CN104822642B - 将硝基衍生物还原成胺的方法 - Google Patents
将硝基衍生物还原成胺的方法 Download PDFInfo
- Publication number
- CN104822642B CN104822642B CN201380056114.1A CN201380056114A CN104822642B CN 104822642 B CN104822642 B CN 104822642B CN 201380056114 A CN201380056114 A CN 201380056114A CN 104822642 B CN104822642 B CN 104822642B
- Authority
- CN
- China
- Prior art keywords
- nitro
- group
- base
- compound
- trichlorosilane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/325—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups reduction by other means than indicated in C07C209/34 or C07C209/36
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/34—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
- C07C209/365—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst by reduction with preservation of halogen-atoms in compounds containing nitro groups and halogen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001489A ITMI20121489A1 (it) | 2012-09-06 | 2012-09-06 | Metodo per la riduzione di nitro derivati ad ammine |
| ITMI2012A001489 | 2012-09-06 | ||
| PCT/EP2013/068371 WO2014037444A1 (en) | 2012-09-06 | 2013-09-05 | Process for the reduction of nitro derivatives to amines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104822642A CN104822642A (zh) | 2015-08-05 |
| CN104822642B true CN104822642B (zh) | 2016-08-24 |
Family
ID=47046692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380056114.1A Active CN104822642B (zh) | 2012-09-06 | 2013-09-05 | 将硝基衍生物还原成胺的方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9284258B2 (enExample) |
| EP (1) | EP2892862B1 (enExample) |
| JP (1) | JP6147345B2 (enExample) |
| KR (1) | KR102074540B1 (enExample) |
| CN (1) | CN104822642B (enExample) |
| CA (1) | CA2884114C (enExample) |
| DK (1) | DK2892862T3 (enExample) |
| ES (1) | ES2614243T3 (enExample) |
| HR (1) | HRP20170204T1 (enExample) |
| HU (1) | HUE032256T2 (enExample) |
| IL (1) | IL237616A (enExample) |
| IN (1) | IN2015DN02567A (enExample) |
| IT (1) | ITMI20121489A1 (enExample) |
| MX (1) | MX373769B (enExample) |
| PL (1) | PL2892862T3 (enExample) |
| PT (1) | PT2892862T (enExample) |
| SI (1) | SI2892862T1 (enExample) |
| WO (1) | WO2014037444A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2933242A1 (en) * | 2014-04-16 | 2015-10-21 | Basf Se | Process for manufacturing amino compounds |
| JP2016117688A (ja) * | 2014-12-22 | 2016-06-30 | 東レ・ファインケミカル株式会社 | ジアミン化合物の製造方法 |
| CN108484522A (zh) * | 2018-04-25 | 2018-09-04 | 山东百诺医药股份有限公司 | 4-(1,2,4-噁二唑-3-基)苯胺的制备方法 |
| CN109053585B (zh) * | 2018-09-13 | 2020-10-23 | 暨明医药科技（苏州）有限公司 | 一种三氯苯达唑的合成方法 |
| CN111777576A (zh) * | 2019-04-05 | 2020-10-16 | 齐鲁制药有限公司 | 尼达尼布关键中间体的制备方法 |
| CN113354543A (zh) * | 2020-03-03 | 2021-09-07 | 深圳有为技术控股集团有限公司 | 若干硝基化合物的硅烷化学还原制备胺基产物及h-酸的新环保生产工艺 |
| CN112010801B (zh) * | 2020-10-16 | 2023-07-28 | 山东汇海医药化工有限公司 | 一种氨氯地平碱的制备方法 |
| US20230357125A1 (en) * | 2022-05-06 | 2023-11-09 | AMPAC Fine Chemicals | Process for Catalytic Reduction of Nitro Compounds to Amines |
| CN117164471A (zh) * | 2023-08-14 | 2023-12-05 | 河北圣雪大成制药有限责任公司 | 一种由9-氨基米诺环素制备替加环素的方法 |
| CN117820127B (zh) * | 2023-12-14 | 2025-11-28 | 清源创新实验室 | 一种芳香胺类化合物的制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485875A (en) * | 1967-06-28 | 1969-12-23 | Texaco Inc | Production of primary amines |
| WO2011016052A2 (en) * | 2009-08-03 | 2011-02-10 | Helvetica Industries (P) Limited | Process for preparing pregabalin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1036300A (ja) * | 1996-07-18 | 1998-02-10 | Souzou Kagaku Kenkyusho:Kk | トリクロロシラン還元によるアルコールおよびアミンの製造方法 |
