CN1040326C - 咪唑并吡啶paf/h1拮抗剂的制备方法 - Google Patents

咪唑并吡啶paf/h1拮抗剂的制备方法 Download PDF

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Publication number
CN1040326C
CN1040326C CN92100974A CN92100974A CN1040326C CN 1040326 C CN1040326 C CN 1040326C CN 92100974 A CN92100974 A CN 92100974A CN 92100974 A CN92100974 A CN 92100974A CN 1040326 C CN1040326 C CN 1040326C
Authority
CN
China
Prior art keywords
pyridine
compound
formula
subunit
piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN92100974A
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English (en)
Chinese (zh)
Other versions
CN1064275A (zh
Inventor
D·阿尔克
R·J·巴斯
K·库珀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CN1064275A publication Critical patent/CN1064275A/zh
Application granted granted Critical
Publication of CN1040326C publication Critical patent/CN1040326C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Prostheses (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
CN92100974A 1991-02-13 1992-02-13 咪唑并吡啶paf/h1拮抗剂的制备方法 Expired - Fee Related CN1040326C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919102997A GB9102997D0 (en) 1991-02-13 1991-02-13 Therapeutic agents
GB9102997.5 1991-02-13

Publications (2)

Publication Number Publication Date
CN1064275A CN1064275A (zh) 1992-09-09
CN1040326C true CN1040326C (zh) 1998-10-21

Family

ID=10689943

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92100974A Expired - Fee Related CN1040326C (zh) 1991-02-13 1992-02-13 咪唑并吡啶paf/h1拮抗剂的制备方法

Country Status (29)

Country Link
US (1) US5358953A (enExample)
EP (1) EP0572425B1 (enExample)
JP (1) JP2506541B2 (enExample)
KR (1) KR970005302B1 (enExample)
CN (1) CN1040326C (enExample)
AT (1) ATE109482T1 (enExample)
AU (1) AU650322B2 (enExample)
BR (1) BR9205615A (enExample)
CA (1) CA2099381C (enExample)
CZ (1) CZ280504B6 (enExample)
DE (1) DE69200304T2 (enExample)
DK (1) DK0572425T3 (enExample)
EG (1) EG20085A (enExample)
ES (1) ES2059212T3 (enExample)
FI (1) FI933531A7 (enExample)
GB (1) GB9102997D0 (enExample)
HU (2) HUT65947A (enExample)
IE (1) IE65125B1 (enExample)
IL (1) IL100887A (enExample)
MX (1) MX9200589A (enExample)
MY (1) MY108437A (enExample)
NO (1) NO300592B1 (enExample)
NZ (1) NZ241597A (enExample)
PL (1) PL169304B1 (enExample)
RU (1) RU2114845C1 (enExample)
TW (1) TW227000B (enExample)
WO (1) WO1992014734A1 (enExample)
YU (1) YU48238B (enExample)
ZA (1) ZA921005B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042421B1 (es) * 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
WO1996005201A1 (en) * 1994-08-10 1996-02-22 British Biotech Pharmaceuticals Limited Imidazopyridine derivatives as dual histamine (h1) and platelet activating factor (paf) antagonists
ES2087038B1 (es) * 1994-11-07 1997-03-16 Uriach & Cia Sa J Nuevas piperidinas con actividad antagonista del paf.
US5567711A (en) * 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
GB9508748D0 (en) * 1995-04-28 1995-06-14 British Biotech Pharm Benzimidazole derivatives
EP0842175A1 (en) * 1995-08-05 1998-05-20 British Biotech Pharmaceuticals Limited Imidazopyridine derivatives
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
CN100553636C (zh) 2000-08-04 2009-10-28 Dmi生物科学公司 二酮基哌嗪和包含它们的组合物的使用方法
EP2517718B1 (en) 2003-05-15 2016-03-02 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
US7687515B2 (en) * 2006-01-17 2010-03-30 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
NZ587050A (en) 2008-01-30 2012-08-31 Nippon Zoki Pharmaceutical Co Compounds featuring a tricyclic group double bonded to a piperidine group, as an antihistamine
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
JP5978296B2 (ja) * 2011-06-28 2016-08-24 フジアン・ミンドン・レジュヴネイション・ファーマスーティカル・カンパニー・リミテッド 抗アレルギ性ベンゾシクロヘプタチオフェン誘導体
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
EA028343B1 (ru) 2011-10-10 2017-11-30 Ампио Фармасьютикалз, Инк. Лечение дегенеративного заболевания сустава
EP2771007B1 (en) * 2011-10-28 2018-04-04 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
BR112015020469A2 (pt) 2013-03-15 2020-01-28 Ampio Pharmaceuticals Inc Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo
RU2736513C2 (ru) 2014-08-18 2020-11-17 Ампио Фармасьютикалз, Инк. Лечение патологических состояний суставов
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES
CN113880801A (zh) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 一类三环化合物、其制备方法及其医药用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989008653A1 (en) * 1988-03-15 1989-09-21 G.D. Searle & Co. 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS
WO1989010363A1 (en) * 1988-04-28 1989-11-02 Schering Corporation Fused polycyclic compounds, compositions, methods of manufacture and their use as paf antagonists, antihistamines and/or antiinflammatory agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (enExample) * 1963-04-24
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
US5114919A (en) * 1990-02-26 1992-05-19 Merck & Co., Inc. Adjuncts in cancer chemotherapy
JPH0678340B2 (ja) * 1990-05-09 1994-10-05 フアイザー・インコーポレイテツド 喘息、関節炎および関連疾患の治療におけるアザベンジミダゾール

