UA114719C2 - Рекомбінантний герпесвірус кої (khv) і вакцина для профілактики захворювання, що викликається khv - Google Patents

Рекомбінантний герпесвірус кої (khv) і вакцина для профілактики захворювання, що викликається khv

Info

Publication number
UA114719C2
UA114719C2 UAA201408626A UAA201408626A UA114719C2 UA 114719 C2 UA114719 C2 UA 114719C2 UA A201408626 A UAA201408626 A UA A201408626A UA A201408626 A UAA201408626 A UA A201408626A UA 114719 C2 UA114719 C2 UA 114719C2
Authority
UA
Ukraine
Prior art keywords
khv
prevention
disease caused
vaccine
koi
Prior art date
Application number
UAA201408626A
Other languages
English (en)
Inventor
Ален Франсіс Клод Вандерплассхен
Original Assignee
Гесваль С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гесваль С.А. filed Critical Гесваль С.А.
Publication of UA114719C2 publication Critical patent/UA114719C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16061—Methods of inactivation or attenuation
    • C12N2710/16062—Methods of inactivation or attenuation by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Farming Of Fish And Shellfish (AREA)

Abstract

Винахід стосується живого рекомбінантного герпесвірусу кої (KHV), в якому відкрита рамка зчитування є неповноцінною, з одержанням в результаті живого рекомбінантного KHV, який є атенуйованим, способів продукування такого KHV, клітин, що містять такий KHV, і застосування такого KHV як вектора і у вакцинах для профілактики і/або терапевтичного лікування у риби захворювання, що викликається герпесвірусом кої у коропа, такого як Cyprinus carpio сагріо або Cyprinus carpio кої.
UAA201408626A 2011-12-30 2012-12-20 Рекомбінантний герпесвірус кої (khv) і вакцина для профілактики захворювання, що викликається khv UA114719C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11196171 2011-12-30
PCT/EP2012/076496 WO2013098214A1 (en) 2011-12-30 2012-12-20 A recombinant koi herpesvirus (khv) and vaccine for the prevention of a disease caused by khv

Publications (1)

Publication Number Publication Date
UA114719C2 true UA114719C2 (uk) 2017-07-25

Family

ID=47429841

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201408626A UA114719C2 (uk) 2011-12-30 2012-12-20 Рекомбінантний герпесвірус кої (khv) і вакцина для профілактики захворювання, що викликається khv
UAA201702576A UA119786C2 (uk) 2011-12-30 2012-12-20 Рекомбінантний герпесвірус кої (khv) і вакцина для профілактики захворювання, що викликається khv

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA201702576A UA119786C2 (uk) 2011-12-30 2012-12-20 Рекомбінантний герпесвірус кої (khv) і вакцина для профілактики захворювання, що викликається khv

Country Status (18)

Country Link
US (2) US20140348875A1 (uk)
EP (1) EP2797627B1 (uk)
JP (3) JP5982009B2 (uk)
CN (1) CN104159609B (uk)
BR (1) BR112014016117A2 (uk)
HU (1) HUE053075T2 (uk)
IL (1) IL232902A0 (uk)
IN (1) IN2014CN04655A (uk)
MD (1) MD4481C1 (uk)
MX (1) MX361408B (uk)
PH (1) PH12014501388A1 (uk)
PL (1) PL2797627T3 (uk)
RS (1) RS61261B1 (uk)
RU (1) RU2662768C2 (uk)
SG (1) SG11201403066TA (uk)
TW (1) TWI484034B (uk)
UA (2) UA114719C2 (uk)
WO (1) WO2013098214A1 (uk)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2662768C2 (ru) * 2011-12-30 2018-07-31 Гесвал с.а. Рекомбинантный герпесвирус кои (khv) и вакцина для профилактики заболевания, вызываемого khv
WO2017177071A1 (en) * 2016-04-08 2017-10-12 William Marsh Rice University Improved galactose utilization
RU2736472C2 (ru) * 2016-11-18 2020-11-17 Общество с ограниченной ответственностью "ЭКСИФАРМ" Химерный белок, синтетическая днк, кодирующая указанный белок, экспрессионный вектор, штамм-продуцент синтетической днк и способ получения плазмидной днк
CN112279897B (zh) * 2018-11-05 2021-12-28 深圳技术大学 一种预防或治疗鱼类感染CyHV-2的试剂及应用
EP3662929A1 (en) * 2018-12-07 2020-06-10 IDT Biologika GmbH A recombinant koi herpesvirus (khv) and a diva vaccine for preventing and/or treating a disease caused by khv
CN110101854B (zh) * 2019-05-14 2022-08-02 四川农业大学 一种鲤疱疹病毒ⅲ型疫苗及其制备方法
CN110468111B (zh) * 2019-08-07 2022-06-17 西北农林科技大学 一种展示CyHV-2膜蛋白的重组杆状病毒及其制备方法和应用
CN110452926B (zh) * 2019-08-07 2022-06-17 西北农林科技大学 一种展示CyHV-2膜蛋白的重组杆状病毒及其制备方法和应用
CN113679832A (zh) * 2021-05-24 2021-11-23 苏州大学 一种利用冷冻干燥制备杆状病毒载鲤疱疹病毒ii型dna疫苗的方法
CN115960903B (zh) * 2022-12-23 2023-09-08 中国水产科学研究院淡水渔业研究中心 一种抑制CyHV-2病毒增殖的反义RNA组、重组载体和纳米粒递送系统及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2068989T3 (es) 1989-02-04 1995-05-01 Akzo Nobel Nv Tocoles como adyuvante en vacunas.
DE19733364A1 (de) 1997-08-01 1999-02-04 Koszinowski Ulrich H Prof Verfahren zur Klonierung eines großen Virusgenoms
IL153775A0 (en) * 2003-01-01 2003-07-31 Yissum Res Dev Co Immunizing fish against viral infection
JP2007223913A (ja) * 2006-02-21 2007-09-06 Kyoritsu Seiyaku Kk コイヘルペスウイルス病ワクチン
JP5239023B2 (ja) * 2006-04-13 2013-07-17 国立大学法人東京海洋大学 コイヘルペスウイルス（ｋｈｖ）病用ｄｎａワクチン
MD20100029A2 (ro) * 2007-08-28 2010-08-31 Льежский Университет Herpesvirus recombinant al crapului de koi (KHV) sau Cyprinid herpesvirus 3 (CyHV-3) şi vaccin pentru prevenirea bolii cauzate de KHV/CyHV-3 la Cyprinus carpio carpio sau Cyprinus carpio koi
DE102007041332A1 (de) * 2007-08-31 2009-03-05 Siemens Ag Transferchuck zur Übertragung, insbesondere von Wafern
RU2662768C2 (ru) * 2011-12-30 2018-07-31 Гесвал с.а. Рекомбинантный герпесвирус кои (khv) и вакцина для профилактики заболевания, вызываемого khv

