IN2014DN10551A - - Google Patents
Info
- Publication number
- IN2014DN10551A IN2014DN10551A IN10551DEN2014A IN2014DN10551A IN 2014DN10551 A IN2014DN10551 A IN 2014DN10551A IN 10551DEN2014 A IN10551DEN2014 A IN 10551DEN2014A IN 2014DN10551 A IN2014DN10551 A IN 2014DN10551A
- Authority
- IN
- India
- Prior art keywords
- derivatives
- antifungal
- semisynthetic
- complexes
- plant
- Prior art date
Links
- 230000000843 anti-fungal effect Effects 0.000 abstract 2
- 229940121375 antifungal agent Drugs 0.000 abstract 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- 229960003942 amphotericin b Drugs 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL39954512 | 2012-06-15 | ||
| PCT/EP2013/062436 WO2013186384A1 (en) | 2012-06-15 | 2013-06-14 | N-substituted second generation derivatives of antifungal antibiotic amphotericin b and methods of their preparation and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN10551A true IN2014DN10551A (enExample) | 2015-08-21 |
Family
ID=48626066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN10551DEN2014 IN2014DN10551A (enExample) | 2012-06-15 | 2013-06-14 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9745335B2 (enExample) |
| EP (1) | EP2861610A1 (enExample) |
| JP (1) | JP2015519389A (enExample) |
| KR (1) | KR20150027217A (enExample) |
| CN (1) | CN104520309B (enExample) |
| AU (1) | AU2013276480B2 (enExample) |
| BR (1) | BR112014031060A2 (enExample) |
| CA (1) | CA2876074A1 (enExample) |
| IN (1) | IN2014DN10551A (enExample) |
| MX (1) | MX2014015249A (enExample) |
| RU (1) | RU2014152459A (enExample) |
| WO (1) | WO2013186384A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX378786B (es) * | 2014-06-12 | 2025-03-11 | Shionogi & Co | Derivado de macrólido de polieno. |
| PT3283171T (pt) | 2015-04-15 | 2021-07-14 | Sfunga Therapeutics Inc | Derivados de anfotericina b |
| KR20200060424A (ko) * | 2017-09-20 | 2020-05-29 | 아토픽 메디컬, 엘엘씨. | 호흡기 질환 및 점막 염증의 치료 및 개선을 위한 조성물 및 방법 |
| RU2688658C1 (ru) * | 2018-04-10 | 2019-05-22 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" | Противогрибковый полусинтетический полиеновый антибиотик, его водорастворимые соли и фармацевтические композиции на их основе |
| CN110669087B (zh) * | 2018-07-02 | 2023-03-31 | 上海医药工业研究院 | 两性霉素b肽衍生物及其制备方法 |
| CN113166188B (zh) * | 2018-12-13 | 2023-06-20 | 正大天晴药业集团股份有限公司 | 两性霉素b肽衍生物 |
| AU2020325163B2 (en) * | 2019-08-08 | 2026-04-23 | The Board Of Trustees Of The University Of Illinois | Hybrid amide derivatives of amphotericin B |
| FR3112145A1 (fr) * | 2020-07-03 | 2022-01-07 | Nanotracks Diagnostics | Derives uree de macrolides polyeniques, composes chimiques particuliers susceptibles d’etre utilises pour obtenir ces derives uree, compositions les contenant et utilisations |
| WO2022003181A1 (fr) * | 2020-07-03 | 2022-01-06 | Nanotracks Diagnostics | Derivés urée de l'amphotéricine amb, compositions les contenant et leurs utilisations, dérivés isocyanate d'alkyle omega-aminés et leur utilisation pour obtenir lesdits dérivés urée |
| CN111875653A (zh) * | 2020-08-11 | 2020-11-03 | 深圳市儿童医院 | 一种含二硫键的两性霉素b衍生物及其用途 |
| RU2751333C1 (ru) * | 2020-12-16 | 2021-07-13 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" | Способ получения противогрибкового полусинтетического полиенового антибиотика |
| CN115536716B (zh) * | 2021-06-29 | 2025-08-08 | 中国科学院上海药物研究所 | 两性霉素b半合成衍生物及其制备方法和用途 |
