CN104822823B8 - 重组代谢微生物及其用途 - Google Patents
重组代谢微生物及其用途 Download PDFInfo
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- CN104822823B8 CN104822823B8 CN201380041086.6A CN201380041086A CN104822823B8 CN 104822823 B8 CN104822823 B8 CN 104822823B8 CN 201380041086 A CN201380041086 A CN 201380041086A CN 104822823 B8 CN104822823 B8 CN 104822823B8
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- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
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- C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
- C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
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- C12Y202/01—Transketolases and transaldolases (2.2.1)
- C12Y202/01007—1-Deoxy-D-xylulose-5-phosphate synthase (2.2.1.7)
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- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
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- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/0101—(2E,6E)-Farnesyl diphosphate synthase (2.5.1.10), i.e. geranyltranstransferase
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- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/0109—All-trans-octaprenyl-diphosphate synthase (2.5.1.90)
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01036—Mevalonate kinase (2.7.1.36)
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01148—4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (2.7.1.148)
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- C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
- C12Y207/04002—Phosphomevalonate kinase (2.7.4.2)
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- C12Y207/07—Nucleotidyltransferases (2.7.7)
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- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
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- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/03027—Isoprene synthase (4.2.3.27)
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- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/03046—Alpha-farnesene synthase (4.2.3.46)
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- C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
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- C12Y503/00—Intramolecular oxidoreductases (5.3)
- C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
- C12Y503/03002—Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
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Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010082952.8A CN111218418A (zh) | 2012-06-01 | 2013-06-04 | 重组代谢微生物及其用途 |
CN202010130561.9A CN111304260A (zh) | 2012-06-01 | 2013-06-04 | 重组代谢微生物及其用途 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261654412P | 2012-06-01 | 2012-06-01 | |
US61/654,412 | 2012-06-01 | ||
PCT/NZ2013/000095 WO2013180584A1 (en) | 2012-06-01 | 2013-06-04 | Recombinant microorganisms and uses therefor |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010082952.8A Division CN111218418A (zh) | 2012-06-01 | 2013-06-04 | 重组代谢微生物及其用途 |
CN202010130561.9A Division CN111304260A (zh) | 2012-06-01 | 2013-06-04 | 重组代谢微生物及其用途 |
Publications (3)
Publication Number | Publication Date |
---|---|
CN104822823A CN104822823A (zh) | 2015-08-05 |
CN104822823B CN104822823B (zh) | 2020-02-14 |
CN104822823B8 true CN104822823B8 (zh) | 2020-05-22 |
Family
ID=49670710
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010130561.9A Pending CN111304260A (zh) | 2012-06-01 | 2013-06-04 | 重组代谢微生物及其用途 |
CN202010082952.8A Pending CN111218418A (zh) | 2012-06-01 | 2013-06-04 | 重组代谢微生物及其用途 |
CN201380041086.6A Active CN104822823B8 (zh) | 2012-06-01 | 2013-06-04 | 重组代谢微生物及其用途 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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CN202010130561.9A Pending CN111304260A (zh) | 2012-06-01 | 2013-06-04 | 重组代谢微生物及其用途 |
CN202010082952.8A Pending CN111218418A (zh) | 2012-06-01 | 2013-06-04 | 重组代谢微生物及其用途 |
