HRP20170204T1 - Postupak za redukciju nitro-derivata u amine - Google Patents
Postupak za redukciju nitro-derivata u amine Download PDFInfo
- Publication number
- HRP20170204T1 HRP20170204T1 HRP20170204TT HRP20170204T HRP20170204T1 HR P20170204 T1 HRP20170204 T1 HR P20170204T1 HR P20170204T T HRP20170204T T HR P20170204TT HR P20170204 T HRP20170204 T HR P20170204T HR P20170204 T1 HRP20170204 T1 HR P20170204T1
- Authority
- HR
- Croatia
- Prior art keywords
- nitro group
- group
- alkali
- compound
- present
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title claims 2
- 150000002828 nitro derivatives Chemical class 0.000 title 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 10
- 239000003513 alkali Substances 0.000 claims 7
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 6
- -1 arylalkyl ethers Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- ZDHXKXAHOVTTAH-UHFFFAOYSA-N trichlorosilane Chemical compound Cl[SiH](Cl)Cl ZDHXKXAHOVTTAH-UHFFFAOYSA-N 0.000 claims 3
- 239000005052 trichlorosilane Substances 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 150000001491 aromatic compounds Chemical class 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 150000002390 heteroarenes Chemical class 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- ATVJXMYDOSMEPO-UHFFFAOYSA-N 3-prop-2-enoxyprop-1-ene Chemical compound C=CCOCC=C ATVJXMYDOSMEPO-UHFFFAOYSA-N 0.000 claims 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- MHDVGSVTJDSBDK-UHFFFAOYSA-N dibenzyl ether Chemical compound C=1C=CC=CC=1COCC1=CC=CC=C1 MHDVGSVTJDSBDK-UHFFFAOYSA-N 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/325—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups reduction by other means than indicated in C07C209/34 or C07C209/36
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/04—Formation or introduction of functional groups containing nitrogen of amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/34—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
- C07C209/365—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst by reduction with preservation of halogen-atoms in compounds containing nitro groups and halogen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Claims (13)
1. Postupak za redukciju nitro skupine koja je prisutna u alifatskom, cikloalifatskom, aromatskom ili heteroaromatskom spoju u amin, naznačen time, da rečeni spoj ragira s triklorosilanom u nazočnosti lužine.
2. Postupak u skladu s patentnim zahtjevom 1, naznačen time, daje molarni omjer triklorosilana na nitro skupinu u rasponu od 1 do 5.
3. Postupak u skladu s patentnim zahtjevom 2, naznačen time, daje molarni omjer triklorosilana na nitro skupinu 3.5.
4. Postupak u skladu s patentnim zahtjevom 1, naznačen time, daje rečena lužina organska lužina odabrana iz skupine koja se sastoji od sekundarnih i tercijarnih amina.
5. Postupak u skladu s patentnim zahtjevom 4, naznačen time, da je organska lužina trictilamin ili diizopropilctilamin.
6. Postupak u skladu s patentnim zahtjevom 4, naznačen time, da je molarni omjer lužine u nitro skupinu u opsegu od 1 do 10.
7. Postupak u skladu s patentnim zahtjevom 6, naznačen time, daje molarni omjer lužine u nitro skupinu 5.
8. Postupak u skladu s patentnim zahtjevima 1-7, naznačen time, daje nitro skupina nazočna u aromatskom ili heteroaromatskom spoju a lužina je trictilamin ili diizopropilctilamin.
9. Postupak u skladu s patentnim zahtjevima 1-7, naznačen time, da je nitro skupina nazočna u alifatskom ili cikcloalifatskom spoju a lužina je diizopropilctilamin.
10. Postupak u skladu s patentnim zahtjevima 1-7, naznačen time, daje nitro skupina nazočna u alkenu.
11. Postupak u skladu s patentnim zahtjevima 1-10, naznačen time, daje nitro skupina nazočna u spoju koji sadrži najmanje jednu funkcionalnu skupinu odabranu iz skupine koja se sastoji od dvostruke ili trostruke ugljik-ugljik veze; karbonilne skupine; halogena; C1-C4 hidroksialkila; alil etera; C7-C18 arilalkil etera; C1-C4 acilamino; nitrila; karboksila; karboksilnog ili tio- karboksilnog estera odabranog iz skupine koja sadrži C1-C4 alkil ester, C6-C14 aril ester ili C7-C18 arilalkil ester.
