CA2099381C - Imidazopyridine paf/h _antagonists - Google Patents

Imidazopyridine paf/h _antagonists

Info

Publication number
CA2099381C
CA2099381C CA002099381A CA2099381A CA2099381C CA 2099381 C CA2099381 C CA 2099381C CA 002099381 A CA002099381 A CA 002099381A CA 2099381 A CA2099381 A CA 2099381A CA 2099381 C CA2099381 C CA 2099381C
Authority
CA
Canada
Prior art keywords
compound
formula
pyrid
pharmaceutically acceptable
piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002099381A
Other languages
English (en)
French (fr)
Other versions
CA2099381A1 (en
Inventor
David Alker
Robert John Bass
Kelvin Cooper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of CA2099381A1 publication Critical patent/CA2099381A1/en
Application granted granted Critical
Publication of CA2099381C publication Critical patent/CA2099381C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Prostheses (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)
CA002099381A 1991-02-13 1992-01-24 Imidazopyridine paf/h _antagonists Expired - Fee Related CA2099381C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9102997.5 1991-02-13
GB919102997A GB9102997D0 (en) 1991-02-13 1991-02-13 Therapeutic agents

Publications (2)

Publication Number Publication Date
CA2099381A1 CA2099381A1 (en) 1992-08-14
CA2099381C true CA2099381C (en) 1996-07-09

Family

ID=10689943

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002099381A Expired - Fee Related CA2099381C (en) 1991-02-13 1992-01-24 Imidazopyridine paf/h _antagonists

Country Status (29)

Country Link
US (1) US5358953A (enExample)
EP (1) EP0572425B1 (enExample)
JP (1) JP2506541B2 (enExample)
KR (1) KR970005302B1 (enExample)
CN (1) CN1040326C (enExample)
AT (1) ATE109482T1 (enExample)
AU (1) AU650322B2 (enExample)
BR (1) BR9205615A (enExample)
CA (1) CA2099381C (enExample)
CZ (1) CZ280504B6 (enExample)
DE (1) DE69200304T2 (enExample)
DK (1) DK0572425T3 (enExample)
EG (1) EG20085A (enExample)
ES (1) ES2059212T3 (enExample)
FI (1) FI933531L (enExample)
GB (1) GB9102997D0 (enExample)
HU (2) HUT65947A (enExample)
IE (1) IE65125B1 (enExample)
IL (1) IL100887A (enExample)
MX (1) MX9200589A (enExample)
MY (1) MY108437A (enExample)
NO (1) NO300592B1 (enExample)
NZ (1) NZ241597A (enExample)
PL (1) PL169304B1 (enExample)
RU (1) RU2114845C1 (enExample)
TW (1) TW227000B (enExample)
WO (1) WO1992014734A1 (enExample)
YU (1) YU48238B (enExample)
ZA (1) ZA921005B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2042421B1 (es) * 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
EP0775139A1 (en) * 1994-08-10 1997-05-28 British Biotech Pharmaceuticals Limited Imidazopyridine derivatives as dual histamine (h1) and platelet activating factor (paf) antagonists
ES2087038B1 (es) * 1994-11-07 1997-03-16 Uriach & Cia Sa J Nuevas piperidinas con actividad antagonista del paf.
US5866588A (en) * 1995-04-05 1999-02-02 British Biotech Pharmaceuticals Ltd. Imidazopyridine derivatives
US5567711A (en) * 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
GB9508748D0 (en) * 1995-04-28 1995-06-14 British Biotech Pharm Benzimidazole derivatives
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
CA2417960C (en) 2000-08-04 2012-07-10 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
ES2579635T3 (es) 2003-05-15 2016-08-12 Ampio Pharmaceuticals, Inc. Tratamiento de enfermedades mediadas por los linfocitos T
US7687515B2 (en) * 2006-01-17 2010-03-30 N.V. Organon 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
AU2008349239B2 (en) 2008-01-30 2012-12-06 Nippon Zoki Pharmaceutical Co., Ltd. Piperidine derivative
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
EP2727919B1 (en) * 2011-06-28 2019-05-08 Fujian Mindong Rejuvenation Pharmaceutical Co., Ltd. Benzocycloheptanethiophene derivatives for anti-allergic reactions
SG10201608087WA (en) 2011-10-10 2016-11-29 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
KR102032400B1 (ko) 2011-10-10 2019-10-15 앰피오 파마슈티컬스 인코퍼레이티드 퇴행성 관절 질환의 치료
BR112014008036A2 (pt) * 2011-10-28 2017-04-11 Ampio Pharmaceuticals Inc tratamento de rinite
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
JP6723222B2 (ja) 2014-08-18 2020-07-15 アンピオ ファーマシューティカルズ，インコーポレイテッド 関節病態の治療
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES
CN113880801A (zh) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 一类三环化合物、其制备方法及其医药用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (enExample) * 1963-04-24
JPH03503889A (ja) * 1988-03-15 1991-08-29 ジー．ディー．サール　アンド　カンパニー ＰＡＦ拮抗剤としての１Ｈ／３Ｈ‐［４‐（Ｎ，Ｎ‐ジシクロアルキル／分枝アルキルカルボキサミド）‐ベンジル］イミダゾ［４，５‐ｃ］ピリジン類
EP0339978B1 (en) * 1988-04-28 1996-08-21 Schering Corporation Fused polycyclic compounds, compositions, methods of manufacture, and their use as PAF antagonists, antihistamines and/or antiinflammatory agents
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
US5114919A (en) * 1990-02-26 1992-05-19 Merck & Co., Inc. Adjuncts in cancer chemotherapy
JPH0678340B2 (ja) * 1990-05-09 1994-10-05 フアイザー・インコーポレイテツド 喘息、関節炎および関連疾患の治療におけるアザベンジミダゾール

