Shenzhen Mindray Biomedical Electronics Co Ltd BLOOD CELL ANALYZER, METHOD AND USE OF AN INFECTION MARKER PARAMETER
CN114931986B (zh) * 2022-04-08 2022-12-27 厦门宝太生物科技股份有限公司 一种核酸检测微流控装置及其核酸检测方法
WO2025210522A1 (en) * 2024-04-02 2025-10-09 Microx Labs Inc. Automated sample preparation system implemented within a disposable cartridge

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL287532A (enExample) 1962-01-23
US4233029A (en) 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
IT1123573B (it) 1979-09-10 1986-04-30 Anic Spa Composizione adatta al controllo di tessuti e/o liquidi biiologici e metodo impiegante la stessa
US4400370A (en) 1980-03-12 1983-08-23 Lawrence Kass Metachromatic dye sorption means for differential determination of leukocytes
US4444879A (en) 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US4500509A (en) 1981-03-11 1985-02-19 Lawrence Kass Metachromatic dye sorption and fluorescent light emmisive means for differential determination of developmental stages of neutrophilic granulocytic cells and other leukocytes
JPS5971141A (ja) 1982-10-14 1984-04-21 Mitsubishi Electric Corp 光学的信号読出し装置
JPS59100862A (ja) 1982-12-01 1984-06-11 Hitachi Ltd 自動分析装置
US4554257A (en) 1983-04-29 1985-11-19 Aladjem Frederick J Assaying immunoreactive and like substances by measurement of aggregate classes
US4660971A (en) 1984-05-03 1987-04-28 Becton, Dickinson And Company Optical features of flow cytometry apparatus
JPH0823558B2 (ja) 1984-11-27 1996-03-06 オ−ジエニクス リミテツド 検定装置
US4745285A (en) 1986-08-21 1988-05-17 Becton Dickinson And Company Multi-color fluorescence analysis with single wavelength excitation
US4882284A (en) 1987-04-13 1989-11-21 Ortho Pharmaceutical Corporation Method for quantitating and differentiating white blood cells
EP0353589B1 (en) 1988-08-02 1996-02-07 Abbott Laboratories Apparatus and method for providing assay calibration data
WO1993005478A1 (en) 1991-08-28 1993-03-18 Becton, Dickinson & Company Gravitational attractor engine for adaptively autoclustering n-dimensional data streams
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5408314A (en) 1993-02-24 1995-04-18 Perry; Jeffrey Dark current subtraction with abbreviated reference cycles and recursive filtering
US5427663A (en) 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5627041A (en) 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US20020186874A1 (en) 1994-09-07 2002-12-12 Jeffrey H. Price Method and means for image segmentation in fluorescence scanning cytometry
WO1997000442A1 (en) 1995-06-16 1997-01-03 The University Of Washington Microfabricated differential extraction device and method
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
JPH09189704A (ja) * 1996-01-10 1997-07-22 Hitachi Ltd 自動化学分析装置
US5747349A (en) 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US20020090644A1 (en) 1999-05-21 2002-07-11 Weigl Bernhard H. Microscale diffusion immunoassay
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6184978B1 (en) 1996-05-15 2001-02-06 International Remote Imaging Systems, Inc. Method and apparatus for verifying uniform flow of a fluid sample through a flow cell and distribution on a slide
JP2000512744A (ja) 1996-05-16 2000-09-26 アフィメトリックス,インコーポレイテッド 標識材料を検出するシステムおよび方法
US5726404A (en) * 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
US5998759A (en) * 1996-12-24 1999-12-07 General Scanning, Inc. Laser processing
DE19802367C1 (de) 1997-02-19 1999-09-23 Hahn Schickard Ges Mikrodosiervorrichtungsarray und Verfahren zum Betreiben desselben
US20030103981A1 (en) 1997-02-27 2003-06-05 Incyte Genomics, Inc. Methods of use of a prostate-associated protease in the diagnosis and treatment of prostate cancer
US6426230B1 (en) 1997-08-01 2002-07-30 Qualigen, Inc. Disposable diagnostic device and method
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
CA2320296A1 (en) * 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
GB9816088D0 (en) 1998-07-23 1998-09-23 Axis Biochemicals Asa System