Country Status (10)
Country | Link |
---|---|
US (5) | US20130323820A1 (zh) |
EP (3) | EP3795680A1 (zh) |
JP (2) | JP6643083B2 (zh) |
CN (3) | CN111304260A (zh) |
DK (2) | DK2855662T3 (zh) |
EA (1) | EA028892B1 (zh) |
ES (2) | ES2841725T3 (zh) |
IN (1) | IN2014DN10236A (zh) |
PL (2) | PL3346008T3 (zh) |
WO (1) | WO2013180584A1 (zh) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130323820A1 (en) * | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
KR102056250B1 (ko) * | 2012-10-23 | 2019-12-16 | 세키스이가가쿠 고교가부시키가이샤 | 재조합 세포, 및 이소프렌의 생산 방법 |
RU2013146377A (ru) * | 2013-10-17 | 2015-04-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") | СПОСОБ ПОЛУЧЕНИЯ ИЗОПРЕНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ РОДА Bacillus |
CA2936251C (en) | 2014-01-28 | 2017-11-07 | Lanzatech New Zealand Limited | Method of producing a recombinant microorganism |
CN106133132A (zh) * | 2014-01-30 | 2016-11-16 | 朗泽科技新西兰有限公司 | 重组微生物和其使用方法 |
JP6325862B2 (ja) * | 2014-03-25 | 2018-05-16 | 積水化学工業株式会社 | 組換え細胞、並びに、環式モノテルペンの生産方法 |
JP2016059313A (ja) * | 2014-09-17 | 2016-04-25 | 積水化学工業株式会社 | 組換え細胞、並びに、イソプレン又は環式イソプレノイドの生産方法 |
CN110066718B (zh) | 2014-10-22 | 2022-09-20 | 朗泽科技新西兰有限公司 | 多阶段系统和用于将co转化成乙醇的多阶段生物学方法 |
JP2017531441A (ja) | 2014-10-22 | 2017-10-26 | ランザテク・ニュージーランド・リミテッド | ガス試験装置及び方法 |
US10590406B2 (en) * | 2014-12-08 | 2020-03-17 | Lanzatech New Zealand Limited | Recombinant microorganisms exhibiting increased flux through a fermentation pathway |
EP3262153A4 (en) | 2015-02-23 | 2018-07-04 | Lanzatech New Zealand Limited | Recombinant acetogenic bacterium for the conversion of methane to products |
DE102015103608A1 (de) * | 2015-03-11 | 2016-09-15 | Basf Se | Verfahren zur mikrobiellen de novo Synthese von Terpenen |
WO2017029549A2 (en) | 2015-08-17 | 2017-02-23 | Conradie Alex Van Eck | Methods, hosts, and reagents related thereto for production of unsaturated pentahydrocarbons, derivatives and intermediates thereof |
US20190017076A1 (en) | 2015-08-17 | 2019-01-17 | Invista North America S.A.R.L. | Methods, cells and reagents for production of isoprene, derivatives and intermediates thereof |
KR20210037002A (ko) * | 2015-10-13 | 2021-04-05 | 란자테크 뉴질랜드 리미티드 | 에너지-생성 발효 경로를 포함하는 유전자 조작된 박테리아 |
US20180334657A1 (en) * | 2015-11-30 | 2018-11-22 | Sekisui Chemical Co., Ltd. | Recombinant cell, method for producing recombinant cell, and method for producing organic compound |
ES2909579T3 (es) | 2015-12-03 | 2022-05-09 | Lanzatech Nz Inc | Arginina como única fuente de nitrógeno para microorganismos fijadores de C1 |
US10358661B2 (en) | 2015-12-28 | 2019-07-23 | Lanzatech New Zealand Limited | Microorganism with modified hydrogenase activity |
ES2955708T3 (es) | 2016-02-01 | 2023-12-05 | Lanzatech Nz Inc | Proceso integrado de fermentación y electrólisis |
SG11201807025SA (en) | 2016-02-26 | 2018-09-27 | Lanzatech New Zealand Ltd | Crispr/cas systems for c-1 fixing bacteria |
EA201892627A1 (ru) | 2016-05-14 | 2019-04-30 | Ланцатек, Инк. | Микроорганизм с модифицированной активностью альдегид:ферредоксин оксидоредуктазы и связанные способы |
EP3498841A4 (en) * | 2016-10-13 | 2020-04-08 | Sekisui Chemical Co., Ltd. | COMPULSORY ANAEROBIC ACETIC ACID PRODUCING MICROORGANISM AND RECOMBINANT MICROORGANISM |
KR102000755B1 (ko) * | 2016-12-27 | 2019-07-17 | 한국과학기술원 | 외부 유전자가 도입된 재조합 미생물 및 상기 미생물을 이용하여 개미산과 이산화탄소로부터 유용물질을 제조하는 방법 |
GB201701548D0 (en) * | 2017-01-31 | 2017-03-15 | Univ Manchester | Process for producing monoterpenes |
US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
US11162115B2 (en) | 2017-06-30 | 2021-11-02 | Inv Nylon Chemicals Americas, Llc | Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons |
ES2926336T3 (es) | 2017-09-08 | 2022-10-25 | Lanzatech Inc | Proceso para la producción de metabolitos utilizando sustratos que contienen C1 ricos en hidrógeno |
US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
CN109722404B (zh) * | 2017-10-30 | 2021-03-12 | 中国石油化工股份有限公司 | 利用纤维素制备金合欢烯的工程菌株及方法 |
