CN104398725A - 一种结肠癌造瘘术后期护理口服药剂及其制备方法 - Google Patents
一种结肠癌造瘘术后期护理口服药剂及其制备方法 Download PDFInfo
- Publication number
- CN104398725A CN104398725A CN201410597211.8A CN201410597211A CN104398725A CN 104398725 A CN104398725 A CN 104398725A CN 201410597211 A CN201410597211 A CN 201410597211A CN 104398725 A CN104398725 A CN 104398725A
- Authority
- CN
- China
- Prior art keywords
- parts
- preparation
- fistulation
- colon cancer
- later stage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 58
- 239000003814 drug Substances 0.000 title claims abstract description 54
- 206010009944 Colon cancer Diseases 0.000 title claims abstract description 47
- 230000000474 nursing effect Effects 0.000 title claims abstract description 41
- 208000001333 Colorectal Neoplasms Diseases 0.000 title abstract description 6
- 201000010989 colorectal carcinoma Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 210000000582 semen Anatomy 0.000 claims abstract description 12
- 208000029742 colonic neoplasm Diseases 0.000 claims description 39
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 229940079593 drug Drugs 0.000 claims description 31
- 239000002671 adjuvant Substances 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 18
- 239000008187 granular material Substances 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 15
- 241000894006 Bacteria Species 0.000 claims description 11
- 241000986012 Carex baccans Species 0.000 claims description 11
- 235000004263 Ocotea pretiosa Nutrition 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 11
- 244000227633 Ocotea pretiosa Species 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008346 aqueous phase Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 6
- 241000208340 Araliaceae Species 0.000 claims description 5
- 235000019082 Osmanthus Nutrition 0.000 claims description 5
- 241000333181 Osmanthus Species 0.000 claims description 5
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 5
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 235000008434 ginseng Nutrition 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000007560 sedimentation technique Methods 0.000 claims description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 4
- 238000005469 granulation Methods 0.000 claims description 4
- 230000003179 granulation Effects 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 239000007779 soft material Substances 0.000 claims description 4
- 238000000638 solvent extraction Methods 0.000 claims description 4