Also Published As

Publication number Publication date
RS61261B1 (sr) 2021-01-29
MD4481B1 (ro) 2017-05-31
MX361408B (es) 2018-12-04
JP5982009B2 (ja) 2016-08-31
CN104159609B (zh) 2018-05-22
TWI484034B (zh) 2015-05-11
RU2662768C2 (ru) 2018-07-31
EP2797627A1 (en) 2014-11-05
CN104159609A (zh) 2014-11-19
EP2797627B1 (en) 2020-10-07
PH12014501388A1 (en) 2014-09-22
JP2016195593A (ja) 2016-11-24
US20140348875A1 (en) 2014-11-27
JP2018078903A (ja) 2018-05-24
IN2014CN04655A (uk) 2015-09-18
IL232902A0 (en) 2014-07-31
TW201333201A (zh) 2013-08-16
MD20120127A2 (en) 2013-07-31
JP2015503914A (ja) 2015-02-05
BR112014016117A2 (pt) 2018-09-25
US9931396B2 (en) 2018-04-03
HUE053075T2 (hu) 2021-06-28
MD4481C1 (ro) 2017-12-31
PL2797627T3 (pl) 2021-06-28
UA119786C2 (uk) 2019-08-12
WO2013098214A1 (en) 2013-07-04
US20170028057A1 (en) 2017-02-02
RU2014131474A (ru) 2016-02-20
MX2014008045A (es) 2014-10-24
SG11201403066TA (en) 2014-10-30

Similar Documents

Publication Publication Date Title
UA114719C2 (uk) Рекомбінантний герпесвірус кої (khv) і вакцина для профілактики захворювання, що викликається khv
MX2016004063A (es) Variante de la proteina pcv2 orf2 y particulas similares al virus compuestas por esta.
NZ630649A (en) Vaccine against rsv
EA201792407A2 (ru) Композиции, содержащие буфер, составы вакцин, которые содержат композиции, содержащие буфер, и пути их применения
NZ630869A (en) Compositions and methods for dengue virus chimeric constructs in vaccines
MX2013013800A (es) Oligodesoxinucleotidos inmunoestimuladores.
MX2014004814A (es) Compuestos y metodos para mejorar las respuestas inmunes innatas.
EA201891124A3 (ru) Новые мукозные адъюванты и системы доставки
PH12015501378A1 (en) Porcine parvovirus 5a, methods of use and vaccine
EA201391200A1 (ru) Способы и композиции для вакцинации от staphylococcus aureus
EP2528931A4 (en) CYCLOVIRUS AND USE METHOD THEREFOR
PH12015501721A1 (en) Porcine parvovirus 5b, methods of use and vaccine
WO2012078051A3 (en) IPN Vaccine
PH12017501100A1 (en) Recombinant swinepox virus and vaccines
EA201592298A1 (ru) Полуживая вирусная вакцина против респираторно-синцитиального вируса
PH12015502207A1 (en) Stabilised fmdv capsids
AR115070A1 (es) Células madre que comprenden un virus vacuna quimérico sintético y métodos para su uso
EA201490758A1 (ru) Вакцины против вируса человеческой папилломы и способы их применения
EA201592299A1 (ru) Полуживая вирусная вакцина против респираторно-синцитиального вируса
WO2012149525A3 (en) Ureaplasma vaccine and antibody for prevention and treatment of human, animal and cell culture infection
AR089868A1 (es) Vacuna vectorial de eimeria para campylobacter jejuni
RU2011108858A (ru) Средство для повышения роста и сохранности молодняка
TH158445A (th) รีคอมบิแนนท์คอยเฮอร์ปีส์ไวรัส (khv) และวัคซีนสำหรับการป้องกันของโรคที่ได้รับการทำให้เกิดขึ้นโดย khv
TN2010000479A1 (en) Inactivated live - attenuated bluetongue virus vaccine
UA106111C2 (uk) Спосіб отримання людського інтерферону з використанням наночастинок оксиду церію