CN104520309B - 抗真菌抗生素两性霉素b的n-取代第二代衍生物及其制备方法和应用 - Google Patents

抗真菌抗生素两性霉素b的n-取代第二代衍生物及其制备方法和应用 Download PDF

Info

Publication number
CN104520309B
CN104520309B CN201380042027.0A CN201380042027A CN104520309B CN 104520309 B CN104520309 B CN 104520309B CN 201380042027 A CN201380042027 A CN 201380042027A CN 104520309 B CN104520309 B CN 104520309B
Authority
CN
China
Prior art keywords
amphotericin
group
alkyl
derivatives
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380042027.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN104520309A (zh
Inventor
爱德华·博罗夫斯基
纳塔利娅·萨莱夫斯卡
乔安娜·博罗斯马耶夫斯卡
玛丽亚·米莱夫斯卡
马尔戈尔热塔·维索茨卡
斯拉沃米尔·米莱夫斯基
伊莎贝拉·查博夫斯卡
米哈尔·扎比斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BLIRT SA
Original Assignee
BLIRT SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BLIRT SA filed Critical BLIRT SA
Publication of CN104520309A publication Critical patent/CN104520309A/zh
Application granted granted Critical
Publication of CN104520309B publication Critical patent/CN104520309B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201380042027.0A 2012-06-15 2013-06-14 抗真菌抗生素两性霉素b的n-取代第二代衍生物及其制备方法和应用 Expired - Fee Related CN104520309B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL39954512 2012-06-15
PLP.399545 2012-06-15
PCT/EP2013/062436 WO2013186384A1 (en) 2012-06-15 2013-06-14 N-substituted second generation derivatives of antifungal antibiotic amphotericin b and methods of their preparation and application

Publications (2)

Publication Number Publication Date
CN104520309A CN104520309A (zh) 2015-04-15
CN104520309B true CN104520309B (zh) 2018-05-04

Family

ID=48626066

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380042027.0A Expired - Fee Related CN104520309B (zh) 2012-06-15 2013-06-14 抗真菌抗生素两性霉素b的n-取代第二代衍生物及其制备方法和应用

Country Status (12)

Country Link
US (1) US9745335B2 (enExample)
EP (1) EP2861610A1 (enExample)
JP (1) JP2015519389A (enExample)
KR (1) KR20150027217A (enExample)
CN (1) CN104520309B (enExample)
AU (1) AU2013276480B2 (enExample)
BR (1) BR112014031060A2 (enExample)
CA (1) CA2876074A1 (enExample)
IN (1) IN2014DN10551A (enExample)
MX (1) MX2014015249A (enExample)
RU (1) RU2014152459A (enExample)
WO (1) WO2013186384A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA39568A1 (fr) * 2014-06-12 2017-09-29 Shionogi & Co Dérivé de macrolide de polyène
WO2016168568A1 (en) 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
AU2018337955B2 (en) * 2017-09-20 2024-01-18 Atopic Medical, Inc. Compositions and methods for treating and ameliorating respiratory conditions and inflammation of mucosa
RU2688658C1 (ru) * 2018-04-10 2019-05-22 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Противогрибковый полусинтетический полиеновый антибиотик, его водорастворимые соли и фармацевтические композиции на их основе
CN110669087B (zh) * 2018-07-02 2023-03-31 上海医药工业研究院 两性霉素b肽衍生物及其制备方法
WO2020119773A1 (zh) * 2018-12-13 2020-06-18 上海医药工业研究院 两性霉素b肽衍生物
AU2020325163A1 (en) * 2019-08-08 2022-03-03 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin B
WO2022003181A1 (fr) * 2020-07-03 2022-01-06 Nanotracks Diagnostics Derivés urée de l'amphotéricine amb, compositions les contenant et leurs utilisations, dérivés isocyanate d'alkyle omega-aminés et leur utilisation pour obtenir lesdits dérivés urée
FR3112145A1 (fr) * 2020-07-03 2022-01-07 Nanotracks Diagnostics Derives uree de macrolides polyeniques, composes chimiques particuliers susceptibles d’etre utilises pour obtenir ces derives uree, compositions les contenant et utilisations
CN111875653A (zh) * 2020-08-11 2020-11-03 深圳市儿童医院 一种含二硫键的两性霉素b衍生物及其用途
RU2751333C1 (ru) * 2020-12-16 2021-07-13 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Способ получения противогрибкового полусинтетического полиенового антибиотика
CN115536716B (zh) * 2021-06-29 2025-08-08 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途
CN113603738B (zh) * 2021-07-23 2023-05-23 西南大学 一种pH响应性两性霉素B衍生物及其制备方法和应用
CN114133428B (zh) * 2021-12-09 2023-10-27 华东理工大学 两性霉素b亲水性多肽衍生物及其应用
WO2025176869A1 (fr) 2024-02-21 2025-08-28 Mayan Pharma Nouveaux dérivés urées de macrolides amphotères et solubilisation d'antibiotiques amphotères par des dérivés urées de glucides