- 238000000151 deposition Methods 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000008280 blood Substances 0.000 abstract description 12
- 210000004369 blood Anatomy 0.000 abstract description 11
- 208000002193 Pain Diseases 0.000 abstract description 9
- 210000000936 intestine Anatomy 0.000 abstract description 7
- 206010028980 Neoplasm Diseases 0.000 abstract description 6
- 208000004880 Polyuria Diseases 0.000 abstract description 3
- 230000017531 blood circulation Effects 0.000 abstract description 3
- 230000035619 diuresis Effects 0.000 abstract description 3
- 241000411851 herbal medicine Species 0.000 abstract description 3
- 210000002784 stomach Anatomy 0.000 abstract description 3
- 206010000060 Abdominal distension Diseases 0.000 abstract 1
- 241001290610 Abildgaardia Species 0.000 abstract 1
- 241001519271 Ajuga Species 0.000 abstract 1
- 244000247812 Amorphophallus rivieri Species 0.000 abstract 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 abstract 1
- 241001562689 Begonia yunnanensis Species 0.000 abstract 1
- 241001328224 Boletus cuticularis Species 0.000 abstract 1
- 241000917739 Cinnamomum wilsonii Species 0.000 abstract 1
- 235000018081 Hibiscus syriacus Nutrition 0.000 abstract 1
- 244000130592 Hibiscus syriacus Species 0.000 abstract 1
- 241001213462 Holothuria leucospilota Species 0.000 abstract 1
- 229920002752 Konjac Polymers 0.000 abstract 1
- 241001620261 Meliosma fordii Species 0.000 abstract 1
- 235000003713 Rhodiola rosea Nutrition 0.000 abstract 1
- 244000042430 Rhodiola rosea Species 0.000 abstract 1
- 241000222355 Trametes versicolor Species 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 244000309464 bull Species 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 235000010485 konjac Nutrition 0.000 abstract 1
- 239000000252 konjac Substances 0.000 abstract 1
- 230000000116 mitigating effect Effects 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 description 14
- 230000003187 abdominal effect Effects 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 8
- 206010010774 Constipation Diseases 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- 229930006000 Sucrose Natural products 0.000 description 6
- 206010016766 flatulence Diseases 0.000 description 6
- 231100000614 poison Toxicity 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 229960004793 sucrose Drugs 0.000 description 6
- 201000004624 Dermatitis Diseases 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 238000012321 colectomy Methods 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 4
