CN103892166A - Method for preparing health food by polypeptide factor and Chinese herb extracts - Google Patents
Method for preparing health food by polypeptide factor and Chinese herb extracts Download PDFInfo
- Publication number
- CN103892166A CN103892166A CN201410143088.2A CN201410143088A CN103892166A CN 103892166 A CN103892166 A CN 103892166A CN 201410143088 A CN201410143088 A CN 201410143088A CN 103892166 A CN103892166 A CN 103892166A
- Authority
- CN
- China
- Prior art keywords
- pig spleen
- hawthorn
- polypeptide
- orange peel
- radix glycyrrhizae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a method for preparing a health food by polypeptide factor and Chinese herb extracts. The health food is characterized by comprising the following components and materials by weight: 1-3kg of pig-spleen polypeptide, 6-16kg of a liquorice, hawthorn and tangerine peel extract, 180-210kg of oligomeric polysaccharide and the balance being water. The preparation process comprises the following steps: (1) preparing the hawthorn, the liquorice and the tangerine peel extract; (2) preparing the pig-spleen polypeptide; (3) batching; and (4) filtering, sterilizing, drying and packaging. The method has the advantages that the synergistic effect the pig-spleen transfer factor, the oligomeric polysaccharide and certain edible traditional Chinese medicines in many aspects is comprehensively utilized, the production process is reasonably designed, and more bioactive-substance functional foods are industrialized, so that the health food has better effects of enhancing the defense function of the organism of a human body, adjusting the physiological rhythm, preventing the disease and promoting rehabilitation, and is balanced in nutrition, good in absorption, good in taste, long in quality guarantee period and low in price so as to have wide market demand and large development potential.
Description
Technical field
The present invention relates to a kind of preparation method of health food, relate in particular to a kind of method that polypeptide factor and Chinese herbal medicine extract are prepared health food.
Background technology
21 century, the main flow of food development was health food, and China is using meeting the specific nutrient of different crowd needs as the development priority of 21 century food industry, and exploitation has bioactive transfer factor and compound sugar functional food is applicable to this trend just.In addition, China's natural resources of Chinese medicinal materials is abundant, but exists research means to fall behind to herbal development aspect, must pay attention to basic research and the developmental research of Chinese herbal medicine.
Scientific experiment shows: the concentration of Chinese medicine has obvious impact to the propagation of Bifidobacterium, although all there is the effect of stimulation of bifidobacteria propagation under each concentration of some Chinese medicine, but the strongest in its effect of a certain concentration: and some Chinese medicine is under variable concentrations, the impact of Bifidobacterium is shown respectively promotion, suppressed or without impact.
Studies have shown that hawthorn, dried orange peel have effect of stomach invigorating eliminate indigestion, Radix Glycyrrhizae can be in the propagation that promotes in varying degrees Bacillus acidi lactici, and these Chinese herbal medicines have possessed the function of synergist, so possessed the function of prebiotics.
The activity research discovery of transfer factor, oral freeze-dried pig spleen transfer factor can improve the many index (drenching rate of rotation, OT test, T cell subsets) of malignant tumor patient cellular immunity, improves patient's quality of life, reduces infection rate.In addition, oral spleen brain transfer factor can not only improve immunologic function, and has regulating action.It is by rising CD4, and CD8 declines, and reaches CD4/ CD8 ratio and transfers normal equilibrium state to from being inverted/reducing, and is conducive to the rehabilitation of tumour patient.And, in the application of pig spleen transfer factor, have no any bad reaction, easy to use effective, patient is easy to accept.
Qiao Dairong and high flourish prepare pig spleen transfer factor (PTF), pork measles specific transfer factor (PSTF) and rabbit spleen transfer factor (RTF) and rabbit spleen pork measles specific transfer factor (RSTF) by dialysis, and inquire into emphatically they physicochemical property and composition on the similarities and differences.Result shows that four kinds of transfer factor exist very big-difference on ribose, polypeptide and amino acid composition.Be between transfer factor RTF and RSTF, PTF and PST and RTF and PTF, RSTF and the PSTF in same source, form different.
