CN104398725A - 一种结肠癌造瘘术后期护理口服药剂及其制备方法 - Google Patents

一种结肠癌造瘘术后期护理口服药剂及其制备方法 Download PDF

Info

Publication number
CN104398725A
CN104398725A CN201410597211.8A CN201410597211A CN104398725A CN 104398725 A CN104398725 A CN 104398725A CN 201410597211 A CN201410597211 A CN 201410597211A CN 104398725 A CN104398725 A CN 104398725A
Authority
CN
China
Prior art keywords
parts
preparation
fistulation
colon cancer
later stage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410597211.8A
Other languages
English (en)
Inventor
张焕秀
赵晓华
李磊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201410597211.8A priority Critical patent/CN104398725A/zh
Publication of CN104398725A publication Critical patent/CN104398725A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/616Echinodermata, e.g. starfish, sea cucumbers or sea urchins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738Rosa (rose)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

本发明公开了一种结肠癌造瘘术后期护理口服药剂及其制备方法,该药剂的原料药组成为:赤小豆50-80份、荡皮参35-70份、香皮树40-90份、刺梨根30-60份、山稗子24-60份、木槿根32-56份、赤芍药18-30份、合树菌22-46份、魔芋18-34份、散瘀草8-20份、云芝20-38份,还包括:柴桂20-50份、山海棠45-86份。本发明药剂组方严谨,配伍合理,具有清热和血,利水通经,宽肠理气,去肠湿热,润肠通便、活血止血,行气止痛、减轻胃肠胀气的功效,再附上利于消化道肿瘤康复和能够调节免疫功能的中草药,由内而外对做造瘘术的结肠癌患者进行调理,对后期造瘘口并发症具有良好的护理功效。

