GB2499681B - Atmospheric pressure ion source by interacting high velocity spray with a target - Google Patents

Atmospheric pressure ion source by interacting high velocity spray with a target

Info

Publication number
GB2499681B
GB2499681B GB1207004.1A GB201207004A GB2499681B GB 2499681 B GB2499681 B GB 2499681B GB 201207004 A GB201207004 A GB 201207004A GB 2499681 B GB2499681 B GB 2499681B
Authority
GB
United Kingdom
Prior art keywords
target
atmospheric pressure
ion source
high velocity
pressure ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1207004.1A
Other languages
English (en)
Other versions
GB201207004D0 (en
GB2499681A (en
Inventor
Stevan Bajic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1106694.1A external-priority patent/GB201106694D0/en
Priority claimed from GBGB1204937.5A external-priority patent/GB201204937D0/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Publication of GB201207004D0 publication Critical patent/GB201207004D0/en
Publication of GB2499681A publication Critical patent/GB2499681A/en
Application granted granted Critical
Publication of GB2499681B publication Critical patent/GB2499681B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/7273—Desolvation chambers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/061—Ion deflecting means, e.g. ion gates
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/142—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using a solid target which is not previously vapourised
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/24—Vacuum systems, e.g. maintaining desired pressures
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
GB1207004.1A 2011-04-20 2012-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target Active GB2499681B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1106694.1A GB201106694D0 (en) 2011-04-20 2011-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target
GBGB1204937.5A GB201204937D0 (en) 2012-03-21 2012-03-21 Atomspheric pressure ion source by interacting high velocity spray with a target

Publications (3)

Publication Number Publication Date
GB201207004D0 GB201207004D0 (en) 2012-06-06
GB2499681A GB2499681A (en) 2013-08-28
GB2499681B true GB2499681B (en) 2016-02-10

Family

ID=46261648

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1207004.1A Active GB2499681B (en) 2011-04-20 2012-04-20 Atmospheric pressure ion source by interacting high velocity spray with a target

Country Status (7)

Country Link
US (3) US8809777B2 (enExample)
EP (2) EP2700086B1 (enExample)
JP (1) JP6080311B2 (enExample)
CN (1) CN103597574B (enExample)
CA (1) CA2833675C (enExample)
GB (1) GB2499681B (enExample)
WO (1) WO2012143737A1 (enExample)

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US10429366B2 (en) 2014-05-28 2019-10-01 Dionex Corporation Methods and systems for detection of non-volatile solutes