| CN113603738B (zh) * | 2021-07-23 | 2023-05-23 | 西南大学 | 一种pH响应性两性霉素B衍生物及其制备方法和应用 |
| CN114133428B (zh) * | 2021-12-09 | 2023-10-27 | 华东理工大学 | 两性霉素b亲水性多肽衍生物及其应用 |
| WO2025176869A1 (fr) | 2024-02-21 | 2025-08-28 | Mayan Pharma | Nouveaux dérivés urées de macrolides amphotères et solubilisation d'antibiotiques amphotères par des dérivés urées de glucides |
| CN121652213A (zh) * | 2024-09-12 | 2026-03-13 | 武汉熙瑞医药科技有限公司 | 一种两性霉素b季铵盐衍生物及其应用 |
| WO2026056991A1 (zh) * | 2024-09-12 | 2026-03-19 | 武汉熙瑞医药科技有限公司 | 一种两性霉素b酰胺类衍生物及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3244590A (en) * | 1960-12-23 | 1966-04-05 | Rutgers Res And Educational Fo | Polyenic compounds and procedures related thereto |
| GB1359473A (en) | 1970-11-03 | 1974-07-10 | Prodotti Antibiotici Spa | Polyenic antibiotic |
| FI60877C (fi) | 1971-08-13 | 1982-04-13 | Politechnika Gdanska | Foerfarande foer framstaellning av terapeutiskt aktiva i vatten laett dispergerbara polyenmakrolidantibiot-n-glykosylderivat |
| PL82224B1 (enExample) | 1971-08-13 | 1975-10-31 | ||
| PL100966B1 (pl) | 1976-04-22 | 1978-11-30 | Sposob otrzymywania n-glikozylowych pochodnych makrolidow polienowych oraz ich soli,zwlaszcza soli n-metyloglukaminowej | |
| US4195172A (en) * | 1976-04-22 | 1980-03-25 | Politechnika Gdanska | Salts of N-glycosyl derivatives of polyene macrolides, especially N-methylglucamine salts as well as the method of their preparation |
| DE2706156C3 (de) | 1977-02-14 | 1981-08-20 | Vsesojuznyj naučno-issledovatel'skij technologičeskij institut antibiotikov i fermentov medicinskogo naznačenija, Leningrad | N,N,N-Trimethylderivate amphoterer, antimykotischer Polyenantibiotika und Verfahren zu deren Herstellung |
| US4144328A (en) | 1977-02-28 | 1979-03-13 | Vainshtein Viktor A | N,N,N-Trimethyl derivatives of polyene amphoteric antibiotics, process of producing same and pharmaceutical composition |
| PL122884B1 (en) | 1978-07-19 | 1982-08-31 | Politechnika Gdanska | Method of manufacture of quaternary trimethylammonium salts of inorganic derivatives of polyene macrolides |
| US4272525A (en) * | 1978-10-23 | 1981-06-09 | Schering Corporation | Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them |
| PL120111B1 (en) | 1978-11-10 | 1982-02-27 | Politechnika Gdanska | Process for preparing novel n-substituted derivatives of antibiotics from the group of polyenic macrolydestibiotikov iz gruppy polienovykh makrolidov |
| PL120035B1 (en) | 1978-12-20 | 1982-02-27 | Politechnika Gdanska | Process for preparing novel methyl esters of n-substituted derivatives of antibiotics from the group of polyenic macrolydesykh proizvodnykh antibiotikov iz gruppy polienovykh makrolidov |
| ZA807892B (en) | 1979-12-24 | 1981-12-30 | Dumex Ltd As | Water soluble guanidine derivatives of polyene marcrolides and the esters thereof |
| PL138831B1 (en) | 1983-11-16 | 1986-11-29 | Politechnika Gdanska | Process for preparing l-aspartates of 3-/n,n-dimethylamino/-propylamides of antibiotics from polyene macrolids group |
| PL142848B1 (en) * | 1984-10-29 | 1987-12-31 | Politechnika Gdanska | Method of obtaining derivatives of n-/n,n-dimethylaminoacyl methyl esters and 3-/n,n-dimethylamino/-propylamides of polyenic acrolydes |
| GB8829592D0 (en) | 1988-12-19 | 1989-02-08 | Beecham Group Plc | Novel compounds |
| GB8829593D0 (en) | 1988-12-19 | 1989-02-08 | Beecham Group Plc | Novel compounds |
| FR2654339B1 (fr) * | 1989-11-14 | 1994-10-28 | Mayoly Spindler Laboratoires | Nouveaux derives solubles et non toxiques des macrolides polyeniques basiques, leur preparation et leurs applications. |
| GB9203476D0 (en) | 1992-02-19 | 1992-04-08 | Smithkline Beecham Plc | Novel compounds |
| PL180253B1 (pl) | 1995-05-13 | 2001-01-31 | Politechnika Gdanska | Pochodne N-metylo-N-glikozylowe estrów metylowych antybiotyków z grupy makrolidów polienowych i ich sole oraz sposób ich otrzymywania PL PL PL PL PL PL |
| US5942495A (en) * | 1996-05-10 | 1999-08-24 | Btg International Limited | Antibiotics |
| US5981721A (en) | 1997-10-23 | 1999-11-09 | Karykion Corporation | Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof |
| FR2776927B1 (fr) * | 1998-04-07 | 2002-07-05 | Univ Paris Curie | Compositions pour la vectorisation de molecules |
| AU780724B2 (en) * | 2000-01-14 | 2005-04-14 | Migenix Inc. | Derivatives of polyene macrolides and preparation and use thereof |
| US6413537B1 (en) | 2000-03-10 | 2002-07-02 | Wisconsin Alumni Research Foundation | Nystatin formulation having reduced toxicity |
| US6664241B2 (en) | 2000-05-31 | 2003-12-16 | Micrologix Biotech Inc. | Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof |
| JP2002096091A (ja) * | 2000-09-21 | 2002-04-02 | Hitachi Ltd | 油脂分解組成物及び油脂分解方法 |
| US20090186838A1 (en) * | 2006-02-23 | 2009-07-23 | Eidgenössische Technische Hochschule Zürich | Amphotericin Derivatives |
| PL210774B1 (pl) * | 2006-06-19 | 2012-02-29 | Politechnika Gdanska | Zawadzone przestrzennie amfoteryczne N-aminoacylowe pochodne amfoterycyny B, (54) sposób ich otrzymywania i zastosowanie do wytwarzania leku do zwalczania drobnoustrojów grzybowych |
| JP2010534688A (ja) | 2007-07-30 | 2010-11-11 | 上海医薬工業研究院 | ポリエン類抗生物質ジエステル化合物 |
-
2013
- 2013-06-14 JP JP2015516640A patent/JP2015519389A/ja active Pending
- 2013-06-14 MX MX2014015249A patent/MX2014015249A/es unknown
- 2013-06-14 WO PCT/EP2013/062436 patent/WO2013186384A1/en not_active Ceased
- 2013-06-14 BR BR112014031060A patent/BR112014031060A2/pt not_active IP Right Cessation
- 2013-06-14 US US14/407,933 patent/US9745335B2/en not_active Expired - Fee Related
- 2013-06-14 CA CA2876074A patent/CA2876074A1/en not_active Abandoned
- 2013-06-14 EP EP13728771.0A patent/EP2861610A1/en not_active Withdrawn
- 2013-06-14 AU AU2013276480A patent/AU2013276480B2/en not_active Ceased
- 2013-06-14 CN CN201380042027.0A patent/CN104520309B/zh not_active Expired - Fee Related
- 2013-06-14 RU RU2014152459A patent/RU2014152459A/ru not_active Application Discontinuation
- 2013-06-14 KR KR20157000820A patent/KR20150027217A/ko not_active Ceased
- 2013-06-14 IN IN10551DEN2014 patent/IN2014DN10551A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104520309B (zh) | 2018-05-04 |
| RU2014152459A (ru) | 2016-08-10 |
| AU2013276480B2 (en) | 2018-01-04 |
| KR20150027217A (ko) | 2015-03-11 |
| EP2861610A1 (en) | 2015-04-22 |
| WO2013186384A1 (en) | 2013-12-19 |
| JP2015519389A (ja) | 2015-07-09 |
| US20150291648A1 (en) | 2015-10-15 |
| BR112014031060A2 (pt) | 2017-06-27 |
| AU2013276480A1 (en) | 2015-01-15 |
| CN104520309A (zh) | 2015-04-15 |
| US9745335B2 (en) | 2017-08-29 |
| CA2876074A1 (en) | 2013-12-19 |
| MX2014015249A (es) | 2015-08-20 |
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