US20010008760A1 (en) * 1998-08-25 2001-07-19 Chester F. King Reagent system and kit for detecting hiv infected cells
US6637463B1 (en) 1998-10-13 2003-10-28 Biomicro Systems, Inc. Multi-channel microfluidic system design with balanced fluid flow distribution
US6136610A (en) * 1998-11-23 2000-10-24 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
US20040053290A1 (en) 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
AU4701200A (en) 1999-05-07 2000-11-21 Quantum Dot Corporation A method of detecting an analyte using semiconductor nanocrystals
EP1192447A2 (en) 1999-05-12 2002-04-03 Aclara BioSciences, Inc. Multiplexed fluorescent detection in microfluidic devices
US6635163B1 (en) 1999-06-01 2003-10-21 Cornell Research Foundation, Inc. Entropic trapping and sieving of molecules
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US7217573B1 (en) 1999-10-05 2007-05-15 Hitachi, Ltd. Method of inspecting a DNA chip
US7024316B1 (en) 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
JP4733331B2 (ja) 2000-03-14 2011-07-27 マイクロニックス、インコーポレーテッド マイクロ流動体分析用デバイス
US7058658B2 (en) 2000-03-28 2006-06-06 Dana-Farber Cancer Institute, Inc. Molecular database for antibody characterization
EP1285106A2 (en) * 2000-03-31 2003-02-26 Micronics, Inc. Protein crystallization in microfluidic structures
CN1214340C (zh) 2000-04-24 2005-08-10 国际遥距成象系统公司 多个神经网络的成像设备和方法
US7236623B2 (en) 2000-04-24 2007-06-26 International Remote Imaging Systems, Inc. Analyte recognition for urinalysis diagnostic system
WO2001088195A1 (en) 2000-05-12 2001-11-22 Caliper Technologies Corp. Detection of nucleic acid hybridization by fluorescence polarization
US20060263888A1 (en) 2000-06-02 2006-11-23 Honeywell International Inc. Differential white blood count on a disposable card
US7471394B2 (en) * 2000-08-02 2008-12-30 Honeywell International Inc. Optical detection system with polarizing beamsplitter
US8071051B2 (en) * 2004-05-14 2011-12-06 Honeywell International Inc. Portable sample analyzer cartridge
US7641856B2 (en) 2004-05-14 2010-01-05 Honeywell International Inc. Portable sample analyzer with removable cartridge
US7630063B2 (en) * 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
US8329118B2 (en) 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
US7277166B2 (en) 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
US6382228B1 (en) 2000-08-02 2002-05-07 Honeywell International Inc. Fluid driving system for flow cytometry
US6875973B2 (en) 2000-08-25 2005-04-05 Amnis Corporation Auto focus for a flow imaging system
US6372516B1 (en) * 2000-09-07 2002-04-16 Sun Biomedical Laboratories, Inc. Lateral flow test device
US6674058B1 (en) 2000-09-20 2004-01-06 Compucyte Corporation Apparatus and method for focusing a laser scanning cytometer
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US6734963B2 (en) 2001-01-22 2004-05-11 Unisearch Associates Inc. Development of a compact Raman spectrometer for detecting product interfaces in a flow path
US7223363B2 (en) * 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
WO2002073200A1 (en) 2001-03-12 2002-09-19 Cellomics, Inc. Methods to increase the capacity of high content cell-based screening assays
WO2002081934A2 (en) 2001-04-03 2002-10-17 Micronics, Inc. Pneumatic valve interface for use in microfluidic structures
CA2446207A1 (en) 2001-05-04 2002-11-14 Health Research, Inc. A high throughput assay for identification of gene expression modifiers
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
AU2002318269A1 (en) 2001-07-18 2003-03-03 The Regents Of The University Of Michigan Gas-focusing flow cytometer cell and flow cytometer detection system with waveguide optics
WO2003014711A1 (en) 2001-08-07 2003-02-20 Mitsubishi Chemical Corporation Surface plasmon resonance sensor chip, and sample analysis method and analysis apparatus using the same
US6636623B2 (en) 2001-08-10 2003-10-21 Visiongate, Inc. Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease
US20030073089A1 (en) * 2001-10-16 2003-04-17 Mauze Ganapati R. Companion cartridge for disposable diagnostic sensing platforms
US7247274B1 (en) 2001-11-13 2007-07-24 Caliper Technologies Corp. Prevention of precipitate blockage in microfluidic channels
US20030166264A1 (en) 2001-12-04 2003-09-04 Dave Smith Drug and alcohol assay assembly
US7192560B2 (en) 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
US7347976B2 (en) 2001-12-20 2008-03-25 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using a hydrophilic solid support in a hydrophobic matrix
US7419821B2 (en) * 2002-03-05 2008-09-02 I-Stat Corporation Apparatus and methods for analyte measurement and immunoassay
IL148664A0 (en) 2002-03-13 2002-09-12 Yeda Res & Dev Auto-focusing method and device
US7223371B2 (en) 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
US7465555B2 (en) 2002-04-02 2008-12-16 Becton, Dickinson And Company Early detection of sepsis
US6843263B2 (en) * 2002-06-24 2005-01-18 Industrial Technology Research Institute Partially closed microfluidic system and microfluidic driving method
EP2359689B1 (en) 2002-09-27 2015-08-26 The General Hospital Corporation Microfluidic device for cell separation and use thereof
CN1739071B (zh) 2002-11-18 2010-12-08 国际遥距成象系统公司 多层次控制器系统
GB0227765D0 (en) 2002-11-28 2003-01-08 Secr Defence Apparatus for processing a fluid sample
US6897954B2 (en) 2002-12-20 2005-05-24 Becton, Dickinson And Company Instrument setup system for a fluorescence analyzer
US20050221281A1 (en) * 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
US7419638B2 (en) 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
EP1603674B1 (en) 2003-02-05 2016-01-06 Iquum, Inc. Sample processing
US20040191783A1 (en) 2003-03-31 2004-09-30 Guy Leclercq Low density micro-array analysis in human breast cancer
JP2004309145A (ja) * 2003-04-02 2004-11-04 Hitachi High-Technologies Corp 化学分析装置及び化学分析用構造体
US20040248205A1 (en) * 2003-04-16 2004-12-09 Stern Lawrence J. Major histocompatibility complex (MHC)-peptide arrays
DE10336849A1 (de) 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
US20050069958A1 (en) 2003-09-26 2005-03-31 Mills Rhonda A. Method for simultaneous evaluation of a sample containing a cellular target and a soluble analyte
EP1689288B1 (en) 2003-11-06 2010-04-21 Grace Laboratories, Inc. Immunosorbent blood tests for assessing paroxysmal cerebral discharges
US7099778B2 (en) 2003-12-30 2006-08-29 Caliper Life Sciences, Inc. Method for determining diffusivity and molecular weight in a microfluidic device
WO2005070291A1 (en) 2004-01-08 2005-08-04 Inlight Solutions, Inc. Noninvasive determination of alcohol in tissue
KR100634498B1 (ko) 2004-01-12 2006-10-13 삼성전자주식회사 체내성분 측정장치 및 방법
US7473529B1 (en) * 2004-03-31 2009-01-06 Iowa State University Research Foundation, Inc. System and method for detecting cells or components thereof
WO2005098379A1 (en) 2004-04-08 2005-10-20 Purdue Research Foundation Multi-spectral detector and analysis system
US8852862B2 (en) * 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7511285B2 (en) 2004-07-16 2009-03-31 The Charles Stark Draper Laboratory, Inc. Methods and apparatus for biomolecule identification
US8097225B2 (en) 2004-07-28 2012-01-17 Honeywell International Inc. Microfluidic cartridge with reservoirs for increased shelf life of installed reagents
US7704730B2 (en) 2004-10-14 2010-04-27 Meso Scale Technologies, Llc Multiplexed assay methods
EP1836557A4 (en) 2004-11-19 2009-01-21 Trillium Diagnostics Llc SOFTWARE-INTEGRATED FLOW CYTOMETRY TEST FOR QUANTITATING THE HUMAN POLYMORPH-ACID LEUKOCYTIC FC RI RECEPTOR (CD64)
CN101099082B (zh) 2004-12-03 2013-03-27 塞通诺米/St有限责任公司 用于粒子处理的整体式盒
US20060205012A1 (en) 2004-12-09 2006-09-14 Meso Scale Technologies, Llc Diagnostic test
WO2006076567A2 (en) 2005-01-13 2006-07-20 Micronics, Inc. Microfluidic rare cell detection device
EP1710579B1 (en) * 2005-03-30 2014-07-30 Sysmex Corporation Method and apparatus for counting megakaryocytes