Description

一种结肠癌造瘘术后期护理口服药剂及其制备方法
技术领域
本发明涉及肿瘤护理技术领域,尤其是涉及一种结肠癌造瘘术后期护理口服药剂。 
背景技术
结肠癌是指结肠粘膜上皮在环境或遗传等多种致癌因素作用下发生的恶性病变。是常见的恶性肿瘤之一,以40岁~50岁年龄组发病率最高,全球每年新发病例约800万人,占所有恶性肿瘤的10%~15%。 
结肠癌治疗原则是以手术切除为主的综合治疗,同时联合化疗、放疗等降低手术后复发率,提高生存率。根治性结肠癌手术的切除范围包括癌肿所在肠袢及其全结肠系膜(complete mesocolic excision,CME)。即切除了癌肿本身,又可以彻底清除了可能转移的区域淋巴结。因此,只有进行了彻底的手术才有可能治愈结肠癌。 
造瘘术常见于经外科手术切除结直肠癌的病例,在这类外科手术中,切除结肠的一部分,或者同时切除全部或部分直肠,所遗留结肠癌患者肠的残端经过腹壁皮肤拉到身体表面,回折成龟颈样后缝在预计形成瘘口的地方。造瘘术分为乙状结肠造瘘术和横结肠造瘘术,乙状结肠造瘘术是将乙状结肠近段移至左下腹壁,形成单口式造瘘。常为永久性人工肛门,也有用作暂时性人工肛门的。横结肠造瘘术是一种暂时性的部分造瘘,少数情况可作为永久性人工肛门。 
造瘘术能解决结肠切除后排便问题,但是其并发症也很多,例如造瘘口周围炎、造瘘口狭窄、出血、造瘘口肠坏死等。所以造瘘术后期护理显得尤为重要。 
对于造瘘术的种种并发症,目前还没有一种能够有效用于结肠癌造瘘术后期造瘘口并发症的特效护理口服药剂。 
发明内容
本发明解决的技术问题为:提供一种能够有效用于结肠癌造瘘术后期造瘘口并发症的特效护理口服药剂及其制备方法。 
本发明的技术方案为:一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆50-80份、荡皮参35-70份、香皮树40-90份、刺梨根30-60份、山稗子24-60份、木槿根32-56份、赤芍药18-30份、合树菌22-46份、魔芋18-34份、散瘀草8-20份、云芝20-38份。 
所述的一种结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,以水或与水相互溶的有机溶剂提取,或按比例取各味原料药,采用水提醇沉法提取;得到的提取物浓缩成85℃时相对密度为1.24-1.36的稠膏,制备成口服制剂。 
进一步地,一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆50-80份、荡皮参35-70份、香皮树40-90份、刺梨根30-60份、山稗子24-60份、木槿根32-56份、赤芍药18-30份、合树菌22-46份、魔芋18-34份、散瘀草8-20份、云芝20-38份,所述的一种结肠癌造瘘术后期护理口服药剂原料药组成还包括:柴桂20-50份、山海棠45-86份。 
所述的一种结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,柴桂、山海棠研末,获得粉末,过65目筛;其余各味原料药以水或与水相互溶的有机溶剂提取,或按比例取各味原料药,采用水提醇沉法提取;得到的提取物浓缩成85℃时相对密度为1.24-1.36的稠膏,与所述粉末混合,制备成口服制剂。 
进一步地,所述与水相互溶的有机溶剂选自甲醇、乙醇、丙酮中的一种或多种;所用的提取方法包括浸泡提取、回流提取、煎煮提取、超声提取或渗漉提取中的一种或多种方式。 
进一步地,所述醇沉法所用的乙醇其醇浓度为60-80%。 
进一步地,所述口服制剂的剂型包括片剂、颗粒剂、胶囊剂。 
进一步地,所述片剂的制备方法为:按照药学常规辅料要求,加辅料混匀,所述辅料为80-120份预胶化淀粉、20-40份蔗糖,用60%乙醇制粒,干燥,压片,包衣,每片重0.25g。 
进一步地,所述颗粒剂的制备方法为:按照药学常规辅料要求,加辅料混匀,所述辅料为25-55份蔗糖粉、8-14份糊精,加水制成软材,制颗粒,在50-60℃干燥,整粒,分装,即得。 
进一步地,所述胶囊剂的制备方法为:按照药学常规辅料要求,加辅料混匀,所述辅料为0.2-0.5份海藻酸钠、0.05-0.09份聚乙二醇、0.01-0.03份苯甲酸钠,干燥,粉碎,过筛,混匀,装入胶囊,即得。 
服用方法: 
1.片剂:口服,每次2-3片,每日3次。 
2.颗粒剂:温开水送服,每次1袋,每日2-3次。 
3.胶囊剂:口服,每次2-3片,每日3次。 
10天为一个疗程。 
注意事项: 
(1)服药后3-4天应观察患者的肠蠕动是否恢复,如排气,可可进流食,以减轻肠道负担,利于伤口愈合。 
(2)进食易消化、高热量、高蛋白、高维生素饮食,但要少食多餐。避免进食刺激性、易产生胀气、不易消化及有臭味的食物,如蛋类、葱姜蒜、辣椒、芹菜等。忌烟酒,同时还要注意饮食卫生,防止因饮食不当引起腹泻或便秘。 
(3)养成定时排便习惯。 
(4)日常沐浴指导:使用有底板的造口袋,只要在底板与皮肤接触处封上一圈防水胶布,即可安心沐浴。 
本发明所用的所有中药原料的药理活性如下: 
赤小豆:味甘、酸,性微寒。清热和血,利水通经,宽肠理气,清热解毒消痈。主水肿;脚气;黄疸;淋病;便血;肿毒疮疡;癣疹。 
荡皮参:味甘、咸,性温。补肾养血;催乳;止血。主虚弱劳怯;产后乳少;肠燥便秘;外伤出血。 
香皮树:滑肠通便,主肠燥便秘。 
刺梨根:甘酸,平。健胃消食,止痛,收涩,止血。,消食去胀。 
山稗子:味甘、微辛;性平。凉血,止血。治消化道出血。 
木槿根:甘;凉。归肺、肾、大肠经。清热解毒,润燥活血,去肠湿热,利湿,消肿。治咳嗽,肺痈,肠痈,肠风泻血,痔疮肿痛,白带,疥癣。 
赤芍药:行瘀,止痛,凉血,消肿。治瘀滞经闭,疝瘕积聚,腹痛,胁痛,衄血,血痢,肠风下血,目赤,痈肿。利小便,益气。"通顺血脉,缓中,散恶血,逐贼血,去水气,利膀胱大小肠 
合树菌:甘;平。顺气;益神;祛风;抗肿瘤。主胃病;麻风病;肿瘤。 
魔芋:辛,寒。有毒。消肿散结,解毒止痛。用于肿瘤,颈淋巴结结核;外用治痈疖肿毒,毒蛇咬伤。 
散瘀草:苦,寒。消炎,凉血,接骨。用于支气管炎,扁桃腺炎,肺热咳血,疮,疖,乳腺炎,脱肛,痔疮,肿瘤,外伤出血,烧烫伤,骨折。 
云芝:甘;淡;微寒。健脾利湿;止咳平喘;清热解毒;抗肿瘤。主慢性活动性肝炎;肝硬变;慢性支气管炎;小儿痉挛性支气管炎;咽喉肿痛;多种肿瘤;类风湿性关节炎;白血病。 
柴桂:辛;甘;温。温通经脉;行气止痛。主寒湿痹痛;脘腹疼痛;痛经;跌打损伤。挥发油对胃有局部刺激作用,能解除或减轻恶心和胃肠胀气。 