Liu Jinhui etc. are taking health pig spleen as raw material, adopt pH value to regulate a ultrafiltration to prepare spleen transfer factor (TransferFactor, be called for short TF), result of the test shows: the pig spleen transfer factor pH value that pH value regulates a ultrafiltration to prepare is 7.00, through ultraviolet spectral analysis, pig spleen transfer factor has peak value at 250 1 260 places, A260/ mark.=2.25; Recording Ribose concentration with two through base toluene method is 33.51ml; Recording many skins content by two vena contracta methods is 313.82ml; High performance liquid chromatograph is measured amino acid content, the relative percentage composition of free amino acid is the highest with glutamic acid, aspartic acid, glycine, threonine and alanine content successively, and the content of half skin propylhomoserin, arginine, histidine, methionine, tyrosine and lysine is relative less.
The activity of compound sugar and concertedness research, Zhou Jingxin and Yuan Jieli, by experiment in vitro and in vivo studies, have inquired into several prebiotic preparations to gut flora action effect.Found that FOS, stachyose, xylo-oligosaccharide, oligoisomaltose all can promote the propagation of Bifidobacterium and lactobacillus, and pH that can acidifying enteron aisle; Can significantly improve B/E value (ratio of Bifidobacterium and enterobacteria quantity l og value in enteron aisle) of enteron aisle, increase the ratio of beneficial bacterium in enteron aisle, be of value to the microecological balance of stablizing enteron aisle.And show that these several prebiotic preparations have the conclusion of good regulating action to gut flora.
China consumer's consumer psychology and consumer behavior reach its maturity, more and more focus on security and effect of food, the development in functional food industry future is that modern science and traditional methods to keep in good health's theory are combined, further investigation and excavation new resources, new raw material, new method and new technology, exploitation has the healthy food of independent intellectual property right.At present, there is the developing direction that how bioactive functional food is medicine and food industries.At present, transfer factor and compound sugar are more in the application of medicine and health products trade, and the commodity of developing are also more.Wherein, that the more employing of transfer factor is pig spleen transfer factor (pig spleen-transfer factor, PS-TF); What compound sugar use was more is oligoisomaltose (claiming again bifurcation oligose), FOS and galactooligosaccharide etc.
At pharmaceutical preparations, at present domestic developed have the oral freeze-dried powder of spleen aminopeptide, spleen aminopeptide oral liquid, transfer factor injection etc., its main component is the polypeptide class and the ucleotides compound that from healthy animal spleen, extract, is mainly used to treat RRTI, bronchitis, asthma, pneumonia, malignant tumour, severe herpes zoster, psoriasis etc.State Food and Drug Administration has also issued the national drug standards of new relevant transfer factor oral solution again in 2008, wherein, polypeptide and nucleotide content have all been made to clearly regulation.Because functional oligose has obvious proliferation function to Bifidobacterium, bifid flora in enteron aisle is rolled up, make it synthetic vitamin B1, B2, B6, K, niacin and folic acid etc. and increase, and be absorbed by the body, strengthen the absorption to calcium ion, be conducive to old children, weakling's health.Long-time edible oligomeric maltose, human activin immunologic function, improve people to the resistance catching and healing power, can effectively decompose carcinogenic substance, the pharmaceutical composition that contains compound sugar by subcutaneous, mouthful or intravenous administration can be for the treatment of early-stage breast cancer, lung cancer, prostate cancer, colon cancer etc.
Aspect health products, the Chinese medicine materials such as current domestic main employing spleen polypeptide and the Huang Qi ﹑ fruit of Chinese wolfberry, hawthorn, lotus nut, honeysuckle are made various capsules, oral liquid, particle etc., and main effect is for strengthening immunity, improving functions of intestines and stomach etc.In addition, there are some researches show, transfer factor and the fruit of Chinese wolfberry have the collaborative function that regulates immunity of organism, can make its performance optimum performance.Compound sugar has become the raw material of novel healthy food as the functional sugar of low sugariness, low temperature, and also can detect its various chemical constitutions and content by the existing food analysis technology of China, this promotes the development important in inhibiting of China's third generation functional food for the relation that discloses compound sugar structure, content and effect.
Up to the present, on market, only have a small amount of transfer factor, medicinal and edible Chinese medicine extract and compound sugar between two between the functional food of compatibility, three simultaneously many active functions food of compatibility there is not yet.
Summary of the invention
The object of the present invention is to provide a kind of polypeptide factor and Chinese herbal medicine extract to prepare the method for health food.
The present invention is achieved like this.It is made up of following component raw material: 1-3kg pig spleen polypeptide, 6-16kg Radix Glycyrrhizae, hawthorn and dried orange peel extracts, 180-210kg oligomeric polysaccharide, all the other are water.