JP4927817B2 (ja) 2005-04-14 2012-05-09 ギロス・パテント・エービー 多数の弁を備えるマイクロ流体装置
US20070015179A1 (en) 2005-04-26 2007-01-18 Trustees Of Boston University Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples
US8841076B2 (en) * 2005-05-09 2014-09-23 Theranos, Inc. Systems and methods for conducting animal studies
US20070059685A1 (en) * 2005-06-03 2007-03-15 Kohne David E Method for producing improved results for applications which directly or indirectly utilize gene expression assay results
US7618590B2 (en) * 2005-06-29 2009-11-17 Cascade Microtech, Inc. Fluid dispensing system
JP4995197B2 (ja) 2005-07-01 2012-08-08 ハネウェル・インターナショナル・インコーポレーテッド 3d流体力学的集束を有する成形カートリッジ
WO2007005973A2 (en) 2005-07-01 2007-01-11 Honeywell International, Inc. A microfluidic card for rbc analysis
CN1715916B (zh) * 2005-07-21 2011-04-20 中国科学院光电技术研究所 一种用于生化分子检测的微纳生化传感芯片
JP2007121275A (ja) * 2005-09-27 2007-05-17 Fujifilm Corp マイクロチップ、このマイクロチップを用いた液体の混合方法及び血液検査方法
US20070098594A1 (en) 2005-11-03 2007-05-03 Roche Molecular Systems, Inc. Analytical multi-spectral optical detection system
US9056291B2 (en) * 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
US7763453B2 (en) * 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
CN101389947B (zh) * 2005-12-29 2013-08-21 霍尼韦尔国际公司 微流格式的测定工具
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
WO2007106580A2 (en) * 2006-03-15 2007-09-20 Micronics, Inc. Rapid magnetic flow assays
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US7470403B2 (en) 2006-04-26 2008-12-30 Wisconsin Alumni Research Foundation Microfluidic platform and method of generating a gradient therein
US20080176253A1 (en) 2006-05-10 2008-07-24 The Board Of Regents Of The University Of Texas System Detecting human or animal immunoglobin-e
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
EP2487248A1 (en) * 2006-05-10 2012-08-15 The Board of Regents of the University of Texas System Detecting tumor biomarker in oral cancer
JP4771864B2 (ja) 2006-05-31 2011-09-14 ローム株式会社 生化学分析装置
EP2038655A2 (en) 2006-06-02 2009-03-25 Luminex Corporation Systems and methods for performing measurements of one or more materials
EP2041573B1 (en) * 2006-06-23 2019-09-04 PerkinElmer Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
WO2008030666A2 (en) 2006-07-25 2008-03-13 The Board Of Trustees Of The University Of Illinois Multispectral plasmonic crystal sensors
JP2008066696A (ja) 2006-08-10 2008-03-21 Denso Corp 半導体製造装置および半導体製造方法
WO2008140568A2 (en) 2006-11-15 2008-11-20 Idaho Technology, Inc. High density self-contained biological analysis
US20100093019A1 (en) 2007-01-12 2010-04-15 Environmental Biotechnology Crc Pty Limited Sample handling device
ES2534579T3 (es) 2007-02-23 2015-04-24 Lonza Cologne Gmbh Dispositivo y procedimiento para estabilizar el flujo a través de una cámara
US8722327B2 (en) 2007-03-28 2014-05-13 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
US8425861B2 (en) 2007-04-04 2013-04-23 Netbio, Inc. Methods for rapid multiplexed amplification of target nucleic acids
CN103977848B (zh) 2007-04-06 2016-08-24 加利福尼亚技术学院 微流体装置
EP2167537A2 (en) 2007-07-03 2010-03-31 Dako Denmark A/S Compiled methods for analysing and sorting samples
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
CN105543084B (zh) 2007-07-23 2019-09-06 美艾利尔技术公司 分析系统
WO2009114532A2 (en) 2008-03-10 2009-09-17 National Jewish Health Markers for diagnosis of pulmonary inflammation and methods related thereto
EP2128617A1 (en) 2008-05-27 2009-12-02 Koninklijke Philips Electronics N.V. Device and methods for detecting analytes in saliva
US8697007B2 (en) 2008-08-06 2014-04-15 The Trustees Of The University Of Pennsylvania Biodetection cassette with automated actuator
US8158082B2 (en) * 2008-08-29 2012-04-17 Incube Labs, Llc Micro-fluidic device
US8247191B2 (en) * 2008-11-13 2012-08-21 Ritzen Kalle Disposable cassette and method of use for blood analysis on blood analyzer
US8672532B2 (en) * 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