WO2019113387A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
CA3079761C (en) | 2017-12-19 | 2023-09-19 | Lanzatech, Inc. | Microorganisms and methods for the biological production of ethylene glycol |
CA3086490A1 (en) | 2017-12-21 | 2019-06-27 | Zymergen Inc. | Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone |
EA202091884A1 (ru) | 2018-02-12 | 2020-10-16 | Ланцатек, Инк. | Способ повышения эффективности конверсии углерода |
KR102122898B1 (ko) * | 2018-02-26 | 2020-06-15 | 주식회사 엠디헬스케어 | 블라우티아 속 세균 유래 나노소포 및 이의 용도 |
EP3781668B1 (en) | 2018-04-20 | 2023-10-04 | Lanzatech, Inc. | Fermentation process for producing ethanol |
JP7280951B2 (ja) | 2018-11-19 | 2023-05-24 | ランザテク,インコーポレイテッド | 発酵とガス化との統合 |
BR112021015449A2 (pt) | 2019-02-08 | 2021-10-05 | Lanzatech, Inc. | Métodos para recuperar produto a partir de um caldo de fermentação e para recuperar produto a partir de uma corrente enriquecida com produto |
CN109666683B (zh) * | 2019-02-27 | 2021-10-29 | 昆明理工大学 | 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用 |
WO2020188033A1 (en) | 2019-03-20 | 2020-09-24 | Global Bioenergies | Improved means and methods for producing isobutene from acetyl-coa |
CN109777815B (zh) * | 2019-03-28 | 2021-10-29 | 昆明理工大学 | HMG-CoA合成酶基因RKHMGCS及其应用 |
SG11202111976TA (en) | 2019-07-11 | 2021-11-29 | Lanzatech Inc | Methods for optimizing gas utilization |
CN110702821B (zh) * | 2019-11-26 | 2022-06-07 | 四川大学华西医院 | 一种慢性阻塞性肺疾病分型检测试剂盒 |
CN115427581A (zh) | 2020-02-17 | 2022-12-02 | 财富科学家股份有限公司 | 将甲醛掺入生物质中的方法 |
MY197253A (en) | 2020-06-06 | 2023-06-08 | Lanzatech Inc | Microorganism with knock-in at acetolactate decarboxylase gene locus |
CA3195088C (en) | 2021-02-08 | 2024-04-23 | Fungmin Liew | Recombinant microorganisms and their use in the production of 3-hydroxypropionate [3-hp] |
TW202307202A (zh) | 2021-08-06 | 2023-02-16 | 美商朗澤科技有限公司 | 用於改良乙二醇之生物產生的微生物及方法 |
CN117980473A (zh) | 2021-09-06 | 2024-05-03 | 环球生物能源公司 | 产生较少巴豆酸的生物体 |
EP4144838A1 (en) | 2021-09-06 | 2023-03-08 | Global Bioenergies | Organisms producing less crotonic acid |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009111513A1 (en) * | 2008-03-03 | 2009-09-11 | Joule Biotechnologies, Inc. | Engineered co2 fixing microorganisms producing carbon-based products of interest |
CN102333866A (zh) * | 2008-12-30 | 2012-01-25 | 丹尼斯科美国公司 | 生产异戊二烯和共同产物的方法 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2002A (en) | 1841-03-12 | Tor and planter for plowing | ||
US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
US6531303B1 (en) * | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
UA72220C2 (uk) | 1998-09-08 | 2005-02-15 | Байоенджініерінг Рісорсиз, Інк. | Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання |
BR0112251B1 (pt) | 2000-07-25 | 2013-04-09 | mÉtodos contÍnuos para produÇço de etanol a partir da fermentaÇço bacteriana anaeràbica de um substrato gasoso. | |
EP1392824B1 (en) * | 2001-06-06 | 2008-08-20 | DSM IP Assets B.V. | Improved isoprenoid production |
US8114645B2 (en) * | 2006-05-19 | 2012-02-14 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
US7704723B2 (en) | 2006-08-31 | 2010-04-27 | The Board Of Regents For Oklahoma State University | Isolation and characterization of novel clostridial species |
BRPI0716954B1 (pt) * | 2006-09-26 | 2024-04-30 | The Regents Of The University Of California | Microrganismos geneticamente modificados capazes de produzir um isoprenóide |
EP2152854A2 (en) * | 2007-05-01 | 2010-02-17 | Acidophil LLC | Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism |
CA2700211C (en) * | 2007-09-20 | 2019-07-30 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
US20090082495A1 (en) * | 2007-09-20 | 2009-03-26 | Rene Jean Zimmer | Pneumatic Tire |
EP2217696B1 (en) | 2007-11-13 | 2015-09-16 | Lanzatech New Zealand Limited | Novel bacteria and methods of use thereof |
MX2010006576A (es) * | 2007-12-13 | 2010-10-15 | Danisco Us Inc | Composiciones y metodos para producir isopreno. |
EP2245137B1 (en) * | 2008-01-22 | 2017-08-16 | Genomatica, Inc. | Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol |
WO2010019696A2 (en) * | 2008-08-12 | 2010-02-18 | Allylix, Inc. | Method for production of isoprenoids |
TWI427149B (zh) * | 2009-06-17 | 2014-02-21 | Danisco Us Inc | 使用dxp及mva途徑之改良之異戊二烯製造 |
US8759047B2 (en) * | 2009-09-16 | 2014-06-24 | Coskata, Inc. | Process for fermentation of syngas from indirect gasification |
US8143037B2 (en) | 2010-03-19 | 2012-03-27 | Coskata, Inc. | Ethanologenic Clostridium species, Clostridium coskatii |
BR112012032276A2 (pt) * | 2010-06-17 | 2016-11-16 | Danisco Us Inc | composições de combustível compreendendo derivados de isopreno |
US8987431B2 (en) * | 2010-07-01 | 2015-03-24 | Coskata, Inc. | Essential genes encoding conserved metabolic pathway function in autotrophic solventogenic clostridial species |
WO2012019169A1 (en) * | 2010-08-06 | 2012-02-09 | Danisco Us Inc. | Production of isoprene under neutral ph conditions |
WO2012024522A2 (en) * | 2010-08-19 | 2012-02-23 | Lanzatech New Zealand Limited | A process for producing chemicals using microbial fermentation of substrates comprising carbon monoxide |
US8759070B2 (en) * | 2010-09-10 | 2014-06-24 | University Of Delaware | Recombinant clostridia that fix CO2 and CO and uses thereof |
US20110236941A1 (en) | 2010-10-22 | 2011-09-29 | Lanzatech New Zealand Limited | Recombinant microorganism and methods of production thereof |
US20110256600A1 (en) * | 2011-02-02 | 2011-10-20 | Lanzatech New Zealand Limited | Recombinant Microorganisms and Methods of Use Thereof |
KR102015672B1 (ko) | 2011-02-25 | 2019-08-29 | 란자테크 뉴질랜드 리미티드 | 재조합 미생물 및 이의 용도 |
US20130273625A1 (en) * | 2011-10-07 | 2013-10-17 | Danisco Us Inc. | Methods for increasing microbial production of isoprene, isoprenoids, and isoprenoid precursor molecules using glucose and acetate co-metabolism |
US20130323820A1 (en) * | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
WO2013181647A2 (en) * | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
WO2015081331A1 (en) | 2013-11-29 | 2015-06-04 | Lanzatech New Zealand Limited | Methods and systems for improving fermentation efficiency |
-
2013
- 2013-06-03 US US13/909,012 patent/US20130323820A1/en not_active Abandoned
- 2013-06-04 EP EP20192584.9A patent/EP3795680A1/en active Pending
- 2013-06-04 WO PCT/NZ2013/000095 patent/WO2013180584A1/en active Application Filing
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- 2013-06-04 EA EA201492206A patent/EA028892B1/ru active IP Right Revival
- 2013-06-04 PL PL18156987T patent/PL3346008T3/pl unknown
- 2013-06-04 CN CN202010082952.8A patent/CN111218418A/zh active Pending
- 2013-06-04 ES ES18156987T patent/ES2841725T3/es active Active
- 2013-06-04 DK DK13797982.9T patent/DK2855662T3/en active
- 2013-06-04 ES ES13797982.9T patent/ES2674984T3/es active Active
- 2013-06-04 PL PL13797982T patent/PL2855662T3/pl unknown
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- 2013-06-04 IN IN10236DEN2014 patent/IN2014DN10236A/en unknown
- 2013-06-04 EP EP13797982.9A patent/EP2855662B1/en active Active
-
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- 2015-03-13 US US14/656,827 patent/US20150191747A1/en not_active Abandoned
-
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- 2018-01-10 US US15/867,306 patent/US10913958B2/en active Active
- 2018-02-07 JP JP2018020464A patent/JP6636550B2/ja active Active
-
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- 2020-11-11 US US17/095,064 patent/US11459589B2/en active Active
-
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- 2022-08-30 US US17/823,471 patent/US20230013524A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009111513A1 (en) * | 2008-03-03 | 2009-09-11 | Joule Biotechnologies, Inc. | Engineered co2 fixing microorganisms producing carbon-based products of interest |
CN102333866A (zh) * | 2008-12-30 | 2012-01-25 | 丹尼斯科美国公司 | 生产异戊二烯和共同产物的方法 |
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EA028892B1 (ru) | 2018-01-31 |
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