山海棠:味辛;苦;性平。解表利湿;行气散瘀。主感冒;风湿痹痛;腹胀;泄泻;痢疾;跌打损伤;湿疹;皮炎。用于消化道出血。治胃肠胀气。 
本发明的有益效果是:本发明的一种结肠癌造瘘术后期护理口服药剂组方严谨,配伍合理,选用清热和血,利水通经,宽肠理气,去肠湿热,润肠通便、活血止血,行气止痛、减轻胃肠胀气的中草药,再附上利于消化道肿瘤康复和能够调节免疫功能的中草药,由内而外对做造瘘术的结肠癌患者进行调理,对后期造瘘口并发症具有良好的护理功效。 
具体实施方式
实施例1: 
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆50份、荡皮参35份、香皮树40份、刺梨根30份、山稗子24份、木槿根32份、赤芍药18份、合树菌22份、魔芋18份、散瘀草8份、云芝20份。 
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,用水煎煮提取,再用醇浓度为60%的乙醇进行醇沉;得到的提取物浓缩成85℃时相对密度为1.24的稠膏,按照药学常规辅料要求,加80份预胶化淀粉、20份蔗糖,用60%乙醇制粒,干燥,压片,包衣,每片重0.25g,制备成片剂。 
实施例2: 
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆65份、荡皮参53份、香皮树65份、刺梨根45份、山稗子42份、木槿根44份、赤芍药24份、合树菌34份、魔芋26份、散瘀草14份、云芝29份。 
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,以乙醇为溶剂,回流提取;得到的提取物浓缩成85℃时相对密度为1.30的稠膏,按照药学常规辅料要求,加辅料混匀,所述辅料为40份蔗糖粉、11份糊精,加水制成软材,制颗粒,在55℃干燥,整粒,分装,即得颗粒剂。 
实施例3: 
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆80份、荡皮参70份、香皮树90份、刺梨根60份、山稗子60份、木槿根56份、赤芍药30份、合树菌46份、魔芋34份、散瘀草20份、云芝38份。 
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,以丙醇为溶剂,超声提取;得到的提取物浓缩成85℃时相对密度为1.36的稠膏,按照药学常规辅料要求,加辅料混匀,所述辅料为0.5份海藻酸钠、0.09份聚乙二醇、0.03份苯甲酸钠,干燥,粉碎,过筛,混匀,装入胶囊,即得胶囊剂。 
实施例4: 
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆50份、荡皮参35份、香皮树40份、刺梨根30份、山稗子24份、木槿根32份、赤芍药18份、合树菌22份、魔芋18份、散瘀草8份、云芝20份、柴桂20份、山海棠45份。 
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,柴桂、山海棠研末,获得粉末,过65目筛;其余各味原料药以甲醇作为溶剂,渗漉提取,得到的提取物浓缩成85℃时相对密度为1.24的稠膏,与所述粉末混合,按照药学常规辅料要求,加辅料混匀,所述辅料为80份预胶化淀粉、20份蔗糖,用60%乙醇制粒,干燥,压片,包衣,每片重0.25g,即得片剂。 
实施例5: 
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆65份、荡皮参53份、香皮树65份、刺梨根45份、山稗子42份、木槿根44份、赤芍药24份、合树菌34份、魔芋26份、散瘀草14份、云芝29份、柴桂35份、山海棠65份。 
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,柴桂、山海棠研末,获得粉末,过65目筛;其余各味原料药以乙醇作为溶剂,回流提取,得到的提取物浓缩成85℃时相对密度为1.30的稠膏,与所述粉末混合,按照药学常规辅料要求,加辅料混匀,所述辅料为40份蔗糖粉、11份糊精,加水制成软材,制颗粒,在55℃干燥,整粒,分装,即得颗粒剂。 
实施例6: 
一种结肠癌造瘘术后期护理口服药剂,该药剂的原料药组成为:赤小豆80份、荡皮参70份、香皮树90份、刺梨根60份、山稗子60份、木槿根56份、赤芍药30份、合树菌46份、魔芋34份、散瘀草20份、云芝38份、柴桂50份、山海棠86份。 
该结肠癌造瘘术后期护理口服药剂的制备方法包括:按比例取各味原料药,柴桂、山海棠研末,获得粉末,过65目筛;其余各味原料药采用水提醇沉法提取,所用的乙醇其醇浓度为80%;得到的提取物浓缩成85℃时相对密度为1.36 的稠膏,与所述粉末混合,按照药学常规辅料要求,加辅料混匀,所述辅料为0.5份海藻酸钠、0.09份聚乙二醇、0.03份苯甲酸钠,干燥,粉碎,过筛,混匀,装入胶囊,即得胶囊剂。 
临床验证: 
病例1:黄某某,女,35岁,由于结肠癌做了根治性结肠癌手术,切除癌肿所在肠袢,所遗留肠的残端经过腹壁皮肤拉到身体表面,回折成龟颈样后缝在腹部表面,即乙状结肠造瘘术,结肠癌完全切除,但是后期造瘘口出现病变,表现为:腹部胀气,有恶臭味的气泡从造瘘口逸出。使用本发明实施例1制备的护理药剂,两日后,胀气症状减轻,造口排气症状消失,继续服药一个疗程后完全恢复正常。 
病例2:李某,男,14岁,由于结肠癌做了结肠切除手术,所遗留肠的残端经过腹壁皮肤拉到身体表面,回折成龟颈样后缝在腹部表面,后期造瘘口出现病变,表现为:腹胀,便秘,肠造口处粘膜色泽青紫,偶尔有气体经肠造口排出。使用本发明实施例3制备的护理药剂,三日后,腹胀感消失,开始排便,五日后肠造口处粘膜色泽变得红润,继续服药一个疗程后完全恢复正常。 
病例3:杨某某,男,52岁,由于结肠癌做了结肠切除手术,所遗留肠的残端经过腹壁皮肤拉到身体表面,回折成龟颈样后缝在腹部表面,后期造瘘口出现病变,表现为:腹泻,肠造口处黏膜色黑,不红润,由于受到排泄物的浸渍后来甚至出现皮肤湿疹。使用本发明实施例6制备的护理药剂,两日后,腹泻症状减轻,四日后肠造口处皮肤湿疹好转,黏膜红润,继续服药一个疗程后完全恢复正常。 
最后应说明的是:以上实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明实施例技术方案的精神和范围。 

