BR112014019196A8 - Método para síntese estereosseletiva de 9-hidróxi-5-oxo-1,4-diaza-espiro[5.5]undecanos 1,4-protegidos - Google Patents
Método para síntese estereosseletiva de 9-hidróxi-5-oxo-1,4-diaza-espiro[5.5]undecanos 1,4-protegidosInfo
- Publication number
- BR112014019196A8 BR112014019196A8 BR112014019196A BR112014019196A BR112014019196A8 BR 112014019196 A8 BR112014019196 A8 BR 112014019196A8 BR 112014019196 A BR112014019196 A BR 112014019196A BR 112014019196 A BR112014019196 A BR 112014019196A BR 112014019196 A8 BR112014019196 A8 BR 112014019196A8
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- compound
- stereosesective
- undecanes
- diaza
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- DFPYCCVFXMWMJM-UHFFFAOYSA-N 1-methyl-3-oxo-1,3-dihydro-benzo[c]isothiazole-5-sulfonic acid amide Chemical compound NS(=O)(=O)C1=CC=C2N(C)SC(=O)C2=C1 DFPYCCVFXMWMJM-UHFFFAOYSA-N 0.000 abstract 1
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12154688 | 2012-02-09 | ||
| PCT/EP2013/052287 WO2013117568A1 (de) | 2012-02-09 | 2013-02-06 | Verfahren zur stereoselektiven synthese von 1,4-geschützten 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014019196A2 BR112014019196A2 (https=) | 2017-06-20 |
| BR112014019196A8 true BR112014019196A8 (pt) | 2017-07-11 |
Family
ID=47678813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014019196A BR112014019196A8 (pt) | 2012-02-09 | 2013-02-06 | Método para síntese estereosseletiva de 9-hidróxi-5-oxo-1,4-diaza-espiro[5.5]undecanos 1,4-protegidos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8629146B2 (https=) |
| EP (1) | EP2812317B1 (https=) |
| JP (1) | JP6105631B2 (https=) |
| KR (1) | KR20140128318A (https=) |
| CN (1) | CN104080775A (https=) |
| AU (1) | AU2013218119A1 (https=) |
| BR (1) | BR112014019196A8 (https=) |
| CA (1) | CA2862520A1 (https=) |
| CL (1) | CL2014001823A1 (https=) |
| EA (1) | EA201400882A1 (https=) |
| IL (1) | IL233370A (https=) |
| MX (1) | MX2014009033A (https=) |
| PH (1) | PH12014501760B1 (https=) |
| WO (1) | WO2013117568A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2289881A1 (de) * | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4575507A (en) * | 1985-05-29 | 1986-03-11 | Pfizer Inc. | Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use |
| JP4776882B2 (ja) | 2002-03-30 | 2011-09-21 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 二環式複素環化合物、これらの化合物を含む医薬組成物、それらの使用及びそれらの調製方法 |
| US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| JP2009518450A (ja) | 2005-12-12 | 2009-05-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二環式複素環化合物、その化合物を含む薬剤、その使用及び製造方法 |
| US8497369B2 (en) * | 2008-02-07 | 2013-07-30 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production |
| EP2289881A1 (de) * | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
| AP3531A (en) | 2011-02-01 | 2016-01-13 | Boehringer Ingelheim Int | 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof |
-
2013
- 2013-02-06 KR KR1020147021922A patent/KR20140128318A/ko not_active Withdrawn
- 2013-02-06 MX MX2014009033A patent/MX2014009033A/es not_active Application Discontinuation
- 2013-02-06 BR BR112014019196A patent/BR112014019196A8/pt not_active IP Right Cessation
- 2013-02-06 AU AU2013218119A patent/AU2013218119A1/en not_active Abandoned
- 2013-02-06 JP JP2014556029A patent/JP6105631B2/ja active Active
- 2013-02-06 EA EA201400882A patent/EA201400882A1/ru unknown
- 2013-02-06 WO PCT/EP2013/052287 patent/WO2013117568A1/de not_active Ceased
- 2013-02-06 CA CA2862520A patent/CA2862520A1/en not_active Abandoned
- 2013-02-06 EP EP13703045.8A patent/EP2812317B1/de active Active
- 2013-02-06 CN CN201380006918.0A patent/CN104080775A/zh active Pending
- 2013-02-07 US US13/761,211 patent/US8629146B2/en active Active
-
2014
- 2014-06-25 IL IL233370A patent/IL233370A/en not_active IP Right Cessation
- 2014-07-09 CL CL2014001823A patent/CL2014001823A1/es unknown
- 2014-08-05 PH PH12014501760A patent/PH12014501760B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015506966A (ja) | 2015-03-05 |
| KR20140128318A (ko) | 2014-11-05 |
| IL233370A0 (en) | 2014-08-31 |
| US20130211081A1 (en) | 2013-08-15 |
| PH12014501760A1 (en) | 2014-11-10 |
| PH12014501760B1 (en) | 2014-11-10 |
| US8629146B2 (en) | 2014-01-14 |
| WO2013117568A1 (de) | 2013-08-15 |
| AU2013218119A1 (en) | 2014-07-17 |
| CA2862520A1 (en) | 2013-08-15 |
| EA201400882A1 (ru) | 2015-01-30 |
| MX2014009033A (es) | 2014-10-17 |
| EP2812317A1 (de) | 2014-12-17 |
| BR112014019196A2 (https=) | 2017-06-20 |
| IL233370A (en) | 2015-04-30 |
| EP2812317B1 (de) | 2016-02-03 |
| JP6105631B2 (ja) | 2017-03-29 |
| CL2014001823A1 (es) | 2015-03-06 |
| CN104080775A (zh) | 2014-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |