CN104220587A - 从经基因改造的微生物生产黏康酸 - Google Patents

从经基因改造的微生物生产黏康酸 Download PDF

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Publication number
CN104220587A
CN104220587A CN201380017560.1A CN201380017560A CN104220587A CN 104220587 A CN104220587 A CN 104220587A CN 201380017560 A CN201380017560 A CN 201380017560A CN 104220587 A CN104220587 A CN 104220587A
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gene
genetically modified
cis
arog
microorganism
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Chinese (zh)
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R·R·约卡姆
龚巍
S·多勒
R·西勒斯
M·甘地
J·G·佩罗
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Myriant Corp
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Myriant Corp
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Priority to CN201710442475.XA priority Critical patent/CN107177540A/zh
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    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
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    • C12N9/0004—Oxidoreductases (1.)
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    • C12N9/10—Transferases (2.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01025—Shikimate dehydrogenase (1.1.1.25)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01054—3-Deoxy-7-phosphoheptulonate synthase (2.5.1.54)
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    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01118—3-Dehydroshikimate dehydratase (4.2.1.118)

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  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201380017560.1A 2012-01-30 2013-01-29 从经基因改造的微生物生产黏康酸 Pending CN104220587A (zh)

Priority Applications (1)

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Applications Claiming Priority (3)

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US201261632777P 2012-01-30 2012-01-30
US61/632,777 2012-01-30
PCT/US2013/023690 WO2013116244A1 (en) 2012-01-30 2013-01-29 Production of muconic acid from genetically engineered microorganisms

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US (2) US20150044755A1 (https=)
EP (2) EP3312267B1 (https=)
JP (3) JP2015504688A (https=)
KR (1) KR102092422B1 (https=)
CN (2) CN104220587A (https=)
BR (1) BR112014017686A2 (https=)
CA (1) CA2862051A1 (https=)
ES (1) ES2663445T3 (https=)
HK (1) HK1243459A1 (https=)
MY (1) MY172307A (https=)
WO (1) WO2013116244A1 (https=)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104911137A (zh) * 2015-04-14 2015-09-16 中国科学院微生物研究所 一种产莽草酸的谷氨酸棒杆菌及其构建方法与应用
CN106947727A (zh) * 2017-02-20 2017-07-14 波顿（上海）生物技术有限公司 一种基因工程菌及其构建方法与生产香兰素的方法
CN108314713A (zh) * 2017-01-16 2018-07-24 中国科学院微生物研究所 L-苏氨酸转运蛋白ThrG及其编码基因与应用
CN108314712A (zh) * 2017-01-16 2018-07-24 中国科学院微生物研究所 L-苏氨酸转运蛋白ThrF及其编码基因与应用
CN109415684A (zh) * 2016-03-02 2019-03-01 Ptt全球化学公众有限公司 从基因工程微生物改进的黏康酸生产
CN112266892A (zh) * 2020-10-21 2021-01-26 中国科学院天津工业生物技术研究所 AroG的突变体及其在产氨基酸基因工程菌中的应用
CN115820518A (zh) * 2022-07-19 2023-03-21 江南大学 高效生产莽草酸的重组大肠杆菌及其应用
CN115927133A (zh) * 2022-07-12 2023-04-07 徐州合谷生命科技有限公司 一种生产原儿茶酸的基因编辑工程菌株及应用
CN119709574A (zh) * 2024-12-27 2025-03-28 天津大学 生产儿茶酚的微生物细胞工厂

