CN104231046A - 具有溶栓、抗栓和自由基清除三重活性的化合物、其制备方法、组合物和应用 - Google Patents
具有溶栓、抗栓和自由基清除三重活性的化合物、其制备方法、组合物和应用 Download PDFInfo
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- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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Abstract
Description
Claims (18)
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Cited By (4)
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CN106608905A (zh) * | 2015-10-22 | 2017-05-03 | 彭莉 | 四氢异喹啉-3-甲酰-k(grpak)rgdv,其合成,活性及应用 |
CN106608902A (zh) * | 2015-10-22 | 2017-05-03 | 彭莉 | 二羟基二甲基四氢异喹啉-3-甲酰-Lys(Lys),其合成,活性及应用 |
CN114555085A (zh) * | 2019-09-25 | 2022-05-27 | 顺天医药生技股份有限公司 | 包含溶栓肽-四氢异喹啉缀合物的药物组合物 |
CN115403653A (zh) * | 2022-05-19 | 2022-11-29 | 首都医科大学 | D(+)-β-(3,4-二羟基苯基)-乳酰-Pro-Ala-Lys,其合成及应用 |
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JP6663774B2 (ja) | 2016-03-30 | 2020-03-13 | 東京エレクトロン株式会社 | 基板搬送方法及び基板処理システム |
CN115843258A (zh) * | 2020-05-15 | 2023-03-24 | 辛希克斯 | 肽支架、其生产方法及其作为可溶性支持物的用途 |
BR112023018812A2 (pt) | 2021-03-22 | 2023-10-31 | Lumosa Therapeutics Co Ltd | D0009 para tratamento de acidente vascular cerebral isquêmico agudo |
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US20040138141A1 (en) * | 2002-12-23 | 2004-07-15 | Han-Cheng Zhang | Novel heteroaryl peptidomimetics as thrombin receptor antagonists |
CN101190941A (zh) * | 2006-11-30 | 2008-06-04 | 首都医科大学 | 具有溶血栓活性的多肽、其制备方法及应用 |
CN102887941A (zh) * | 2012-09-05 | 2013-01-23 | 永光制药有限公司 | Pak/咪唑啉/rgd三元缀合物及其制备方法和用途 |
CN103450330A (zh) * | 2012-06-01 | 2013-12-18 | 首都医科大学 | 二羟基四氢异喹啉-3-甲酰氨基酸、其合成、抗血栓作用和应用 |
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JPS5222632B2 (zh) * | 1972-08-22 | 1977-06-18 | ||
US7291619B2 (en) | 2001-01-23 | 2007-11-06 | Eli Lilly And Company | Melanocortin receptor agonists |
ES2274201T3 (es) | 2002-01-23 | 2007-05-16 | Eli Lilly And Company | Agonistas del receptor de melanocortina. |
CN101190895B (zh) | 2006-11-30 | 2010-05-26 | 首都医科大学 | N-[(3s)-1,2,3,4-四氢异喹啉-3-甲酰基]氨基酸、其制备方法及应用 |
CN101200493B (zh) | 2006-12-11 | 2011-11-09 | 首都医科大学 | (3s)-n-(l-氨基酰)-1,2,3,4-四氢异喹啉-3-羧酸、其制备方法及应用 |
CN102241740B (zh) * | 2008-01-30 | 2014-02-19 | 首都医科大学 | 具有溶血栓活性的化合物、其制备方法、其应用 |
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