Claims (10)

1.一种结肠癌造瘘术后期护理口服药剂,其特征在于该药剂的原料药组成为:赤小豆50-80份、荡皮参35-70份、香皮树40-90份、刺梨根30-60份、山稗子24-60份、木槿根32-56份、赤芍药18-30份、合树菌22-46份、魔芋18-34份、散瘀草8-20份、云芝20-38份。
2.如权利要求1所述的一种结肠癌造瘘术后期护理口服药剂,其特征在于该药剂的原料药组成为:赤小豆50-80份、荡皮参35-70份、香皮树40-90份、刺梨根30-60份、山稗子24-60份、木槿根32-56份、赤芍药18-30份、合树菌22-46份、魔芋18-34份、散瘀草8-20份、云芝20-38份,该药剂的原料药组成还包括:柴桂20-50份、山海棠45-86份。
3.如权利要求1所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于该方法包括:按比例取各味原料药,以水或与水相互溶的有机溶剂提取,或按比例取各味原料药,采用水提醇沉法提取;得到的提取物浓缩成稠膏,制备成口服制剂。
4.如权利要求2所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于该方法包括:按比例取各味原料药,柴桂、山海棠研末,获得粉末;其余各味原料药以水或与水相互溶的有机溶剂提取,或按比例取各味原料药,采用水提醇沉法提取;得到的提取物浓缩成稠膏,与所述粉末混合,制备成口服制剂。
5.如权利要求3或4所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述与水相互溶的有机溶剂选自甲醇、乙醇、丙酮中的一种或多种;所用的提取方法包括浸泡提取、回流提取、煎煮提取、超声提取或渗漉提取中的一种或多种方式。
6.如权利要求3或4所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述醇沉法所用的乙醇其醇浓度为60-80%。
7.如权利要求3或4所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述口服制剂的剂型包括片剂、颗粒剂、胶囊剂。
8.如权利要求7所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述片剂的制备方法为:按照药学常规辅料要求,加辅料混匀,用60%乙醇制粒,干燥,压片,包衣,每片重0.25g。
9.如权利要求7所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述颗粒剂的制备方法为:按照药学常规辅料要求,加辅料混匀,加水制成软材,制颗粒,在50-60℃干燥,整粒,分装,即得。
10.如权利要求7所述的一种结肠癌造瘘术后期护理口服药剂的制备方法,其特征在于所述胶囊剂的制备方法为:按照药学常规辅料要求,加辅料混匀,干燥,粉碎,过筛,混匀,装入胶囊,即得。
CN201410597211.8A 2014-10-30 2014-10-30 一种结肠癌造瘘术后期护理口服药剂及其制备方法 Pending CN104398725A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410597211.8A CN104398725A (zh) 2014-10-30 2014-10-30 一种结肠癌造瘘术后期护理口服药剂及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410597211.8A CN104398725A (zh) 2014-10-30 2014-10-30 一种结肠癌造瘘术后期护理口服药剂及其制备方法