Its step of preparation process is as follows:
One, the preparation of hawthorn, Radix Glycyrrhizae, dried orange peel mixed extract: hawthorn, Radix Glycyrrhizae, dried orange peel are pulverized, then add decocting to boil, filter and remove residue obtains filtrate, adopt ultrafiltration apparatus filtrate is carried out to ultrafiltration concentration to obtain extracts of Chinese herbal medicine, inspection extracts of Chinese herbal medicine also calculates the content of Chinese herbal medicine extract;
Two, pig spleen polypeptide preparation: choose fresh pig spleen and roughly grind, fine grinding obtains slurry again, continuous stirring makes its homogeneous, under the condition of-15 DEG C to the slurry after homogeneous freezing 72 hours, the filter residue that thaws afterwards obtains filtrate, with obtaining pig spleen polypeptide extract in Hollow Fiber Ultrafiltration pipe ultrafiltration gained filtrate, the concentrated pig spleen polypeptide concentrate that obtains, the content of pig spleen polypeptide in inspection pig spleen polypeptide concentrate;
Three, batching: take 1-3kg pig spleen polypeptide, 6-16kg Radix Glycyrrhizae, hawthorn, dried orange peel extracts, 180-210kg oligomeric polysaccharide, wherein pig spleen polypeptide converts by the content in pig spleen polypeptide concentrate, it is actual that what take is pig spleen polypeptide concentrate, Radix Glycyrrhizae, hawthorn, dried orange peel extracts convert by the content in extract, and actual what take is Radix Glycyrrhizae, hawthorn, dried orange peel extract; Each component is evenly mixed, remove unnecessary water and regulate gross weight to 270kg, be then heated to 95-100 DEG C of insulation sterilization 30min, transfer in storage tank after being cooled to 60-70 DEG C temporary;
Four, filtration, sterilization, dry and packaging: the batching that inspection prepares, use 100 screen filtrations as qualified, then use Semi-automatic liquid filling machine filling and sealing, be heated to afterwards 95-100 DEG C of insulation 30min sterilization, then use hot water injection, temporary drying afterwards, finally packaging sampling inspection, warehouse-in is up to the standards.
Technique effect of the present invention: comprehensive utilization pig spleen transfer factor, oligomeric polysaccharide and some medicinal and edible Chinese medicine are in many-sided synergy, and appropriate design production technology, by the industrialization of various bioactivators functional food, make it there is effect of better enhancing human body body defense function, adjusting circadian rhythm, prevent disease and promotion rehabilitation.Of the present invention how bioactive health food has the immunity of organisms of raising, regulating intestinal canal function, promote the effect of digesting and assimilating, and function synergic, effect is obvious, balanced in nutrition, good absorbing, mouthfeel is good, long shelf-life, and price is lower, therefore have the wide market demand, development potentiality is huge.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is done to further specific descriptions, its operational instances is only to further illustrate of the present invention, should not be used as limitation of the present invention.
Embodiment 1
The present invention is made up of following component raw material: 1kg pig spleen polypeptide, 6kg Radix Glycyrrhizae, hawthorn, dried orange peel extracts, 210kg oligomeric polysaccharide, all the other are water.
Its step of preparation process is as follows:
One, Chinese herbal medicine extract preparation: Radix Glycyrrhizae, hawthorn, dried orange peel are pulverized, then add decocting to boil secondary, each 1 hour, filtration obtains filtrate, adopt ultrafiltration apparatus to carry out ultrafiltration concentration to filtrate and obtain Radix Glycyrrhizae, hawthorn, dried orange peel aqueous extract, inspection Radix Glycyrrhizae, hawthorn, dried orange peel aqueous extract, and the active principle calculating outside wherein dewatering is the content of Radix Glycyrrhizae, hawthorn, dried orange peel water extract;
Two, pig spleen polypeptide preparation: choose fresh pig spleen, roughly grind, fine grinding obtains slurry again, continuous stirring makes its homogeneous, under the condition of-15 DEG C to the slurry after homogeneous freezing 72 hours, the filter residue that thaws afterwards obtains filtrate, obtain pig spleen polypeptide extract with the ultrafiltration of Hollow Fiber Ultrafiltration pipe, the concentrated pig spleen polypeptide concentrate that obtains, the content of pig spleen polypeptide in inspection pig spleen polypeptide concentrate;
Three, batching: take pig spleen polypeptide concentrate by the metering of 1kg pig spleen polypeptide, press 6kg Radix Glycyrrhizae, hawthorn, dried orange peel water extract weighing balance extracting liquorice, hawthorn, dried orange peel aqueous extract, take 210kg oligomeric polysaccharide, each component is evenly mixed, removing unnecessary water regulates gross weight to 270kg, then be heated to 95 DEG C of insulation sterilization 30min, transfer in storage tank after being cooled to 60 DEG C temporary;
Four, filtration, sterilization, dry and packaging: the batching that inspection prepares, filter with 100 eye mesh screens as qualified, then use Semi-automatic liquid filling machine filling and sealing, be heated to afterwards 100 DEG C of insulation 30min sterilization, then use hot water injection, temporary drying afterwards, finally packaging sampling inspection, warehouse-in is up to the standards.
