CN103946231A - 齐墩果酸酰胺化衍生物、及其制备方法和应用 - Google Patents
齐墩果酸酰胺化衍生物、及其制备方法和应用 Download PDFInfo
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- CN103946231A CN103946231A CN201280056912.XA CN201280056912A CN103946231A CN 103946231 A CN103946231 A CN 103946231A CN 201280056912 A CN201280056912 A CN 201280056912A CN 103946231 A CN103946231 A CN 103946231A
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- oleanolic acid
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- acceptable salt
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07—ORGANIC CHEMISTRY
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- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/74—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
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Abstract
本发明属于天然药物及药物化学领域,具体涉及通式I的新型齐墩果酸酰胺化衍生物或其药学上可接受的盐,制备这些化合物的方法、包含该化合物的药物组合物及其在制备抗肿瘤药物中的用途。
Description
PCT国内申请,说明书已公开。
Claims (1)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011083295 | 2011-12-01 | ||
CNPCT/CN2011/083295 | 2011-12-01 | ||
PCT/CN2012/085671 WO2013079024A1 (zh) | 2011-12-01 | 2012-11-30 | 齐墩果酸酰胺化衍生物、及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103946231A true CN103946231A (zh) | 2014-07-23 |
CN103946231B CN103946231B (zh) | 2016-10-26 |
Family
ID=48534683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201280056912.XA Active CN103946231B (zh) | 2011-12-01 | 2012-11-30 | 齐墩果酸酰胺化衍生物、及其制备方法和应用 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8987502B2 (zh) |
EP (1) | EP2787002B1 (zh) |
JP (1) | JP6043361B2 (zh) |
CN (1) | CN103946231B (zh) |
DK (1) | DK2787002T3 (zh) |
WO (1) | WO2013079024A1 (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2787002B1 (en) | 2011-12-01 | 2016-06-01 | Hangzhou Bensheng Pharmaceutical Co., Ltd. | Oleanolic acid amidate derivatives, preparation methods and uses thereof |
CN104861028A (zh) * | 2014-02-24 | 2015-08-26 | 上海兰蒂斯生物医药科技有限公司 | 新型熊果酸衍生物、其制备方法及其应用 |
CN104861027A (zh) * | 2014-02-24 | 2015-08-26 | 上海兰蒂斯生物医药科技有限公司 | 新型齐墩果酸衍生物、其制备方法及其应用 |
JP2015168633A (ja) * | 2014-03-05 | 2015-09-28 | 東レ・ファインケミカル株式会社 | 安息香酸類の製造方法 |
CN105566435B (zh) * | 2014-10-11 | 2017-12-19 | 中国科学院上海有机化学研究所 | 一种齐墩果酸衍生物及其制备方法和用途 |
CN108290922B (zh) | 2015-09-23 | 2021-12-07 | 里亚塔医药公司 | 用于抑制il-17和其它用途的c4-改性的齐墩果酸衍生物 |
WO2019055119A1 (en) | 2017-09-14 | 2019-03-21 | Phoenix Biotechnology, Inc. | METHOD AND COMPOSITION FOR TREATING VIRAL INFECTION |
RU2758376C2 (ru) | 2017-09-14 | 2021-10-28 | Феникс Байотекнолоджи, Инк. | Способ и улучшенная нейропротекторная композиция для лечения неврологических патологических состояний |
JP7153083B2 (ja) | 2020-03-31 | 2022-10-13 | フェニックス・バイオテクノロジー・インコーポレイテッド | コロナウイルス感染を治療するための方法および組成物 |
EP4295854A3 (en) | 2020-03-31 | 2024-04-03 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
CN113372406A (zh) * | 2021-06-09 | 2021-09-10 | 山东大学 | 一种齐墩果酸衍生物及其制备方法和应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101367861A (zh) * | 2007-08-15 | 2009-02-18 | 中国药科大学 | 2-羟基-3-脱氧五环三萜类化合物及其衍生物、其制备方法及用途 |
WO2009146216A2 (en) * | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals. Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
CN102050861A (zh) * | 2009-11-10 | 2011-05-11 | 中国药科大学 | 13(18)-烯齐墩果烷型五环三萜及其衍生物的制备 |
CN102083442A (zh) * | 2008-04-18 | 2011-06-01 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:在c-17具有氨基和其它修饰的齐墩果酸衍生物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1164609C (zh) | 2002-10-24 | 2004-09-01 | 青岛海洋大学 | 一种齐墩果酸乳糖缀合物及其制备方法和用途 |
CN1715291A (zh) * | 2004-06-28 | 2006-01-04 | 田振坤 | 齐墩果酸丁二酸单酯的合成及其治疗急慢性肝炎药物制剂 |
CN102133219A (zh) | 2010-09-27 | 2011-07-27 | 林秀坤 | 齐墩果酸的抗宫颈癌作用及其药物制剂 |
CN102151275A (zh) | 2010-11-07 | 2011-08-17 | 林秀坤 | 齐墩果酸的抗胰腺癌作用及其药物制剂 |
CN102070697A (zh) | 2010-12-09 | 2011-05-25 | 中国药科大学 | 一种齐墩果酸衍生物、其制备方法及用途 |
EP2787002B1 (en) | 2011-12-01 | 2016-06-01 | Hangzhou Bensheng Pharmaceutical Co., Ltd. | Oleanolic acid amidate derivatives, preparation methods and uses thereof |
-
2012
- 2012-11-30 EP EP12852963.3A patent/EP2787002B1/en not_active Not-in-force
- 2012-11-30 JP JP2014543763A patent/JP6043361B2/ja not_active Expired - Fee Related
- 2012-11-30 WO PCT/CN2012/085671 patent/WO2013079024A1/zh active Application Filing
- 2012-11-30 US US14/361,991 patent/US8987502B2/en not_active Expired - Fee Related
- 2012-11-30 DK DK12852963.3T patent/DK2787002T3/en active
- 2012-11-30 CN CN201280056912.XA patent/CN103946231B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101367861A (zh) * | 2007-08-15 | 2009-02-18 | 中国药科大学 | 2-羟基-3-脱氧五环三萜类化合物及其衍生物、其制备方法及用途 |
WO2009146216A2 (en) * | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals. Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
CN102083442A (zh) * | 2008-04-18 | 2011-06-01 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:在c-17具有氨基和其它修饰的齐墩果酸衍生物 |
CN102050861A (zh) * | 2009-11-10 | 2011-05-11 | 中国药科大学 | 13(18)-烯齐墩果烷型五环三萜及其衍生物的制备 |
Also Published As
Publication number | Publication date |
---|---|
DK2787002T3 (en) | 2016-08-29 |
US8987502B2 (en) | 2015-03-24 |
JP6043361B2 (ja) | 2016-12-14 |
EP2787002A4 (en) | 2015-05-06 |
EP2787002A1 (en) | 2014-10-08 |
EP2787002B1 (en) | 2016-06-01 |
WO2013079024A1 (zh) | 2013-06-06 |
US20140343108A1 (en) | 2014-11-20 |
CN103946231B (zh) | 2016-10-26 |
JP2014534269A (ja) | 2014-12-18 |
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Effective date of registration: 20180510 Address after: Room 102, No. 131, Kai Qing Road, Pudong New Area, Shanghai Patentee after: Bunsen Pharmaceutical (Shanghai) Co., Ltd. Address before: 310051 4 4, 6 Jiangling Road, Binjiang District, Hangzhou, Zhejiang. Patentee before: Hangzhou Bensheng Pharmaceutical Co., Ltd. |
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