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US9305761B2 (en) 2013-08-14 2016-04-05 Waters Technologies Corporation Ion source for mass spectrometer and method of producing analyte ion stream
US9768004B2 (en) * 2013-11-26 2017-09-19 Waters Technologies Corporation Systems, devices, and methods for connecting a chromatography system to a mass spectrometer
US9953819B2 (en) 2014-02-26 2018-04-24 Micromass Uk Limited Impactor spray atmospheric pressure ion source with target paddle
DE112015000977B4 (de) 2014-02-26 2023-05-17 Micromass Uk Limited Umgebungsionisation mit einer Impaktorsprayquelle
GB201403370D0 (en) * 2014-02-26 2014-04-09 Micromass Ltd Impactor spray atmospheric pressure ion source with target paddle
WO2015132579A1 (en) * 2014-03-04 2015-09-11 Micromass Uk Limited Sample introduction system for spectrometers
JP6368254B2 (ja) * 2015-01-28 2018-08-01 花王株式会社 脂質の網羅的解析方法
US11139156B2 (en) 2015-03-06 2021-10-05 Micromass Uk Limited In vivo endoscopic tissue identification tool
EP3726562B1 (en) 2015-03-06 2023-12-20 Micromass UK Limited Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue
WO2016142679A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Chemically guided ambient ionisation mass spectrometry
WO2016142681A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Spectrometric analysis of microbes
GB2556436B (en) 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
WO2016142691A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of swabs and biopsy samples
US10777398B2 (en) 2015-03-06 2020-09-15 Micromass Uk Limited Spectrometric analysis
KR102158736B1 (ko) * 2015-03-06 2020-09-23 마이크로매스 유케이 리미티드 개선된 이온화용 충돌 표면
GB2554202B (en) 2015-03-06 2021-08-18 Micromass Ltd Imaging guided ambient ionisation mass spectrometry
GB2556994B (en) 2015-03-06 2021-05-12 Micromass Ltd Identification of bacterial strains in biological samples using mass spectrometry
EP3265797B1 (en) 2015-03-06 2022-10-05 Micromass UK Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("reims") device
CA2978048A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Liquid trap or separator for electrosurgical applications
KR102017409B1 (ko) * 2015-03-06 2019-10-21 마이크로매스 유케이 리미티드 기체성 샘플의 개선된 이온화 방법
GB2551669B (en) 2015-03-06 2021-04-14 Micromass Ltd Physically guided rapid evaporative ionisation mass spectrometry ("Reims")
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
WO2017178833A1 (en) 2016-04-14 2017-10-19 Micromass Uk Limited Spectrometric analysis of plants
GB2563194B (en) 2016-04-21 2020-08-05 Waters Technologies Corp Dual mode ionization device
GB2567793B (en) * 2017-04-13 2023-03-22 Micromass Ltd A method of fragmenting and charge reducing biomolecules
GB201721700D0 (en) * 2017-12-22 2018-02-07 Micromass Ltd Ion source
GB201807914D0 (en) * 2018-05-16 2018-06-27 Micromass Ltd Impactor spray or electrospray ionisation ion source
EP3951379B1 (en) * 2019-05-24 2023-11-22 National Institute Of Advanced Industrial Science And Technology Spray ionization device, analysis device, and surface coating device
JP7186471B2 (ja) 2019-07-31 2022-12-09 国立研究開発法人産業技術総合研究所 スプレーイオン化装置、分析装置および表面塗布装置
GB201915843D0 (en) * 2019-10-31 2019-12-18 Micromass Ltd Ion source
JP7249064B2 (ja) 2020-02-03 2023-03-30 国立研究開発法人産業技術総合研究所 スプレーイオン化装置
EP4086935B1 (en) 2020-03-11 2025-02-26 National Institute Of Advanced Industrial Science and Technology Spray ionization device, analysis device, and surface coating device
CN113217247B (zh) * 2021-06-01 2022-04-29 哈尔滨工程大学 一种柴油机多次喷射喷雾贯穿距预测方法

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JPS59153164A (ja) * 1983-02-21 1984-09-01 Jeol Ltd 液体クロマトグラフ質量分析装置
JPH10267806A (ja) * 1997-03-27 1998-10-09 Jeol Ltd 超音波霧化装置
JPH1151902A (ja) * 1997-08-05 1999-02-26 Jeol Ltd Ｌｃ／ｍｓインターフェイス
JP2002190272A (ja) * 2000-12-21 2002-07-05 Jeol Ltd エレクトロスプレー・イオン源
US20030119193A1 (en) * 2001-04-25 2003-06-26 Robert Hess System and method for high throughput screening of droplets
GB2394830A (en) * 2002-08-19 2004-05-05 Jeol Ltd Electrospray mass spectrometer
US20060145089A1 (en) * 2002-10-10 2006-07-06 Universita' Degli Studi Di Milano Ionization source for mass spectrometry analysis
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10429366B2 (en) 2014-05-28 2019-10-01 Dionex Corporation Methods and systems for detection of non-volatile solutes

Also Published As

Publication number Publication date
US20150155151A1 (en) 2015-06-04
EP3582251B1 (en) 2020-12-16
US8809777B2 (en) 2014-08-19
EP2700086A1 (en) 2014-02-26
US9082603B2 (en) 2015-07-14
CA2833675C (en) 2019-01-15
EP2700086B1 (en) 2019-09-11
GB201207004D0 (en) 2012-06-06
US20140339420A1 (en) 2014-11-20
EP3582251A1 (en) 2019-12-18
US8921777B2 (en) 2014-12-30
JP2014515831A (ja) 2014-07-03
CA2833675A1 (en) 2012-10-26
WO2012143737A1 (en) 2012-10-26
GB2499681A (en) 2013-08-28
CN103597574B (zh) 2016-09-07
JP6080311B2 (ja) 2017-02-15
US20140151547A1 (en) 2014-06-05
CN103597574A (zh) 2014-02-19

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