CN1046334A - 新的2′-卤代亚甲基、2′-亚乙烯基和2′-乙炔基腺苷衍生物 - Google Patents

新的2′-卤代亚甲基、2′-亚乙烯基和2′-乙炔基腺苷衍生物 Download PDF

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Publication number
CN1046334A
CN1046334A CN89108169A CN89108169A CN1046334A CN 1046334 A CN1046334 A CN 1046334A CN 89108169 A CN89108169 A CN 89108169A CN 89108169 A CN89108169 A CN 89108169A CN 1046334 A CN1046334 A CN 1046334A
Authority
CN
China
Prior art keywords
base
hydrogen
chloro
compound
adenosine derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN89108169A
Other languages
English (en)
Chinese (zh)
Inventor
詹姆斯·R·麦卡锡
迈克尔·L·爱德华兹
戴维·M·施泰默里克
埃萨·T·贾维
内利库杰·J·帕克什
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Ltd filed Critical Merrell Dow Pharmaceuticals Ltd
Publication of CN1046334A publication Critical patent/CN1046334A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN89108169A 1988-09-27 1989-09-26 新的2′-卤代亚甲基、2′-亚乙烯基和2′-乙炔基腺苷衍生物 Pending CN1046334A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24991188A 1988-09-27 1988-09-27
US249,911 1988-09-27
US38939189A 1989-08-03 1989-08-03
US389,391 1989-08-03

Publications (1)

Publication Number Publication Date
CN1046334A true CN1046334A (zh) 1990-10-24

Family

ID=26940460

Family Applications (1)

Application Number Title Priority Date Filing Date
CN89108169A Pending CN1046334A (zh) 1988-09-27 1989-09-26 新的2′-卤代亚甲基、2′-亚乙烯基和2′-乙炔基腺苷衍生物

Country Status (18)

Country Link
EP (1) EP0365849B1 (pt)
JP (1) JP2968002B2 (pt)
KR (1) KR0146333B1 (pt)
CN (1) CN1046334A (pt)
AR (1) AR248283A1 (pt)
AT (1) ATE111477T1 (pt)
AU (1) AU621664B2 (pt)
CA (1) CA1336903C (pt)
DE (1) DE68918215T2 (pt)
DK (1) DK171237B1 (pt)
ES (1) ES2063796T3 (pt)
FI (1) FI94763C (pt)
HU (1) HU204843B (pt)
IE (1) IE63561B1 (pt)
IL (1) IL91773A (pt)
NO (1) NO171857C (pt)
NZ (1) NZ230766A (pt)
PT (1) PT91803B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340816A (en) * 1990-10-18 1994-08-23 E. R. Squibb & Sons, Inc. Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
WO1993023414A1 (en) * 1992-05-12 1993-11-25 Merrell Dow Pharmaceuticals Inc. A process for the preparation of ribonucleotide reductase inhibitors
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
EP0770621A4 (en) * 1994-07-12 1998-01-28 Yamasa Corp 2'-DESOXY-2 '- (METHYLIDENE SUBSTITUTED OR NON-SUBSTITUTED) -4'-THIONUCLEOSIDE
EP1183034B1 (en) * 1999-06-09 2005-11-23 Anticancer, Inc. Modulators of methylation for control of bacterial virulence
US6579857B1 (en) 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
JP2005522443A (ja) * 2002-02-14 2005-07-28 フアーマセツト・リミテツド 改変フッ素化ヌクレオシド類似体
US9073960B2 (en) 2011-12-22 2015-07-07 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84414A0 (en) * 1986-11-14 1988-04-29 Ciba Geigy Ag N9-cyclopentyl-substituted adenine derivatives
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
NZ225906A (en) * 1987-08-26 1990-10-26 Merrell Dow Pharma Aristeromycin/adenosine derivatives and pharmaceutical compositions
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives

Also Published As

Publication number Publication date
HUT50844A (en) 1990-03-28
FI894546A (fi) 1990-03-28
NO171857B (no) 1993-02-01
EP0365849B1 (en) 1994-09-14
ATE111477T1 (de) 1994-09-15
AR248283A1 (es) 1995-07-12
JPH02160769A (ja) 1990-06-20
DE68918215T2 (de) 1995-02-02
DE68918215D1 (de) 1994-10-20
IE893080L (en) 1990-03-27
HU204843B (en) 1992-02-28
FI94763B (fi) 1995-07-14
EP0365849A2 (en) 1990-05-02
IL91773A (en) 1994-02-27
DK473289D0 (da) 1989-09-26
KR900004736A (ko) 1990-04-12
FI894546A0 (fi) 1989-09-26
JP2968002B2 (ja) 1999-10-25
CA1336903C (en) 1995-09-05
NO893826D0 (no) 1989-09-26
AU4176089A (en) 1990-04-05
AU621664B2 (en) 1992-03-19
PT91803B (pt) 1995-05-31
NO171857C (no) 1993-05-12
DK473289A (da) 1990-03-28
IE63561B1 (en) 1995-05-17
ES2063796T3 (es) 1995-01-16
DK171237B1 (da) 1996-08-05
FI94763C (fi) 1995-10-25
KR0146333B1 (ko) 1998-08-01
NO893826L (no) 1990-03-28
EP0365849A3 (en) 1990-12-27
IL91773A0 (en) 1990-06-10
NZ230766A (en) 1992-07-28
PT91803A (pt) 1990-03-30

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