Also Published As

Publication number Publication date
MX9200589A (es) 1992-10-01
ATE109482T1 (de) 1994-08-15
IE65125B1 (en) 1995-10-04
ES2059212T3 (es) 1994-11-01
JP2506541B2 (ja) 1996-06-12
DE69200304D1 (de) 1994-09-08
JPH06504992A (ja) 1994-06-09
CS42592A3 (en) 1992-09-16
EG20085A (en) 1997-05-31
CN1040326C (zh) 1998-10-21
MY108437A (en) 1996-09-30
NO932889L (no) 1993-08-13
CN1064275A (zh) 1992-09-09
YU14392A (sh) 1994-11-15
EP0572425B1 (en) 1994-08-03
FI933531A0 (fi) 1993-08-10
TW227000B (enExample) 1994-07-21
PL169304B1 (pl) 1996-06-28
HUT65947A (en) 1994-08-29
WO1992014734A1 (en) 1992-09-03
IL100887A0 (en) 1992-11-15
NZ241597A (en) 1993-04-28
KR970005302B1 (ko) 1997-04-15
NO300592B1 (no) 1997-06-23
HU211202A9 (en) 1995-11-28
HU9302327D0 (en) 1993-10-28
GB9102997D0 (en) 1991-03-27
DE69200304T2 (de) 1994-12-08
FI933531A7 (fi) 1993-08-10
IE920449A1 (en) 1992-08-12
AU1168392A (en) 1992-09-15
EP0572425A1 (en) 1993-12-08
AU650322B2 (en) 1994-06-16
YU48238B (sh) 1997-08-22
FI933531L (fi) 1993-08-10
CZ280504B6 (cs) 1996-02-14
NO932889D0 (no) 1993-08-13
RU2114845C1 (ru) 1998-07-10
CA2099381A1 (en) 1992-08-14
US5358953A (en) 1994-10-25
BR9205615A (pt) 1994-05-17
DK0572425T3 (da) 1994-09-12
IL100887A (en) 1996-01-19
ZA921005B (en) 1993-08-12

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