CN104080775A - 立体选择性合成1,4-保护的9-羟基-5-氧代-1,4-二氮杂-螺[5.5]十一烷的方法 - Google Patents
立体选择性合成1,4-保护的9-羟基-5-氧代-1,4-二氮杂-螺[5.5]十一烷的方法 Download PDFInfo
- Publication number
- CN104080775A CN104080775A CN201380006918.0A CN201380006918A CN104080775A CN 104080775 A CN104080775 A CN 104080775A CN 201380006918 A CN201380006918 A CN 201380006918A CN 104080775 A CN104080775 A CN 104080775A
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- optionally
- reaction
- tautomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 Cc1cccc(Nc2ncnc(cc3OC)c2cc3OC(CC2)CC*2C(NCC[N-])=O)c1F Chemical compound Cc1cccc(Nc2ncnc(cc3OC)c2cc3OC(CC2)CC*2C(NCC[N-])=O)c1F 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12154688 | 2012-02-09 | ||
| EP12154688.1 | 2012-02-09 | ||
| PCT/EP2013/052287 WO2013117568A1 (de) | 2012-02-09 | 2013-02-06 | Verfahren zur stereoselektiven synthese von 1,4-geschützten 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104080775A true CN104080775A (zh) | 2014-10-01 |
Family
ID=47678813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380006918.0A Pending CN104080775A (zh) | 2012-02-09 | 2013-02-06 | 立体选择性合成1,4-保护的9-羟基-5-氧代-1,4-二氮杂-螺[5.5]十一烷的方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8629146B2 (https=) |
| EP (1) | EP2812317B1 (https=) |
| JP (1) | JP6105631B2 (https=) |
| KR (1) | KR20140128318A (https=) |
| CN (1) | CN104080775A (https=) |
| AU (1) | AU2013218119A1 (https=) |
| BR (1) | BR112014019196A8 (https=) |
| CA (1) | CA2862520A1 (https=) |
| CL (1) | CL2014001823A1 (https=) |
| EA (1) | EA201400882A1 (https=) |
| IL (1) | IL233370A (https=) |
| MX (1) | MX2014009033A (https=) |
| PH (1) | PH12014501760A1 (https=) |
| WO (1) | WO2013117568A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2289881A1 (de) * | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4575507A (en) * | 1985-05-29 | 1986-03-11 | Pfizer Inc. | Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use |
| CA2476008C (en) | 2002-03-30 | 2011-12-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| BRPI0619603A2 (pt) | 2005-12-12 | 2011-10-11 | Boehringer Ingelheim Int | heterociclos bicìclicos, sais fisiologicamante compatìveis, medicamentos que contêm esses compostos, bem como uso e processos para produção dos heterociclos bicìclicos |
| CA2711582A1 (en) | 2008-02-07 | 2009-08-13 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles, formulations containing said compounds, use thereof and processes for the preparation thereof |
| EP2289881A1 (de) | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
| EA023573B1 (ru) | 2011-02-01 | 2016-06-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Дималеат 9-[4-(3-хлор-2-фторфениламино)-7-метоксихиназолин-6-илокси]-1,4-диазаспиро[5.5]ундекан-5-она, его применение в качестве лекарственного средства и его получение |
-
2013
- 2013-02-06 EA EA201400882A patent/EA201400882A1/ru unknown
- 2013-02-06 CN CN201380006918.0A patent/CN104080775A/zh active Pending
- 2013-02-06 CA CA2862520A patent/CA2862520A1/en not_active Abandoned
- 2013-02-06 MX MX2014009033A patent/MX2014009033A/es not_active Application Discontinuation
- 2013-02-06 AU AU2013218119A patent/AU2013218119A1/en not_active Abandoned
- 2013-02-06 BR BR112014019196A patent/BR112014019196A8/pt not_active IP Right Cessation
- 2013-02-06 EP EP13703045.8A patent/EP2812317B1/de active Active
- 2013-02-06 JP JP2014556029A patent/JP6105631B2/ja active Active
- 2013-02-06 KR KR1020147021922A patent/KR20140128318A/ko not_active Withdrawn
- 2013-02-06 WO PCT/EP2013/052287 patent/WO2013117568A1/de not_active Ceased
- 2013-02-07 US US13/761,211 patent/US8629146B2/en active Active
-
2014
- 2014-06-25 IL IL233370A patent/IL233370A/en not_active IP Right Cessation
- 2014-07-09 CL CL2014001823A patent/CL2014001823A1/es unknown
- 2014-08-05 PH PH12014501760A patent/PH12014501760A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2862520A1 (en) | 2013-08-15 |
| EP2812317B1 (de) | 2016-02-03 |
| JP2015506966A (ja) | 2015-03-05 |
| PH12014501760B1 (en) | 2014-11-10 |
| CL2014001823A1 (es) | 2015-03-06 |
| MX2014009033A (es) | 2014-10-17 |
| EA201400882A1 (ru) | 2015-01-30 |
| US8629146B2 (en) | 2014-01-14 |
| PH12014501760A1 (en) | 2014-11-10 |
| EP2812317A1 (de) | 2014-12-17 |
| IL233370A (en) | 2015-04-30 |
| KR20140128318A (ko) | 2014-11-05 |
| AU2013218119A1 (en) | 2014-07-17 |
| US20130211081A1 (en) | 2013-08-15 |
| BR112014019196A8 (pt) | 2017-07-11 |
| JP6105631B2 (ja) | 2017-03-29 |
| BR112014019196A2 (https=) | 2017-06-20 |
| IL233370A0 (en) | 2014-08-31 |
| WO2013117568A1 (de) | 2013-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141001 |