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989008653A1 (en) * 1988-03-15 1989-09-21 G.D. Searle & Co. 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS
WO1989010363A1 (en) * 1988-04-28 1989-11-02 Schering Corporation Fused polycyclic compounds, compositions, methods of manufacture and their use as paf antagonists, antihistamines and/or antiinflammatory agents

Also Published As

Publication number Publication date
NO932889L (no) 1993-08-13
ES2059212T3 (es) 1994-11-01
ZA921005B (en) 1993-08-12
WO1992014734A1 (en) 1992-09-03
NZ241597A (en) 1993-04-28
AU650322B2 (en) 1994-06-16
IL100887A (en) 1996-01-19
AU1168392A (en) 1992-09-15
EG20085A (en) 1997-05-31
YU14392A (sh) 1994-11-15
GB9102997D0 (en) 1991-03-27
FI933531L (fi) 1993-08-10
PL169304B1 (pl) 1996-06-28
TW227000B (enExample) 1994-07-21
MY108437A (en) 1996-09-30
JP2506541B2 (ja) 1996-06-12
NO932889D0 (no) 1993-08-13
DE69200304T2 (de) 1994-12-08
CN1064275A (zh) 1992-09-09
KR970005302B1 (ko) 1997-04-15
BR9205615A (pt) 1994-05-17
HU211202A9 (en) 1995-11-28
RU2114845C1 (ru) 1998-07-10
IL100887A0 (en) 1992-11-15
IE920449A1 (en) 1992-08-12
IE65125B1 (en) 1995-10-04
MX9200589A (es) 1992-10-01
HUT65947A (en) 1994-08-29
EP0572425B1 (en) 1994-08-03
EP0572425A1 (en) 1993-12-08
CA2099381A1 (en) 1992-08-14
FI933531A0 (fi) 1993-08-10
FI933531A7 (fi) 1993-08-10
JPH06504992A (ja) 1994-06-09
CA2099381C (en) 1996-07-09
NO300592B1 (no) 1997-06-23
DK0572425T3 (da) 1994-09-12
US5358953A (en) 1994-10-25
YU48238B (sh) 1997-08-22
CZ280504B6 (cs) 1996-02-14
HU9302327D0 (en) 1993-10-28
DE69200304D1 (de) 1994-09-08
CS42592A3 (en) 1992-09-16
ATE109482T1 (de) 1994-08-15

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