BR112014019196A8 - METHOD FOR STEREOSESECTIVE SYNTHESIS OF 9-HYDROXY-5-OXO-1,4-DIAZA-SPIRO[5.5]1,4-PROTECTED UNDECANES - Google Patents

METHOD FOR STEREOSESECTIVE SYNTHESIS OF 9-HYDROXY-5-OXO-1,4-DIAZA-SPIRO[5.5]1,4-PROTECTED UNDECANES

Info

Publication number
BR112014019196A8
BR112014019196A8 BR112014019196A BR112014019196A BR112014019196A8 BR 112014019196 A8 BR112014019196 A8 BR 112014019196A8 BR 112014019196 A BR112014019196 A BR 112014019196A BR 112014019196 A BR112014019196 A BR 112014019196A BR 112014019196 A8 BR112014019196 A8 BR 112014019196A8
Authority
BR
Brazil
Prior art keywords
formula
compound
stereosesective
undecanes
diaza
Prior art date
Application number
BR112014019196A
Other languages
Portuguese (pt)
Other versions
BR112014019196A2 (en
Inventor
Schnaubelt Juergen
Tang Wenjun
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112014019196A2 publication Critical patent/BR112014019196A2/pt
Publication of BR112014019196A8 publication Critical patent/BR112014019196A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

MÉTODO PARA SÍNTESE ESTEREOSSELETIVA DE 9-HIDRÓXI-5-OXO-1,4-DIAZA-ESPIRO[5.5]UNDECANOS 1,4-PROTEGIDOS. A presente invenção refere-se a um método para a preparação estereosseletiva de um composto de fórmula (5), opcionalmente na forma dos tautômeros do mesmo, (5) em que SG1 denota um grupo protetor selecionado dentre trifluoroacetila, acetila, benzoíla e pivaloíla, SG2 denota um grupo protetor selecionado dentre terc.-butoxicarbonila, etoxicarbonila e metoxicarbonila, compreendendo ainda as etapas de reação (C) e (D), em que (C) é a reação do composto de fórmula (3) para formar um composto de fórmula (4) e (D) é a redução do composto de fórmula (4) para formar um composto de fórmula (5), enquanto as etapas do processo (C) e (D) são realizadas sucessivamente na ordem mencionada.METHOD FOR STEREOSESECTIVE SYNTHESIS OF 1,4-PROTECTED 9-HYDROXY-5-OXO-1,4-DIAZA-SPIRO[5.5]UNDECANES. The present invention relates to a method for the stereoselective preparation of a compound of formula (5), optionally in the form of tautomers thereof, (5) in which SG1 denotes a protecting group selected from among trifluoroacetyl, acetyl, benzoyl and pivaloyl, SG2 denotes a protecting group selected from tert.-butoxycarbonyl, ethoxycarbonyl and methoxycarbonyl, further comprising reaction steps (C) and (D), wherein (C) is the reaction of the compound of formula (3) to form a compound of formula (3) formula (4) and (D) is the reduction of the compound of formula (4) to form a compound of formula (5), while process steps (C) and (D) are carried out successively in the mentioned order.

BR112014019196A 2012-02-09 2013-02-06 METHOD FOR STEREOSESECTIVE SYNTHESIS OF 9-HYDROXY-5-OXO-1,4-DIAZA-SPIRO[5.5]1,4-PROTECTED UNDECANES BR112014019196A8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12154688 2012-02-09
PCT/EP2013/052287 WO2013117568A1 (en) 2012-02-09 2013-02-06 Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecanes

Publications (2)

Publication Number Publication Date
BR112014019196A2 BR112014019196A2 (en) 2017-06-20
BR112014019196A8 true BR112014019196A8 (en) 2017-07-11

Family

ID=47678813

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014019196A BR112014019196A8 (en) 2012-02-09 2013-02-06 METHOD FOR STEREOSESECTIVE SYNTHESIS OF 9-HYDROXY-5-OXO-1,4-DIAZA-SPIRO[5.5]1,4-PROTECTED UNDECANES

Country Status (14)

Country Link
US (1) US8629146B2 (en)
EP (1) EP2812317B1 (en)
JP (1) JP6105631B2 (en)
KR (1) KR20140128318A (en)
CN (1) CN104080775A (en)
AU (1) AU2013218119A1 (en)
BR (1) BR112014019196A8 (en)
CA (1) CA2862520A1 (en)
CL (1) CL2014001823A1 (en)
EA (1) EA201400882A1 (en)
IL (1) IL233370A (en)
MX (1) MX2014009033A (en)
PH (1) PH12014501760B1 (en)
WO (1) WO2013117568A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289881A1 (en) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Method for stereoselective synthesis of bicyclical heterocycles