Publications (1)

Publication Number Publication Date
CN104398725A true CN104398725A (zh) 2015-03-11

Family

ID=52636434

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410597211.8A Pending CN104398725A (zh) 2014-10-30 2014-10-30 一种结肠癌造瘘术后期护理口服药剂及其制备方法

Country Status (1)

Country Link
CN (1) CN104398725A (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106728694A (zh) * 2017-02-14 2017-05-31 广州华河科技有限公司 一种肿瘤术后病人康复用中药制剂及其制备方法
CN107050066A (zh) * 2017-02-14 2017-08-18 厦门华言科技有限公司 虾青素‑昆布自乳化软胶囊及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1689443A (zh) * 2004-04-27 2005-11-02 雷安乐 一种魔芋方便食品的加工方法
JP2010265202A (ja) * 2009-05-13 2010-11-25 Kibun Foods Inc 細胞増殖抑制剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1689443A (zh) * 2004-04-27 2005-11-02 雷安乐 一种魔芋方便食品的加工方法
JP2010265202A (ja) * 2009-05-13 2010-11-25 Kibun Foods Inc 細胞増殖抑制剤

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
刘忠良: ""中西医结合治疗急性结肠癌性肠梗阻68例"", 《现代中医药》 *
吴继萍等: ""中医辨证论治结直肠癌术后的临床研究"", 《光明中医》 *
官金宝: ""结肠癌急性梗阻Ⅰ期手术的中西医结合治疗"", 《实用中西医结合临床》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106728694A (zh) * 2017-02-14 2017-05-31 广州华河科技有限公司 一种肿瘤术后病人康复用中药制剂及其制备方法
CN107050066A (zh) * 2017-02-14 2017-08-18 厦门华言科技有限公司 虾青素‑昆布自乳化软胶囊及其制备方法和应用

Similar Documents

Publication Publication Date Title
CN101612360B (zh) 治疗肝炎、肝硬化、肝癌的药物
CN102940843B (zh) 一种治疗消化不良的药物组合物
CN104225441A (zh) 一种治疗胃病的中药组合物及其颗粒剂和胶囊剂的制备方法
CN105213974A (zh) 一种治疗淋巴瘤的中药组合物及其应用
CN104398725A (zh) 一种结肠癌造瘘术后期护理口服药剂及其制备方法
CN104740535A (zh) 一种治疗直肠癌的药物栓剂
CN104873926A (zh) 治疗腹泻的中药制剂及其制备方法与应用
CN104352728A (zh) 治疗乳腺纤维瘤的中药制剂
CN103520623B (zh) 一种治疗胃溃疡的中药制剂
CN104399002A (zh) 一种治疗直肠癌的中药组合物
CN103212026A (zh) 一种治疗胆石症的中药及其制备方法和服用方法
CN104491587B (zh) 减轻化疗所致肝肾功能损伤副反应的药剂及制备
CN103230480B (zh) 一种治疗血虚挟风型肛门湿疹的中药
CN102961555B (zh) 一种治疗肝病的中药组合物及其制备方法
CN106214809A (zh) 一种治疗湿疹的外用中药组合物及制备方法
CN104888148A (zh) 一种治疗慢性乙型肝炎的药物
CN105902878A (zh) 一种治疗尿路结石的药物及其制备
CN105125860A (zh) 一种有效治疗骨质疏松的制剂
CN105012642A (zh) 一种活血化瘀,止血止痛的中药组合物的制备方法
CN104998019A (zh) 一种活血化瘀,止血止痛的中药组合物
CN104306491B (zh) 治疗口舌生疮的中药组合物及制法
CN103989837A (zh) 一种预防和治疗痔疮的中药组合物及其制备方法
CN103611098B (zh) 一种治疗皮肤瘙痒的中药
CN104107241A (zh) 疏肝退黄散
CN103623355B (zh) 一种治疗滑动性斜疝的中药制剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20150311