CN104159609B - 用于预防锦鲤疱疹病毒(khv)引起的疾病的重组khv和疫苗 - Google Patents

用于预防锦鲤疱疹病毒(khv)引起的疾病的重组khv和疫苗 Download PDF

Info

Publication number
CN104159609B
CN104159609B CN201280065496.XA CN201280065496A CN104159609B CN 104159609 B CN104159609 B CN 104159609B CN 201280065496 A CN201280065496 A CN 201280065496A CN 104159609 B CN104159609 B CN 104159609B
Authority
CN
China
Prior art keywords
khv
recombinant
herpes virus
bac
koi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201280065496.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN104159609A (zh
Inventor
A.F.C.范德普拉斯臣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gus Val AG
Original Assignee
University of Liège
Gesval SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Liège, Gesval SA filed Critical University of Liège
Publication of CN104159609A publication Critical patent/CN104159609A/zh
Application granted granted Critical
Publication of CN104159609B publication Critical patent/CN104159609B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16061—Methods of inactivation or attenuation
    • C12N2710/16062—Methods of inactivation or attenuation by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Farming Of Fish And Shellfish (AREA)
CN201280065496.XA 2011-12-30 2012-12-20 用于预防锦鲤疱疹病毒(khv)引起的疾病的重组khv和疫苗 Active CN104159609B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11196171 2011-12-30
EP11196171.0 2011-12-30
PCT/EP2012/076496 WO2013098214A1 (en) 2011-12-30 2012-12-20 A recombinant koi herpesvirus (khv) and vaccine for the prevention of a disease caused by khv

Publications (2)

Publication Number Publication Date
CN104159609A CN104159609A (zh) 2014-11-19
CN104159609B true CN104159609B (zh) 2018-05-22

Family

ID=47429841

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280065496.XA Active CN104159609B (zh) 2011-12-30 2012-12-20 用于预防锦鲤疱疹病毒(khv)引起的疾病的重组khv和疫苗

Country Status (18)

Country Link
US (2) US20140348875A1 (enExample)
EP (1) EP2797627B1 (enExample)
JP (3) JP5982009B2 (enExample)
CN (1) CN104159609B (enExample)
BR (1) BR112014016117A2 (enExample)
HU (1) HUE053075T2 (enExample)
IL (1) IL232902A0 (enExample)
IN (1) IN2014CN04655A (enExample)
MD (1) MD4481C1 (enExample)
MX (1) MX361408B (enExample)
PH (1) PH12014501388A1 (enExample)
PL (1) PL2797627T3 (enExample)
RS (1) RS61261B1 (enExample)
RU (1) RU2662768C2 (enExample)
SG (1) SG11201403066TA (enExample)
TW (1) TWI484034B (enExample)
UA (2) UA119786C2 (enExample)
WO (1) WO2013098214A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014CN04655A (enExample) * 2011-12-30 2015-09-18 Université de Liège
WO2017177071A1 (en) * 2016-04-08 2017-10-12 William Marsh Rice University Improved galactose utilization
CN112279898B (zh) * 2018-11-05 2022-06-21 共鳞实业(深圳)有限公司 预防或治疗鱼类感染CyHV-2的试剂及其应用
EP3662929A1 (en) * 2018-12-07 2020-06-10 IDT Biologika GmbH A recombinant koi herpesvirus (khv) and a diva vaccine for preventing and/or treating a disease caused by khv
CN110101854B (zh) * 2019-05-14 2022-08-02 四川农业大学 一种鲤疱疹病毒ⅲ型疫苗及其制备方法
CN110452926B (zh) * 2019-08-07 2022-06-17 西北农林科技大学 一种展示CyHV-2膜蛋白的重组杆状病毒及其制备方法和应用
CN110468111B (zh) * 2019-08-07 2022-06-17 西北农林科技大学 一种展示CyHV-2膜蛋白的重组杆状病毒及其制备方法和应用
CN113679832A (zh) * 2021-05-24 2021-11-23 苏州大学 一种利用冷冻干燥制备杆状病毒载鲤疱疹病毒ii型dna疫苗的方法
CN115960903B (zh) * 2022-12-23 2023-09-08 中国水产科学研究院淡水渔业研究中心 一种抑制CyHV-2病毒增殖的反义RNA组、重组载体和纳米粒递送系统及应用
CN120775802B (zh) * 2025-06-13 2026-04-21 中国水产科学研究院珠江水产研究所 一种鲤疱疹病毒3型orf136基因失活株及其制备方法和应用
CN120775801B (zh) * 2025-06-13 2026-07-31 中国水产科学研究院珠江水产研究所 一种鲤疱疹病毒3型orf138基因失活株及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1742083A (zh) * 2003-01-01 2006-03-01 耶路撒冷希伯来大学伊萨姆研发公司 对鱼进行抗病毒感染的免疫
WO2009027412A1 (en) * 2007-08-28 2009-03-05 Universite De Liege A recombinant koi herpesvirus (khv) or cyprinid herpesvirus 3 (cyhv-3) and a vaccine for the prevention of a disease caused by khv/cyhv-3 in cyprinus carpio carpio or cyprinus carpio koi
CN101495636A (zh) * 2006-04-13 2009-07-29 国立大学法人东京海洋大学 锦鲤疱疹病毒(khv)病用dna疫苗