EP2440672B1 (en) * 2009-06-12 2016-03-30 Micronics, Inc. Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices
DE102009032744A1 (de) 2009-07-11 2011-01-13 Thinxxs Microtechnology Ag Fluidspeicher
US20120329878A1 (en) 2009-07-20 2012-12-27 University College Dublin Phenotyping tumor-infiltrating leukocytes
US20120164036A1 (en) 2009-07-21 2012-06-28 Seth Stern Microfluidic devices and uses thereof
WO2011042422A1 (de) 2009-10-05 2011-04-14 Boehringer Ingelheim Microparts Gmbh Fügeverfahren und fügeverbindung für mikrofluidische bauteile
KR101472581B1 (ko) 2009-10-21 2014-12-16 비오까르띠 엔브이 평행한 공압 계면판을 갖춘 마이크로 유체 카트리지
US20110094577A1 (en) 2009-10-28 2011-04-28 Dilip Kumar Chatterjee Conductive metal oxide films and photovoltaic devices
GB0919159D0 (en) 2009-11-02 2009-12-16 Sec Dep For Environment Food A Device and apparatus
EP3514519B1 (en) 2009-12-07 2022-02-09 Meso Scale Technologies, LLC. Assay cartridges
CN102740976B (zh) * 2010-01-29 2016-04-20 精密公司 取样-应答微流体盒
EP2558870B1 (en) 2010-04-15 2017-06-07 Leukodx Ltd System and method for rapid determination of a medical condition
DE102011015184B4 (de) 2010-06-02 2013-11-21 Thinxxs Microtechnology Ag Vorrichtung für den Transport kleiner Volumina eines Fluids, insbesondere Mikropumpe oder Mikroventil
CA2802531C (en) 2010-07-21 2017-02-14 F. Hoffmann-La Roche Ag Increase of usable dynamic range in photometry
US20130323737A1 (en) 2010-08-10 2013-12-05 Bioaccel Method and system for analyzing a sample
WO2012037369A1 (en) * 2010-09-15 2012-03-22 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
EP2615445B1 (en) 2010-10-13 2014-05-21 Olympus Corporation Method of measuring a diffusion characteristic value of a particle
US20120225475A1 (en) * 2010-11-16 2012-09-06 1087 Systems, Inc. Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells
EP3290534B1 (en) 2010-11-22 2023-10-25 Barrick Gold Corporation Alkaline and acid pressure oxidation of precious metal-containing materials
JP5727218B2 (ja) * 2010-12-24 2015-06-03 積水化学工業株式会社 マイクロ流体デバイス、微生物夾雑物検出システム、並びに、微生物夾雑物の検出方法
WO2012092010A1 (en) * 2010-12-29 2012-07-05 Abbott Point Of Care Inc. Multi-fluidic cartridges for sample analysis and methods for using same
EP2661485A4 (en) 2011-01-06 2018-11-21 Meso Scale Technologies, LLC Assay cartridges and methods of using the same
KR101779611B1 (ko) 2011-01-20 2017-09-18 엘지전자 주식회사 표적 항원 검출용 카트리지 및 이를 이용한 표적 항원의 검출 방법
JP6116490B2 (ja) * 2011-03-09 2017-04-19 ピクセル メディカル テクノロジーズ リミテッド 分析対象の細胞を含む試料流体の調製に用いる使い捨てカートリッジ
KR101799518B1 (ko) 2011-05-03 2017-11-21 삼성전자 주식회사 형광 검출 광학계 및 이를 포함하는 다채널 형광 검출 장치
EP2718721A4 (en) * 2011-06-07 2014-10-01 Caris Life Sciences Luxembourg Holdings S A R L CIRCULATING BIOMARKERS FOR CANCER
EP2743682B1 (en) * 2011-08-11 2017-05-31 Olympus Corporation Method for detecting target particles
JP5772425B2 (ja) 2011-09-13 2015-09-02 ソニー株式会社 微小粒子測定装置
US8894946B2 (en) 2011-10-21 2014-11-25 Integenx Inc. Sample preparation, processing and analysis systems
US20130137135A1 (en) 2011-11-28 2013-05-30 California Institute Of Technology Compositions and methods for leukocyte differential counting
US20130177543A1 (en) 2011-12-20 2013-07-11 Creative Medical Health Inc. Natural Means of Augmenting Endogenous Stem Cell Numbers
JP5870851B2 (ja) 2012-05-29 2016-03-01 ソニー株式会社 情報処理装置、情報処理方法、及びプログラム
US9513224B2 (en) 2013-02-18 2016-12-06 Theranos, Inc. Image analysis and measurement of biological samples
JP1628116S (enExample) 2012-10-24 2019-04-01
US20150338401A1 (en) 2012-11-16 2015-11-26 Ayal Ram Multiplexed bioassay techniques
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
EP2932266A4 (en) 2012-12-17 2016-11-30 Leukodx Ltd SYSTEMS AND METHOD FOR DETERMINING A CHEMICAL CONDITION
US10060937B2 (en) 2013-06-28 2018-08-28 William Marsh Rice University Integrated instrumentation for the analysis of biofluids at the point-of-care
JP5989251B2 (ja) 2013-09-12 2016-09-07 三菱電機株式会社 操作入力装置及び方法、並びにプログラム及び記録媒体

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