- 210000004877 mucosa Anatomy 0.000 description 4
- 210000001599 sigmoid colon Anatomy 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 229920001353 Dextrin Polymers 0.000 description 3
- 239000004375 Dextrin Substances 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 229920000881 Modified starch Polymers 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 208000019790 abdominal distention Diseases 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 206010006451 bronchitis Diseases 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 235000019425 dextrin Nutrition 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 235000010413 sodium alginate Nutrition 0.000 description 3
- 229940005550 sodium alginate Drugs 0.000 description 3
- 239000000661 sodium alginate Substances 0.000 description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 235000010234 sodium benzoate Nutrition 0.000 description 3
- 239000004299 sodium benzoate Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 230000013872 defecation Effects 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 230000001882 diuretic effect Effects 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 208000014617 hemorrhoid Diseases 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000003750 lower gastrointestinal tract Anatomy 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 230000002175 menstrual effect Effects 0.000 description 2
- -1 reflux Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000003384 transverse colon Anatomy 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000234282 Allium Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 241000001667 Eueretagrotis sigmoides Species 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 208000012895 Gastric disease Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 206010019755 Hepatitis chronic active Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 206010021750 Infantile Spasms Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 244000009660 Sassafras variifolium Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 206010046792 Uterine hypotonus Diseases 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 208000013257 developmental and epileptic encephalopathy Diseases 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000001983 lactogenic effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 210000000713 mesentery Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000000771 oncological effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 208000018556 stomach disease Diseases 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/616—Echinodermata, e.g. starfish, sea cucumbers or sea urchins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种结肠癌造瘘术后期护理口服药剂及其制备方法,该药剂的原料药组成为:赤小豆50-80份、荡皮参35-70份、香皮树40-90份、刺梨根30-60份、山稗子24-60份、木槿根32-56份、赤芍药18-30份、合树菌22-46份、魔芋18-34份、散瘀草8-20份、云芝20-38份,还包括:柴桂20-50份、山海棠45-86份。本发明药剂组方严谨,配伍合理,具有清热和血,利水通经,宽肠理气,去肠湿热,润肠通便、活血止血,行气止痛、减轻胃肠胀气的功效,再附上利于消化道肿瘤康复和能够调节免疫功能的中草药,由内而外对做造瘘术的结肠癌患者进行调理,对后期造瘘口并发症具有良好的护理功效。
Description
技术领域
本发明涉及肿瘤护理技术领域,尤其是涉及一种结肠癌造瘘术后期护理口服药剂。
背景技术
结肠癌是指结肠粘膜上皮在环境或遗传等多种致癌因素作用下发生的恶性病变。是常见的恶性肿瘤之一,以40岁~50岁年龄组发病率最高,全球每年新发病例约800万人,占所有恶性肿瘤的10%~15%。
结肠癌治疗原则是以手术切除为主的综合治疗,同时联合化疗、放疗等降低手术后复发率,提高生存率。根治性结肠癌手术的切除范围包括癌肿所在肠袢及其全结肠系膜(complete mesocolic excision,CME)。即切除了癌肿本身,又可以彻底清除了可能转移的区域淋巴结。因此,只有进行了彻底的手术才有可能治愈结肠癌。
造瘘术常见于经外科手术切除结直肠癌的病例,在这类外科手术中,切除结肠的一部分,或者同时切除全部或部分直肠,所遗留结肠癌患者肠的残端经过腹壁皮肤拉到身体表面,回折成龟颈样后缝在预计形成瘘口的地方。造瘘术分为乙状结肠造瘘术和横结肠造瘘术,乙状结肠造瘘术是将乙状结肠近段移至左下腹壁,形成单口式造瘘。常为永久性人工肛门,也有用作暂时性人工肛门的。横结肠造瘘术是一种暂时性的部分造瘘,少数情况可作为永久性人工肛门。
造瘘术能解决结肠切除后排便问题,但是其并发症也很多,例如造瘘口周围炎、造瘘口狭窄、出血、造瘘口肠坏死等。所以造瘘术后期护理显得尤为重要。
对于造瘘术的种种并发症,目前还没有一种能够有效用于结肠癌造瘘术后期造瘘口并发症的特效护理口服药剂。
发明内容
本发明解决的技术问题为:提供一种能够有效用于结肠癌造瘘术后期造瘘口并发症的特效护理口服药剂及其制备方法。
本发明的技术方案为:一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆50-80份、荡皮参35-70份、香皮树40-90份、刺梨根30-60份、山稗子24-60份、木槿根32-56份、赤芍药18-30份、合树菌22-46份、魔芋18-34份、散瘀草8-20份、云芝20-38份。
所述的一种结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,以水或与水相互溶的有机溶剂提取,或按比例取各味原料药,采用水提醇沉法提取;得到的提取物浓缩成85℃时相对密度为1.24-1.36的稠膏,制备成口服制剂。
进一步地,一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆50-80份、荡皮参35-70份、香皮树40-90份、刺梨根30-60份、山稗子24-60份、木槿根32-56份、赤芍药18-30份、合树菌22-46份、魔芋18-34份、散瘀草8-20份、云芝20-38份,所述的一种结肠癌造瘘术后期护理口服药剂原料药组成还包括:柴桂20-50份、山海棠45-86份。
所述的一种结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,柴桂、山海棠研末,获得粉末,过65目筛;其余各味原料药以水或与水相互溶的有机溶剂提取,或按比例取各味原料药,采用水提醇沉法提取;得到的提取物浓缩成85℃时相对密度为1.24-1.36的稠膏,与所述粉末混合,制备成口服制剂。
进一步地,所述与水相互溶的有机溶剂选自甲醇、乙醇、丙酮中的一种或多种;所用的提取方法包括浸泡提取、回流提取、煎煮提取、超声提取或渗漉提取中的一种或多种方式。
进一步地,所述醇沉法所用的乙醇其醇浓度为60-80%。
进一步地,所述口服制剂的剂型包括片剂、颗粒剂、胶囊剂。
进一步地,所述片剂的制备方法为:按照药学常规辅料要求,加辅料混匀,所述辅料为80-120份预胶化淀粉、20-40份蔗糖,用60%乙醇制粒,干燥,压片,包衣,每片重0.25g。
进一步地,所述颗粒剂的制备方法为:按照药学常规辅料要求,加辅料混匀,所述辅料为25-55份蔗糖粉、8-14份糊精,加水制成软材,制颗粒,在50-60℃干燥,整粒,分装,即得。
进一步地,所述胶囊剂的制备方法为:按照药学常规辅料要求,加辅料混匀,所述辅料为0.2-0.5份海藻酸钠、0.05-0.09份聚乙二醇、0.01-0.03份苯甲酸钠,干燥,粉碎,过筛,混匀,装入胶囊,即得。
服用方法:
1.片剂:口服,每次2-3片,每日3次。
2.颗粒剂:温开水送服,每次1袋,每日2-3次。
3.胶囊剂:口服,每次2-3片,每日3次。
10天为一个疗程。
注意事项:
(1)服药后3-4天应观察患者的肠蠕动是否恢复,如排气,可可进流食,以减轻肠道负担,利于伤口愈合。
(2)进食易消化、高热量、高蛋白、高维生素饮食,但要少食多餐。避免进食刺激性、易产生胀气、不易消化及有臭味的食物,如蛋类、葱姜蒜、辣椒、芹菜等。忌烟酒,同时还要注意饮食卫生,防止因饮食不当引起腹泻或便秘。
(3)养成定时排便习惯。
(4)日常沐浴指导:使用有底板的造口袋,只要在底板与皮肤接触处封上一圈防水胶布,即可安心沐浴。
本发明所用的所有中药原料的药理活性如下:
赤小豆:味甘、酸,性微寒。清热和血,利水通经,宽肠理气,清热解毒消痈。主水肿;脚气;黄疸;淋病;便血;肿毒疮疡;癣疹。
荡皮参:味甘、咸,性温。补肾养血;催乳;止血。主虚弱劳怯;产后乳少;肠燥便秘;外伤出血。
香皮树:滑肠通便,主肠燥便秘。
刺梨根:甘酸,平。健胃消食,止痛,收涩,止血。,消食去胀。
山稗子:味甘、微辛;性平。凉血,止血。治消化道出血。
木槿根:甘;凉。归肺、肾、大肠经。清热解毒,润燥活血,去肠湿热,利湿,消肿。治咳嗽,肺痈,肠痈,肠风泻血,痔疮肿痛,白带,疥癣。
赤芍药:行瘀,止痛,凉血,消肿。治瘀滞经闭,疝瘕积聚,腹痛,胁痛,衄血,血痢,肠风下血,目赤,痈肿。利小便,益气。"通顺血脉,缓中,散恶血,逐贼血,去水气,利膀胱大小肠
合树菌:甘;平。顺气;益神;祛风;抗肿瘤。主胃病;麻风病;肿瘤。
魔芋:辛,寒。有毒。消肿散结,解毒止痛。用于肿瘤,颈淋巴结结核;外用治痈疖肿毒,毒蛇咬伤。
散瘀草:苦,寒。消炎,凉血,接骨。用于支气管炎,扁桃腺炎,肺热咳血,疮,疖,乳腺炎,脱肛,痔疮,肿瘤,外伤出血,烧烫伤,骨折。
云芝:甘;淡;微寒。健脾利湿;止咳平喘;清热解毒;抗肿瘤。主慢性活动性肝炎;肝硬变;慢性支气管炎;小儿痉挛性支气管炎;咽喉肿痛;多种肿瘤;类风湿性关节炎;白血病。
柴桂:辛;甘;温。温通经脉;行气止痛。主寒湿痹痛;脘腹疼痛;痛经;跌打损伤。挥发油对胃有局部刺激作用,能解除或减轻恶心和胃肠胀气。
山海棠:味辛;苦;性平。解表利湿;行气散瘀。主感冒;风湿痹痛;腹胀;泄泻;痢疾;跌打损伤;湿疹;皮炎。用于消化道出血。治胃肠胀气。
本发明的有益效果是:本发明的一种结肠癌造瘘术后期护理口服药剂组方严谨,配伍合理,选用清热和血,利水通经,宽肠理气,去肠湿热,润肠通便、活血止血,行气止痛、减轻胃肠胀气的中草药,再附上利于消化道肿瘤康复和能够调节免疫功能的中草药,由内而外对做造瘘术的结肠癌患者进行调理,对后期造瘘口并发症具有良好的护理功效。
具体实施方式
实施例1:
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆50份、荡皮参35份、香皮树40份、刺梨根30份、山稗子24份、木槿根32份、赤芍药18份、合树菌22份、魔芋18份、散瘀草8份、云芝20份。
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,用水煎煮提取,再用醇浓度为60%的乙醇进行醇沉;得到的提取物浓缩成85℃时相对密度为1.24的稠膏,按照药学常规辅料要求,加80份预胶化淀粉、20份蔗糖,用60%乙醇制粒,干燥,压片,包衣,每片重0.25g,制备成片剂。
实施例2:
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆65份、荡皮参53份、香皮树65份、刺梨根45份、山稗子42份、木槿根44份、赤芍药24份、合树菌34份、魔芋26份、散瘀草14份、云芝29份。
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,以乙醇为溶剂,回流提取;得到的提取物浓缩成85℃时相对密度为1.30的稠膏,按照药学常规辅料要求,加辅料混匀,所述辅料为40份蔗糖粉、11份糊精,加水制成软材,制颗粒,在55℃干燥,整粒,分装,即得颗粒剂。
实施例3:
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆80份、荡皮参70份、香皮树90份、刺梨根60份、山稗子60份、木槿根56份、赤芍药30份、合树菌46份、魔芋34份、散瘀草20份、云芝38份。
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,以丙醇为溶剂,超声提取;得到的提取物浓缩成85℃时相对密度为1.36的稠膏,按照药学常规辅料要求,加辅料混匀,所述辅料为0.5份海藻酸钠、0.09份聚乙二醇、0.03份苯甲酸钠,干燥,粉碎,过筛,混匀,装入胶囊,即得胶囊剂。
实施例4:
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆50份、荡皮参35份、香皮树40份、刺梨根30份、山稗子24份、木槿根32份、赤芍药18份、合树菌22份、魔芋18份、散瘀草8份、云芝20份、柴桂20份、山海棠45份。
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,柴桂、山海棠研末,获得粉末,过65目筛;其余各味原料药以甲醇作为溶剂,渗漉提取,得到的提取物浓缩成85℃时相对密度为1.24的稠膏,与所述粉末混合,按照药学常规辅料要求,加辅料混匀,所述辅料为80份预胶化淀粉、20份蔗糖,用60%乙醇制粒,干燥,压片,包衣,每片重0.25g,即得片剂。
实施例5:
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆65份、荡皮参53份、香皮树65份、刺梨根45份、山稗子42份、木槿根44份、赤芍药24份、合树菌34份、魔芋26份、散瘀草14份、云芝29份、柴桂35份、山海棠65份。
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,柴桂、山海棠研末,获得粉末,过65目筛;其余各味原料药以乙醇作为溶剂,回流提取,得到的提取物浓缩成85℃时相对密度为1.30的稠膏,与所述粉末混合,按照药学常规辅料要求,加辅料混匀,所述辅料为40份蔗糖粉、11份糊精,加水制成软材,制颗粒,在55℃干燥,整粒,分装,即得颗粒剂。