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
BR0308902A (en) 2002-03-30 2005-01-04 Boehringer Ingelheim Pharma 4- (n-phenylamino) -quinazolines / quinolines as tyrosine kinase inhibitors
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
AU2006326157A1 (en) 2005-12-12 2007-06-21 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for the production thereof
WO2009098061A1 (en) 2008-02-07 2009-08-13 Boehringer Ingelheim International Gmbh Spirocyclic heterocycles, medicaments containing said compounds, use thereof and method for their production
EP2289881A1 (en) 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Method for stereoselective synthesis of bicyclical heterocycles
EA023573B1 (en) * 2011-02-01 2016-06-30 Бёрингер Ингельхайм Интернациональ Гмбх 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diazaspiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof

Also Published As

Publication number Publication date
EP2812317A1 (en) 2014-12-17
WO2013117568A1 (en) 2013-08-15
IL233370A0 (en) 2014-08-31
CA2862520A1 (en) 2013-08-15
AU2013218119A1 (en) 2014-07-17
EA201400882A1 (en) 2015-01-30
BR112014019196A2 (en) 2017-06-20
IL233370A (en) 2015-04-30
KR20140128318A (en) 2014-11-05
US8629146B2 (en) 2014-01-14
CN104080775A (en) 2014-10-01
JP2015506966A (en) 2015-03-05
PH12014501760A1 (en) 2014-11-10
PH12014501760B1 (en) 2014-11-10
CL2014001823A1 (en) 2015-03-06
JP6105631B2 (en) 2017-03-29
MX2014009033A (en) 2014-10-17
US20130211081A1 (en) 2013-08-15
EP2812317B1 (en) 2016-02-03

Similar Documents

Publication Publication Date Title
PH12014501134A1 (en) 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
BR112015001608A2 (en) lfa-1 inhibitor and polymorph thereof
BR112014018756A8 (en) PROCESS FOR PREPARING N-(4-CYCLO-HEXYL-3-TRIFLUOROMETHYL-BENZYLOXY)-ACETIMIDIC ACID ETHYL ESTER
BR112013009029A2 (en) methods and compositions for polymerase inhibition
BRPI0813284A8 (en) PROCESS FOR THE PREPARATION OF A COMPOUND OF FORMULA (I) AND COMPOUND
MY182428A (en) Crystalline forms of a prolyl hydroxylase inhibitor
BR112012019762A2 (en) compound, composition, and method for treating a disease.
MX2010007587A (en) Compounds comprising a cyclobutoxy group.
PH12015500211A1 (en) 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes
BR112012032244A2 (en) process for preparing tetrazole-substituted anthranilamide derivatives and new crystalline polymorphs and derivatives thereof
BR112015001839A2 (en) deuterated ibrutinib
BR112013016578A2 (en) process for preparing methylmercaptopropionaldehyde
BR112013011593A2 (en) 7-carbamoyl-6,7-unsaturated morfinan derivative crystal and method for producing the same
CR20180412A (en) PROCESS TO PREPARE ANTIVIRAL COMPOUNDS
BR112015029504A2 (en) kinase inhibitors
UA110128C2 (en) Normal;heading 1;heading 2;heading 3;INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES
IN2015DN02424A (en)
BR112012027625A2 (en) monolithic refractory binder, monolithic refractory, and method of construction of monolithic refractory
EA201300647A1 (en) OPTIMIZED SYNTHESIS OF PURE NONPOLYMORPHIC CRYSTALLINE YELLOW ACIDS WITH A PARTICLE SIZE
MX2013000294A (en) Intermediates and process for preparing a thrombin specific inhibitor.
BR112014009266A8 (en) shortened, biocatalytic and isoxazolyl-methoxy-nicotinic acid preparation processes
MX337997B (en) New method for synthesising ivabradine and its added salts with a pharmaceutically acceptable acid.
BR112014019196A8 (en) METHOD FOR STEREOSESECTIVE SYNTHESIS OF 9-HYDROXY-5-OXO-1,4-DIAZA-SPIRO[5.5]1,4-PROTECTED UNDECANES
TN2014000329A1 (en) Method for preparing compound by novel michael addition reaction using water or various acids as additive
GB2523674A (en) Compounds as inhibitor of DNA double-strand break repair, methods and applications thereof

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]