CN104955445A - 多晶型物组合物及其制造方法和用途 - Google Patents

多晶型物组合物及其制造方法和用途 Download PDF

Info

Publication number
CN104955445A
CN104955445A CN201380023989.1A CN201380023989A CN104955445A CN 104955445 A CN104955445 A CN 104955445A CN 201380023989 A CN201380023989 A CN 201380023989A CN 104955445 A CN104955445 A CN 104955445A
Authority
CN
China
Prior art keywords
nimodipine
polymer
bioactivator
microgranule
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380023989.1A
Other languages
English (en)
Chinese (zh)
Inventor
R·洛赫·麦克唐纳
卡拉·R·戴维斯
凯文·伯顿
加里·温切斯特
安吉拉·R·斯特拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Corp
PDS Biotechnology Corp
Original Assignee
Evonik Stockhausen LLC
Edge Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Stockhausen LLC, Edge Therapeutics Inc filed Critical Evonik Stockhausen LLC
Publication of CN104955445A publication Critical patent/CN104955445A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380023989.1A 2012-05-09 2013-05-09 多晶型物组合物及其制造方法和用途 Pending CN104955445A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261644523P 2012-05-09 2012-05-09
US61/644523 2012-05-09
US13/800480 2013-03-13
US13/800,480 US9399019B2 (en) 2012-05-09 2013-03-13 Polymorph compositions, methods of making, and uses thereof
PCT/US2013/040265 WO2013169979A2 (en) 2012-05-09 2013-05-09 Polymorph compositions, methods of making, and uses thereof

Publications (1)

Publication Number Publication Date
CN104955445A true CN104955445A (zh) 2015-09-30

Family

ID=49548793

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380023989.1A Pending CN104955445A (zh) 2012-05-09 2013-05-09 多晶型物组合物及其制造方法和用途

Country Status (15)

Country Link
US (2) US9399019B2 (https=)
EP (1) EP2846775A4 (https=)
JP (1) JP6338573B2 (https=)
KR (1) KR101784260B1 (https=)
CN (1) CN104955445A (https=)
AU (1) AU2013259476B2 (https=)
BR (1) BR112014027965A2 (https=)
CA (2) CA2872887C (https=)
GB (1) GB2517096A (https=)
HK (2) HK1202264A1 (https=)
IL (1) IL235262A0 (https=)
NZ (1) NZ629727A (https=)
RU (1) RU2014149362A (https=)
SG (1) SG11201407266PA (https=)
WO (1) WO2013169979A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105944152A (zh) * 2016-06-13 2016-09-21 龙岩紫荆创新研究院 可吸收防粘医用膜的制备方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10092524B2 (en) * 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
US9399019B2 (en) * 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
CN107921036A (zh) * 2015-05-29 2018-04-17 优势医疗公司 用于减少视力丧失的组合物和方法
US20190054022A1 (en) * 2016-04-07 2019-02-21 Edge Therapeutics, Inc. Formulations of site-specific, microparticulate compositions and their use to improve outcome after aneursymal subarachnoid hemorrhage
WO2018039039A1 (en) * 2016-08-23 2018-03-01 Edge Therapeutics, Inc. Scalable microparticulate formulations containing polymorphic nimodipine form 2 prepared by a solvent evaporation process
WO2019018306A1 (en) * 2017-07-17 2019-01-24 Edge Therapeutics, Inc. ADVANCED MICROPARTICULAR FORMULATIONS CONTAINING FORM 2 OF MICRONIZED POLYMORPHIC NIMODIPINE
CN112912066B (zh) * 2018-09-08 2022-03-29 江苏九旭药业有限公司 一种尼莫地平注射液组合物及其制备方法
US12281226B2 (en) 2018-10-04 2025-04-22 Organo Plastica Polyvinyl chloride-free lipophilic polymer based aromatized plastisol
KR102181231B1 (ko) * 2018-11-22 2020-11-20 주식회사 메디포럼제약 로티고틴 함유 고분자 미립자의 제조방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101873858A (zh) * 2007-06-11 2010-10-27 R·骆克·麦克唐纳 用于预防脑血管痉挛的药物递送系统