实施例6:
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆80份、荡皮参70份、香皮树90份、刺梨根60份、山稗子60份、木槿根56份、赤芍药30份、合树菌46份、魔芋34份、散瘀草20份、云芝38份、柴桂50份、山海棠86份。
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,柴桂、山海棠研末,获得粉末,过65目筛;其余各味原料药采用水提醇沉法提取,所用的乙醇其醇浓度为80%;得到的提取物浓缩成85℃时相对密度为1.36 的稠膏,与所述粉末混合,按照药学常规辅料要求,加辅料混匀,所述辅料为0.5份海藻酸钠、0.09份聚乙二醇、0.03份苯甲酸钠,干燥,粉碎,过筛,混匀,装入胶囊,即得胶囊剂。
临床验证:
病例1:黄某某,女,35岁,由于结肠癌做了根治性结肠癌手术,切除癌肿所在肠袢,所遗留肠的残端经过腹壁皮肤拉到身体表面,回折成龟颈样后缝在腹部表面,即乙状结肠造瘘术,结肠癌完全切除,但是后期造瘘口出现病变,表现为:腹部胀气,有恶臭味的气泡从造瘘口逸出。使用本发明实施例1制备的护理药剂,两日后,胀气症状减轻,造口排气症状消失,继续服药一个疗程后完全恢复正常。
病例2:李某,男,14岁,由于结肠癌做了结肠切除手术,所遗留肠的残端经过腹壁皮肤拉到身体表面,回折成龟颈样后缝在腹部表面,后期造瘘口出现病变,表现为:腹胀,便秘,肠造口处粘膜色泽青紫,偶尔有气体经肠造口排出。使用本发明实施例3制备的护理药剂,三日后,腹胀感消失,开始排便,五日后肠造口处粘膜色泽变得红润,继续服药一个疗程后完全恢复正常。
病例3:杨某某,男,52岁,由于结肠癌做了结肠切除手术,所遗留肠的残端经过腹壁皮肤拉到身体表面,回折成龟颈样后缝在腹部表面,后期造瘘口出现病变,表现为:腹泻,肠造口处黏膜色黑,不红润,由于受到排泄物的浸渍后来甚至出现皮肤湿疹。使用本发明实施例6制备的护理药剂,两日后,腹泻症状减轻,四日后肠造口处皮肤湿疹好转,黏膜红润,继续服药一个疗程后完全恢复正常。
最后应说明的是:以上实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明实施例技术方案的精神和范围。
Claims (10)
1.一种结肠癌造瘘术后期护理口服药剂,其特征在于该药剂的原料药组成为:赤小豆50-80份、荡皮参35-70份、香皮树40-90份、刺梨根30-60份、山稗子24-60份、木槿根32-56份、赤芍药18-30份、合树菌22-46份、魔芋18-34份、散瘀草8-20份、云芝20-38份。
2.如权利要求1所述的一种结肠癌造瘘术后期护理口服药剂,其特征在于该药剂的原料药组成为:赤小豆50-80份、荡皮参35-70份、香皮树40-90份、刺梨根30-60份、山稗子24-60份、木槿根32-56份、赤芍药18-30份、合树菌22-46份、魔芋18-34份、散瘀草8-20份、云芝20-38份,该药剂的原料药组成还包括:柴桂20-50份、山海棠45-86份。
3.如权利要求1所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于该方法包括:按比例取各味原料药,以水或与水相互溶的有机溶剂提取,或按比例取各味原料药,采用水提醇沉法提取;得到的提取物浓缩成稠膏,制备成口服制剂。
4.如权利要求2所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于该方法包括:按比例取各味原料药,柴桂、山海棠研末,获得粉末;其余各味原料药以水或与水相互溶的有机溶剂提取,或按比例取各味原料药,采用水提醇沉法提取;得到的提取物浓缩成稠膏,与所述粉末混合,制备成口服制剂。
5.如权利要求3或4所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述与水相互溶的有机溶剂选自甲醇、乙醇、丙酮中的一种或多种;所用的提取方法包括浸泡提取、回流提取、煎煮提取、超声提取或渗漉提取中的一种或多种方式。
6.如权利要求3或4所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述醇沉法所用的乙醇其醇浓度为60-80%。
7.如权利要求3或4所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述口服制剂的剂型包括片剂、颗粒剂、胶囊剂。
8.如权利要求7所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述片剂的制备方法为:按照药学常规辅料要求,加辅料混匀,用60%乙醇制粒,干燥,压片,包衣,每片重0.25g。
9.如权利要求7所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述颗粒剂的制备方法为:按照药学常规辅料要求,加辅料混匀,加水制成软材,制颗粒,在50-60℃干燥,整粒,分装,即得。
10.如权利要求7所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述胶囊剂的制备方法为:按照药学常规辅料要求,加辅料混匀,干燥,粉碎,过筛,混匀,装入胶囊,即得。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410597211.8A CN104398725A (zh) | 2014-10-30 | 2014-10-30 | 一种结肠癌造瘘术后期护理口服药剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410597211.8A CN104398725A (zh) | 2014-10-30 | 2014-10-30 | 一种结肠癌造瘘术后期护理口服药剂及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104398725A true CN104398725A (zh) | 2015-03-11 |