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
KR102064475B1 (ko) * 2014-04-17 2020-01-10 (주)에스티알바이오텍 뮤코닉산 생산용 미생물 및 그 제조방법
WO2016036748A1 (en) * 2014-09-03 2016-03-10 Coffa Gianguido Production of cis, cis-muconic acid from carbonaceous material
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2016207403A1 (en) 2015-06-24 2016-12-29 Deinove Method of producing muconic acid
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
WO2018203947A2 (en) 2017-02-06 2018-11-08 Zymergen Inc. Engineered biosynthetic pathways for production of tyramine by fermentation
US11708590B2 (en) 2017-07-18 2023-07-25 Arizona Board Of Regents On Behalf Of Arizona State University Synthetic metabolic funneling for biochemical production
KR102003911B1 (ko) * 2018-02-23 2019-07-25 씨제이제일제당 주식회사 마이코스포린 유사 아미노산을 생산하는 미생물 및 이를 이용한 마이코스포린 유사 아미노산의 생산방법
CN113785069A (zh) * 2019-05-10 2021-12-10 东丽株式会社 用于生产3-羟基己二酸、α-氢化己二烯二酸和/或己二酸的基因修饰微生物以及该化学品的制造方法
EP3967763A4 (en) 2019-05-10 2024-01-03 Toray Industries, Inc. GENETICALLY MODIFIED MICROORGANISM FOR THE PRODUCTION OF 3-HYDROXYHEXANIC ACID, (E)-HEX-2-ENDIONIC ACID AND/OR HEXANEDIONIC ACID AND PRODUCTION PROCESS FOR THESE CHEMICALS
CN110184288A (zh) * 2019-05-28 2019-08-30 南京趣酶生物科技有限公司 没食子酸和原儿茶酸的制备方法及其反应催化剂的制备方法
CN111662892B (zh) * 2020-07-29 2022-07-01 上海市农业科学院 β-酮己二酸代谢相关三个基因的结构优化与应用
US20230392112A1 (en) 2020-11-11 2023-12-07 Toray Industries, Inc. Genetically modified microorganism for producing 3-hydroxyadipic acid and/or alpha-hydromuconic acid, and method for producing chemical product
US20250305014A1 (en) * 2021-04-30 2025-10-02 Cj Cheiljedang Corporation Corynebacterium glutamicum variant with improved l-lysine production ability, and method for producing l-lysine using same
CN117004547B (zh) * 2023-09-27 2023-12-22 北京化工大学 一种以葡萄糖为底物从头合成顺，顺-粘康酸的基因工程菌及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616496A (en) * 1993-09-16 1997-04-01 Purdue Research Foundation Bacterial cell tranformants for production of cis, cis-muconic acid and catechol
WO2011085311A1 (en) * 2010-01-08 2011-07-14 Draths Corporation Methods for producing isomers of muconic acid and muconate salts