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244590A (en) * 1960-12-23 1966-04-05 Rutgers Res And Educational Fo Polyenic compounds and procedures related thereto
US4195172A (en) * 1976-04-22 1980-03-25 Politechnika Gdanska Salts of N-glycosyl derivatives of polyene macrolides, especially N-methylglucamine salts as well as the method of their preparation
US5314999A (en) * 1989-11-14 1994-05-24 Laboratoires Mayoly-Spindler Derivatives of basic polyene macrolides and their preparation
US6562796B2 (en) * 2000-01-14 2003-05-13 Micrologix Biotech Inc. Derivatives of polyene macrolides and preparation and use thereof
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
WO2007096137A1 (en) * 2006-02-23 2007-08-30 Eth Zurich Amphotericin derivatives

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1359473A (en) 1970-11-03 1974-07-10 Prodotti Antibiotici Spa Polyenic antibiotic
PL82224B1 (enExample) 1971-08-13 1975-10-31
FI60877C (fi) 1971-08-13 1982-04-13 Politechnika Gdanska Foerfarande foer framstaellning av terapeutiskt aktiva i vatten laett dispergerbara polyenmakrolidantibiot-n-glykosylderivat
PL100966B1 (pl) * 1976-04-22 1978-11-30 Sposob otrzymywania n-glikozylowych pochodnych makrolidow polienowych oraz ich soli,zwlaszcza soli n-metyloglukaminowej
DE2706156C3 (de) 1977-02-14 1981-08-20 Vsesojuznyj naučno-issledovatel'skij technologičeskij institut antibiotikov i fermentov medicinskogo naznačenija, Leningrad N,N,N-Trimethylderivate amphoterer, antimykotischer Polyenantibiotika und Verfahren zu deren Herstellung
US4144328A (en) 1977-02-28 1979-03-13 Vainshtein Viktor A N,N,N-Trimethyl derivatives of polyene amphoteric antibiotics, process of producing same and pharmaceutical composition
PL122884B1 (en) * 1978-07-19 1982-08-31 Politechnika Gdanska Method of manufacture of quaternary trimethylammonium salts of inorganic derivatives of polyene macrolides
US4272525A (en) * 1978-10-23 1981-06-09 Schering Corporation Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them
PL120111B1 (en) 1978-11-10 1982-02-27 Politechnika Gdanska Process for preparing novel n-substituted derivatives of antibiotics from the group of polyenic macrolydestibiotikov iz gruppy polienovykh makrolidov
PL120035B1 (en) 1978-12-20 1982-02-27 Politechnika Gdanska Process for preparing novel methyl esters of n-substituted derivatives of antibiotics from the group of polyenic macrolydesykh proizvodnykh antibiotikov iz gruppy polienovykh makrolidov
ZA807892B (en) 1979-12-24 1981-12-30 Dumex Ltd As Water soluble guanidine derivatives of polyene marcrolides and the esters thereof
PL138831B1 (en) 1983-11-16 1986-11-29 Politechnika Gdanska Process for preparing l-aspartates of 3-/n,n-dimethylamino/-propylamides of antibiotics from polyene macrolids group
PL142848B1 (en) * 1984-10-29 1987-12-31 Politechnika Gdanska Method of obtaining derivatives of n-/n,n-dimethylaminoacyl methyl esters and 3-/n,n-dimethylamino/-propylamides of polyenic acrolydes
GB8829592D0 (en) 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
GB8829593D0 (en) 1988-12-19 1989-02-08 Beecham Group Plc Novel compounds
GB9203476D0 (en) 1992-02-19 1992-04-08 Smithkline Beecham Plc Novel compounds
PL180253B1 (pl) * 1995-05-13 2001-01-31 Politechnika Gdanska Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL
US5942495A (en) * 1996-05-10 1999-08-24 Btg International Limited Antibiotics
US5981721A (en) 1997-10-23 1999-11-09 Karykion Corporation Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof
FR2776927B1 (fr) 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
US6413537B1 (en) 2000-03-10 2002-07-02 Wisconsin Alumni Research Foundation Nystatin formulation having reduced toxicity
JP2002096091A (ja) * 2000-09-21 2002-04-02 Hitachi Ltd 油脂分解組成物及び油脂分解方法
PL210774B1 (pl) 2006-06-19 2012-02-29 Politechnika Gdanska Zawadzone przestrzennie amfoteryczne N-aminoacylowe pochodne amfoterycyny B, (54) sposób ich otrzymywania i zastosowanie do wytwarzania leku do zwalczania drobnoustrojów grzybowych
EP2174944A4 (en) 2007-07-30 2010-09-22 Shanghai Inst Pharm Industry POLYENDIESTERANTIBIOTIKA