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE115862T1 (de) 1989-02-04 1995-01-15 Akzo Nobel Nv Tocole als impfstoffadjuvans.
DE19733364A1 (de) 1997-08-01 1999-02-04 Koszinowski Ulrich H Prof Verfahren zur Klonierung eines großen Virusgenoms
JP2007223913A (ja) * 2006-02-21 2007-09-06 Kyoritsu Seiyaku Kk コイヘルペスウイルス病ワクチン
DE102007041332A1 (de) * 2007-08-31 2009-03-05 Siemens Ag Transferchuck zur Übertragung, insbesondere von Wafern
IN2014CN04655A (enExample) * 2011-12-30 2015-09-18 Université de Liège

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1742083A (zh) * 2003-01-01 2006-03-01 耶路撒冷希伯来大学伊萨姆研发公司 对鱼进行抗病毒感染的免疫
CN101495636A (zh) * 2006-04-13 2009-07-29 国立大学法人东京海洋大学 锦鲤疱疹病毒(khv)病用dna疫苗
WO2009027412A1 (en) * 2007-08-28 2009-03-05 Universite De Liege A recombinant koi herpesvirus (khv) or cyprinid herpesvirus 3 (cyhv-3) and a vaccine for the prevention of a disease caused by khv/cyhv-3 in cyprinus carpio carpio or cyprinus carpio koi

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cloning of the Koi Herpesvirus Genome as an Infectious Bacterial Artificial Chromosome Demonstrates That Disruption of the Thymidine Kinase Locus Induces Partial Attenuation in Cyprinus carpio koi;B. Costes等;《JOURNAL OF VIROLOGY》;20080531;第82卷(第10期);4955–4964 *

Also Published As

Publication number Publication date
SG11201403066TA (en) 2014-10-30
BR112014016117A2 (pt) 2018-09-25
EP2797627B1 (en) 2020-10-07
EP2797627A1 (en) 2014-11-05
HUE053075T2 (hu) 2021-06-28
US9931396B2 (en) 2018-04-03
CN104159609A (zh) 2014-11-19
WO2013098214A1 (en) 2013-07-04
MD4481B1 (ro) 2017-05-31
MD20120127A2 (en) 2013-07-31
JP2018078903A (ja) 2018-05-24
TWI484034B (zh) 2015-05-11
MX2014008045A (es) 2014-10-24
MX361408B (es) 2018-12-04
IN2014CN04655A (enExample) 2015-09-18
TW201333201A (zh) 2013-08-16
US20140348875A1 (en) 2014-11-27
US20170028057A1 (en) 2017-02-02
PL2797627T3 (pl) 2021-06-28
JP5982009B2 (ja) 2016-08-31
PH12014501388A1 (en) 2014-09-22
JP2016195593A (ja) 2016-11-24
RS61261B1 (sr) 2021-01-29
UA119786C2 (uk) 2019-08-12
UA114719C2 (uk) 2017-07-25
RU2014131474A (ru) 2016-02-20
JP2015503914A (ja) 2015-02-05
RU2662768C2 (ru) 2018-07-31
MD4481C1 (ro) 2017-12-31
IL232902A0 (en) 2014-07-31

Similar Documents

Publication Publication Date Title
US9931396B2 (en) Koi herpesvirus vaccine
EP2195021B1 (en) A recombinant koi herpesvirus (khv) or cyprinid herpesvirus 3 (cyhv-3) and a vaccine for the prevention of a disease caused by khv/cyhv-3 in cyprinus carpio carpio or cyprinus carpio koi
CN113201507B (zh) 一种重组的伪狂犬病病毒及其疫苗组合物
CN110628730B (zh) 表达猪繁殖与呼吸综合征病毒gp蛋白的重组猪伪狂犬病病毒及应用
CN108368488B (zh) 鸭肠炎病毒及其用途
CN109310750B (zh) 编码传染性喉气管炎病毒和传染性法氏囊病病毒抗原的重组非致病性马立克氏病病毒构建体
JP2019524154A (ja) アヒル腸炎ウイルス及びその使用
JP2003503039A (ja) 弱毒化したワクチンの操作のための方法および組成物
JP7387623B2 (ja) 標的タンパク質を安定して発現できる組換えウイルス
WO2022090131A1 (en) Recombinant african swine fever virus as live attenuated vaccine against african swine fever
JP2024500225A (ja) 安定細胞株において効率的な増殖を可能にする、アフリカ豚熱ワクチンにおけるゲノム欠失
EP2031065A1 (en) A recombinant koi herpesvirus (KHV) or Cyprinid herpesvirus 3 (CyHV-3) and a vaccine for the prevention of a disease caused by KHV/CyHV-3 in Cyprinus carpio carpio or Cyprinus carpio koi
WO2025044922A2 (en) Vectored dev avian influenza h9 vaccines
KR20260066090A (ko) 신규한 dev 벡터
WO2025044920A2 (en) New dev vectors for avian vaccines
US20160045593A1 (en) Vaccine against bovine leukemia virus
CN121931060A (zh) 用于预防或治疗由鳗鲡疱疹病毒1引起的疾病的重组鳗鲡疱疹病毒1

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20160719

Address after: Belgium Aung San

Applicant after: Gus Val AG

Address before: Belgium Aung San

Applicant before: University of Liege

GR01 Patent grant
GR01 Patent grant
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20141119

Assignee: NINGBO SANSHENG BIOLOGICAL TECHNOLOGY Co.,Ltd.

Assignor: GESVAL S.A.

Contract record no.: X2021990000218

Denomination of invention: Recombinant KHV and vaccine for prevention of diseases caused by Koi herpesvirus (KHV)

Granted publication date: 20180522

License type: Exclusive License

Record date: 20210413

EE01 Entry into force of recordation of patent licensing contract