12. Postupak u skladu s patentnim zahtjevom 11, naznačen time, daje funkcionalna skupina odabrana iz skupine koja se sastoji od acetila, formila, hidroksimetila, benzil etera, acetilamino i benzil estera.
13. Postupak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time, pri čemu je na kraju redukcije nitro skupine u amin spoj ostao ncizoliran.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001489A ITMI20121489A1 (it) | 2012-09-06 | 2012-09-06 | Metodo per la riduzione di nitro derivati ad ammine |
EP13766240.9A EP2892862B1 (en) | 2012-09-06 | 2013-09-05 | Process for the reduction of nitro derivatives to amines |
PCT/EP2013/068371 WO2014037444A1 (en) | 2012-09-06 | 2013-09-05 | Process for the reduction of nitro derivatives to amines |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20170204T1 true HRP20170204T1 (hr) | 2017-06-02 |
Family
ID=47046692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20170204TT HRP20170204T1 (hr) | 2012-09-06 | 2017-02-08 | Postupak za redukciju nitro-derivata u amine |
Country Status (18)
Country | Link |
---|---|
US (1) | US9284258B2 (hr) |
EP (1) | EP2892862B1 (hr) |
JP (1) | JP6147345B2 (hr) |
KR (1) | KR102074540B1 (hr) |
CN (1) | CN104822642B (hr) |
CA (1) | CA2884114C (hr) |
DK (1) | DK2892862T3 (hr) |
ES (1) | ES2614243T3 (hr) |
HR (1) | HRP20170204T1 (hr) |
HU (1) | HUE032256T2 (hr) |
IL (1) | IL237616A (hr) |
IN (1) | IN2015DN02567A (hr) |
IT (1) | ITMI20121489A1 (hr) |
MX (1) | MX2015003039A (hr) |
PL (1) | PL2892862T3 (hr) |
PT (1) | PT2892862T (hr) |
SI (1) | SI2892862T1 (hr) |
WO (1) | WO2014037444A1 (hr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2933242A1 (en) * | 2014-04-16 | 2015-10-21 | Basf Se | Process for manufacturing amino compounds |
JP2016117688A (ja) * | 2014-12-22 | 2016-06-30 | 東レ・ファインケミカル株式会社 | ジアミン化合物の製造方法 |
CN108484522A (zh) * | 2018-04-25 | 2018-09-04 | 山东百诺医药股份有限公司 | 4-(1,2,4-噁二唑-3-基)苯胺的制备方法 |
CN109053585B (zh) * | 2018-09-13 | 2020-10-23 | 暨明医药科技(苏州)有限公司 | 一种三氯苯达唑的合成方法 |
CN111777576A (zh) * | 2019-04-05 | 2020-10-16 | 齐鲁制药有限公司 | 尼达尼布关键中间体的制备方法 |
CN113354543A (zh) * | 2020-03-03 | 2021-09-07 | 深圳有为技术控股集团有限公司 | 若干硝基化合物的硅烷化学还原制备胺基产物及h-酸的新环保生产工艺 |
CN112010801B (zh) * | 2020-10-16 | 2023-07-28 | 山东汇海医药化工有限公司 | 一种氨氯地平碱的制备方法 |
US20230357125A1 (en) * | 2022-05-06 | 2023-11-09 | AMPAC Fine Chemicals | Process for Catalytic Reduction of Nitro Compounds to Amines |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3485875A (en) * | 1967-06-28 | 1969-12-23 | Texaco Inc | Production of primary amines |
JPH1036300A (ja) * | 1996-07-18 | 1998-02-10 | Souzou Kagaku Kenkyusho:Kk | トリクロロシラン還元によるアルコールおよびアミンの製造方法 |
US6162929A (en) * | 1997-12-23 | 2000-12-19 | Hoffmann-La Roche Inc. | Process for the manufacture of bisphosphine oxide and bisphosphonate compounds |
