CN103635475A - 5-位碳取代的汉防己甲素衍生物、及其制备方法和应用 - Google Patents
5-位碳取代的汉防己甲素衍生物、及其制备方法和应用 Download PDFInfo
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- CN103635475A CN103635475A CN201280027456.6A CN201280027456A CN103635475A CN 103635475 A CN103635475 A CN 103635475A CN 201280027456 A CN201280027456 A CN 201280027456A CN 103635475 A CN103635475 A CN 103635475A
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- alkyl
- hanfangchin
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- heteroaryl
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- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- SVEUVITYHIHZQE-UHFFFAOYSA-N n-methylpyridin-2-amine Chemical class CNC1=CC=CC=N1 SVEUVITYHIHZQE-UHFFFAOYSA-N 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N n-propyl alcohol Natural products CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- ZRWRYPIDQULHRE-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N.N#CC#N ZRWRYPIDQULHRE-UHFFFAOYSA-N 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
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- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
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- BIWOSRSKDCZIFM-UHFFFAOYSA-N piperidin-3-ol Chemical class OC1CCCNC1 BIWOSRSKDCZIFM-UHFFFAOYSA-N 0.000 description 1
- VUNPWIPIOOMCPT-UHFFFAOYSA-N piperidin-3-ylmethanol Chemical class OCC1CCCNC1 VUNPWIPIOOMCPT-UHFFFAOYSA-N 0.000 description 1
- HDOWRFHMPULYOA-UHFFFAOYSA-N piperidin-4-ol Chemical class OC1CCNCC1 HDOWRFHMPULYOA-UHFFFAOYSA-N 0.000 description 1
- FSDNTQSJGHSJBG-UHFFFAOYSA-N piperidine-4-carbonitrile Chemical class N#CC1CCNCC1 FSDNTQSJGHSJBG-UHFFFAOYSA-N 0.000 description 1
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- ZDHURYWHEBEGHO-UHFFFAOYSA-N potassiopotassium Chemical compound [K].[K] ZDHURYWHEBEGHO-UHFFFAOYSA-N 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003217 pyrazoles Chemical class 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- HDOUGSFASVGDCS-UHFFFAOYSA-N pyridin-3-ylmethanamine Chemical class NCC1=CC=CN=C1 HDOUGSFASVGDCS-UHFFFAOYSA-N 0.000 description 1
- JHHZLHWJQPUNKB-UHFFFAOYSA-N pyrrolidin-3-ol Chemical class OC1CCNC1 JHHZLHWJQPUNKB-UHFFFAOYSA-N 0.000 description 1
- 150000003235 pyrrolidines Chemical class 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
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- 239000004334 sorbic acid Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明属于天然药物及药物化学领域,具体涉及通式(I)的新型5-位碳取代的汉防己甲素衍生物或其药学上可接受的加成物,复合物和盐,制备这些化合物的方法、包含该化合物的药物组合物及其在制备抗肿瘤药物中的用途。
Description
PCT国内申请,说明书已公开。
Claims (1)
- PCT国内申请,权利要求书已公开。
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CN201280027456.6A CN103635475B (zh) | 2011-08-19 | 2012-08-20 | 5-位碳取代的汉防己甲素衍生物、及其制备方法和应用 |
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CNPCT/CN2011/078622 | 2011-08-19 | ||
CN2011078622 | 2011-08-19 | ||
PCT/CN2012/080384 WO2013026383A1 (zh) | 2011-08-19 | 2012-08-20 | 5-位碳取代的汉防己甲素衍生物、及其制备方法和应用 |
CN201280027456.6A CN103635475B (zh) | 2011-08-19 | 2012-08-20 | 5-位碳取代的汉防己甲素衍生物、及其制备方法和应用 |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0344323A (ja) * | 1989-07-13 | 1991-02-26 | Kao Corp | 抗アレルギー剤 |
CN1810247A (zh) * | 2005-01-28 | 2006-08-02 | 中国医学科学院血液学研究所 | 小檗胺衍生物ebb在抑制人体肿瘤细胞侵袭转移的药物应用 |
CN101273989A (zh) * | 2008-04-09 | 2008-10-01 | 浙江大学 | 一类小檗胺衍生物及其盐的应用 |
CN101780082A (zh) * | 2009-01-20 | 2010-07-21 | 张宏 | 双苄基异喹啉类生物碱作为抗感染药物增效剂的用途及其药物组合物 |
US20100298369A1 (en) * | 2009-05-19 | 2010-11-25 | David Horne | Berbamine derivatives |
-
2012
- 2012-08-20 CN CN201280027456.6A patent/CN103635475B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0344323A (ja) * | 1989-07-13 | 1991-02-26 | Kao Corp | 抗アレルギー剤 |
CN1810247A (zh) * | 2005-01-28 | 2006-08-02 | 中国医学科学院血液学研究所 | 小檗胺衍生物ebb在抑制人体肿瘤细胞侵袭转移的药物应用 |
CN101273989A (zh) * | 2008-04-09 | 2008-10-01 | 浙江大学 | 一类小檗胺衍生物及其盐的应用 |
CN101780082A (zh) * | 2009-01-20 | 2010-07-21 | 张宏 | 双苄基异喹啉类生物碱作为抗感染药物增效剂的用途及其药物组合物 |
US20100298369A1 (en) * | 2009-05-19 | 2010-11-25 | David Horne | Berbamine derivatives |
Non-Patent Citations (2)
Title |
---|
谢进文: "吲哚啉-2-酮和小檗胺衍生物的设计、合成及其生物活性研究", 《浙江大学博士学位论文》, 15 October 2009 (2009-10-15), pages 57 - 114 * |
贡岳松,等: "四种小檗胺衍生物对钙调素诱导的肌球蛋白轻链激酶的抑制作用", 《中国药科大学学报》, vol. 22, no. 2, 31 December 1991 (1991-12-31), pages 93 - 95 * |
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