CN104394885B - 抗癌剂所致的末梢神经障碍性疼痛的预防和/或治疗剂 - Google Patents

抗癌剂所致的末梢神经障碍性疼痛的预防和/或治疗剂 Download PDF

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Publication number
CN104394885B
CN104394885B CN201380028318.4A CN201380028318A CN104394885B CN 104394885 B CN104394885 B CN 104394885B CN 201380028318 A CN201380028318 A CN 201380028318A CN 104394885 B CN104394885 B CN 104394885B
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thrombomodulin
administration
amino acid
sequence
seq
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CN104394885A (zh
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川畑笃史
铃木秀明
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Asahi Kasei Pharma Corp
Kindai University
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Asahi Kasei Pharma Corp
Kindai University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/366—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380028318.4A 2012-05-31 2013-05-17 抗癌剂所致的末梢神经障碍性疼痛的预防和/或治疗剂 Active CN104394885B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012125316 2012-05-31
JP2012-125316 2012-05-31
PCT/JP2013/063743 WO2013179910A1 (ja) 2012-05-31 2013-05-17 抗癌剤に起因する末梢性神経障害性疼痛の予防及び／又は治療剤

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Publication Number Publication Date
CN104394885A CN104394885A (zh) 2015-03-04
CN104394885B true CN104394885B (zh) 2017-06-30

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US (1) US10709767B2 (enExample)
EP (1) EP2857037B1 (enExample)
JP (3) JP6124417B2 (enExample)
KR (1) KR101672114B1 (enExample)
CN (1) CN104394885B (enExample)
AU (1) AU2013268725B2 (enExample)
BR (1) BR112014028852A2 (enExample)
CA (1) CA2875069C (enExample)
DK (1) DK2857037T3 (enExample)
ES (1) ES2743767T3 (enExample)
HU (1) HUE045997T2 (enExample)
IL (1) IL235984B (enExample)
IN (1) IN2014DN10075A (enExample)
MX (1) MX364934B (enExample)
NZ (1) NZ702242A (enExample)
PL (1) PL2857037T3 (enExample)
PT (1) PT2857037T (enExample)
RU (1) RU2595857C2 (enExample)
WO (1) WO2013179910A1 (enExample)
ZA (1) ZA201408769B (enExample)

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AU2018245892B2 (en) * 2017-03-31 2022-02-24 Toray Industries, Inc. Therapeutic or prophylactic agent for peripheral neuropathies
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RU2707954C1 (ru) * 2019-01-24 2019-12-02 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ лечения онкологической боли
CN116897010A (zh) * 2021-02-26 2023-10-17 韦博辛斯动力公司 用于预测化疗引起的神经病变的生物标志物

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Publication number Publication date
JP2018095652A (ja) 2018-06-21
ZA201408769B (en) 2015-12-23
CA2875069A1 (en) 2013-12-05
PT2857037T (pt) 2019-07-19
JP2017141268A (ja) 2017-08-17
JP6279788B2 (ja) 2018-02-14
US20150148296A1 (en) 2015-05-28
IN2014DN10075A (enExample) 2015-08-21
JP6124417B2 (ja) 2017-05-10
WO2013179910A1 (ja) 2013-12-05
EP2857037A1 (en) 2015-04-08
IL235984B (en) 2019-09-26
RU2014148171A (ru) 2016-07-20
EP2857037B1 (en) 2019-06-26
JP6427284B2 (ja) 2018-11-21
AU2013268725B2 (en) 2017-02-16
MX364934B (es) 2019-03-28
ES2743767T3 (es) 2020-02-20
DK2857037T3 (da) 2019-07-22
BR112014028852A2 (pt) 2018-04-24
US10709767B2 (en) 2020-07-14
CN104394885A (zh) 2015-03-04
JPWO2013179910A1 (ja) 2016-01-18
KR20150004855A (ko) 2015-01-13
EP2857037A4 (en) 2016-04-06
PL2857037T3 (pl) 2019-12-31
KR101672114B1 (ko) 2016-11-02
HK1203846A1 (en) 2015-11-06
IL235984A0 (en) 2015-01-29
RU2595857C2 (ru) 2016-08-27
NZ702242A (en) 2016-03-31
AU2013268725A1 (en) 2014-12-18
MX2014014505A (es) 2015-06-02
HUE045997T2 (hu) 2020-01-28
CA2875069C (en) 2018-01-02

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