Embodiment 2
The present invention is made up of following component raw material: 3kg pig spleen polypeptide, 16kg Radix Glycyrrhizae, hawthorn, dried orange peel extracts, 180kg oligomeric polysaccharide, all the other are water.
Its step of preparation process is as follows:
One, Chinese herbal medicine extract preparation: Radix Glycyrrhizae, hawthorn, dried orange peel are pulverized, then add decocting to boil secondary, each 1 hour, filtration obtains filtrate, adopt ultrafiltration apparatus to carry out ultrafiltration concentration to filtrate and obtain Radix Glycyrrhizae, hawthorn, dried orange peel aqueous extract, inspection Radix Glycyrrhizae, hawthorn, dried orange peel aqueous extract, and the active principle calculating outside wherein dewatering is the content of Radix Glycyrrhizae, hawthorn, dried orange peel water extract;
Two, pig spleen polypeptide preparation: choose fresh pig spleen, roughly grind, fine grinding obtains slurry again, continuous stirring makes its homogeneous, under the condition of-15 DEG C to the slurry after homogeneous freezing 72 hours, the filter residue that thaws afterwards obtains filtrate, obtain pig spleen polypeptide extract with the ultrafiltration of Hollow Fiber Ultrafiltration pipe, the concentrated pig spleen polypeptide concentrate that obtains, the content of pig spleen polypeptide in inspection pig spleen polypeptide concentrate;
Three, batching: take pig spleen polypeptide concentrate by the metering of 3kg pig spleen polypeptide, press 16kg Radix Glycyrrhizae, hawthorn, dried orange peel water extract weighing balance extracting liquorice, hawthorn, dried orange peel aqueous extract, take 180kg oligomeric polysaccharide, each component is evenly mixed, removing unnecessary water regulates gross weight to 270kg, then be heated to 95 DEG C of insulation sterilization 30min, transfer in storage tank after being cooled to 60 DEG C temporary;
Four, filtration, sterilization, dry and packaging: the batching that inspection prepares, use 100 screen filtrations as qualified, then use Semi-automatic liquid filling machine filling and sealing, be heated to afterwards 100 DEG C of insulation 30min sterilization, then use hot water injection, temporary drying afterwards, finally packaging sampling inspection, warehouse-in is up to the standards.
In order to verify effect of the present invention, there is following drug effect confirmatory experiment.
Use Radix Glycyrrhizae, hawthorn, dried orange peel extracts to do the research on Bifidobacterium Bifidum, lactobacter growth impact, result is as shown in table 1, table 2, table 3.
The respectively average colony counting comparison of group Bifidobacterium Bifidum, lactic acid bacteria of table 1 (± s)
The 20h of the each group of table 2 Bifidobacterium Bifidum, lactic acid bacteria, the E value of 24h relatively
The 20h of the each group of table 3 Bifidobacterium Bifidum, lactic acid bacteria, the pH value comparison of 24h
The experimental result explanation low concentration Radix Glycyrrhizae of table 1 table 2 table 3, hawthorn, dried orange peel extracts extract can promote Bifidobacterium Bifidum, lactic acid bacteria to grow in vitro, and high concentration Radix Glycyrrhizae, hawthorn, dried orange peel extracts extract suppress the growth in vitro of Bifidobacterium Bifidum, lactic acid bacteria.
The effect of research transfer factor treatment infantile respiratory tract infection repeatedly, in table 4 and table 5.