| US6162929A (en) * | 1997-12-23 | 2000-12-19 | Hoffmann-La Roche Inc. | Process for the manufacture of bisphosphine oxide and bisphosphonate compounds |
| JP2000256305A (ja) * | 1999-03-10 | 2000-09-19 | Sumitomo Chem Co Ltd | 光学活性アミン化合物の製造法 |
| JP2001270851A (ja) * | 2000-03-24 | 2001-10-02 | Tokuyama Corp | 含窒素化合物の製造方法 |
| JP2004307369A (ja) * | 2003-04-03 | 2004-11-04 | Seiko Epson Corp | ４−フェニルベンゾフェノン誘導体および４−フェニルベンゾフェノン誘導体の製造方法 |
| BRPI0510994A (pt) * | 2004-05-11 | 2007-12-04 | Univ Hong Kong Polytechnic | composições farmacêuticas |
| JP5008063B2 (ja) * | 2006-11-22 | 2012-08-22 | 独立行政法人産業技術総合研究所 | ジホスフィンコア型両親媒性デンドリマー、その製造方法、二座ホスフィン配位子及びその配位構造を有する含パラジウム錯体化合物 |
-
2012
- 2012-09-06 IT IT001489A patent/ITMI20121489A1/it unknown
-
2013
- 2013-09-05 CA CA2884114A patent/CA2884114C/en active Active
- 2013-09-05 PT PT137662409T patent/PT2892862T/pt unknown
- 2013-09-05 MX MX2015003039A patent/MX373769B/es active IP Right Grant
- 2013-09-05 ES ES13766240.9T patent/ES2614243T3/es active Active
- 2013-09-05 PL PL13766240T patent/PL2892862T3/pl unknown
- 2013-09-05 JP JP2015530387A patent/JP6147345B2/ja active Active
- 2013-09-05 CN CN201380056114.1A patent/CN104822642B/zh active Active
- 2013-09-05 WO PCT/EP2013/068371 patent/WO2014037444A1/en not_active Ceased
- 2013-09-05 HR HRP20170204TT patent/HRP20170204T1/hr unknown
- 2013-09-05 HU HUE13766240A patent/HUE032256T2/en unknown
- 2013-09-05 DK DK13766240.9T patent/DK2892862T3/en active
- 2013-09-05 KR KR1020157008317A patent/KR102074540B1/ko active Active
- 2013-09-05 EP EP13766240.9A patent/EP2892862B1/en active Active
- 2013-09-05 SI SI201330516A patent/SI2892862T1/sl unknown
- 2013-09-05 IN IN2567DEN2015 patent/IN2015DN02567A/en unknown
- 2013-09-05 US US14/426,221 patent/US9284258B2/en active Active
-
2015
- 2015-03-08 IL IL237616A patent/IL237616A/en active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485875A (en) * | 1967-06-28 | 1969-12-23 | Texaco Inc | Production of primary amines |
| WO2011016052A2 (en) * | 2009-08-03 | 2011-02-10 | Helvetica Industries (P) Limited | Process for preparing pregabalin |
Non-Patent Citations (1)
| Title |
|---|
| 《Pd−C-Induced Catalytic Transfer Hydrogenation with Triethylsilane》;Pijus K. Mandal and John S. McMurray;《J. Org. Chem.》;20070714;第72卷(第17期);6599-6601 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014037444A1 (en) | 2014-03-13 |
| CN104822642A (zh) | 2015-08-05 |
| SI2892862T1 (sl) | 2017-06-30 |
| IL237616A (en) | 2017-03-30 |
| CA2884114A1 (en) | 2014-03-13 |
| IN2015DN02567A (enExample) | 2015-09-11 |
| KR102074540B1 (ko) | 2020-02-06 |
| IL237616A0 (en) | 2015-04-30 |
| US20150232412A1 (en) | 2015-08-20 |
| MX373769B (es) | 2020-04-10 |
| US9284258B2 (en) | 2016-03-15 |
| JP6147345B2 (ja) | 2017-06-14 |
| EP2892862B1 (en) | 2016-11-09 |
| HUE032256T2 (en) | 2017-09-28 |
| PL2892862T3 (pl) | 2017-07-31 |
| ES2614243T3 (es) | 2017-05-30 |
| CA2884114C (en) | 2020-08-18 |
| EP2892862A1 (en) | 2015-07-15 |
| JP2015527381A (ja) | 2015-09-17 |
| MX2015003039A (es) | 2015-09-21 |
| DK2892862T3 (en) | 2017-02-20 |
| KR20150060740A (ko) | 2015-06-03 |
| ITMI20121489A1 (it) | 2014-03-07 |
| HRP20170204T1 (hr) | 2017-06-02 |
| PT2892862T (pt) | 2017-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240529 Address after: Germany Patentee after: Dude Chemical Co.,Ltd. Country or region after: Germany Address before: Berlin, Germany Patentee before: UNIVERSITA' DEGLI STUDI DI MILANO Country or region before: Germany |
|
| TR01 | Transfer of patent right |