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3932645A (en) 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylic acid
US4757128A (en) 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
DK0471036T4 (da) * 1989-05-04 2004-07-19 Southern Res Inst Indkapslingsfremgangsmåde
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
DE4130173A1 (de) 1991-09-11 1993-03-18 Bayer Ag Pharmazeutische zubereitungen mit einer speziellen kristallmodifikation des 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarbonsaeure-isopropyl-(2-methoxyethyl)-esters
IT1255792B (it) 1992-08-05 1995-11-16 Bayer Italia Spa Composizioni farmaceutiche per la somministrazione orale di diidropiridine in forma di bevanda
US5399665A (en) 1992-11-05 1995-03-21 Massachusetts Institute Of Technology Biodegradable polymers for cell transplantation
AU704183B2 (en) 1994-01-05 1999-04-15 Arqule, Inc. Systematic modular production of aminimide- and oxazolone-based molecules having selected properties
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
US5968542A (en) 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
JP2909418B2 (ja) 1995-09-18 1999-06-23 株式会社資生堂 薬物の遅延放出型マイクロスフイア
CN1304058C (zh) 1996-03-12 2007-03-14 Pg－Txl有限公司 水溶性紫杉醇产品
KR100236771B1 (ko) 1997-04-01 2000-02-01 성재갑 히아루론산을 이용한 약물의 서방성 미세입자 제형
US6123956A (en) 1997-07-10 2000-09-26 Keith Baker Methods for universally distributing therapeutic agents to the brain
US6224794B1 (en) 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
US6455526B1 (en) * 1998-12-16 2002-09-24 Aventis Pharmaceuticals, Inc. Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same
US6869551B2 (en) * 2001-03-30 2005-03-22 Picoliter Inc. Precipitation of solid particles from droplets formed using focused acoustic energy
US20040235801A1 (en) 2001-10-25 2004-11-25 Jean-Pierre Julien Therapy for stroke
ES2427092T3 (es) * 2003-04-10 2013-10-28 Evonik Corporation Un método para la producción de micropartículas a base de emulsión
US20070207211A1 (en) 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
EP1628664A4 (en) * 2003-06-04 2008-11-05 Alkermes Inc POLYMORPHIC FORMS OF NALTREXONE
JP5165240B2 (ja) 2003-07-23 2013-03-21 ピーアール ファーマシューティカルズ， インコーポレイテッド 徐放組成物
US20060205733A1 (en) 2004-08-26 2006-09-14 Encysive Pharmaceuticals Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
WO2006084005A2 (en) 2005-02-02 2006-08-10 University Of Vermont And State Agricultural College Emergence of a r-type ca2+channel(cav2.3) contributes to cerebral artery constriction following subarachnoid hemorrhage
US20060217340A1 (en) 2005-03-23 2006-09-28 University Of Vermont And State Agricultural College Methods and products for treating hypertension by modulation of TRPC3 channel activity
CN101045054A (zh) 2006-03-29 2007-10-03 上海医药工业研究院 尼莫地平纳米混悬剂冻干组合物、其制备方法及应用
WO2008132712A2 (en) 2007-05-01 2008-11-06 Sigmoid Pharma Limited Combination pharmaceutical compositions
WO2009085952A1 (en) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
US20100008968A1 (en) 2008-06-26 2010-01-14 Lampe John W Method for treating cardiovascular diseases using rho kinase inhibitor compounds
WO2010030868A1 (en) * 2008-09-11 2010-03-18 Surmodics Pharmaceuticals, Inc. Solvent extraction microencapsulation with tunable extraction rates
JP5769626B2 (ja) 2008-09-18 2015-08-26 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ 溶媒および塩を用いるマイクロカプセル封入プロセス
CN101416963A (zh) 2008-12-02 2009-04-29 沈阳万爱普利德医药科技有限公司 注射用尼莫地平冻干亚微乳剂及其制备方法
US20130059008A1 (en) 2009-01-23 2013-03-07 Jeffrey L. Atkinson Drying methods for tuning microparticle properties
CA2750003A1 (en) 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Controlled release systems from polymer blends
WO2010085608A1 (en) 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Polymer mixtures comprising polymers having different non-repeating units and methods for making and using same
CN101485632B (zh) 2009-02-11 2011-05-18 西安德天药业股份有限公司 尼莫地平脂质微球注射液及其制备方法
US20100291027A1 (en) 2009-05-14 2010-11-18 Jason Campbell Hyaluronic acid (ha) injection vehicle
CA2784287C (en) 2009-12-22 2017-07-18 Evonik Degussa Corporation Emulsion-based process for preparing microparticles and workhead assembly for use with same
EP2538956A4 (en) 2010-02-22 2015-04-22 Edge Therapeutics Inc METHODS AND COMPOSITIONS FOR TREATING HEMORRHAGIC BRAIN DISORDERS
CA2794328C (en) 2010-03-29 2018-01-16 Evonik Degussa Corporation Compositions and methods for improved retention of a pharmaceutical composition at a local administration site
KR20140063513A (ko) 2011-02-11 2014-05-27 에쥐 세라피틱스, 인코포레이티드 거미막밑 출혈을 갖는 인간의 예후를 개선시키기 위한 조성물 및 방법
RU2606169C2 (ru) 2011-04-05 2017-01-10 Эдж Терапьютикс Система интравентрикулярной доставки лекарственного средства для улучшения исхода после повреждения головного мозга, нарушающего мозговое кровообращение
CN102274176B (zh) 2011-08-04 2013-11-20 上海天氏利医药科技有限公司 一种尼莫地平注射液的组合物及其制备方法与应用
US9399019B2 (en) * 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101873858A (zh) * 2007-06-11 2010-10-27 R·骆克·麦克唐纳 用于预防脑血管痉挛的药物递送系统