Family
ID=52636434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410597211.8A Pending CN104398725A (zh) | 2014-10-30 | 2014-10-30 | 一种结肠癌造瘘术后期护理口服药剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104398725A (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106728694A (zh) * | 2017-02-14 | 2017-05-31 | 广州华河科技有限公司 | 一种肿瘤术后病人康复用中药制剂及其制备方法 |
CN107050066A (zh) * | 2017-02-14 | 2017-08-18 | 厦门华言科技有限公司 | 虾青素‑昆布自乳化软胶囊及其制备方法和应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1689443A (zh) * | 2004-04-27 | 2005-11-02 | 雷安乐 | 一种魔芋方便食品的加工方法 |
JP2010265202A (ja) * | 2009-05-13 | 2010-11-25 | Kibun Foods Inc | 細胞増殖抑制剤 |
-
2014
- 2014-10-30 CN CN201410597211.8A patent/CN104398725A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1689443A (zh) * | 2004-04-27 | 2005-11-02 | 雷安乐 | 一种魔芋方便食品的加工方法 |
JP2010265202A (ja) * | 2009-05-13 | 2010-11-25 | Kibun Foods Inc | 細胞増殖抑制剤 |
Non-Patent Citations (3)
Title |
---|
刘忠良: ""中西医结合治疗急性结肠癌性肠梗阻68例"", 《现代中医药》 * |
吴继萍等: ""中医辨证论治结直肠癌术后的临床研究"", 《光明中医》 * |
官金宝: ""结肠癌急性梗阻Ⅰ期手术的中西医结合治疗"", 《实用中西医结合临床》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106728694A (zh) * | 2017-02-14 | 2017-05-31 | 广州华河科技有限公司 | 一种肿瘤术后病人康复用中药制剂及其制备方法 |
CN107050066A (zh) * | 2017-02-14 | 2017-08-18 | 厦门华言科技有限公司 | 虾青素‑昆布自乳化软胶囊及其制备方法和应用 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101612360B (zh) | 治疗肝炎、肝硬化、肝癌的药物 | |
CN102940843B (zh) | 一种治疗消化不良的药物组合物 | |
CN104225441A (zh) | 一种治疗胃病的中药组合物及其颗粒剂和胶囊剂的制备方法 | |
CN105213974A (zh) | 一种治疗淋巴瘤的中药组合物及其应用 | |
CN104398725A (zh) | 一种结肠癌造瘘术后期护理口服药剂及其制备方法 | |
CN104740535A (zh) | 一种治疗直肠癌的药物栓剂 | |
CN104873926A (zh) | 治疗腹泻的中药制剂及其制备方法与应用 | |
CN104352728A (zh) | 治疗乳腺纤维瘤的中药制剂 | |
CN103520623B (zh) | 一种治疗胃溃疡的中药制剂 | |
CN104399002A (zh) | 一种治疗直肠癌的中药组合物 | |
CN103212026A (zh) | 一种治疗胆石症的中药及其制备方法和服用方法 | |
CN104491587B (zh) | 减轻化疗所致肝肾功能损伤副反应的药剂及制备 | |
CN103230480B (zh) | 一种治疗血虚挟风型肛门湿疹的中药 | |
CN102961555B (zh) | 一种治疗肝病的中药组合物及其制备方法 | |
CN106214809A (zh) | 一种治疗湿疹的外用中药组合物及制备方法 | |
CN104888148A (zh) | 一种治疗慢性乙型肝炎的药物 | |
CN105902878A (zh) | 一种治疗尿路结石的药物及其制备 | |
CN105125860A (zh) | 一种有效治疗骨质疏松的制剂 | |
CN105012642A (zh) | 一种活血化瘀,止血止痛的中药组合物的制备方法 | |
CN104998019A (zh) | 一种活血化瘀,止血止痛的中药组合物 | |
CN104306491B (zh) | 治疗口舌生疮的中药组合物及制法 | |
CN103611098B (zh) | 一种治疗皮肤瘙痒的中药 | |
CN103623355B (zh) | 一种治疗滑动性斜疝的中药制剂 | |
CN103989837A (zh) | 一种预防和治疗痔疮的中药组合物及其制备方法 | |
CN104107241A (zh) | 疏肝退黄散 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150311 |