Respiratory tract infection number of times comparison after 3 groups of treatments of table 4 (± s time)
2 groups of cellular immune function comparisons of table 5 (± s)
Table 4 table 5 result shows, pig spleen transfer factor can obviously improve children's body's immunity, remarkable to the result for the treatment of of infantile respiratory tract infection repeatedly.
Embodiment 1 products obtained therefrom is as shown in table 6 to the regulating action result of study of gut flora.
Table 6 regulating intestinal canal flora group mouse intestinal flora testing result (logCFU/g, ± s, n=40)
From table 6, per os gives after mouse tested material, and 4 kinds of bacterial numbers in mouse intestinal change.Low dose group gavages front and gavages rear comparison, and the quantity of enterococcus and enterobacteria obviously reduces, and difference has utmost point conspicuousness (P < 0. 05); Middle dosage group gavages front and gavages rear comparison, and the quantity of Bifidobacterium and lactobacillus obviously increases, and difference has conspicuousness (P < 0. 01); High dose group gavages front and gavages rear comparison, and the quantity of Bifidobacterium and lactobacillus obviously increases, and difference has utmost point conspicuousness (P < 0. 01).Result shows this product compatibility composition synergy obviously, obvious to pernicious bacteria (enterococcus, enterobacteria) inhibitory action, profitable strain is had to good cultivation effect, thereby gut flora is had to good dual regulation.
Embodiment 1 products obtained therefrom strengthens immunity result of study as shown in table 7-8.
The impact of table 7 trial target on mouse macrophage (± s)
The impact of table 8 trial target on NK cells in mice activity (± s)
From table 7 table 8, with control group comparison, the middle dosage of trial target and high dose are significantly improved to mouse macrophage phagocytic index and NK cells in mice activity, and difference has conspicuousness, show trial target compatibility composition synergy obviously, there is the effect of enhanced machine body immunity function.
Claims (1)
1. polypeptide factor and Chinese herbal medicine extract are prepared a method for health food, and it is made up its feature of following component raw material: 1-3kg pig spleen polypeptide, 6-16kg Radix Glycyrrhizae, hawthorn and dried orange peel extracts, 180-210kg oligomeric polysaccharide, all the other are water; Its step of preparation process is as follows:
1) preparation of hawthorn, Radix Glycyrrhizae, dried orange peel mixed extract: hawthorn, Radix Glycyrrhizae, dried orange peel are pulverized, then add decocting to boil, filter and remove residue obtains filtrate, adopt ultrafiltration apparatus filtrate is carried out to ultrafiltration concentration to obtain extracts of Chinese herbal medicine, inspection extracts of Chinese herbal medicine also calculates the content of Chinese herbal medicine extract;
2) pig spleen polypeptide preparation: choose fresh pig spleen and roughly grind, fine grinding obtains slurry again, continuous stirring makes its homogeneous, under the condition of-15 DEG C to the slurry after homogeneous freezing 72 hours, the filter residue that thaws afterwards obtains filtrate, with obtaining pig spleen polypeptide extract in Hollow Fiber Ultrafiltration pipe ultrafiltration gained filtrate, the concentrated pig spleen polypeptide concentrate that obtains, the content of pig spleen polypeptide in inspection pig spleen polypeptide concentrate;
3) batching: take 1-3kg pig spleen polypeptide, 6-16kg Radix Glycyrrhizae, hawthorn, dried orange peel extracts, 180-210kg oligomeric polysaccharide, wherein pig spleen polypeptide converts by the content in pig spleen polypeptide concentrate, it is actual that what take is pig spleen polypeptide concentrate, Radix Glycyrrhizae, hawthorn, dried orange peel extracts convert by the content in extract, and actual what take is Radix Glycyrrhizae, hawthorn, dried orange peel extract; Each component is evenly mixed, remove unnecessary water and regulate gross weight to 270kg, be then heated to 95-100 DEG C of insulation sterilization 30min, transfer in storage tank after being cooled to 60-70 DEG C temporary;
4) filtration, sterilization, dry and packaging: the batching that inspection prepares, use 100 screen filtrations as qualified, then use Semi-automatic liquid filling machine filling and sealing, be heated to afterwards 95-100 DEG C of insulation 30min sterilization, then use hot water injection, temporary drying afterwards, finally packaging sampling inspection, warehouse-in is up to the standards.
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