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SOFIA PAPADIMITRIOU等: "Nanoencapsulation of nimodipine in Novel Biocompatible Poly(propylene-co-butylene succinate)Aliphatic Copolyesters for Sustained Release", 《JOURNAL OF NANOMATERIALS》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105944152A (zh) * 2016-06-13 2016-09-21 龙岩紫荆创新研究院 可吸收防粘医用膜的制备方法
CN105944152B (zh) * 2016-06-13 2019-02-12 龙岩紫荆创新研究院 可吸收防粘医用膜的制备方法

Also Published As

Publication number Publication date
HK1202264A1 (en) 2015-09-25
AU2013259476A1 (en) 2014-10-30
JP2015522534A (ja) 2015-08-06
GB201418703D0 (en) 2014-12-03
US8821944B1 (en) 2014-09-02
GB2517096A (en) 2015-02-11
AU2013259476B2 (en) 2016-10-06
NZ629727A (en) 2016-06-24
IL235262A0 (en) 2014-12-31
CA2872887C (en) 2017-08-22
EP2846775A2 (en) 2015-03-18
JP6338573B2 (ja) 2018-06-06
SG11201407266PA (en) 2014-12-30
US9399019B2 (en) 2016-07-26
BR112014027965A2 (pt) 2017-06-27
WO2013169979A3 (en) 2015-06-18
KR101784260B1 (ko) 2017-11-06
RU2014149362A (ru) 2016-06-27
HK1207824A1 (en) 2016-02-12
CA2872887A1 (en) 2013-11-14
KR20150021517A (ko) 2015-03-02
WO2013169979A9 (en) 2015-01-08
US20130302431A1 (en) 2013-11-14
CA2961123A1 (en) 2013-11-14
WO2013169979A2 (en) 2013-11-14
EP2846775A4 (en) 2016-04-13
US20140271895A1 (en) 2014-09-18

Similar Documents

Publication Publication Date Title
CN104955445A (zh) 多晶型物组合物及其制造方法和用途
Zhang et al. Precision-guided long-acting analgesia by Gel-immobilized bupivacaine-loaded microsphere
US11576862B2 (en) Methods and compositions for preparing a silk microsphere
EP2785324B1 (en) Hydrophobic drug-delivery material, method for manufacturing thereof and methods for delivery of a drug-delivery composition
Merkle Drug delivery’s quest for polymers: Where are the frontiers?
JPH10502673A (ja) 持続性の局所麻酔を施すための製剤および方法
JP2000511941A (ja) 関節間隙および身体間隙における持効性麻酔
KR20140052992A (ko) 뇌혈류에 영향을 미치는 뇌손상 후 결과를 개선시키기 위한 뇌실내 약물 전달 시스템
ES2637379T3 (es) Material polimérico de administración de fármacos, método para fabricar el mismo y método para la administración de una composición de administración de fármacos
US7087246B2 (en) Controlled release preparation of insulin and its method
KR20130024986A (ko) 옥트레오티드 및 ２종 이상의 폴리락티드-코-글리콜리드 중합체를 포함하는 서방형 제제
US20180098977A1 (en) Scalable microparticulate formulations containing polymorphic nimodipine form 2 prepared by a solvent evaporation process
WO2018108164A1 (zh) 一种硼替佐米药物组合物及其应用
WO2018108163A1 (zh) 一种Talazoparib药物组合物及其应用
CN117530933A (zh) 一种吡仑帕奈长效缓释微球、制备方法及缓释注射剂
CN104784105A (zh) 一种单克隆抗体药物的凝胶组合物
US8808664B2 (en) Lipidated glycoprotein particles and methods of use
KR100720056B1 (ko) 성장인자가 함유된 나노입자가 코팅된 마이크로스피어의제조 및 이의 신경분화로의 이용 방법
CN114668717A (zh) 抗新生血管药物滴眼剂及其制备方法
KR20140063513A (ko) 거미막밑 출혈을 갖는 인간의 예후를 개선시키기 위한 조성물 및 방법
KR20160046570A (ko) 염증성 또는 통증성 질환 치료를 위한 복합 약물 전달 제형 및 이것의 제조방법
Wei et al. Multi-Technology Empowers Dissolving Microneedles: A Novel Strategy in Rheumatoid Arthritis
Thakur et al. Parenteral Controlled Drug Delivery System

Legal Events

Date Code Title Description
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information
CB03 Change of inventor or designer information

Inventor after: R: Macdonald

Inventor after: Cara R Davies

Inventor after: Kevin Borden

Inventor after: Gary Winchester

Inventor after: Angela R Stella

Inventor after: P. heshmati

Inventor before: R: Macdonald

Inventor before: Cara R Davies

Inventor before: Kevin Borden

Inventor before: Gary Winchester

Inventor before: Angela R Stella

WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150930