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3128411A1 (de) 1980-07-18 1983-09-15 Unisearch Ltd., 2033 Kensington, New South Wales Kulturstamm-mutante von esccherichia coli sowie verfahren zur herstellung von phenylalanin
US4588688A (en) 1981-07-27 1986-05-13 Celanese Corporation Process for the production of muconic acid
US4608338A (en) 1982-06-10 1986-08-26 Celanese Corporation Process for bioconversion-product recovery
US4480034A (en) 1982-06-10 1984-10-30 Celanese Corporation Continuous fermentation process and bioconversion-product recovery
US4535059A (en) 1983-01-13 1985-08-13 Celanese Corporation Muconic acid productivity by a stabilized mutant microorganism population
US4833078A (en) 1984-06-22 1989-05-23 Celgene Corporation Semi-continuous fermentation process for aromatic hydrocarbon bioconversion
US4968612A (en) 1984-07-27 1990-11-06 Celgene Corporation Continuous fermentation process for aromatic hydrocarbon bioconversion
US4753883A (en) 1986-05-07 1988-06-28 Biotechnica International, Inc. Enzyme deregulation
EP0488424B1 (en) * 1990-11-30 1997-03-05 Ajinomoto Co., Inc. Recombinant DNA sequences encoding feedback inhibition released enzymes, plasmids comprising the recombinant DNA sequences, transformed microorganisms useful in the production of aromatic amino acids, and a process for preparing aromatic amino acids by fermentation
US5168056A (en) 1991-02-08 1992-12-01 Purdue Research Foundation Enhanced production of common aromatic pathway compounds
JP3225597B2 (ja) * 1992-06-15 2001-11-05 味の素株式会社 発酵法によるｌ−フェニルアラニンの製造法
US5272073A (en) 1992-06-30 1993-12-21 Purdue Research Foundation Biocatalytic synthesis of catechol from glucose
DE4232468A1 (de) 1992-09-28 1994-03-31 Consortium Elektrochem Ind Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung
EP1947186B1 (en) 1995-05-05 2011-11-16 Danisco US Inc. Application of glucose transport mutants for production of aromatic pathway compounds
DE19644566A1 (de) * 1996-10-26 1998-04-30 Forschungszentrum Juelich Gmbh Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / I
US6210937B1 (en) 1997-04-22 2001-04-03 Bechtel Bwxt Idaho, Llc Development of genetically engineered bacteria for production of selected aromatic compounds
US6600077B1 (en) 1999-01-29 2003-07-29 Board Of Trustees Operating Michigan State University Biocatalytic synthesis of quinic acid and conversion to hydroquinone
US6613552B1 (en) 1999-01-29 2003-09-02 Board Of Trustees Operating Michigan State University Biocatalytic synthesis of shikimic acid
JP2002105641A (ja) 2000-10-03 2002-04-10 Murakami Corp 複合材およびその製造方法
JP4229700B2 (ja) 2001-01-19 2009-02-25 ビーエーエスエフ ソシエタス・ヨーロピア パントテネートの産生増強のための微生物と方法
AU2003282687A1 (en) * 2002-10-04 2004-05-04 Genencor International, Inc. Glucose transport mutants for production of biomaterial
US7790431B2 (en) 2003-09-24 2010-09-07 Board Of Trustees Operating Michigan State University Methods and materials for the production of shikimic acid
KR101142885B1 (ko) 2003-12-15 2012-05-10 씨제이제일제당 (주) 트립토판 생합성 관련 변이유전자를 함유한 대장균 변이주및 이를 이용한 트립토판 제조방법
KR20080039906A (ko) 2005-08-18 2008-05-07 바스프 에스이 증가된 메티오닌 합성 효율을 갖는 미생물
WO2009115114A1 (en) * 2008-03-18 2009-09-24 Metabolic Explorer Polypeptide having glyoxylase iii activity, polynucleotide encoding the same and uses thereof
DE102008040352A1 (de) * 2008-07-11 2010-01-14 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Tryptophan unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
WO2010148049A2 (en) 2009-06-16 2010-12-23 Draths Corporation Preparation of trans, trans muconic acid and trans, trans muconates
WO2011017560A1 (en) 2009-08-05 2011-02-10 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
US8871489B2 (en) * 2009-11-18 2014-10-28 Myriant Corporation Metabolic evolution of Escherichia coli strains that produce organic acids
EP2501797A4 (en) * 2009-11-18 2013-04-17 Myriant Corp TECHNIQUES OF MICROBES FOR THE EFFECTIVE MANUFACTURE OF CHEMICALS
US9909135B2 (en) * 2010-07-06 2018-03-06 Yeda Research And Development Co. Ltd. Transgenic plants having altered DAHP synthase activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616496A (en) * 1993-09-16 1997-04-01 Purdue Research Foundation Bacterial cell tranformants for production of cis, cis-muconic acid and catechol
WO2011085311A1 (en) * 2010-01-08 2011-07-14 Draths Corporation Methods for producing isomers of muconic acid and muconate salts

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NIU,WEI: "Bezene-free synthesis of apidic acid", 《BIOTECHNOLOGY PROGRESS》, 12 February 2002 (2002-02-12), pages 201 - 211 *

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CN108314712A (zh) * 2017-01-16 2018-07-24 中国科学院微生物研究所 L-苏氨酸转运蛋白ThrF及其编码基因与应用
CN106947727A (zh) * 2017-02-20 2017-07-14 波顿（上海）生物技术有限公司 一种基因工程菌及其构建方法与生产香兰素的方法
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CN115820518A (zh) * 2022-07-19 2023-03-21 江南大学 高效生产莽草酸的重组大肠杆菌及其应用
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EP2809771A1 (en) 2014-12-10
ES2663445T3 (es) 2018-04-12
US20190345437A1 (en) 2019-11-14
CA2862051A1 (en) 2013-08-08
HK1243459A1 (zh) 2018-07-13
US20150044755A1 (en) 2015-02-12
EP2809771A4 (en) 2016-01-27
CN107177540A (zh) 2017-09-19
BR112014017686A2 (pt) 2017-06-27
EP2809771B1 (en) 2017-12-27
JP2017184746A (ja) 2017-10-12
KR20140131939A (ko) 2014-11-14
WO2013116244A1 (en) 2013-08-08
EP3312267B1 (en) 2020-03-11
MY172307A (en) 2019-11-21

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