JP2000256305A (ja) * | 1999-03-10 | 2000-09-19 | Sumitomo Chem Co Ltd | 光学活性アミン化合物の製造法 |
JP2001270851A (ja) * | 2000-03-24 | 2001-10-02 | Tokuyama Corp | 含窒素化合物の製造方法 |
JP2004307369A (ja) * | 2003-04-03 | 2004-11-04 | Seiko Epson Corp | 4−フェニルベンゾフェノン誘導体および4−フェニルベンゾフェノン誘導体の製造方法 |
JP4926043B2 (ja) * | 2004-05-11 | 2012-05-09 | ザ・ホンコン・ポリテクニック・ユニバーシティ | 医薬組成物 |
JP5008063B2 (ja) * | 2006-11-22 | 2012-08-22 | 独立行政法人産業技術総合研究所 | ジホスフィンコア型両親媒性デンドリマー、その製造方法、二座ホスフィン配位子及びその配位構造を有する含パラジウム錯体化合物 |
WO2011016052A2 (en) * | 2009-08-03 | 2011-02-10 | Helvetica Industries (P) Limited | Process for preparing pregabalin |
-
2012
- 2012-09-06 IT IT001489A patent/ITMI20121489A1/it unknown
-
2013
- 2013-09-05 WO PCT/EP2013/068371 patent/WO2014037444A1/en active Application Filing
- 2013-09-05 MX MX2015003039A patent/MX2015003039A/es active IP Right Grant
- 2013-09-05 PL PL13766240T patent/PL2892862T3/pl unknown
- 2013-09-05 EP EP13766240.9A patent/EP2892862B1/en active Active
- 2013-09-05 US US14/426,221 patent/US9284258B2/en active Active
- 2013-09-05 IN IN2567DEN2015 patent/IN2015DN02567A/en unknown
- 2013-09-05 HU HUE13766240A patent/HUE032256T2/en unknown
- 2013-09-05 SI SI201330516A patent/SI2892862T1/sl unknown
- 2013-09-05 CA CA2884114A patent/CA2884114C/en active Active
- 2013-09-05 KR KR1020157008317A patent/KR102074540B1/ko active IP Right Grant
- 2013-09-05 JP JP2015530387A patent/JP6147345B2/ja active Active
- 2013-09-05 PT PT137662409T patent/PT2892862T/pt unknown
- 2013-09-05 DK DK13766240.9T patent/DK2892862T3/en active
- 2013-09-05 CN CN201380056114.1A patent/CN104822642B/zh active Active
- 2013-09-05 ES ES13766240.9T patent/ES2614243T3/es active Active
-
2015
- 2015-03-08 IL IL237616A patent/IL237616A/en active IP Right Grant
-
2017
- 2017-02-08 HR HRP20170204TT patent/HRP20170204T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
CA2884114C (en) | 2020-08-18 |
IN2015DN02567A (hr) | 2015-09-11 |
JP6147345B2 (ja) | 2017-06-14 |
US20150232412A1 (en) | 2015-08-20 |
CN104822642B (zh) | 2016-08-24 |
PL2892862T3 (pl) | 2017-07-31 |
EP2892862A1 (en) | 2015-07-15 |
SI2892862T1 (sl) | 2017-06-30 |
CA2884114A1 (en) | 2014-03-13 |
ES2614243T3 (es) | 2017-05-30 |
JP2015527381A (ja) | 2015-09-17 |
IL237616A0 (en) | 2015-04-30 |
EP2892862B1 (en) | 2016-11-09 |
PT2892862T (pt) | 2017-02-10 |
CN104822642A (zh) | 2015-08-05 |
WO2014037444A1 (en) | 2014-03-13 |
HUE032256T2 (en) | 2017-09-28 |
MX2015003039A (es) | 2015-09-21 |
ITMI20121489A1 (it) | 2014-03-07 |
KR102074540B1 (ko) | 2020-02-06 |
IL237616A (en) | 2017-03-30 |
KR20150060740A (ko) | 2015-06-03 |
DK2892862T3 (en) | 2017-02-20 |
US9284258B2 (en) | 2016-03-15 |
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