CN103635475A - 5-位碳取代的汉防己甲素衍生物、及其制备方法和应用 - Google Patents

5-位碳取代的汉防己甲素衍生物、及其制备方法和应用 Download PDF

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Publication number
CN103635475A
CN103635475A CN201280027456.6A CN201280027456A CN103635475A CN 103635475 A CN103635475 A CN 103635475A CN 201280027456 A CN201280027456 A CN 201280027456A CN 103635475 A CN103635475 A CN 103635475A
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hanfangchin
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heteroaryl
derivative
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CN103635475B (zh
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徐荣臻
荣风光
谢福文
赖洪喜
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Hangzhou Bensheng Pharmaceutical Co Ltd
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Hangzhou Bensheng Pharmaceutical Co Ltd
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Priority claimed from PCT/CN2012/080384 external-priority patent/WO2013026383A1/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明属于天然药物及药物化学领域，具体涉及通式(I)的新型5-位碳取代的汉防己甲素衍生物或其药学上可接受的加成物，复合物和盐，制备这些化合物的方法、包含该化合物的药物组合物及其在制备抗肿瘤药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201280027456.6A 2011-08-19 2012-08-20 5-位碳取代的汉防己甲素衍生物、及其制备方法和应用 Expired - Fee Related CN103635475B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201280027456.6A CN103635475B (zh) 2011-08-19 2012-08-20 5-位碳取代的汉防己甲素衍生物、及其制备方法和应用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNPCT/CN2011/078622 2011-08-19
CN2011078622 2011-08-19
PCT/CN2012/080384 WO2013026383A1 (zh) 2011-08-19 2012-08-20 5-位碳取代的汉防己甲素衍生物、及其制备方法和应用
CN201280027456.6A CN103635475B (zh) 2011-08-19 2012-08-20 5-位碳取代的汉防己甲素衍生物、及其制备方法和应用

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CN103635475A true CN103635475A (zh) 2014-03-12
CN103635475B CN103635475B (zh) 2016-06-08

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112480140B (zh) * 2020-12-28 2022-04-01 杭州医学院 C5-位取代汉防己甲素衍生物及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0344323A (ja) * 1989-07-13 1991-02-26 Kao Corp 抗アレルギー剤
CN1810247A (zh) * 2005-01-28 2006-08-02 中国医学科学院血液学研究所 小檗胺衍生物ebb在抑制人体肿瘤细胞侵袭转移的药物应用
CN101273989A (zh) * 2008-04-09 2008-10-01 浙江大学 一类小檗胺衍生物及其盐的应用
CN101780082A (zh) * 2009-01-20 2010-07-21 张宏 双苄基异喹啉类生物碱作为抗感染药物增效剂的用途及其药物组合物
US20100298369A1 (en) * 2009-05-19 2010-11-25 David Horne Berbamine derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0344323A (ja) * 1989-07-13 1991-02-26 Kao Corp 抗アレルギー剤
CN1810247A (zh) * 2005-01-28 2006-08-02 中国医学科学院血液学研究所 小檗胺衍生物ebb在抑制人体肿瘤细胞侵袭转移的药物应用
CN101273989A (zh) * 2008-04-09 2008-10-01 浙江大学 一类小檗胺衍生物及其盐的应用
CN101780082A (zh) * 2009-01-20 2010-07-21 张宏 双苄基异喹啉类生物碱作为抗感染药物增效剂的用途及其药物组合物
US20100298369A1 (en) * 2009-05-19 2010-11-25 David Horne Berbamine derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
谢进文: "吲哚啉-2-酮和小檗胺衍生物的设计、合成及其生物活性研究", 《浙江大学博士学位论文》, 15 October 2009 (2009-10-15), pages 57 - 114 *
贡岳松，等: "四种小檗胺衍生物对钙调素诱导的肌球蛋白轻链激酶的抑制作用", 《中国药科大学学报》, vol. 22, no. 2, 31 December 1991 (1991-12-31), pages 93 - 95 *

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