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244590A (en) * 1960-12-23 1966-04-05 Rutgers Res And Educational Fo Polyenic compounds and procedures related thereto
US4195172A (en) * 1976-04-22 1980-03-25 Politechnika Gdanska Salts of N-glycosyl derivatives of polyene macrolides, especially N-methylglucamine salts as well as the method of their preparation
US5314999A (en) * 1989-11-14 1994-05-24 Laboratoires Mayoly-Spindler Derivatives of basic polyene macrolides and their preparation
US6562796B2 (en) * 2000-01-14 2003-05-13 Micrologix Biotech Inc. Derivatives of polyene macrolides and preparation and use thereof
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
WO2007096137A1 (en) * 2006-02-23 2007-08-30 Eth Zurich Amphotericin derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Interaction of amphotericin B and its low toxic derivative，N-methyl-N-D-fructosyl amphotericin B methyl ester, with fungal,mammalian and bacterial cells measured by the energy transfer method;Joanna Szlinder-Richert，等;《IL Farmaco》;20040430;第59卷(第4期);第289页Fig 1B，MFAME，摘要 *
Significant Improvement of Antifungal Activity of Polyene Macrolides by Bisalkylation of the Mycosamine;Valerie Paquet，等;《Organic Letters》;20060329;第8卷(第9期);第1807-1809页 *
Synthesis and biological evaluation of amphotericin B derivatives;Astrid A. Volmer，等;《Nat. Prod. Rep.》;20101231;第27卷(第9期);第1337-1341页Table 1-4，Scheme 1-2、5 *
The role of amphotericin B amine group basicity in its antifungal action. A theoretical approach;Maciej Baginski，等;《Biophysical Chemistry》;19940430;第49卷(第3期);第241-250页 *

Also Published As

Publication number Publication date
AU2013276480B2 (en) 2018-01-04
US9745335B2 (en) 2017-08-29
US20150291648A1 (en) 2015-10-15
EP2861610A1 (en) 2015-04-22
AU2013276480A1 (en) 2015-01-15
RU2014152459A (ru) 2016-08-10
IN2014DN10551A (enExample) 2015-08-21
WO2013186384A1 (en) 2013-12-19
MX2014015249A (es) 2015-08-20
BR112014031060A2 (pt) 2017-06-27
JP2015519389A (ja) 2015-07-09
CA2876074A1 (en) 2013-12-19
KR20150027217A (ko) 2015-03-11
CN104520309A (zh) 2015-04-15

Similar Documents

Publication Publication Date Title
CN104520309B (zh) 抗真菌抗生素两性霉素b的n-取代第二代衍生物及其制备方法和应用
Volmer et al. Synthesis and biological evaluation of amphotericin B derivatives
CN106456795A (zh) 靶向治疗学
JP2003529609A (ja) 核酸結合部分を含む荷電した化合物およびその利用法
CA2822806C (en) New amphotericin analogous compounds and pharmaceutical compositions containing them
Panda et al. Synthesis, computational studies, antimycobacterial and antibacterial properties of pyrazinoic acid–isoniazid hybrid conjugates
RU2680138C2 (ru) Трициклические ингибиторы гиразы
US11014891B2 (en) Reduction-triggered antibacterial sideromycins
CN101107000A (zh) 3,6-双环大环内酯物
WO2008094203A2 (en) Polar ester prodrugs of heterocyclic hybrid antibacterial compounds and salts thereof
US9447136B2 (en) Semisynthetic derivatives of Nystatin A1
CN104892626B (zh) 氨基脲二氢青蒿素衍生物及其制备方法与应用
KR0185200B1 (ko) 폴리엔 마크로라이드 유도체
CN110981888B (zh) N-芳基二硫吡咯酮脲类和氨基酯类衍生物及其制备和应用
US20170355671A1 (en) Peripherally substituted monocyclic beta-lactams
WO2016040779A1 (en) Urea derivatives of polyene macrolide antibiotics
CN111393368A (zh) 一种茚并吡唑盐酸盐类衍生物及其制备方法与应用
CN111662351B (zh) 新奥克梯隆型皂苷元衍生物及制备抗耐药菌药物应用
WO2018067663A2 (en) Ketolides having antibacterial activity
PL210774B1 (pl) Zawadzone przestrzennie amfoteryczne N-aminoacylowe pochodne amfoterycyny B, (54) sposób ich otrzymywania i zastosowanie do wytwarzania leku do zwalczania drobnoustrojów grzybowych
TW202313656A (zh) 一種阿尼芬淨衍生物的製備方法
JP5788175B2 (ja) 安定なエルサミトルシン塩製剤
MX2008015971A (es) Sales de elsamitrucina estables adecuadas para formulaciones farmaceuticas.

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180504

Termination date: 20190614

CF01 Termination of patent right due to non-payment of annual fee