CN103597574B - 通过高速喷雾与靶材互相作用的大气压离子源 - Google Patents

通过高速喷雾与靶材互相作用的大气压离子源 Download PDF

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Publication number
CN103597574B
CN103597574B CN201280027496.0A CN201280027496A CN103597574B CN 103597574 B CN103597574 B CN 103597574B CN 201280027496 A CN201280027496 A CN 201280027496A CN 103597574 B CN103597574 B CN 103597574B
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China
Prior art keywords
ion
target
droplet
capillary
guns according
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CN201280027496.0A
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English (en)
Chinese (zh)
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CN103597574A (zh
Inventor
斯特万·巴伊奇
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Micromass UK Ltd
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Micromass UK Ltd
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Priority claimed from GBGB1106694.1A external-priority patent/GB201106694D0/en
Priority claimed from GBGB1204937.5A external-priority patent/GB201204937D0/en
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Publication of CN103597574A publication Critical patent/CN103597574A/zh
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/7273—Desolvation chambers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/061—Ion deflecting means, e.g. ion gates
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/142—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using a solid target which is not previously vapourised
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/24—Vacuum systems, e.g. maintaining desired pressures
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CN201280027496.0A 2011-04-20 2012-04-20 通过高速喷雾与靶材互相作用的大气压离子源 Active CN103597574B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB1106694.1A GB201106694D0 (en) 2011-04-20 2011-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target
GB1106694.1 2011-04-20
US201161478725P 2011-04-25 2011-04-25
US61/478,725 2011-04-25
GBGB1204937.5A GB201204937D0 (en) 2012-03-21 2012-03-21 Atomspheric pressure ion source by interacting high velocity spray with a target
GB1204937.5 2012-03-21
US201261614734P 2012-03-23 2012-03-23
US61/614,734 2012-03-23
PCT/GB2012/050888 WO2012143737A1 (en) 2011-04-20 2012-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target

Publications (2)

Publication Number Publication Date
CN103597574A CN103597574A (zh) 2014-02-19
CN103597574B true CN103597574B (zh) 2016-09-07

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CN201280027496.0A Active CN103597574B (zh) 2011-04-20 2012-04-20 通过高速喷雾与靶材互相作用的大气压离子源

Country Status (7)

Country Link
US (3) US8809777B2 (enExample)
EP (2) EP2700086B1 (enExample)
JP (1) JP6080311B2 (enExample)
CN (1) CN103597574B (enExample)
CA (1) CA2833675C (enExample)
GB (1) GB2499681B (enExample)
WO (1) WO2012143737A1 (enExample)

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US10777398B2 (en) 2015-03-06 2020-09-15 Micromass Uk Limited Spectrometric analysis
KR102158736B1 (ko) * 2015-03-06 2020-09-23 마이크로매스 유케이 리미티드 개선된 이온화용 충돌 표면
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GB2551669B (en) 2015-03-06 2021-04-14 Micromass Ltd Physically guided rapid evaporative ionisation mass spectrometry ("Reims")
DE102016007402A1 (de) 2015-06-23 2016-12-29 Dionex Corporation Verfahren und systeme zur erkennung von nichtflüchtigen gelösten stoffen
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
WO2017178833A1 (en) 2016-04-14 2017-10-19 Micromass Uk Limited Spectrometric analysis of plants
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GB2567793B (en) * 2017-04-13 2023-03-22 Micromass Ltd A method of fragmenting and charge reducing biomolecules
GB201721700D0 (en) * 2017-12-22 2018-02-07 Micromass Ltd Ion source
GB201807914D0 (en) * 2018-05-16 2018-06-27 Micromass Ltd Impactor spray or electrospray ionisation ion source
EP3951379B1 (en) * 2019-05-24 2023-11-22 National Institute Of Advanced Industrial Science And Technology Spray ionization device, analysis device, and surface coating device
JP7186471B2 (ja) 2019-07-31 2022-12-09 国立研究開発法人産業技術総合研究所 スプレーイオン化装置、分析装置および表面塗布装置
GB201915843D0 (en) * 2019-10-31 2019-12-18 Micromass Ltd Ion source
JP7249064B2 (ja) 2020-02-03 2023-03-30 国立研究開発法人産業技術総合研究所 スプレーイオン化装置
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Also Published As

Publication number Publication date
US20150155151A1 (en) 2015-06-04
EP3582251B1 (en) 2020-12-16
US8809777B2 (en) 2014-08-19
EP2700086A1 (en) 2014-02-26
US9082603B2 (en) 2015-07-14
CA2833675C (en) 2019-01-15
EP2700086B1 (en) 2019-09-11
GB201207004D0 (en) 2012-06-06
US20140339420A1 (en) 2014-11-20
EP3582251A1 (en) 2019-12-18
US8921777B2 (en) 2014-12-30
JP2014515831A (ja) 2014-07-03
CA2833675A1 (en) 2012-10-26
WO2012143737A1 (en) 2012-10-26
GB2499681A (en) 2013-08-28
JP6080311B2 (ja) 2017-02-15
GB2499681B (en) 2016-02-10
US20140151547A1 (en) 2014-06-05
CN103597574A (zh) 2014-02-19

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